Day: November 2, 2022

On August 31, 2010, Nirmalram, Jeyaraman Selvaraj; Muthiah, Packianathan Thomas published an article.Formula: C5H5NO3S The title of the article was Hydrogen-bonding patterns in pyrimethaminium pyridine-3-sulfonate. And the article contained the following:

In the asym. unit of the title salt [systematic name: 2,4-diamino-5-(4-chlorophenyl)-6-ethylpyrimidin-1-ium pyridine-3-sulfonate], C12H14N4Cl+·C5H4NSO3-, there are two independent pyrimethaminium cations and two 3-pyridine sulfonate anions. Each sulfonate group interacts with the corresponding protonated pyrimidine ring through two N-H…O hydrogen bonds, forming a cyclic hydrogen-bonded bimol. R22(8) motif. Even though the primary mode of association is the same, the next higher level of supramol. architectures are different due to different hydrogen-bonded networks. In one of the independent mols. in the asym. unit, the pyrimethamine cation is paired centrosym. through N-H…N hydrogen bonds, generating an R22(8) ring motif. In the other mol., the pyrimethamine cation does not form any base pairs; instead it forms hydrogen bonds with the 3-pyridine sulfonate anion. The structure is further stabilized by C-H…O, C-H…N and π-π stacking [centroid-centroid distance = 3.9465 (13) Å] interactions. Crystallog. data are given. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Formula: C5H5NO3S

The Article related to pyrimethaminium pyridine sulfonate salt crystal structure, supramol mol structure pyrimethaminium pyridinesulfonate salt, hydrogen bond pi stacking pyrimethaminium pyridinesulfonate salt and other aspects.Formula: C5H5NO3S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 29, 2005, Delorme, Daniel; Woo, Soon Hyung; Vaisburg, Arkadii; Moradei, Oscar; Leit, Silvana; Raeppel, Stephane; Frechette, Sylvie; Bouchain, Giliane published a patent.Category: pyridine-derivatives The title of the patent was Preparation of triazinyl and other carboxamides as inhibitors of histone deacetylase. And the patent contained the following:

The invention provides compounds and methods for inhibiting histone deacetylase enzymic activity. Such compounds include carboxamides I [Cy2 = (un)substituted cycloalkyl, aryl, heteroaryl, heterocyclyl (each of which is optionally fused to one or two aryl or heteroaryl rings, or to one or two (un)saturated cycloalkyl or heterocyclic rings); X1 = a bond, M1L2M1, L2M2L2 (wherein L2 = a bond, alkylene, alkenylene, alkynylene; M1 = O, S, SO, NHCO, etc.; M2 = M1, heteroarylene, heterocyclylene); Ar2 = (un)substituted (hetero)arylene; R5, R6 = H, alkyl, aryl, aralkyl; q = 0-1; Ay2 = (un)substituted 5-6 membered cycloalkkyl, heterocyclyl or heteroaryl substituted with an amino or hydroxy moiety; with provisos] which were prepared and claimed. E.g., a multi-step synthesis of II, starting from Me 4-(aminomethyl)benzoate.HCl, was given. The invention also provides compositions and methods for treating cell proliferative diseases and conditions. Antineoplastic effects of some I are illustrated for colorectal, pulmonary and pancreatic neoplasms; also the combined antineoplastic effect of histone deacetylase inhibitors and histone deacetylase antisense oligonucleotides on tumor cells in vivo was demonstrated. Although the methods of preparation are not claimed, hundreds of example preparations are included. The experimental process involved the reaction of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine(cas: 199522-66-2).Category: pyridine-derivatives

The Article related to carboxamide preparation inhibitor histone deacetylase hdac proliferative disease antitumor, triazinyl carboxamide preparation inhibitor histone deacetylase proliferative disease antitumor and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 1, 1987, Heinisch, Gottfried; Loetsch, Gerhard published an article.Synthetic Route of 97483-79-9 The title of the article was Homolytic alkoxycarbonylation reactions in two-phase systems. 3. Introduction of a single carboxylic acid ester function into cyano- or (alkoxycarbonyl)-substituted N-heteroaromatics. And the article contained the following:

Radical alkoxycarbonylation of pyridines I (R = cyano, CO2Et, R1-R3 = H; R = R2 = R3 = H, R1 = cyano, CO2Et; R = R1 = R3 = H, R2 = cyano, CO2Et) with MeCOCO2Me or MeCOCO2Et in H2O-CH2Cl2 containing H2O2-FeSO4 gave mainly monosubstitution products. Thus, I (R = cyano, R1-R3 = H) was treated with MeCOCO2Et to give 34% I (R = cyano, R1 = R3 = H, R2 = CO2Et) and 13% I (R = cyano, R1 = R2 = H, R3 = CO2Et). Similarly, I (R = R2 = R3 = H, R1 = CO2Et) reacted with MeCOCO2Me to give 29% I (R = CO2Me, R1 = CO2Et, R2 = R3 = H), 36% I (R = R3 = H, R1 = CO2Et, R2 = CO2Me), and 20% I (R = R2 = H, R1 = CO2Et, R3 = CO2Me). Only the mixed ester I (R = CO2Me, R1 = R3 = H, R2 = CO2Et) was obtained (in 81% yield) by treating I (R = R1 = R3 = H, R2 = CO2Et) with MeCOCO2Me. The experimental process involved the reaction of Ethyl 6-cyanopicolinate(cas: 97483-79-9).Synthetic Route of 97483-79-9

The Article related to pyridine alkoxycarbonyl cyano, cyanopyridinecarboxylate, pyridazinedicarboxylate, homolytic alkoxycarbonylation cyanopyridine pyruvate, radical alkoxycarbonylation pyridinecarboxylate pyruvate and other aspects.Synthetic Route of 97483-79-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 30, 2013, Zhao, Hongwu; Yue, Yuanyuan; Li, Hailong; Sheng, Zhihui; Yang, Zhao; Meng, Wei published an article.Name: [2,2′-Bipyridine]-3,3′-diamine The title of the article was Asymmetric synthesis of novel axially chiral 2,2′-bipyridine N,N’-dioxides bearing α-amino acid residues and their applications in enantioselective allylation of aromatic aldehydes with allyltrichlorosilane. And the article contained the following:

A series of novel axially chiral 2,2′-bipyridine N,N’-dioxides bearing C1 or C2-symmetry were synthesized by the use of enantiopure α-amino acids as chiral sources. The absolute stereochem. of the axial chirality of these organocatalysts was clearly assigned by CD measurements together with literature protocols. The reactivities and enantioselectivities of these organocatalysts were examined in the reactions of aromatic aldehydes with allyltrichlorosilane, thus providing the desired products with moderate yields and enantioselectivies. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Name: [2,2′-Bipyridine]-3,3′-diamine

The Article related to amino acid bipyridine oxide asym synthesis allylation catalyst, aromatic aldehyde allylchlorosilane enantioselective allylation bipyridine oxide catalyst, benzylic homoallyl alc asym synthesis and other aspects.Name: [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 30, 1979, Brown, Norman M. D.; Cowley, David J.; Hashmi, Mahoud published an article.Synthetic Route of 52243-87-5 The title of the article was Kinetic studies of the photoreduction of 4,4′-di-n-alkylbipyridylium salts by alkanols in aqueous solution. And the article contained the following:

The photoreduction of ≤10-3 M solutions of I (R = Me, Et, Pr, Bu, pentyl, hexyl, heptyl; X = halide) by RCH(OH)R1 (II; R = H, R1 = Me, Et, Pr, Bu; R = R1 = Me) on irradiation at 254 nm was studied. Triplet excited I react initially with the alc. to give an exciplex which by H atom transfer gives a cation radical. Halide ions exerted a strong quenching effect, and the quantum yield of photoreduction was greatly influenced by the R groups in I and the R and R1 groups in II. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Synthetic Route of 52243-87-5

The Article related to alkylbipyridylium photoreduction alc kinetics, bipyridylium alkyl photoreduction alc kinetics, reduction photochem alkylbipyridylium kinetics, substituent effect alkylbipyridylium photoreduction and other aspects.Synthetic Route of 52243-87-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 20, 1997, Ankersen, Michael; Stidsen, Carsten Enggaard; Andersen, Henrik Sune published a patent.HPLC of Formula: 199522-66-2 The title of the patent was Preparation of thioureas and guanidines as somatostatin agonists and antagonists. And the patent contained the following:

The title compounds [I and II; m = 2-6; n = 1-3; p = 1-6; R1, R2 = H, (un)substituted C1-6 alkyl; X = S, O, NH, NC(O)Ph, N(CN); A, B, D = (un)substituted aryl, heteroaryl] and their salts, useful for treating medical disorders related to binding to human somatostatin receptor subtypes, were prepared and formulated. Thus, reaction of N-(4-bromobenzyl)-N-(3-isothiocyanatopropyl)-N-(pyridin-2-yl)amine and 3-(1-triphenylmethylimidazol-4-yl)propylamine in CHCl3 followed by treatment of the triphenylmethyl intermediate with HCl afforded 80% III.2HCl. Compounds I are effective at 0.001-50 mg/kg/day. The experimental process involved the reaction of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine(cas: 199522-66-2).HPLC of Formula: 199522-66-2

The Article related to somatostatin agonist antagonist thiourea guanidine preparation, thiourea preparation formulation somatostatin agonist antagonist, guanidine preparation formulation somatostatin agonist antagonist and other aspects.HPLC of Formula: 199522-66-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 5, 2012, Akiri, Kalyanachakravarthi; Cherukuvada, Suryanarayan; Rana, Soumendra; Nangia, Ashwini published an article.Related Products of 636-73-7 The title of the article was Crystal Structures of Pyridine Sulfonamides and Sulfonic Acids. And the article contained the following:

Despite the widespread occurrence of pyridinesulfonic acid and pyridinesulfonamide functional groups in drugs and pharmaceuticals, and their use as ligands in metal-organic frameworks, a systematic structural study of their H bonding and mol. packing is lacking. Crystal structures of 2-, 3-, and 4-pyridinesulfonic acids/amides in terms of N+-H···O- H bonds, N-H···O dimer/catemer synthons, and graph set notations are discussed. This model study provides a background for polymorph screening and solid form hunting of pharmacol. active sulfonamides. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Related Products of 636-73-7

The Article related to crystal structure pyridinesulfonamide pyridinesulfonic acid, mol structure pyridinesulfonamide pyridinesulfonic acid, hydrogen bond dimer catemer synthon pyridinesulfonamide pyridinesulfonic acid and other aspects.Related Products of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 1, 2003, El Ali, Bassam published an article.Application of 636-73-7 The title of the article was Rh6(CO)16-H3PW12O40-catalyzed one pot hydroformylation-cyclotrimerization of cyclohexene and cyclopentene to 2,4,6-trisubstituted 1,3,5-trioxanes. And the article contained the following:

One-pot hydroformylation-cyclotrimerization of cyclopentene and cyclohexene was selectively catalyzed by Rh6(CO)16 and H3PW12O40·xH2O (HPA-W12) in THF at 40 atm (CO/H2 = 1/1) and afforded 2,4,6-tris(cycloalkyl)-1,3,5-trioxanes as major products along with the corresponding aldehydes. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Application of 636-73-7

The Article related to hydroformylation cyclotrimerization cyclohexene cyclopentene rhodium tungstophosphoric acid catalyst, trioxane tricycloalkyl preparation hexarhodium hexadecacarbonyl tungstophosphoric acid catalyst and other aspects.Application of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sarkar, Suman De; Kumar, N. Y. Phani; Ackermann, Lutz published an article in 2017, the title of the article was Ruthenium(II) Biscarboxylate-Catalyzed Borylations of C(sp2)-H and C(sp3)-H Bonds.Quality Control of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine And the article contains the following content:

Versatile borylations of C(sp2)-H and C(sp3)-H were achieved with Ru(II) biscarboxylate complexes as catalysts. The robust nature of the Ru(II) catalyst enabled C(sp3)-H borylation on pyrrolidines, piperidines, aromatic compounds and azepanes with ample scope and excellent positional selectivity control. The experimental process involved the reaction of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine(cas: 1349171-28-3).Quality Control of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine

The Article related to ruthenium catalyzed borylation benzene pyrrolidine piperidine azepane, monoborylated arene heterocycle pyrrolidine piperidine azepane preparation, c−h activation, alkanes, boron, mechanism, ruthenium and other aspects.Quality Control of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Maity, Ayan; Anderson, Bryce Lane; Deligonul, Nihal; Gray, Thomas G. published an article in 2013, the title of the article was Room-temperature synthesis of cyclometalated iridium(III) complexes: kinetic isomers and reactive functionalities.Reference of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine And the article contains the following content:

Cyclometalated iridium(III) complexes have been prepared in high yields from base-assisted transmetalation reactions of cis-bis(aquo)iridium(III) complexes with boronated aromatic proligands. Reactions proceed at room temperature Potassium hydroxide and potassium phosphate are effective supporting bases. Kinetic, meridional isomers are isolated because of the mildness of the new technique. Syntheses are faster with KOH, but the gentler base K3PO4 broadens the reaction’s scope. Complexes of chelated ketone, aldehyde, and alc. complexes are reported that bind iridium through formally neutral oxygen and formally anionic carbon. The new complexes luminesce with microsecond-scale(coating) lifetimes at 77 K and nanosecond-scale lifetimes at room temperature; emission quenches in air. Two complexes, an aldehyde and its reduced (alc.) derivative, are crystallog. characterized. Their bonding is examined with d.-functional theory calculations Time-dependent computations suggest that the Franck-Condon triplet states of these complexes have mixed orbital parentage, arising from one-particle transitions that mingle through CI. The experimental process involved the reaction of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine(cas: 1349171-28-3).Reference of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine

The Article related to phenylpyridine phenylpyrazole phenylquinoline benzothienylpyridine cyclometalated iridium preparation luminesce, crystal mol structure difluorophenylpyridine cyclometalated iridium formyltolyl complex and other aspects.Reference of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem