Day: November 2, 2022

On August 4, 2021, Tanaka, Jin; Nagashima, Yuki; Araujo Dias, Antonio Junio; Tanaka, Ken published an article.Formula: C17H20BNO2 The title of the article was Photo-Induced ortho-C-H Borylation of Arenes through In Situ Generation of Rhodium(II) Ate Complexes. And the article contained the following:

Photoinduced in situ “oxidation” of half-sandwich metal complexes to “high-valent” cationic metal complexes has been used to accelerate catalytic reactions. Here, we report the unprecedented photoinduced in situ “reduction” of half-sandwich metal [Rh(III)] complexes to “low-valent” anionic metal [Rh(II)] ate complexes, which facilitate ligand exchange with electron-deficient elements (diboron). This strategy was realized by using a functionalized cyclopentadienyl (CpA3) Rh(III) catalyst we developed, which enabled the basic group-directed room temperature ortho-C-H borylation of arenes. The experimental process involved the reaction of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine(cas: 1349171-28-3).Formula: C17H20BNO2

The Article related to photocatalyzed regioselective borylation arene rhodium ate in situ catalyst, mol structure optimized rhodium complex transition state potential energy, half sandwich rhodium ate complex in situ catalyst borylation and other aspects.Formula: C17H20BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 21, 2021, Arnold, Lee D.; Lopatin, Uri; Keung, Walter published a patent.Synthetic Route of 39919-70-5 The title of the patent was Preparation of peptidomimetics as inhibitors of cysteine proteases for treatment of viral infections including COVID-19. And the patent contained the following:

The invention is related to the preparation of broad spectrum, viral protease inhibitor compounds, e.g., I, comprising a warhead covalently bound to a 3CL protease inhibitor, wherein the inhibitor compound covalently binds to Cys on the protease, and wherein the inhibitor compound is active against multiple such as viruses caliciviruses, picornaviruses and coronaviruses. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease. Thus, I was prepared by Ugi reaction between pyridine-3-carbaldehyde, 4-tert-butylaniline, (2R,4S)-1-tert-butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid and isocyanocyclohexane followed by cleavage of the tert-butoxycarbonyl group in II and treatment with BrCN. Select compounds of the invention were evaluated for their antiviral activity against COVID-19 (nCoV-2019, SARS-CoV2) Mpro in an enzymic assay and against human coronavirus 229E and OC43 in the cytopathic effect assays. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Synthetic Route of 39919-70-5

The Article related to peptidomimetic preparation viral cysteine protease inhibitor viral infection treatment, cysteine protease inhibitor antiviral sarscov2 covid19 mpro peptidomimetic preparation, covid19 treatment peptidomimetic preparation and other aspects.Synthetic Route of 39919-70-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 31, 2021, Si, Xue-Jian; Jia, Jing; Bao, Yu-Liang; Wu, Ya-Pan; Liu, Yunling; Dong, Wen-Wen; Zhao, Jun; Li, Dong-Sheng published an article.Safety of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid The title of the article was Superprotonic conductivity of a 3D anionic metal-organic framework by synergistic effect of guest [Me2NH2]+ cations, water molecules and host carboxylates. And the article contained the following:

A new 3D anionic metal-organic framework material, namely, [Me2NH2]2[Cd3(L)]·2H2O (1, H4L = 2,5′-di(3′,5′-dicarboxylphenyl)pyridine) has been synthesized under solvothermal conditions and characterized by single crystal x-ray diffraction, PXRD, thermogravimetric anal. and proton conduction investigation. In 1, the adjacent Cd(II) ions are joined to form a trinuclear [Cd3(COO)8] secondary building unit (SBU) by eight bridging carboxylate groups of L4- ligands. The trinuclear [Cd3(COO)8] SBUs are connected by L4- ligands into a 3D (4,8)-connected framework with 1D channels. Most interestingly, due to the guest [Me2NH2]+ cations, water mols. and carboxylates sites are lined the pore channels, 1 possesses a remarkable proton conductivity of 1.12 x 10-1 S cm-1 at 60° and 98% RH, which is comparable to com. available Nafion. The mechanism of proton conduction was also well discussed. The experimental process involved the reaction of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid(cas: 1431292-15-7).Safety of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid

The Article related to dicarboxylphenylpyridine cadmium metal organic framework preparation crystal mol structure, superprotonic conductivity three dimensional anionic metal organic framework, synergistic guest cation water mol host carboxylate and other aspects.Safety of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 3, 2001, Makinen, Silja K.; Melcer, Natalia J.; Parvez, Masood; Shimizu, George K. H. published an article.SDS of cas: 636-73-7 The title of the article was Highly selective guest uptake in a silver sulfonate network imparted by a tetragonal to triclinic shift in the solid state. And the article contained the following:

The Ag sulfonate network presented herein, Ag 3-pyridinesulfonate, reversibly and selectively absorbs MeCN while undergoing a major structural rearrangement. The origin of this structural flexibility is a coupling of the weak coordinating ability of the SO3 group with the geometrically pliant Ag(I) center. Single crystal and powder x-ray structures of both the desolvated and solvated forms are presented in addition to the mechanism of their reversible interconversion. A heterogeneous gas chromatog. study showing selective extraction of the MeCN is also presented. Extended solid frameworks which reorder to any extent are not common but the structure presented herein transforms from a tetragonal to a triclinic crystal system. The results indicate that cooperative interactions in systems based on supposedly weaker interactions can yield softer yet functional networks with behavior unlike that observed in more rigid inorganic frameworks. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).SDS of cas: 636-73-7

The Article related to silver pyridinesulfonic acid supramol network complex preparation, acetonitrile reversible sorption silver pyridinesulfonic acid supramol network complex, crystal structure silver pyridinesulfonic acid supramol network complex and other aspects.SDS of cas: 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 27, 2008, Soll, Mark David; Le Hir De Fallois, Loic Patrick; Huber, Scot Kevin; Lee, Hyoung Ik; Wilkinson, Douglas Edward; Jacobs, Robert Toms published a patent.Recommanded Product: 1086838-13-2 The title of the patent was Preparation of aryl-fused triazole and pyrazole derivatives and their use as antiparasitic agents against endo- and ectoparasites. And the patent contained the following:

Title compounds I [P = CR1 or N; Q = CR2 or N; V = CR8 or N; W = CR9 or N; X = CR10 or N; Y = CR11 or N; R1, R2, R8, R9, R10 and R11 independently = H, NH2, amido, CN, NO2, halo. etc.; R3, R4 and R5 independently = H, halo, alkyl, hydroxyalkyl, alkylthioalkyl, etc.; R4 and R5 together with the carbon to which they are attached formed a cycloalkyl ring; R6 = H, alkyl, alkoxyalkyl, alkylcarbonyl, alkylthiocarbonyl or (un)substituted benzyl; R7 = H, alkyl, alkoxyalkyl, alkylcarbonyl, alkylthiocarbonyl or (un)substituted phenyl; Z = direct bond, CO, CS or S(O)p; m = 1-3; p = 0-2], and pesticidally acceptable salts, are prepared Thus, e.g., II was prepared by amidation of 4-trifluoromethoxybenzoyl chloride with 2-amino-2-methyl-3-(4,5,7-trichloro-2H-benzotriazol-2-yl)propionitrile which was prepared starting from 4,5,7-trichloro-1H-benzotriazole in a multi-step. I are antiparasitic agents, e.g., II gave at least 90% motility inhibition against Haemonchus contortus at a test concentration of 0.0025 ppm at the 4 days assessment. Therefore, I and pesticidal compositions are particularly useful for controlling endo- and ectoparasites which parasitize animals. The experimental process involved the reaction of 5-Chloro-3-nitropicolinaldehyde(cas: 1086838-13-2).Recommanded Product: 1086838-13-2

The Article related to benzotriazole cyanoethylamino preparation antiparasitic endoparasite ectoparasite, indazole cyanoethylamino preparation parasiticidal infection, endoparasite ectoparasite pesticidal pyrazolopyridine cyanoethylamino preparation and other aspects.Recommanded Product: 1086838-13-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 13, 1999, Cheng, Jianjun; Deming, Timothy J. published an article.COA of Formula: C10H12N2O The title of the article was Screening of Optically Active Nickel Initiators for Enantioasymmetric Polymerization of γ-Benzyl Glutamate-N-Carboxyanhydride. And the article contained the following:

The use of chiral pyridinyl oxazoline ligands in nickel initiators to enantioasym. polymerize γ-benzyl glutamate N-carboxyanhydride (I) was studied. Catalysts prepared from 4,4-dimethyl-(2-pyridinyl)-2-oxazoline and Ni(COD) displayed I polymerization activity which was virtually identical to that of bipyridine-Ni(COD). The kinetic selectivity for the D-antipode displayed by catalyst prepared from (4S)-4-tert-butyl-(2-pyridinyl)-2-oxazoline in homopolymerization was also displayed in polymerization of the racemate. The selectivity of the catalysts was highly sensitive to substitution on the 4 position of the oxazoline ring. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).COA of Formula: C10H12N2O

The Article related to oxazoline nickel catalyst polymerization benzyl glutamate, enantioasym polymerization benzyl glutamate nickel catalyst, polybenzyl glutamate preparation catalyst nickel, pyridine nickel catalyst polymerization benzyl glutamate and other aspects.COA of Formula: C10H12N2O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 31, 1987, Dondoni, Alessandro; Fantin, Giancarlo; Fogagnolo, Marco; Medici, Alessandro; Pedrini, Paola published an article.Synthetic Route of 109660-12-0 The title of the article was Palladium-catalyzed coupling of oxazol-2-yl- and 2-oxazolin-2-yltrimethylstannanes with aromatic halides. A new entry to 2-aryl and 2-heteroaryl oxazoles and oxazolines. And the article contained the following:

Coupling of lithiated 4-methyloxazole and 4,4-dimethyl-2-oxazoline with RX (R = Ph, p-FC6H4, p-tolyl, p-MeSC6H4, o-CNC6H4, thienyl, pyridyl, 2-thiazolyl, 3-furyl, naphthyl, quinolyl, X = Cl, Br, iodo) in benzene in the presence of (Ph3P)4P gave 70-100% 4 oxazoles I and 16 oxazolines II. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Synthetic Route of 109660-12-0

The Article related to safety toxic chlorotrimethylstannane, oxazole aryl, oxazoline aryl, coupling oxazolylstannane aryl halide, arylation oxazoline oxazole, stannane oxazolyl coupling aryl halide, palladium catalyst coupling oxazolylstannanehaloarene and other aspects.Synthetic Route of 109660-12-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 14, 2005, Munoz, M. Paz; Adrio, Javier; Carretero, Juan Carlos; Echavarren, Antonio M. published an article.Recommanded Product: 109660-12-0 The title of the article was Ligand Effects in Gold- and Platinum-Catalyzed Cyclization of Enynes: Chiral Gold Complexes for Enantioselective Alkoxycyclization. And the article contained the following:

Phosphine and bidentate N-N ligands inhibit the Alder-ene-type cycloisomerization of enynes catalyzed by Pt(II) and favor the alkoxycyclization process. The enantioselective Pt(II)-catalyzed alkoxycyclization has been studied in the presence of chiral mono- and bidentate phosphines, as well as chiral bidentate N-N ligands. Modest levels of enantioselection (up to 50% ee) have been obtained with Tol-BINAP as ligand. The alkoxycyclizations with a catalyst formed from [Au(L)Cl]/AgX proceed more readily, and up to 94% ee’s have been obtained using [(AuCl)2(Tol-BINAP)] (1) as the precatalyst. X-ray crystal structures of Au(I) complexes 1 and chloro-(R)-2-(tert-butylsulfenyl)-1-(diphenylphosphino)ferrocene gold(I) show the AuCl fragments monocoordinated with the P centers of the chiral phosphine ligands. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Recommanded Product: 109660-12-0

The Article related to enyne phosphine platinum gold complex catalyzed stereoselective alkoxycyclization alc, platinum chiral phosphine complex preparation methoxycyclization catalyst, gold chiral phosphine complex preparation alkoxycyclization catalyst and other aspects.Recommanded Product: 109660-12-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 27, 2005, Toele, P.; Glasbeek, M. published an article.Electric Literature of 75449-26-2 The title of the article was Ultrafast excited-state intramolecular double proton transfer dynamics of [2,2′-bipyridyl]-3,3′-diamine. And the article contained the following:

A femtosecond fluorescence upconversion study of [2,2′-bipyridyl]-3,3′-diamine (BP(NH2)2), in liquid solution, is reported. It is concluded that photoexcited BP(NH2)2 undergoes a branched intramol. double proton transfer reaction comprising two trajectories: (a) ultrafast double proton transfer (<100 fs) followed by twisting (∼250 fs); (b) a combined process of double proton transfer and twisting, with an overall reaction time of ∼250 fs. Picosecond transient fluorescence is attributed to vibrational cooling in the excited product state. The lifetime of ∼10 ps of the tautomer product state is indicative of conical intersection of the product- and ground-state potential energy surfaces. The experimental process involved the reaction of [2,2'-Bipyridine]-3,3'-diamine(cas: 75449-26-2).Electric Literature of 75449-26-2

The Article related to fluorescence upconversion study bipyridyldiamine photoinduced intramol double proton transfer, excited state intramol double proton transfer dynamics bipyridyldiamine, photoinduced tautomerization photophys photochem bipyridyldiamine and other aspects.Electric Literature of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 30, 2009, Li, Hong Liang published an article.Computed Properties of 75449-26-2 The title of the article was 2,2′-[(2,2′-Bipyridine-3,3′-diyl)bis(nitrilomethylidyne)]diphenol. And the article contained the following:

The title mol., C24H18N4O2, lies on a 2-fold rotation axis with a dihedral angle of 73.7(1)° between the mean planes of the symmetry-related pyridine rings. The dihedral angle between unique benzene and pyridine rings is 8.0(1)°. An intramol. O-H…N H bond may influence the mol. conformation. In the crystal structure, there are weak π-π stacking interactions with a centroid-centroid distance of 3.7838(15) Å. Crystallog. data and at. coordinates are given. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Computed Properties of 75449-26-2

The Article related to mol structure bipyridinediyl nitrilomethylidyne phenol, crystal structure bipyridinediyl nitrilomethylidyne phenol, hydrogen bond bipyridinediylnitrilomethylidynediphenol, pi stacking interaction bipyridinediylnitrilomethylidynediphenol and other aspects.Computed Properties of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem