Day: October 28, 2022

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Name: Pyridine-3-sulfonyl chloride.

Song, Mengmeng;Zhang, Zhiguo;Zheng, Dan;Li, Xiang;Liang, Rui;Zhao, Xu-na;Shi, Lei;Zhang, Guisheng research published 《 Hypervalent organoiodine promoted dearylation reaction of N-aryl sulfonamides》, the research content is summarized as follows. An efficient Dess-Martin periodinane (DMP)-promoted dearylation of N-arylsulfonamides RS(O)₂NHR¹ (R = Ph, 2-naphthyl, 2-thienyl, etc.; R¹ = quinolin-8-yl, 2-methylphenyl, 4-methylbenzyl, etc.) was developed through a highly selective oxidative cleavage of the inert C (aryl)-N bonds in secondary sulfonamides while leaving the S-N bond unchanged. This metal-free reaction proceeds under mild conditions and provides access to various biol. important primary sulfonamides, some of which are otherwise unattainable using conventional aminolysis and hydrolysis methods. The concise and efficient dearylation reaction provides the use of an aryl group as a removable protecting sulfonamide group under metal catalyst-free conditions.

Name: Pyridine-3-sulfonyl chloride, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Reference of 16133-25-8.

Song, Fan;Shao, Xiaotao;Zhu, Jing;Bao, Xiaofeng;Du, Lei;Kan, Chun research published 《 Reversible “turn-off-on” fluorescence response of Fe(III) towards Rhodamine B based probe in vivo and plant tissues》, the research content is summarized as follows. A Fe³⁺-specific probe (N-TC)(I) based on Rhodamine B was designed and synthesized. N-TC has a good spectral response to Fe³⁺ in the EtOH/H₂O solution (1:1, volume/volume, HEPES, 0.5 mM, pH = 7.38) with low detection limits and high binding constants N-TC displays the reversible “turn-off-on” fluorescence response with 1:1 binding stoichiometry. It is further proven to be practical in sensitively monitoring trace Fe³⁺ in environmental water specimens. Biol. experiments demonstrated that N-TC can be resp. used as a probe for detection of Fe³⁺ in living cells, animals and plant tissues.

16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Reference of 16133-25-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Electric Literature of 16133-25-8.

Song, Fan;Yang, Chao;Shao, Xiaotao;Du, Lei;Zhu, Jing;Kan, Chun research published 《 A reversible “turn-off-on” fluorescent probe for real-time visualization of mercury(II) in environmental samples and its biological applications》, the research content is summarized as follows. In this study, we synthesized a novel fluorescent probe (S-TC) based on Thiooxo-Rhodamine B. In the design of the probe, we sulfided carbonyl groups of rhodamine spironolactam to thiocarbonyl groups. C=S functional group was used as a recognition group for Hg²⁺. S-TC has a good spectral response to Hg²⁺ in the EtOH/H₂O solution (1:1, volume/volume) with low detection limits and high binding constants The detection limit and the association constant was calculated as 0.077 μM and 1.70 × 10⁴ M^-1, resp. S-TC displayed the traditional reversible “turn-off-on” fluorescence change with 1:1 binding stoichiometry. It is feasible to detect Hg²⁺ in real environmental water by S-TC. Biol. experiments demonstrated that S-TC can be used to detect to Hg²⁺ in living cells, animals and plant tissues.

16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Electric Literature of 16133-25-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. Formula: C5H3BrFN.

Song, A-Xiang;Zeng, Xiao-Xiao;Ma, Bei-Bei;Xu, Chang;Liu, Feng-Shou research published 《 Direct (Hetero)arylation of Heteroarenes Catalyzed by Unsymmetrical Pd-PEPPSI-NHC Complexes under Mild Conditions》, the research content is summarized as follows. With the aim of developing a facile and efficient method to access structurally intriguing and valuable functionalized (hetero)aryls, two unsym. Pd-PEPPSI-type NHC complexes (PEPPSI, pyridine-enhanced precatalyst preparation, stabilization, and initiation; NHC, N-heterocyclic carbene) were designed and synthesized to catalyze the direct arylation of heteroarenes with (hetero)aryl bromides. The use of this unsym. strategy led to much higher efficiency in comparison to the commonly used C₂-sym. Pd-PEPPSI-type NHC complexes. Also, a broad range of heteroaromatics and (hetero)aryl bromide partners with a wide variety of functional groups were all amenable to the developed protocol even at ≥0.05 mol % catalyst loading and under aerobic conditions. More importantly, along with the authors’ study, also the present protocol could provide expedient access to the gram-scale synthesis of the muscle relaxant drug dantrolene and conjugated mesopolymers.

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Formula: C5H3BrFN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Related Products of 5315-25-3.

Solea, Atena B.;Wang, Sining;Xue, Xiao-Song;Crochet, Aurelien;Fromm, Katharina M.;Houk, Kendall N.;Mamula, Olimpia;Allemann, Christophe research published 《 Efficient synthesis of isoindolones by intramolecular cyclization of pyridinylbenzoic acids》, the research content is summarized as follows. A straightforward one-pot method for the synthesis of unreported pyrido-[2,1-a]isoindolones in excellent yield is described. Two novel isoindolones were synthesized and fully characterized. The alkyl substituents on the pyridine play an important role in the outcome of the reaction. The mechanism, investigated through DFT calculations, features an unprecendented intramol. cyclization reaction involving a carboxylic acid activated by tosyl chloride and an electron-poor pyridinic nitrogen. This protocol completes the known strategies to obtain functionalized isoindolones.

Related Products of 5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. For this reason, pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Application of C6H4BrNO.

So, Haeri;Lee, Minji;Kim, Cheal research published 《 A Unique Thiosemicarbazide-Based Colorimetric Chemosensor for Fe²⁺ in Pure Aqueous Solution with the Lowest Detection Limit》, the research content is summarized as follows. A unique colorimetric chemosensor Hy-bp based on thiosemicarbazide was prepared Hy-bp showed an obvious red-shifted spectrum and unique color change from colorless to deep green only for Fe2+. Detection limit for Fe2+ was 0.34 μM, which is the lowest among those of colorimetric chemosensors previously reported for Fe2+ in pure aqueous solution Hy-bp can be utilized in paper strips and water samples as a colorimetric sensor for detecting Fe2+. The sensing mechanism of Hy-bp for Fe2+ was demonstrated by UV-vis spectroscopy, Job plot, FT-IR and 1H NMR titrations

31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., Application of C6H4BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Quality Control of 31181-90-5.

So, Haeri;Lee, Hangyul;Kim, Cheal research published 《 A heterocyclic-based bifunctional sensor for detecting cobalt and zinc ion》, the research content is summarized as follows. A new bifunctional chemosensor HBP ((E)-2-(2-((5-bromopyridin-2-yl)methylene)hydrazinyl) quinoline) based on heterocyclic compounds was designed and studied. The HBP showed successful detecting ability toward cobalt ion with a UV-visible red-shift and a color change of colorless to pink. Moreover, toward zinc ion, the HBP showed an obvious fluorescence turn-on response. The binding ratio of the HBP to cobalt and zinc was a 2 to 1 for both ions. The detection limits were found to be 10 nM for Co²⁺ and 18 nM for Zn²⁺. Based on UV-vis and fluorescent spectral variations, Job plots, ESI-MS, FT-IR and calculations, the binding mechanisms of the HBP toward cobalt and zinc ions were proposed.

Quality Control of 31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Quality Control of 766-11-0.

Smolinski, Michael P.;Bu, Yahao;Clements, James;Gelman, Irwin H.;Hegab, Taher;Cutler, David L.;Fang, Jane W. S.;Fetterly, Gerald;Kwan, Rudolf;Barnett, Allen;Lau, Johnson Y. N.;Hangauer, David G. research published 《 Discovery of Novel Dual Mechanism of Action Src Signaling and Tubulin Polymerization Inhibitors (KX2-391 and KX2-361)》, the research content is summarized as follows. The discovery of potent, peptide site directed, tyrosine kinase inhibitors has remained an elusive goal. Herein we describe the discovery of two such clin. candidates that inhibit the tyrosine kinase Src. Compound 1 is a phase 3 clin. trial candidate that is likely to provide a first in class topical treatment for actinic keratosis (AK) with good efficacy and dramatically less toxicity compared to existing standard therapy. Compound 2 is a phase 1 clin. trial candidate that is likely to provide a first in class treatment of malignant glioblastoma and induces 30% long-term complete tumor remission in animal models. The discovery strategy for these compounds iteratively utilized mol. modeling, along with the synthesis and testing of increasingly elaborated proof of concept compounds, until the final clin. candidates were arrived at. This was followed with mechanism of action (MOA) studies that revealed tubulin polymerization inhibition as the second MOA.

Quality Control of 766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , 766-11-0.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reference of 5315-25-3.

Singh, Reena;Ganguly, Gaurab;Malinkin, Sergey O.;Demeshko, Serhiy;Meyer, Franc;Nordlander, Ebbe;Paine, Tapan Kanti research published 《 A Mononuclear Nonheme Iron(IV)-Oxo Complex of a Substituted N4Py Ligand: Effect of Ligand Field on Oxygen Atom Transfer and C-H Bond Cleavage Reactivity》, the research content is summarized as follows. A mononuclear iron(II) complex [Fe^II(N4Py^Me2)(OTf)](OTf) (1), supported by a new pentadentate ligand, bis(6-methylpyridin-2-yl)-N,N-bis((pyridin-2-yl)methyl)methanamine (N4Py^Me2), has been isolated and characterized. Introduction of Me groups in the 6-position of two pyridine rings makes the N4Py^Me2 a weaker field ligand compared to the parent N4Py ligand. Complex 1 is high-spin in the solid state and converts to [Fe^II(N4Py^Me2)(CH₃CN)](OTf)₂ (1a) in acetonitrile solution The iron(II) complex in acetonitrile displays temperature-dependent spin-crossover behavior over a wide range of temperature In its reaction with m-CPBA or oxone in acetonitrile at -10°, the iron(II) complex converts to an iron(IV)-oxo species, [Fe^IV(O)(N4Py^Me2)]²⁺ (2). Complex 2 exhibits the Moessbauer parameters δ = 0.05 mm/s and ΔE_q = 0.62 mm/s, typical of N-ligated S = 1 iron(IV)-oxo species. The iron(IV)-oxo complex has a half-life of only 14 min at 25° and is reactive toward oxygen-atom-transfer and hydrogen-atom-transfer (HAT) reactions. Compared to the parent complex [Fe^IV(O)(N4Py)]²⁺, 2 is more reactive in oxidizing thioanisole and oxygenates the C-H bonds of aliphatic substrates including that of cyclohexane. The enhanced reactivity of 2 toward cyclohexane results from the involvement of the S = 2 transition state in the HAT pathway and a lower triplet-quintet splitting compared to [Fe^IV(O)(N4Py)]²⁺, as supported by DFT calculations The second-order rate constants for HAT by 2 is well correlated with the C-H bond dissociation energies of aliphatic substrates. Surprisingly, the slope of this correlation is different from that of [Fe^IV(O)(N4Py)]²⁺, and 2 is more reactive only in the case of strong C-H bonds (>86 kcal/mol), but less reactive in the case of weaker C-H bonds. Using oxone as the oxidant, the iron(II) complex displays catalytic oxidations of substrates with low activity but with good selectivity.

Reference of 5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The critical parameters of pyridine are pressure 6.70 MPa, temperature 620 K and volume 229 cm3·mol−1. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. In the temperature range 340–426 °C its vapor pressure p can be described with the Antoine equation.. Electric Literature of 31181-90-5.

Singh, Dharmender;Sharma, Shubham;Kumar, Mukesh;Kaur, Inderpreet;Shankar, Ravi;Pandey, Satyendra Kumar;Singh, Virender research published 《 An AcOH-mediated metal free approach towards the synthesis of bis-carbolines and imidazopyridoindole derivatives and assessment of their photophysical properties》, the research content is summarized as follows. An AcOH-mediated concise, atom-economical and environmentally sustainable tandem strategy was formulated to access highly fluorescent (φ_F up to 40%) bis-carbolines I [R¹ = Me, Et, allyl, Bn, etc.; R² = H, CO₂Me, CO₂Et, CO₂i-Pr], imidazopyrido[3,4-b]indoles II [R³ = H, Me, 2-HOC₆H₄, etc.] and imidazo[1,5-a]pyridines III [R⁴ = H, n-Pr, 2-pyridyl, etc.; R⁵ = H, 5-Br, 6-Br, 7-Cl] via the formation of three C-N bonds in a single operation. The multicomponent character of the reaction, easy to execute reaction conditions, simple purification procedure and excellent light emitting properties of the product afforded thereof provide a huge scope.

Electric Literature of 31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem