Day: November 2, 2022

On May 7, 2021, Milic, Mira; Targos, Karina; Tellez Chavez, Magda; Thompson, Madison A. M.; Jennings, Julia J.; Franz, Annaliese K. published an article.Reference of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine The title of the article was NMR Quantification of Hydrogen-Bond-Accepting Ability for Organic Molecules. And the article contained the following:

The hydrogen-bond-accepting abilities for more than 100 organic mols. are quantified using 19F and 31P NMR spectroscopy with pentafluorobenzoic acid (PFBA) and phenylphosphinic acid (PPA) as com. available, inexpensive probes. Anal. of pyridines and anilines with a variety of electronic modifications demonstrates that changes in NMR shifts can predict the secondary effects that contribute to H-bond-accepting ability, establishing the ability of PFBA and PPA binding to predict electronic trends. The H-bond-accepting abilities of various metal-chelating ligands and organocatalysts are also quantified. The measured Δδ(31P) and Δδp(19F) values correlate strongly with Hammett parameters, pKa of the protonated HBA, and proton-transfer basicity (pKBH+). The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Reference of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine

The Article related to hydrogen bond accepting ability nmr chem shift, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Reference of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 31, 2004, Schilf, Wojciech published an article.Electric Literature of 75449-26-2 The title of the article was The spectroscopic study of hydrogen bonding in some 3,3′-derivatives of 2,2′-bipyridyl. And the article contained the following:

Four 3,3′-derivatives of 2,2′-bipyridyl have been investigated by multinuclear NMR, IR and X-ray methods. In all cases the weak intramol. hydrogen bonds between exocyclic nitrogen-containing substituent and pyridine-type ring nitrogen atom were found. In contrast to the previous results the nitrogen chem. shifts of pyridine ring atom do not provide valuable information about hydrogen bond strength. The presence of intramol. hydrogen bonds was confirmed by nitrogen chem. shifts of exocyclic amino and acetamide groups, deuterium isotope effects in the solid state and IR measurements in both chloroform solution and the solid state. The X-ray structures obtained for asym. 3-amino-3′-methylamino and 3,3′-diacetamide derivatives confirmed conclusions made on the base of spectral results. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Electric Literature of 75449-26-2

The Article related to hydrogen bond bipyridyl derivative nmr ir crystallog, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Electric Literature of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 1, 1981, Dommisse, Roger; Freyne, Eddy; Esmans, Eddy; Lepoivre, Josef; Alderweireldt, Frank published an article.Product Details of 73591-69-2 The title of the article was Carbon-13 NMR shift increments for 3-substituted pyridines. And the article contained the following:

The 13C NMR spectra of sixteen 3-substituted and 3,5-disubstituted pyridines are assigned. The substituent shift increment for the 3-Ac group is reassigned, and new shift increments for 3- and 5-substituents are proposed. The experimental process involved the reaction of 5-Isopropylnicotinic acid(cas: 73591-69-2).Product Details of 73591-69-2

The Article related to nmr pyridine substituent effect, acetylpyridine carbon nmr, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Product Details of 73591-69-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pham, Ngoc H.; Wenzel, Thomas J. published an article in 2011, the title of the article was A sulfonated calix[4]resorcinarene with α-methyl-L-prolinylmethyl groups as a water-soluble chiral NMR solvating agent.Category: pyridine-derivatives And the article contains the following content:

A water-soluble calix[4]resorcinarene containing α-methyl-L-prolinylmethyl groups was investigated as a chiral NMR solvating agent. Substrates form complexes by insertion of the aromatic ring into the cavity of the calix[4]resorcinarene. Amino acid derivatives with Ph or indole rings, ammonium substrates with pyridyl, indane or dihydroindole rings, and phenyl-containing substrates with carboxylic acid and/or hydroxyl groups were studied. The effectiveness of the α-methyl-L-prolinylmethyl calix[4]resorcinarene is compared to similar reagents with proline and hydroxyproline moieties that have previously been reported. The α-methyl-L-prolinylmethyl derivative causes larger enantiomeric discrimination of one or more 1H resonances than the previous systems for most of the substrates. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Category: pyridine-derivatives

The Article related to chiral nmr solvating agent sulfonated calixarene prolinylmethyl derivative, Physical Organic Chemistry: Resonance Spectra (Electron Spin, Nuclear Magnetic and Fourier Transform Nuclear Magnetic, Quadrupole, etc.) and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 1, 2019, Sun, Jiyun; Tang, Ruikun; Wang, Lu; Xu, Hao; Zhang, Xiaofei; Fan, Wei published a patent.Product Details of 1820711-82-7 The title of the patent was GluN2B subunit-targeted positron tracer for central nervous system and preparation thereof. And the patent contained the following:

The invention relates to GluN2B subunit-targeted positron tracer for central nervous system and preparation thereof, which has the advantages of stable structure, low metabolic rate, good electron tracing effect, mild reaction condition and high purity. In particular, the present invention relates to GluN2B subunit-targeted positron tracer for central nervous system with general formula I, wherein, R1 = Ph, benzene derivative, thienyl, thiophene derivatives GluN2B subunit-targeted positron tracer for central nervous system with general formulaIwas prepared by the following steps: methylation of the intermediate II with 11CH3I to obtain final product. The experimental process involved the reaction of tert-Butyl 6-bromo-1H-pyrrolo[3,2-b]pyridine-1-carboxylate(cas: 1820711-82-7).Product Details of 1820711-82-7

The Article related to glun2b subunit targeted positron tracer preparation central nervous system, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Product Details of 1820711-82-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kaczmarek, Lukasz published an article in 1985, the title of the article was Bipyridines. Part XVII. A convenient synthesis of some bipyridinediols and furodipyridines.SDS of cas: 75449-26-2 And the article contains the following content:

A convenient method of preparation of some bipyridinediols e.g. I, II and furodipyridines III (X or X1 or X2 = N) based on diazotization of corresponding diamines in H2SO4 has been described. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).SDS of cas: 75449-26-2

The Article related to bipyridinediamine diazotization cyclization, bipyridinediol, furodipyridine, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.SDS of cas: 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 31, 1978, Da Settimo, A.; Biagi, G.; Primofiore, G.; Ferrarini, P. L.; Livi, O. published an article.Related Products of 68638-67-5 The title of the article was Synthesis of some 11H-indolo[3,2-c][1,8]naphthyridines. And the article contained the following:

Twelve 11H-indolo[3,2-c][1,8]naphthyridines I (R = OEt, OH, SH, H; R1 = H, F, Br, Me, MeO, OH; R2 = H, MeO, OH) were prepared in 11.9-93.6% yield by 2 methods, e.g., by the Fischer indole synthesis. The UV of I were discussed. Several I were prepared from II, which was prepared in 70.9% yield from 7-bromo-2,3-dihydro-1,8-naphthyridin-4(1H)-one. II displayed a passive cutaneous anaphylaxis inhibition when administered i.p. in the rat at a dose of 25 mg/kg, but it exhibited no oral activity. The experimental process involved the reaction of 3-((6-Bromopyridin-2-yl)amino)propanoic acid(cas: 68638-67-5).Related Products of 68638-67-5

The Article related to anaphylaxis ethoxydihydronaphthyridinone, indolonaphthyridine uv nmr preparation, fischer indole synthesis indolonaphthyridine, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Related Products of 68638-67-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 3, 2005, Dress, Klaus Ruprecht; Hu, Qiyue; Johnson, Ted William; Plewe, Michael Bruno; Tanis, Steven Paul; Wang, Hai; Yang, Anle; Yin, Chunfeng; Zhang, Junhu published a patent.Category: pyridine-derivatives The title of the patent was Preparation of N-hydroxy pyrrolopyrimidinecarboxamides as inhibitors of HIV integrase.. And the patent contained the following:

Title compounds [I; R1 = H, (substituted) alkyl, alkenyl, heteroalkyl; R2, R5 = H; R3 = (CR8R9)tNR10R11, (substituted) heteroalkyl; R4 = H, halo, alkyl, heteroalkyl, (substituted) alkenyl, alkynyl, OR12a, NR12aR12b; R6 = H, alkyl, heteroalkyl, (substituted) alkenyl; R8, R9 = H, alkyl; R10R11N = (substituted) cycloheteroalkyl; R12a, R12b, R12c = H, alkyl; t = 1-3], were prepared Thus, 1-(2,4-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxylic acid (preparation given) was stirred with O-(7-azabenzotriazol-1-yl)-1,1,3,3-tetramethyluronium hexafluorophosphate, Et3N, and NH2OH.HCl in DMF for 16 h to give 48% N-hydroxy-1-(2,4-difluorobenzyl)-1H-pyrrolo[2,3-c]pyridine-5-carboxamide. The latter showed an EC50 = 0.00795 μM in an HIV-1 cell protection assay. The experimental process involved the reaction of Methyl 5-amino-4-methylpicolinate(cas: 868551-99-9).Category: pyridine-derivatives

The Article related to pyrrolopyrimidinecarboxamide hydroxy preparation hiv integrase inhibitor, aids arc treatment hydroxamide pyrrolopyrimidine preparation, Heterocyclic Compounds (More Than One Hetero Atom): Fused-Ring Systems With Two Or More Hetero Atoms, No More Than One Hetero Atom Per Ring and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zahn, Stefan; Reckien, Werner; Kirchner, Barbara; Staats, Holger; Matthey, Jens; Luetzen, Arne published an article in 2009, the title of the article was Towards allosteric receptors: adjustment of the rotation barrier of 2,2′-bipyridine derivatives.Computed Properties of 75449-26-2 And the article contains the following content:

Quantum-chem. calculations at the BP86/TZVP level of theory were performed to determine the energy differences between the syn and the anti conformers, as well as the energy barrier for the rotation of the aryl-aryl bond of 2,2′-bipyridine mols. and a number of disubstituted derivatives Substituents with hydrogen-bond donor (or electron acceptor) functions or hydrogen-bond acceptors (or electron donors) are generally found to have large effects on the difference and the barrier. Substitution with a hydrogen-bond donor (or an electron acceptor) at position 6 and 6′ leads to a decrease owing to a charge transfer from the pyridine nitrogen lone pair to the donor, which is caused by the formation of weak intramol. hydrogen bonds and/or dipolar interactions, resp. Conversely, substitution at position 4 and 4′ causes an increase in the energy barrier. Substitution with a hydrogen-bond accept- or (or an electron donor) shows the opposite behavior, which can be explained by the weak intramol. interactions. Interestingly, even very weak CH hydrogen-bond donors (electron acceptors) such as Me groups have a significant influence. This indicates the importance of such weak interactions for the structure and energetics of supramol. systems. The energy differences are mainly governed by the substituents directly attached to the bipyridine core as the introduction of sterically demanding groups in the periphery hardly influences the barriers or energy differences of the conformers. These findings are important for the design of heterotropic pos. cooperative allosteric receptors with 2,2′-bipyridines as the allosteric center. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Computed Properties of 75449-26-2

The Article related to allosterism electron donor receptor rotation barrier bipyridine, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Computed Properties of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Vela, Sonia; Berrocal, Jose Augusto; Atienza, Carmen; Meijer, E. W.; Martin, Nazario published an article in 2017, the title of the article was Mesoscopic helical architectures via self-assembly of porphyrin-based discotic systems.Category: pyridine-derivatives And the article contains the following content:

Mesoscopic super-helixes with preferred helicity were serendipitously formed from the self-assembly of electroactive extended core discotic mols. The study at dilute concentrations reveals intramol. hydrogen-bonding and π-π stacking interactions as the driving force of the chiral self-assembly at different length scales. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Category: pyridine-derivatives

The Article related to mesoscopic helical architecture chiral selfassembly porphyrin discotic, Physical Organic Chemistry: Stereochemistry and Stereochemical Relationships, Including Conformational Inversions and Rotational Isomerization and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem