Day: October 31, 2022

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. SDS of cas: 766-11-0.

Zhang, Yao;Ma, Jiawei;Chen, Jian;Meng, Lingpu;Liang, Yong;Zhu, Shaolin research published 《 A relay catalysis strategy for enantioselective nickel-catalyzed migratory hydroarylation forming chiral α-aryl alkylboronates》, the research content is summarized as follows. Ligand-controlled reactivity plays an important role in transition-metal catalysis, enabling a vast number of efficient transformations to be discovered and developed. However, a single ligand is generally used to promote all steps of the catalytic cycle (e.g., oxidative addition, reductive elimination), a requirement that makes ligand design challenging and limits its generality, especially in relay asym. transformations. Herein it is hypothesized that multiple ligands with a metal center might be used to sequentially promote multiple catalytic steps, thereby combining complementary catalytic reactivities through a simple combination of simple ligands. With this relay catalysis strategy (L/L*), the first highly regio- and enantioselective remote hydroarylation process is reported. By synergistic combination of a known chain-walking ligand and a simple asym. cross-coupling ligand with the nickel catalyst, enantioenriched α-aryl alkylboronates could be rapidly obtained as versatile synthetic intermediates through this formal asym. remote C(sp³)-H arylation process.

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , SDS of cas: 766-11-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. HPLC of Formula: 5315-25-3.

Zhang, Yan;Xia, Mingze;Li, Min;Ping, Qian;Yuan, Zhenbo;Liu, Xuanzhong;Yin, Huimin;Huang, Shuping;Rao, Yijian research published 《 Energy-transfer-mediated photocatalysis by a bioinspired organic perylene photosensitizer HiBRCP》, the research content is summarized as follows. Energy transfer plays a special role in photocatalysis by utilizing the potential energy of the excited state through indirect excitation, in which a photosensitizer determines the thermodn. feasibility of the reaction. Bioinspired by the energy-transfer ability of natural product Cercosporin, here we developed a green and highly efficient organic photosensitizer HiBRCP (hexaisobutyryl reduced Cercosporin) through structural modification of Cercosporin. After structural manipulation, its triplet energy was greatly improved, and then, it could markedly promote the efficient geometrical isomerization of alkenes from the E-isomer to the Z-isomer. Moreover, it was also effective for energy-transfer-mediated organometallic catalysis, which allowed realization of the cross-coupling of aryl bromides and carboxylic acids through efficient energy transfer from HiBRCP to nickel complexes. Thus, the study on the relationship between structural manipulation and their photophys. properties provided guidance for further modification of Cercosporin, which could be applied to more meaningful and challenging energy-transfer reactions.

5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., HPLC of Formula: 5315-25-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Related Products of 31181-90-5.

Zhang, Yan;Li, Yuhao;Su, Chengyong;Barboiu, Mihail research published 《 Dynameric Frameworks with Aggregation-Induced Emission for Selective Detection of Adenosine Triphosphate》, the research content is summarized as follows. Luminogenic materials with aggregation-induced emission (AIE) have attracted considerable interest for applications. If these systems aggregate, the free rotation of their scaffold is restricted, and as a consequence the photoluminescence increases. Herein, the first exptl. observation of a “dynameric effect” on AIE is described. A comparison is made of the AIE of mol. and dynameric sensors that exhibit non-linear turn-on switching of fluorescence upon their interaction with ATP (ATP). Confirmation was obtained from the enhanced ATP detection with multivalent dynameric networks compared with a mol. sensor. The dynamic, reversible behavior of the imine linkages is critical to produce this enhancement, as a static, imine-reduced, polymeric sensor showed decreased AIE activity. The dynameric frameworks showed selectivity for ATP over ADP, and adenosine monophosphate over guanosine triphosphate or cytidine triphosphate. Together, these results will accelerate the systematic discovery of efficient adaptive biomimetic sensors.

Related Products of 31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. HPLC of Formula: 31181-90-5.

Zhang, Xuan;Nottingham, Kyle G.;Patel, Chirag;Alegre-Requena, Juan V.;Levy, Jeffrey N.;Paton, Robert S.;McNally, Andrew research published 《 Phosphorus-mediated sp²-sp³ couplings for C-H fluoroalkylation of azines》, the research content is summarized as follows. Fluoroalkyl groups profoundly affect the phys. properties of pharmaceuticals and influence almost all metrics associated with their pharmacokinetic and pharmacodynamic profile. Drug candidates increasingly contain trifluoromethyl (CF₃) and difluoromethyl (CF₂H) groups, and the same trend in agrochem. development shows that the effect of fluoroalkylation translates across human, insect and plant life. New fluoroalkylation reactions have undoubtedly stimulated this shift; however, methods that directly convert C-H bonds into C-CF₂X groups (where X is F or H) in complex drug-like mols. are rare. Pyridines are the most common aromatic heterocycles in pharmaceuticals, but only one approach – via fluoroalkyl radicals – is viable for achieving pyridyl C-H fluoroalkylation in the elaborate structures encountered during drug development. Here we develop a set of bench-stable fluoroalkylphosphines that directly convert the C-H bonds in pyridine building blocks, drug-like fragments and pharmaceuticals into fluoroalkyl derivatives No preinstalled functional groups or directing groups are required. The reaction tolerates a variety of sterically and electronically distinct pyridines, and is exclusively selective for the 4-position in most cases. The reaction proceeds through initial formation of phosphonium salts followed by sp²-sp³ coupling of phosphorus ligands – an underdeveloped manifold for forming C-C bonds. Thus, e.g., treatment of 2-phenylpyridine with (fluoroalkyl)phosphine I, Tf₂O and DBU afforded intermediate phosphonium salt (not isolated) which, upon treatment with TfOH, MeOH and water afforded II (89%).

HPLC of Formula: 31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. Computed Properties of 31181-90-5.

Zhang, Xin-Hui;Bo-Wang;Tao, Yuan-Yuan;Ma, Qin;Wang, Hao-Jie;He, Zhang-Xu;Wu, Hui-Pan;Li, Yi-Han;Zhao, Bing;Ma, Li-Ying;Liu, Hong-Min research published 《 Thiosemicarbazone-based lead optimization to discover high-efficiency and low-toxicity anti-gastric cancer agents》, the research content is summarized as follows. A series of thiosemicarbazone derivatives I [R¹ = H, 4-MeO, 2-Br, 3-Br, 4-Br; R² = H, Me, 2-pyridyl, etc.; R³ = 2-furyl, 3-indolyl, 2-pyridyl, etc.; n = 0, 1, 2] containing different aromatic heterocyclic groups was synthesized and the tridentate donor system of the lead compound was optimized. Most of the target compounds I showed improved antiproliferative activity against MGC803 cells. SAR studies revealed that compound I [R¹ = 4-MeO, R² = Me, R³ = 2-pyridyl, n = 0] displayed significant advantages in inhibition effect with an IC₅₀ value of 0.031μM, and better selectivity between cancer and normal cells than 3-AP and DpC (about 15- and 5-fold improved resp.). Besides, compound I [R¹ = 4-MeO, R² = Me, R³ = 2-pyridyl, n = 0] showed selective antiproliferative activity in not only other cancer cells but also different gastric cancer cell lines. In-depth mechanism studies showed that compound I [R¹ = 4-MeO, R² = Me, R³ = 2-pyridyl, n = 0] could induce mitochondria-related apoptosis which might be related to the elevation of intracellular ROS level, and cause cell cycle arrest at S phase. Moreover, compound I [R¹ = 4-MeO, R² = Me, R³ = 2-pyridyl, n = 0] could evidently suppressed the cell migration and invasion by blocking the EMT (epithelial-mesenchymal transition) process. Consequently, our studies provided a lead optimization strategy of thiosemicarbazone derivatives I which would contribute to discover high-efficiency and low-toxicity agents for the treatment of gastric cancer.

Computed Properties of 31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. HPLC of Formula: 31181-90-5.

Zhang, Xiaomeng;Wang, Yazhou;Li, Xue;Wu, Jie;Zhao, Liwen;Li, Wei;Liu, Jian research published 《 Dynamics-Based Discovery of Novel, Potent Benzoic Acid Derivatives as Orally Bioavailable Selective Estrogen Receptor Degraders for ERα+ Breast Cancer》, the research content is summarized as follows. The estrogen receptor α (ERα) is identified as an effective target for the treatment of ERα+ breast cancer; thus, discovery of novel selective estrogen receptor degraders (SERDs) are developed as an effective method to overcome the resistance of breast cancer. Herein, the hot-spot residues for protein-ligand interaction between SERDs and ERα are analyzed by mol. dynamic simulation technol., focusing on the hot-spot residues for four series of designed and synthesized SERDs. SAR studies revealed that while the acrylic acid moiety of AZD9496 is scaffold hopping into benzoic acid, compound D24 exhibits potent binding affinity with ERα, good degradation efficacy of ERα, and inhibitory effect against the MCF-7 breast cancer cell line. Besides, D24 also displays good antitumor efficacy in the MCF-7 human breast cancer xenograft model in vivo, favorable pharmacokinetic properties, excellent druggability, and good safety property, making D24 as a promising drug candidate of SERD for further evaluation.

HPLC of Formula: 31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Formula: C6H6BrN.

Zhang, Shi-Qi;Guo, Bin;Xu, Ze;Li, Hong-Xi;Li, Hai-Yan;Lang, Jian-Ping research published 《 Ligand-controlled phosphine-free Co(II)-catalysed cross-coupling of secondary and primary alcohols》, the research content is summarized as follows. Cobalt(II) complexes (5 mol% Co) bearing phosphine-free N N N pincer ligands efficiently catalyze C-C coupling of secondary and primary alcs. to selectively form α-alkylated ketones with a good functional group compatibility using NaOH (20 mol%) as a base at 120 °C. The NH group on the N N N-Co(II) precatalyst controlled the activity and selectivity. This simple catalytic system was also involved in the synthesis of 2-aryl quinolines, e.g., I, via the dehydrogenative annulation of 2-aminobenzyl alcs. with secondary alcs.

Formula: C6H6BrN, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Recommanded Product: 2-Amino-5-methylpyridine.

Zhang, Ruizhong;Cheng, Jun;Yang, Liuqing;Wong, Jonathan M.;Ralph Adsetts, Jonathan;Wang, Ruiyao;Liu, Jiyan;Ding, Zhifeng;Wang, Hong-Bo research published 《 Optimizing the Electrochemiluminescence of Readily Accessible Pyrido[1,2-α]pyrimidines through “Green” Substituent Regulation》, the research content is summarized as follows. Bright and low-cost emitting organic mols. are very desirable for electrochemiluminescence (ECL). Here, we report a facile one-step, three-component reaction of readily available precursors to synthesize pyrido[1,2-α]pyrimidine derivatives (1-4), all which give off green photoluminescence (PL). In contrast, the electrochem. and ECL properties of these luminophores are affected by the extent of the conjugation and the nature of the peripheral substituents. D. functional theory (DFT) calculations identified the aromatic chain substitution could extend the conjugation of pyrido[1,2-α]pyrimidine core and stabilize the electrogenerated radicals required for generation of an excited state, affording pyrido[1,2-α]pyrimidine 3 the highest ECL activity among the studied samples. ECL in annihilation route confirmed weak emission, but great improvement was made using oxidizing co-reactant species (benzoate radical from benzoyl peroxide, BPO) with an efficiency of 43% relative to that of Ru(bpy)₃(PF₆)₂. The pyrido[1,2-α]pyrimidine 3/BPO system is more robust than those of reducing co-reactant species [tri-n-propylamine radical or 2-(dibutylamino) ethanol radical] and is one of the highest among the reported organic electrochemiluminophores. ECL spectroscopy revealed that the monomeric excited states were the main species to emit light. Their straightforward, one-step, green synthesis, and their structure tunability represent significant advantages in the development of readily accessible dyes for PL and especially ECL applications.

1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, Recommanded Product: 2-Amino-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Safety of 5-Bromopicolinaldehyde.

Zhang, Min;Fan, Shiyong;Zhou, Xinbo;Xie, Fei;Li, Song;Zhong, Wu research published 《 Design, synthesis and biological evaluation of 2-hydrazinyladenosine derivatives as A_2A adenosine receptor ligands》, the research content is summarized as follows. To obtain potential A_2A adenosine receptor agonists, a series of 2-hydrazinyladenosine derivatives were synthesized and assayed for adenosine receptors activity using radioligand binding activity assays. The binding activity of the subtypes was examined, and the structure-activity relationship of this class of compounds at the A_2A receptor was investigated. A fragment-based computer-aided design method was used to modify the 2-position side chain structures with different structural fragments, and the newly generated mols. were docked to the A_2A receptor to assess scoring and screening activity. To synthesize compounds with better scoring activity, the newly synthesized compounds were tested for in vitro receptor binding activity. 2-Hydrazinyladenosine derivatives of 32 new structural types were designed and synthesized, with the most potent adenosine derivative I exhibiting a K_i value of 1.8 nM for A_2AAR and significant selectivity for the A_2A receptor compared to the A₁ receptor. In addition to, other compounds also exhibited potent A_2A receptor selectivity, with Ki values for the A_2A receptor of 6.4, 20, 67 and 6.3 nM, resp. We also found that compound II has a high A₁ receptor selectivity, with a K_i value for the A₁ receptor of 4.5 nM. Further functional assays also demonstrated that these compounds have potent A_2A receptor agonist activity. The study shows the applicability of an in silico fragment-based mol. design for rational lead optimization in A_2AAR.

Safety of 5-Bromopicolinaldehyde, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. HPLC of Formula: 16133-25-8.

Zhang, Mao-feng;Luo, Xiao-yu;Zhang, Cheng;Wang, Chao;Wu, Xi-shan;Xiang, Qiu-ping;Xu, Yong;Zhang, Yan research published 《 Design, synthesis and pharmacological characterization of N-(3-ethylbenzo[d]isoxazol-5-yl) sulfonamide derivatives as BRD4 inhibitors against acute myeloid leukemia》, the research content is summarized as follows. BRD4 plays a key role in the regulation of gene transcription and has been identified as an attractive target for cancer treatment. In this study, we designed 26 new compounds by modifying 3-ethyl-benzo[d]isoxazole core with sulfonamides. Most compounds exhibited potent BRD4 binding activities with ΔT_m values exceeding 6 °C. Two crystal structures of N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-2methoxybenzenesulfonamide and N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide in complex with BRD4(1) were obtained to characterize the binding patterns. Compounds N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-2methoxybenzenesulfonamide and N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide were effective for BRD4(1) binding and showed remarkable anti-proliferative activity against MV4-11 cells with IC₅₀ values of 0.78 and 0.87 μM. Furthermore, N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide (0.5-10 μM) concentration-dependently inhibited the expression levels of oncogenes including c-Myc and CDK6 in MV4-11 cells. Moreover, N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide (0.5-10 μM) concentration-dependently blocked cell cycle in MV4-11 cells at G₀/G₁ phase and induced cell apoptosis. Compound N-(3-Ethyl-6-methoxybenzo[d]isoxazol-5-yl)-4methoxybenzenesulfonamide may serve as a new lead compound for further drug development.

16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., HPLC of Formula: 16133-25-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem