Day: October 31, 2022

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Application of C6H6BrN.

Yeung, Chi-Fung;Chung, Lai-Hon;Tse, Sheung-Ying;Shek, Hau-Lam;Tse, Man-Kit;Yiu, Shek-Man;Wong, Chun-Yuen research published 《 Conventional and unconventional alkyne activations by Ru and Os for unprecedented dimetalated quinolizinium complexes》, the research content is summarized as follows. Two types of unexpected quinolizinium complexes were obtained from the reactions between pyridine-functionalized propargylic alc. HCCC(OH)(Ph)(CH₂(2-py)) (L1) and cis-[M(L-L)₂Cl₂] (M = Ru, Os; L-L = 1,1-bis(diphenylphosphino)methane (dppm), 2,2′-bipyridine (bpy)). Their mol. structures revealed that L1 can be activated by Ru and Os via the conventional vinylidene-involving or unconventional nonvinylidene-involving pathways.

Application of C6H6BrN, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., 5315-25-3.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

At 25 °C pyridine has a viscosity of 0.88 mPa/s and thermal conductivity of 0.166 W·m−1·K−1. 766-11-0, formula is C5H3BrFN, Name is 5-Bromo-2-fluoropyridine. The enthalpy of vaporization is 35.09 kJ·mol−1 at the boiling point and normal pressure.The enthalpy of fusion is 8.28 kJ·mol−1 at the melting point. Application of C5H3BrFN.

Ye, Pengqing;Shao, Yinlin;Zhang, Fangjun;Zou, Jinxuan;Ye, Xuanzeng;Chen, Jiuxi research published 《 Rare-Earth-Metal-Catalyzed Synthesis of Azaindolines and Naphthyridines via C-H Cyclization of Functionalized Pyridines》, the research content is summarized as follows. A rare-earth-metal-catalyzed insertion of a 2-pyridine C(sp²)-H bond into an intramol. unactivated vinyl bond was reported. This reaction provides streamlined access to a range of azaindolines in moderate to excellent yields. The salient features of this reaction include simple and mild reaction conditions, 100% atom efficiency, and wide substrate scope. This methodol. is also used to construct other nitrogen-containing compounds such as naphthyridine derivatives A plausible mechanism for the formation of azaindolines involving initial C-H bond activation by the lanthanide complex followed by C=C insertion into a Ln-C bond to form an alkyl lanthanide species that subsequently undergoes cyclization was proposed.

766-11-0, 5-Bromo-2-fluoropyridine is a useful research compound. Its molecular formula is C5H3BrFN and its molecular weight is 175.99 g/mol. The purity is usually 95%.
5-Bromo-2-fluoropyridine is a boronic acid that has been shown to react with iodides and form 5-bromo-2-fluoroiodobenzene. The reaction of 5-bromo-2-fluoropyridine with benzene gives the same product as the reaction with 1,3,5-trioxane. The UV absorption of 5-bromo-2-fluoropyridine is found at 230 nm and 260 nm. It also has an absorption band in the infrared region at 1625 cm−1. Vibrational progressions have been observed for this molecule, which are due to dipole moments and electron density distributions in the molecule.
5-bromo-2-fluoropyridine is used in the synthesis of heteroaromatic and aniline derivatives of piperidines as potent ligands used for vesicular acetylcholine transport. , Application of C5H3BrFN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 5315-25-3, formula is C6H6BrN, Name is 2-Bromo-6-methylpyridine. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Synthetic Route of 5315-25-3.

Yazdani, Sima;Silva, Braden E.;Cao, Thomas C.;Rheingold, Arnold L.;Grotjahn, Douglas B. research published 《 X-ray crystallography and electrochemistry reveal electronic and steric effects of phosphine and phosphite ligands in complexes Ru^II(κ⁴-bda)(PR₃)₂ and Ru^II(κ³-bda)(PR₃)₃ (bda = 2,2′-bipyridine-6,6′-dicarboxylato)》, the research content is summarized as follows. The authors have examined coordination of PR₃ = triphenylphosphine, triethylphosphine, triisopropyl phosphite, tri-Me phosphite, and 1,3,5-triaza-7-phosphaadamantane (PTA) to the fragment Ru^II(bda) to better understand how different phosphine and phosphite ligands influence the electronic and structural properties of the Ru^II complexes. PTA and P(OMe)₃ afforded complexes with three phosphorus ligands bound to Ru, with the bda being tridentate (κ³-N,N,O) in complexes 4 and 5; for the other three phosphorus ligands, even in the presence of >2 equiv, only Ru^II(κ⁴-bda)(PR₃)₂ species 1–3 were seen. Both exptl. and computational methods were used to study the complexes. Steric effects are the main factor determining whether bis- or tris(PR₃) complexes are formed. Cyclic voltammetry studies of the complexes revealed an increase in Ru^III/II potential upon having another phosphorus ligand in the equatorial position. Computational studies predict that the addnl. phosphine ligand in the equatorial plane of 4 engages in significant orbital mixing with the ruthenium center that results in lower energy bonding as compared to the axial phosphine ligands. This work provides the first evaluation of phosphorus ligand steric and electronic effects on the Ru^II(bda) fragment.

5315-25-3, 2-Bromo-6-methylpyridine (2BMPy) is a bromopyridine derivative. It is formed when 2-chloro-6-methylpyridine is heated with bromotrimethylsilane. Its synthesis from various methods have been reported.
2-Bromo-6-methylpyridine is a building block in the preparation of nitrogen containing heterocyclic compounds.
2-Bromo-6-methylpyridine is an organic compound that belongs to the group of pyridinium halides. It is soluble in common solvents such as water, ethanol, and acetone. 2BMPy has been shown to act as a glutamate receptor antagonist and has been used in the study of glutamate receptors, including their subtypes. This chemical has also been shown to have antioxidant properties and can be used in the prevention of atherosclerosis., Synthetic Route of 5315-25-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine has a conjugated system of six π electrons that are delocalized over the ring. 1603-41-4, formula is C6H8N2, Name is 2-Amino-5-methylpyridine. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Computed Properties of 1603-41-4.

Yao, Hua;Zhong, Xiaoyang;Wang, Bingqing;Lin, Sen;Yan, Zhaohua research published 《 Cyanomethylation of the Benzene Rings and Pyridine Rings via Direct Oxidative Cross-Dehydrogenative Coupling with Acetonitrile》, the research content is summarized as follows. A novel and efficient approach for the amine-directed dehydrogenative C(sp₂)-C(sp₃) coupling of arylamines RNH₂ (R = Ph, 5-chloropyridin-2-yl, pyrazin-2-yl, etc.) with acetonitrile was reported by using FeCl₂ as the catalyst. Arylamines react with inactive acetonitrile to form the corresponding arylacetonitriles R¹CH₂CN (R¹ = 2-amino-5-chloropyridin-3-yl, 2-aminophenyl, 6-amino-1,3-benzothiazol-7-yl, etc.) in moderate to good yields. This protocol features nontoxic iron catalysis, efficient atom economy, nonprefunctionalized starting materials, good regioselectivity, and excellent compatibility of functional groups and aromatic rings, providing a novel, straightforward, and green approach toward arylacetonitriles.

Computed Properties of 1603-41-4, 2-Amino-5-methylpyridine, also known as 2-Amino-5-methylpyridine, is a useful research compound. Its molecular formula is C6H8N2 and its molecular weight is 108.14 g/mol. The purity is usually 95%.
2-Amino-5-methylpyridine is a chemical compound that belongs to the group of methyl ketones. It has a nitrogen atom and an oxygen atom in its structure, which allows it to form hydrogen bonds with other molecules. 2-Amino-5-methylpyridine can be obtained by reacting hydrochloric acid and xanthone in the presence of a base. The compound is highly reactive and has been shown to have antiinflammatory properties. This can be attributed to its ability to inhibit prostaglandin synthesis. 2-Amino-5-methylpyridine also has fluorescence properties that are sensitive to pH changes and can be used as a probe for metal ions. 2-Amino-5-methylpyridine is an organic compound that contains a methyl group, two nitrogen atoms, and one oxygen atom in its chemical structure. This molecule can form hydrogen bonds with other molecules due to its nitrogen atoms and oxygen atom,, 1603-41-4.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Category: pyridine-derivatives.

Yang, Qing;Yan, Xiao-Tong;Feng, Cheng-Tao;Chen, De-Xiang;Yan, Zhong-Zhong;Xu, Kun research published 《 Tandem Strecker/C(sp³)-H amination reactions for the construction of cyanide-functionalized imidazo[1,5-a]pyridines with NH₄SCN as a cyanating agent》, the research content is summarized as follows. An I₂O₅ promoted tandem Strecker/C(sp³)-H amination reaction of pyridine-2-carboxaldehydes, benzylamines and NH₄SCN was reported. This multicomponent reaction that allowed the single-step construction of biol. important cyano-functionalized imidazo[1,5-a]pyridines with mol. diversity was realized for the first time. Moreover, the use of safe and easy-to-handle NH₄SCN as a surrogate cyanating agent made this protocol appealing for potential applications.

Category: pyridine-derivatives, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. TThe standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Recommanded Product: Pyridine-3-sulfonyl chloride.

Yang, Chengbin;Lu, Mingzhu;Chen, Yi;Xiang, Ruiqing;Qiu, Tianze;Jia, Yu;Yang, Yongtai;Liu, Xiaofeng;Deng, Mingli;Ling, Yun;Zhou, Yaming research published 《 Development of anti-breast cancer PI3K inhibitors based on 7-azaindole derivatives through scaffold hopping: Design, synthesis and in vitro biological evaluation》, the research content is summarized as follows. Breast cancer is the cancer with the highest incidence all over the world. Phosphatidylinositol 3-kinase is an important regulator of intracellular signaling pathways, which is frequently mutated and overexpressed in majority of human breast cancers, and the inhibition of PI3K has been considered as a promising approach for the treatment of the cancer. Here, we report our design and synthesis of new 7-azaindole derivatives as PI3K inhibitors through the scaffold hopping strategy. By varying the groups at the 3-position of 7-azaindole, we identified a series of potent PI3K inhibitors, whose antiproliferative activities against two human breast cancer MCF-7 and MDA-MB-231 cell lines were evaluated. Representative derivatives FD2054 and FD2078 showed better activity than BKM120 in antiproliferation, reduced the levels of phospho-AKT and induced cell apoptosis. All these results suggested that FD2054 and FD2078 are potent PI3K inhibitors that could be considered as potential candidates for the development of anticancer agents.

16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., Recommanded Product: Pyridine-3-sulfonyl chloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is colorless, but older or impure samples can appear yellow. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Historically, pyridine was produced from coal tar. SDS of cas: 31181-90-5.

Yang, Chaofu;Feng, Yan;Yang, Xu;Sun, Mingxia;Li, Zhenwang;Liu, Xuan;Lu, Liang;Sun, Xianyu;Zhang, Jiwen;He, Xinhua research published 《 Synthesis and evaluation of 4-(1,3,4-oxadiazol-2-yl)-benzenesulfonamides as potent carbonic anhydrase inhibitors》, the research content is summarized as follows. Human carbonic anhydrases (hCA) I and II are targets for agents treating acute altitude sickness. Twenty-one 4-(1,3,4-oxadiazol-2-yl) benzenesulfonamides were synthesized and screened against these two isoforms. 4-(5-(2,4-Dimethylphenyl)-1,3,4-oxadiazol-2-yl) benzenesulfonamide , 4-(5-(2,3-dichlorophenyl)-1,3,4-oxadiazol-2-yl) benzenesulfonamide, 4-(5-(4-(dimethylamino) phenyl)-1,3,4-oxadiazol-2-yl) benzenesulfonamide, 4-(5-(naphthalen-2-yl)-1,3,4-oxadiazol-2-yl) benzenesulfonamide were more potent against both hCA I and II than clin. drug AAZ. In particular, the value of compound 4-(5-(2,4-dimethylphenyl)-1,3,4-oxadiazol-2-yl) benzenesulfonamide with hCA I (18.08 nM) was over 84-fold more than of AAZ with hCA I. The data of docking simulations were also in accord with the tendency of inhibitive activities. Furthermore, methanesulfonate of 4-(5-(4-(dimethylamino) phenyl)-1,3,4-oxadiazol-2-yl) benzenesulfonamide, showed better anti-hypoxia activity than AAZ in vivo, making it interesting lead compound

SDS of cas: 31181-90-5, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Recommanded Product: Pyridine-3-sulfonyl chloride.

Yang, Cai-Yun;Li, Xia;Liu, Bo;Huang, Guo-Li research published 《 I₂-Promoted Direct C-H Sulfenylation of Isoquinolin-1(2H)-ones with Sulfonyl Chlorides》, the research content is summarized as follows. A simple, efficient, and green method for the iodine-promoted regioselective C-4 sulfenylation of isoquinolin-1(2H)-ones using com. available aryl sulfonyl chlorides as the sulfur source was described under metal- and solvent-free conditions. The reaction proceeded smoothly under simple conditions to obtain 4-arylthioisoquinolin-1(2H)-ones, e.g. I, in moderate to good yields, and showed high regioselectivity, broad substrate scope, and good functional group tolerance. A radical reaction mechanism involving ArS^. radicals as key intermediates is proposed for the present transformation.

Recommanded Product: Pyridine-3-sulfonyl chloride, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. 31181-90-5, formula is C6H4BrNO, Name is 5-Bromopicolinaldehyde. For this reason, pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Application of C6H4BrNO.

Yang, Bo;Yu, Shang-Bo;Zhang, Pan-Qing;Wang, Ze-Kun;Qi, Qiao-Yan;Wang, Xu-Qing;Xu, Xun-Hui;Yang, Hai-Bo;Wu, Zong-Quan;Liu, Yi;Ma, Da;Li, Zhan-Ting research published 《 Self-Assembly of a Bilayer 2D Supramolecular Organic Framework in Water》, the research content is summarized as follows. Accurate control of the layer number of orderly stacked 2D polymers has been an unsettled challenge in self-assembly. Herein we describe the fabrication of a bilayer 2D supramol. organic framework from a monolayer 2D supramol. organic framework in water by utilizing the cooperative coordination of a rod-like bipyridine ligands to zinc porphyrin subunits of the monolayer network. The monolayer supramol. framework is prepared from the co-assembly of an octacationic zinc porphyrin monomer and cucurbit[8]uril (CB[8]) in water through CB[8]-encapsulation-promoted dimerization of 4-phenylpyridiunium subunits that the zinc porphyrin monomer bear. The bilayer 2D supramol. organic framework exhibits structural regularity in both solution and the solid state, which is characterized by synchrotron small-angle X-ray scattering and high-resolution transmission electron microscopic techniques. Atomic force microscopic imaging confirms that the bilayer character of the 2D supramol. organic framework can be realized selectively on the micrometer scale.

Application of C6H4BrNO, 5-Bromopyridine-2-carbaldehyde is a useful research compound. Its molecular formula is C6H4BrNO and its molecular weight is 186.01 g/mol. The purity is usually 95%.

5-Bromopyridine-2-carbaldehyde is a water soluble organic molecule that has been shown to inhibit the mitochondrial respiratory chain. It is a structural analog of the natural substrate for mitochondrial cytochrome c oxidase, 5-aminolevulinic acid. This compound has been shown to be selective against cancer cells and has anti-viral properties. The photophysical properties of 5-bromopyridine-2-carbaldehyde have been studied extensively. The fluorescence quantum yield of this molecule in aqueous solution is 0.06%., 31181-90-5.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridine is a basic heterocyclic organic compound with the chemical formula C5H5N. It is structurally related to benzene, with one methine group (=CH−) replaced by a nitrogen atom. 16133-25-8, formula is C5H4ClNO2S, Name is Pyridine-3-sulfonyl chloride. It is a highly flammable, weakly alkaline, water-miscible liquid with a distinctive, unpleasant fish-like smell. Related Products of 16133-25-8.

Yan, Qiuli;Cui, Wenwen;Song, Xiuyan;Xu, Guiyun;Jiang, Min;Sun, Kai;Lv, Jian;Yang, Daoshan research published 《 Sulfonylation of Aryl Halides by Visible Light/Copper Catalysis》, the research content is summarized as follows. An efficient visible-light-assisted, copper-catalyzed sulfonylation of aryl halides with sulfinates was reported. In this protocol, a single ligand CuI photocatalyst formed in-situ was used in the photocatalytic transformation. Diverse organosulfones were obtained in moderate to good yields. This strategy demonstrated a promising approach toward the synthesis of diverse and useful organosulfones.

Related Products of 16133-25-8, Pyridine-3-sulfonyl chloride is a useful research compound. Its molecular formula is C5H4ClNO2S and its molecular weight is 177.61 g/mol. The purity is usually 95%.
Pyridine-3-sulfonyl chloride is a reagent used in the synthesis of pyrimidine derivatives with anti-proliferative activity against negative breast cancer cells.
Pyridine-3-sulfonyl chloride is a chemical compound that binds to the active site of cytochrome P450 enzymes. It can be used to study the effects of matrix effect on reaction solution. Pyridine-3-sulfonyl chloride has been shown to have an UV absorption spectrum with a maximum at 280 nm and a p450 activity that is proportional to the concentration of human serum. This compound has been shown to inhibit kinase domain in vitro assays, which may have clinical relevance in the treatment of obesity., 16133-25-8.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem