Month: October 2022

Category: pyridine-derivativesIn 2022, Zheng, Shixin;Wang, Dong;Huang, Mindong;Yu, Peng published 《Rapid Generation of Tetrahydropyridines and Tetrahydroquinolines by Dearomative Cyanation/Grignard Addition》. 《Chemistry – An Asian Journal》published the findings. The article contains the following contents:

A rapid, practical and scalable method for the reductant and tansition-metal-free synthesis of a variety of novel 2,4-disubstituted tetrahydropyridines and tetrahydroquinolines was disclosed. The method was based upon dearomative functionalization of pyridines or quinolines to generate amino nitrile intermediates as masked iminium ions, which then react rapidly with various Grignard reagents in complete stereocontrol. To complete the study, the researchers used 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Category: pyridine-derivatives

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Category: pyridine-derivatives《Energetically significant nitrile···nitrile and unconventional C-H···π(nitrile) interactions in pyridine based Ni(II) and Zn(II) coordination compounds: Antiproliferative evaluation and theoretical studies》 was published in 2021. The authors were Das, Amal;Sharma, Pranay;Frontera, Antonio;Verma, Akalesh K.;Barcelo-Oliver, Miquel;Hussain, Sahid;Bhattacharyya, Manjit K., and the article was included in《Journal of Molecular Structure》. The author mentioned the following in the article:

Two new coordination compounds viz. [Ni(2,6-PDC)(Hdmpz)(H₂O)₂]•H₂O (1) and [Zn(3-CNpy)₂Cl₂] (2) (2,6-PDC = 2,6-pyridinedicarboxylate, Hdmpz = 3,5-dimethylpyrazole, 3-CNpy = 3-cyanopyridine) were synthesized and characterized using elemental anal., TGA, electronic, IR spectroscopy and single crystal x-ray diffraction techniques. Crystal structure analyses reveal supramol. assemblies involving interesting dimers with unconventional contacts in the compounds DFT (D. Functional Theory) calculations on the supramol. dimers in the crystal structure of 1 reveal that the sum of contributions of anion-π, π-π and other long range interactions due to the approximation of the bulk monomers is energetically significant. Mol. Electrostatic Potential (MEP) surface and Quantum Theory of Atoms in Mols. (QTAIM) analyses on the interesting supramol. dimers of the crystal structures of 2 reveal unconventional anion···π contacts involving coordinated chlorido ligands and C-H···π(nitrile) interactions involving the π-system of the nitrile moiety of 3-cyanopyridine. Remarkably, Atoms in Mols. anal. also confirms the existence of energetically significant unconventional anti-parallel nitrile···nitrile interaction in the crystal structure of 2. Cell cytotoxicity of the compounds performed in Da’s lymphoma (DL) malignant cancer cell line showed effective potency with negligible cytotoxicity in normal cells (∼12%). Compound 1 has excellent cytotoxic potency with IC₅₀ closer to cisplatin and can bind different biol. targets with similar signaling pathways. Structure activity relation (SAR) analyses of 1 and 2 based on pharmacophore modeling reveal that the mol. features associated with the structures of the compounds play important role in the biol. activities. The experimental procedure involved many compounds, such as 3-Cyanopyridine (cas: 100-54-9) .

3-Cyanopyridine(cas: 100-54-9) is an antimicrobial agent that can be used in the treatment of infectious diseases.Category: pyridine-derivatives It has been shown to be effective against a variety of bacteria, including methicillin-resistant Staphylococcus aureus (MRSA) and Streptococcus pneumoniae.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide《Pharmaceuticals and personal care products in the seawater around a typical subtropical tourist city of China and associated ecological risk》 was published in 2021. The authors were Chen, Hongzhe;Chen, Wenfeng;Guo, Huige;Lin, Hui;Zhang, Yuanbiao, and the article was included in《Environmental Science and Pollution Research》. The author mentioned the following in the article:

Pharmaceuticals and personal care products (PPCPs) in the sea area surrounding a densely populated tourist city in southeastern China were investigated. In total, 32 PPCP pollutants classified into 23 categories were detected. Different spatial distribution patterns of PPCPs indicated possible contamination from runoff and multiple local sources. The labile-to-conservative ratios of PPCPs showed the influence of untreated domestic sewage. In addition, increased concentrations of ciprofloxacin, enrofloxacin, and erythromycin around aquaculture farms imply that aquaculture cannot be neglected as a source. The concentrations of oxytetracycline, ranitidine, ciprofloxacin, miconazole, and sulfamethizole were higher in the wet season than those in the dry season, and the difference in pharmaceutical consumption was suspected to be the main driving factor of this seasonal variation. The risk quotients calculated with the maximum concentrations of miconazole, triclosan, dehydronifedipine, and triclocarban exceeded 0.1, indicating potential moderate or high risks. Antibacterial agents in daily chems. and azole broad-spectrum antifungals were associated with the highest risks in this study; this might be another significant pollution characteristic in the sea area around this subtropical tourist city. And 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) was used in the research process.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Quality Control of 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Related Products of 80-32-0In 2022, Liu, Yuan;Neal, Andrew L.;Zhang, Xiaoxian;Fan, Haiyan;Liu, Honglu;Li, Zhongyang published 《Cropping system exerts stronger influence on antibiotic resistance gene assemblages in greenhouse soils than reclaimed wastewater irrigation》. 《Journal of Hazardous Materials》published the findings. The article contains the following contents:

The effects of reclaimed wastewater (RW) irrigation on the spread of antibiotic resistance genes (ARGs) in soil is modulated by a myriad of biotic and abiotic factors and their relative significance remains vague. We compared microbial communities, assemblages of genes associated with microbial resistance to antibiotics, biocides and metals, and insertion sequences (ISs) in soils following 16 years of irrigation with groundwater (GW), RW or alternately with GW and RW in two greenhouses with different cropping systems, using shotgun metagenome sequencing. The results showed that cropping system exerted greater influence than irrigation on the profile of ISs and resistance genes. This influence was most strongly associated with concentrations of copper, mercury and perfloxacin in the soils. There was no significant difference in soil ARG profiles between continuous RW irrigation and alternating GW and RW irrigation. Proteobacteria, Actinobacteria and Firmicutes and a limited number of ISs were closely associated with the detected ARGs. Most ARGs were found to co-occur with metal and biocide resistance genes through the mechanism of efflux pumps. These findings highlight the significance of understanding and improving crop management in mitigating the dissemination of ARGs in soils irrigated with RW. And 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) was used in the research process.

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) is a sulfonamide antibiotic that is usually used as antibacterial anti-inflammatory drug, which has been applied in the treatment of acute urinary tract infections in childhood.Related Products of 80-32-0Due to its antibiotic activity, this chemical has been selected as an ingredient to prepare antibacterial composition.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Cheng;Li, Yang;Li, Xinyu;Ma, Xupu;Ru, Shuhua;Qiu, Tianlei;Lu, Anxiang published 《Veterinary antibiotics and estrogen hormones in manures from concentrated animal feedlots and their potential ecological risks》 in 2021. The article was appeared in 《Environmental Research》. They have made some progress in their research.Product Details of 80-32-0 The article mentions the following:

The spread of pharmaceutically active chems. (PACs), such as antibiotics and estrogenic hormones from animal manures can pose threats to the ecol. environment. In this work, animal manure samples were collected from 71 concentrated animal feedlots in Northern China and investigated for 24 antibiotics and 4 estrogenic hormones. Results showed that these micropollutants were ubiquitous in manures with the concentration ranges of undetectable (ND)-543,445μg/kg (mean: 44,568μg/kg) for antibiotics and ND-249.8μg/kg (mean: 24.78μg/kg) for estrogens. There was a significant variation in the amounts of PACs in different animal manures. The amounts of antibiotics in manures had following order: swine (83,177μg/kg) μchicken (52,932μg/kg) > beef (37,120μg/kg) > dairy (305μg/kg), while the estrogens in dairy (mean: 39.27μg/kg) and chicken manures (mean: 40.08μg/kg) were higher than those in beef (2.7μg/kg) and swine manures (1.8μg/kg). Based on the estimated farmland application rate of manure, antibiotics and estrogens may cause high ecol. risks to terrestrial organisms according to the risk quotient evaluation. Estrogens could pose a relatively higher risk than antibiotics. The toxicol. effects of antibiotics and estrogens to the terrestrial environment should receive more intensive study. To complete the study, the researchers used 4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide (cas: 80-32-0) .

4-Amino-N-(6-chloropyridazin-3-yl)benzenesulfonamide(cas: 80-32-0) can be introduced in the drinking water to fabricate aqueous liquid formulations for combating bacterial and protozoal in animals.Product Details of 80-32-0 Besides, sulfachloropyridazine associated to tripelennamine hydrocholoride has been demonstrated to function as an anti-stress agent in poultry after vaccinations.

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fan, Weibin;Zhang, Yuan;Li, Yinghua;Zhang, Wei;Huang, Deguang published 《Solvent-Free Strategy for Direct Access to Versatile Quaternary Ammonium Salts with Complete Atom Economy》 in 2022. The article was appeared in 《ChemSusChem》. They have made some progress in their research.Quality Control of 3-Cyanopyridine The article mentions the following:

A solvent-free method for the synthesis of quaternary ammonium salts (QAS) such as 1-(2-Iodo-1-phenylethyl)-4-pyridinium triiodide I [R¹ = Ph, 4-MeC₆H₄, 2-ClC₆H₄, etc.; R² = H, 4-OMe, 4-C(O)OMe, etc.; X = H, N; Y = H, N] by iodoquaternization of alkenes with N-heteroarenes was reported. Its advantages lied in energy-saving and clean production by using iodine as the oxidant and manual grinding the starting materials, together with the complete atom economy and low process mass intensity (PMI) value. Generated QAS converted to pyrroles such as II [R¹ = Ph, 4-MeC₆H₄, 2-ClC₆H₄, etc.; R² = 5-SMe, C(O)Ome, C(O)Ph, etc.]. Demonstrated by 50 examples, the generated QAS was proved to be able to produce valuable chems., such as biol. protease inhibitors, anti-cancer agents, and organic fluorescent materials. And 3-Cyanopyridine (cas: 100-54-9) was used in the research process.

3-Cyanopyridine(cas: 100-54-9) has been shown to have a number of pharmacological effects: it inhibits the production of prostaglandin E2 and nitric oxide in congestive heart failure patients; it prevents the formation of diazonium salt from benzene and nitrogen dioxide; it inhibits the growth of tumor cell lines; and it protects mice from radiation injury by scavenging reactive oxygen species. Quality Control of 3-Cyanopyridine

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Wei, Jun;Liang, Huamin;Ni, Chuanfa;Sheng, Rong;Hu, Jinbo published 《Transition-Metal-Free Desulfinative Cross-Coupling of Heteroaryl Sulfinates with Grignard Reagents》. The research results were published in《Organic Letters》 in 2019.Product Details of 2098851-48-8 The article conveys some information:

A mild cross-coupling reaction of heteroaryl sulfinates with Grignard reagents has been developed under transition-metal-free conditions. This study provides an example of the SO₂^2- as a leaving group in an aromatic system and an effective methodol. for the construction of C-C bond.Sodium 5-(trifluoromethyl)pyridine-2-sulfinate (cas: 2098851-48-8) were involved in the experimental procedure.

N-Arylation of a wide range of NH substrates by reaction with boronic acid in the presence of cupric acetate and either triethylamine or pyridine at room temperature. The reaction works even for poorly nucleophilic substrates such as arylamide. So Sodium 5-(trifluoromethyl)pyridine-2-sulfinate(cas: C6H3F3NNaO2S) can also undergo this reaction.Product Details of 2098851-48-8

Reference:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem