Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Application of C6H6BrN.
Mowbray, Charles E.;Braillard, Stephanie;Glossop, Paul A.;Whitlock, Gavin A.;Jacobs, Robert T.;Speake, Jason;Pandi, Bharathi;Nare, Bakela;Maes, Louis;Yardley, Vanessa;Freund, Yvonne;Wall, Richard J.;Carvalho, Sandra;Bello, Davide;Van den Kerkhof, Magali;Caljon, Guy;Gilbert, Ian H.;Corpas-Lopez, Victoriano;Lukac, Iva;Patterson, Stephen;Zuccotto, Fabio;Wyllie, Susan research published 《 DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis》, the research content is summarized as follows. Visceral leishmaniasis (VL) is a parasitic disease endemic across multiple regions of the world and is fatal if untreated. Current therapies are unsuitable, and there is an urgent need for safe, short-course, and low-cost oral treatments to combat this neglected disease. The benzoxaborole chemotype has previously delivered clin. candidates for the treatment of other parasitic diseases. Here, we describe the development and optimization of this series, leading to the identification of compounds with potent in vitro and in vivo antileishmanial activity. The lead compound (DNDI-6148) combines impressive in vivo efficacy (>98% reduction in parasite burden) with pharmaceutical properties suitable for onward development and an acceptable safety profile. Detailed mode of action studies confirm that DNDI-6148 acts principally through the inhibition of Leishmania cleavage and polyadenylation specificity factor (CPSF3) endonuclease. As a result of these studies and its promising profile, DNDI-6148 has been declared a preclin. candidate for the treatment of VL.
5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., Application of C6H6BrN