Day: November 3, 2022

On November 25, 2010, Maue, Michael; Adelt, Isabelle; Giencke, Wolfgang; Heil, Markus; Jeschke, Peter; Kapferer, Tobias; Krueger, Bernd-Wieland; Muehltau, Friedrich August; Sudau, Alexander; Adamczewski, Martin; Drewes, Mark Wilhelm; Ebbinghaus-Kintscher, Ulrich; Raming, Klaus; Voerste, Arnd; Franken, Eva-Maria; Becker, Angela; Goergens, Ulrich published a patent.Synthetic Route of 1227002-03-0 The title of the patent was Preparation of halogen-substituted compounds as pesticides. And the patent contained the following:

The invention relates to halogen-substituted compounds of formula I and to the use of these compounds for controlling animal pests. The invention furthermore relates to processes and intermediates for the preparation of the compounds of the formula I. Compounds of formula I wherein R1 is H, (un)substituted C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, etc.; A1 is CR2, G, G-amino, G-oxy and G-thio; A2 is CR3, G, G-amino, G-oxy and G-thio; A4 is CR4, G, G-amino, G-oxy and G-thio; A5 is CR5, G, G-amino, G-oxy and G-thio; R2, R3, R4 and R5 are independently H, halo, CN, NO2, (un)substituted C1-6 alkyl, etc.; G is H, (un)substituted C1-6 alkyl, C1-4 alkenyl, C1-4 alkynyl, C1-6 haloalkyl, etc.; U is CO, CS, SO and SO2; L is CONH, and derivatives, and CONHSO2; Q is (un)substituted Ph and (un)substituted pyridinyl; T is substituted thienyl, substituted azolyl, substituted furanyl, etc.; m is 1; are claimed. Example compound II was prepared by chlorination of 2-pentafluoroethyl-4-trifluoromethylpyrimidine-5-carboxylic acid; the resulting 2-pentafluoroethyl-4-trifluoromethylpyrimidine-5-carbonyl chloride underwent amidation with 5-amino-2-chloro-N-(3-chlorophenyl)benzamide to give compound II. All the invention compounds were evaluated for their pesticidal activity (some data given). The experimental process involved the reaction of Methyl 2-amino-5-chloroisonicotinate(cas: 1227002-03-0).Synthetic Route of 1227002-03-0

The Article related to halogen substituted compound preparation pesticide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Synthetic Route of 1227002-03-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 25, 2022, Lee, Hee Jin; Park, Jin Young; Lee, Hye Mi; Yang, Deok Mo; Nam, Eun Hye; Kim, Hak Do; Jung, Hui Jin; Choung, Won Ken published a patent.SDS of cas: 868551-99-9 The title of the patent was Preparation of pyrimidine-fused ring compounds with DNA-PK inhibition activity and use thereof. And the patent contained the following:

The invention relates to a pyrimidine-fused ring compounds of formula I, stereoisomers, pharmaceutically acceptable salts, or pharmaceutical compositions thereof that are useful for the prevention or treatment of cancer. The pyrimidine-fused ring compounds of the present invention exhibits excellent inhibitory activity against DNA-PK and thus can be advantageously used as a therapeutic agent for DNA-PK-related diseases. Compounds of formula I wherein the normalized bond is a single or double bond; n is 0-2; X1 is NR1 or CR2R3; X2 and X3 are independently -CR2R3-, -CR2-, -(C=O)-, or -(C=S)-; L1 is null or alkylene; Y is alkoxy, Q1, Q2, or (un)substituted (hetero)aryl; W1 is -CH2-, -NH-, -O-, or -S-; W2 is -CH- or -N-; a – d are independently 0-3; L2 is null or alkylene; Z is -Z1-L3-Z2; Z1 is (un)substituted (hetero)aryl or (un)substituted benzene-fused ring; L3 is alkylene, -(C=O)-, -(C=O)NH-, -NH-, etc.; Z2 is H, alkyl, hydroxyalkyl, alkoxyalkyl, etc.; R is H or alkyl; R1 – R3 are independently H or alkyl; are claimed. Example compound II was prepared by palladium-catalyzed cross-coupling reaction of 2-chloro-7-methyl-9-(tetrahydro-2H-pyran-4-yl)-7,9-dihydro-8H-purin-8-one with 2,5-dimethylbenzo[d]thiazol-6-amine in 11% yield. The invention compounds were evaluated for the DNA-pk inhibition activity (biol. data given). The experimental process involved the reaction of Methyl 5-amino-4-methylpicolinate(cas: 868551-99-9).SDS of cas: 868551-99-9

The Article related to pyrimidine fused ring preparation dnapk inhibition cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.SDS of cas: 868551-99-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 12, 1973, there was a patent about defoliants, herbicides.Category: pyridine-derivatives The title of the patent was Herbicidal N,N’-disubstituted dipyridylium bistribromides. And the patent contained the following:

Herbicidal and defoliant bipyridine derivatives I (n = 2, 3, X = Br3; n = 2, X = ClBr2) and II (R = Me, X = Br3, ClBr2; R = Pr, X = Br3) were prepared Thus 2,2′-bipyridine was treated with Br(CH2)3Br to give 94% I (n = 3, X = Br), which on treatment with Br gave 47% I (n = 3, X = Br3). Wettable powders were prepared using HiSil 233 carrier, Daxad 11 dispersant, and Emcol L72-34 wetting agent. The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).Category: pyridine-derivatives

The Article related to herbicide bipyridylium halide, defoliant bipyridylium halide, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 11, 2014, Wang, Shaomeng; Ran, Xu; Zhao, Yujun; Yang, Chao-Yie; Liu, Liu; Bai, Longchuan; McEachern, Donna; Stuckey, Jeanne; Meagher, Jennifer Lynn; Sun, Duxin; Li, Xiaoqin; Zhou, Bing; Karatas, Hacer; Luo, Ruijuan; Chinnaiyan, Arul; Asangani, Irfan A. published a patent.Quality Control of 4-Bromo-2-isopropylpyridine The title of the patent was Preparation of pyridoindole, pyridazinoindole and pyrimidinoindole compounds as BET bromodomain inhibitors. And the patent contained the following:

The title compounds I [X = NRa, O or S; Y1, Y3 = CH or N; Y2 = CH, CRa (wherein Ra = H, alkyl, benzyl), or absent; Z = H, II (wherein B = (un)substituted aryl, heteroaryl, heterocycloalkyl, etc.; Rb = alkyl, halo, aryl, etc.; n = 0-3), G(L)C(Rc)3 (G = N, O, or S; L = absent, H, C(Rd)3; Rc, Rd = H, alkyl, (un)substituted aryl, etc.), halo, OH, or absent; A = (un)substituted 5-membered heterocyclyl; R1 = H, halo, OH, etc.] that are inhibitors of BET bromodomains useful in the treatment of diseases and conditions wherein inhibition of BET bromodomain provides a benefit, like cancers, were prepared E.g., a multi-step synthesis of III, starting from 4-hydroxypyridin-2(1H)-one, was described. The ability of exemplified compounds I to bind to BET bromodomain proteins was evaluated (data given for representative compounds I). Pharmaceutical compositions comprising compound I, alone or in combination with second therapeutic agent, surgery and radiation, were disclosed. The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).Quality Control of 4-Bromo-2-isopropylpyridine

The Article related to pyridoindole pyridazinoindole pyrimidinoindole preparation bet bromodomain inhibitor antitumor, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Quality Control of 4-Bromo-2-isopropylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 11, 2018, Crowley, Brendan M.; Bell, Ian M.; Harvey, Andrew John; Campbell, Brian T.; Greshock, Thomas J.; Rada, Vanessa L. published a patent.Product Details of 908267-63-0 The title of the patent was Preparation of substituted 6-membered aryl or heteroaryl allosteric modulators of nicotinic acetylcholine receptors. And the patent contained the following:

The present disclosure relates to compounds of formula I that are useful as modulators of α7 nAChR, compositions comprising such compounds, and the use of such compounds for preventing, treating, or ameliorating disease, particularly disorders of the central nervous system such as cognitive impairments in Alzheimer’s disease, Parkinson’s disease, and schizophrenia, as well as for L-DOPA induced-dyskinesia and inflammation. Compounds of formula I wherein X is SONH2 and derivatives, OSONH2 and derivatives, SO2H and SO2-C1-4 alkyl; Y is from 1 to 4 substituents and each are independently H, (un)substituted C1-4 alkyl, halo and OH; A is substituted 6-membered aryl and heteroaryl; R3 and R4 are independently H, halo and (un)substituted C1-4 alkyl; R3R4 can be taken together to form (un)substituted cyclopropyl, (un)substituted cyclobutyl, (un)substituted cyclopentyl and (un)substituted cyclohexyl; R5 and R6 are independently H and C1-4 alkyl; and pharmaceutically acceptable salts thereof, are claimed. Example compound II was prepared by cyclization of (1R,3R)-2,2-dimethyl-3-(4-sulfamoylphenyl)cyclopropanecarboximidamide with 3-(dimethylamino)-1-[5-(trifluoromethyl)pyridin-3-yl]prop-2-en-1-one. The invention compounds were evaluated for their α7 nAChR modulatory activity (some data given). The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).Product Details of 908267-63-0

The Article related to heteroaryl phenylcyclopropane preparation nicotinic acetylcholine receptor modulator allosteric modulator, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Product Details of 908267-63-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 12, 1996, Kelly, T. Ross; Lang, Fengrui published an article.Safety of Methyl 6-bromo-5-methoxypicolinate The title of the article was Total Synthesis of Dimethyl Sulfomycinamate. And the article contained the following:

Di-Me sulfomycinamate, a methanolysis product from the natural antibiotic sulfomycin I, is synthesized in 11 steps. The chem. of various pyridine, thiazole, and oxazole heterocycles and their coupling reactions under palladium catalysis are examined The key transformations in the synthesis are the selective palladium-catalyzed coupling reactions on a doubly-activated pyridine and the condensation reaction between bromo ketone and amide to form the oxazole moiety. The first preparation of oxazole triflates is described, as is some of their chem. properties. The experimental process involved the reaction of Methyl 6-bromo-5-methoxypicolinate(cas: 170235-18-4).Safety of Methyl 6-bromo-5-methoxypicolinate

The Article related to sulfomycinamate preparation, oxazole triflate preparation coupling reaction, pyridyl triflate preparation coupling thiazole, Biomolecules and Their Synthetic Analogs: Other Bacterial and Fungal Metabolites and other aspects.Safety of Methyl 6-bromo-5-methoxypicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 30, 2021, Zhou, Enxing; Liu, Yuan; Wang, Hanping; Wang, Jing; Shao, Ning; Wu, Guanglong published a patent.Recommanded Product: 908267-63-0 The title of the patent was Preparation of heteroaryl compounds as casein kinase inhibitors. And the patent contained the following:

The title compounds with general formula I [wherein R1 = halogen; n = 0-2, X = independently C or N; R2 = absent or O; R3 = absent or CN; A = absent, a 4- to 7- membered (un)substituted cycloalkyl, heterocycloalkyl, a 5- to 6- membered (un)substituted heteroaryl, etc.; ring B = a 4- to 7-membered (un)substituted cycloalkyl, heterocycloalkyl, or a 5- to 6-membered (un)substituted heteroaryl, wherein up to 2 carbon atoms are replaced with a heteroatom selected from =N- or -O-] or pharmaceutically acceptable salts thereof were prepared novel casein kinase inhibitors. For example, compound II was prepared in a multi-step synthesis. Corresponding pharmaceutical compositions were also disclosed for the treatment of mood disorder, depression, bipolar disorder, solid tumor, blood cancer, lymphoma, breast cancer, melanoma, leukemia, liver cancer, and brain cancer. The experimental process involved the reaction of 4-Bromo-2-isopropylpyridine(cas: 908267-63-0).Recommanded Product: 908267-63-0

The Article related to preparation heteroaryl pyrazolopyrazine pyrimidine imidazopyrazine furopyridine, human casein kinase inhibitor treatment mood disorder cancer, Heterocyclic Compounds (More Than One Hetero Atom): Pyrimidines and Quinazolines and other aspects.Recommanded Product: 908267-63-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 13, 2015, Liu, Jun; Dou, Chuandong published a patent.Electric Literature of 75449-26-2 The title of the patent was Bis(boron-nitrogen-bridged) bipyridyl and organic/high polymer material prepared with the same. And the patent contained the following:

The present invention relates to a kind of bis(boron-nitrogen-bridged) bipyridyl (I, R1 is 4-20 alkyl group, R2, e.g., Ph, F, Et etc.), and organic/high polymer material prepared with the same, belonging to organic/high polymer area of solar cell. The object of the invention is to take classic pyrene unit as starting point to develop new BN receptor unit for further expanding receptor material system. The bis(boron-nitrogen-bridged) bipyridyl in this invention contains BN unit so that it has a number of advantages: such as complanation structure is conducive to orderly close accumulation of material mol., so as to increase mobility of material carrier; BN coordination has strong electron-drawing action, which is conducive to reducing mol. energy level; introducing alkyl chain with different lengths contributes to regulating material dissoly.; reaction site with functionalization can be used for preparing organic/high polymer material, and it has good application prospect if applied to solar cell. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Electric Literature of 75449-26-2

The Article related to boron nitrogen bridged bipyridyl organic polymer material solar cell, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Electric Literature of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 8, 2014, Yang, Yonggang; Li, Yi; Li, Baozong; Wang, Qingfeng published a patent.Application of 75449-26-2 The title of the patent was Chiral silsesquioxane containing arylene, manufacture method, and application in absorbent, chiral separation, and asymmetric catalysis. And the patent contained the following:

Title chiral silsesquioxane is homopolymer of I (OEt)3Si(CH2)mNHC(O)NHCH(R)C(O)NH-A-NHC(O)CH(R)NHC(O)NH(CH2)mSi(OEt)3; wherein R is residual group of valine, isoleucine, alanine, or phenylalanine, A is aromatic group of diamine, and m is integer of 3-10. Title manufacture method comprises the steps: (1) reacting Boc-protected amino acid with aromatic diamine to give Boc-protected intermediate; (2) deprotecting Boc group; (3) reacting deprotected intermediate with isocyanate (EtO)3Si(CH2)mNCO (m is integer of 3-10) to give monomer; and (4) polycondensing the monomer to obtain chiral silsesquioxane. Title chiral silsesquioxane has stable chem. property, simple production, and convenient use, has good adsorption effect on aryl compound and heavy metal ion, also has great application value in chiral resolution and asym. catalysis. In an example, I (R = iPr, A = biphenylene, m = 3) was manufactured from Boc-L-valine, 4,4′-diaminobiphenyl, and (3-isocyanato)propyltriethoxysilane; I was polymerized to give right-hand helical fiber with diameter 50-100 nm and length 2-10 μm. The obtained silsesquioxane 50 mg was added to nitrobenzene/cyclohexane solution (volume ratio 1:99) 850 μl; after 5 h, nitrobenzene 19.3 % was absorbed by silsesquioxane, which indicated that the silsesquioxane could be used as absorbent to absorb aromatic compound The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Application of 75449-26-2

The Article related to chiral silsesquioxane arylene manufacture absorbent resolution asym catalysis, Chemistry of Synthetic High Polymers: Organic Condensation and Step Polymerization and other aspects.Application of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 15, 2013, Duan, Lele; Wang, Lei; Inge, A. Ken; Fischer, Andreas; Zou, Xiaodong; Sun, Licheng published an article.Category: pyridine-derivatives The title of the article was Insights into Ru-Based Molecular Water Oxidation Catalysts: Electronic and Noncovalent-Interaction Effects on Their Catalytic Activities. And the article contained the following:

A series of Ru-bda water oxidation catalysts [Ru(bda)L2] (H2bda = 2,2′-bipyridine-6,6′-dicarboxylic acid; L = [HNEt3][3-SO3-pyridine], 1; 4-(EtOOC)-pyridine, 2; 4-bromopyridine, 3; pyridine, 4; 4-methoxypyridine, 5; 4-(Me2N)-pyridine, 6; 4-[Ph(CH2)3]-pyridine, 7) were synthesized with electron-donating/-withdrawing groups and hydrophilic/hydrophobic groups in the axial ligands. These complexes were characterized by 1H NMR spectroscopy, high-resolution mass spectrometry, elemental anal., and electrochem. In addition, complexes 1 and 6 were further identified by single crystal X-ray crystallog., revealing a highly distorted octahedral configuration of the Ru coordination sphere. All of these complexes are highly active toward CeIV-driven (CeIV = Ce(NH4)2(NO3)6) water oxidation with oxygen evolution rates up to 119 mols of O2 per mol of catalyst per s. Their structure-activity relationship was investigated. Electron-withdrawing and noncovalent interactions (attraction) exhibit pos. effect on the catalytic activity of Ru-bda catalysts. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Category: pyridine-derivatives

The Article related to ruthenium based mol water oxidation catalyst electronic noncovalent interaction, Catalysis, Reaction Kinetics, and Inorganic Reaction Mechanisms: Reaction Kinetics and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem