Day: November 3, 2022

On July 10, 2008, Minter, Aaron; Stokes, Berlin published a patent.HPLC of Formula: 51566-22-4 The title of the patent was Preparation of diaminopyridines from glutarimidines. And the patent contained the following:

I is prepared by contacting II with a chem. oxidant and/or a dehydrogenation catalyst in liquid ammonia neat, or in a mixture of liquid ammonia and a polar, aprotic solvent, to form a reaction mixture; and heating the reaction mixture to produce I; wherein R1 and R2 are each independently selected from (a) H; (b) a hydrocarbyl group; (c) NR3R4 wherein R3 and R4 are each independently selected from H and a hydrocarbyl group; (d) -CO-R5wherein R5 is a hydrocarbyl group; and (e) YR6 wherein Y is selected from O and S and R6 is selected from H , a hydrocarbyl group, and -COR5 wherein R5 is a hydrocarbyl group. Thus, glutarimidine (111 mg, 0.99 mmol) was combined with Pd-C (100 mg, 0.10 mmol, 10 mol% of 10% Pd on carbon), and then mixed with liquidNH3 (1.0 g, 58.7 mmol) then heated at 200° for 45 h to give 0.14 mmol of 2,6-diaminopyridine in yield 13.7%. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).HPLC of Formula: 51566-22-4

The Article related to glutarimidine dehydrogenation diaminopyridine preparation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.HPLC of Formula: 51566-22-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 27, 2011, Minter, Aaron; Stokes, Berlin published a patent.Quality Control of 3-Methylpyridine-2,6-diamine The title of the patent was Process for the synthesis of diaminopyridines from glutarimidines. And the patent contained the following:

A liquid-phase process is provided for the synthesis from glutarimidines of diaminopyridines and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Quality Control of 3-Methylpyridine-2,6-diamine

The Article related to glutarimidine dehydrogenation diaminopyridine preparation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Quality Control of 3-Methylpyridine-2,6-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 15, 2021, Flohr, Alexander; Eidam, Olive; Fasching, Bernhard; Meniconi, Mirco; Sadok, Amine; Chopra, Rajesh; Zhuai Wang, Hannah; Caldwell, John Jamieson; Collins, Ian; Ryckmans, Thomas published a patent.Recommanded Product: 39919-70-5 The title of the patent was Isoindolinone compounds as cereblon inhibitors and GSPT1 degraders and their preparation. And the patent contained the following:

Disclosed herein is a compound of formula I or pharmaceutically acceptable salts or stereoisomers thereof. Compounds of formula I wherein X1 is (un)branched C1-6 alkyl, C3-6 cycloalkyl, -C1-6 alkyl-C3-6 cycloalkyl, C6-10 aryl, 5- to 10-membered heteroaryl, etc.; X2 is H, C6-10 aryl, 5- to 10-membered heteroaryl, 5- to 10-membered heteroaryloxy, 4- to 8-membered heterocycloalkyl, etc.; n is 0, 1 and 2; and pharmaceutically acceptable salts, and stereoisomers thereof, are claimed. Example compound II was prepared by a multistep procedure (procedure given). The invention compounds were evaluated for their cereblon inhibitory activity and GSPT1 degradation activity. From the assay, it was determined that compound II exhibited IC50 value of 1037 nM and a DC50 value of > 300 nM. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Recommanded Product: 39919-70-5

The Article related to isoindolinone preparation cereblon inhibitor gspt1 degrader, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: 39919-70-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 19, 2002, Owa, Takashi; Yoshino, Hiroshi; Okauchi, Tatsuo; Okabe, Tadashi; Ozawa, Yoichi; Hata Sugi, Naoko; Yoshimatsu, Kentaro; Nagasu, Takeshi; Koyanagi, Nozomu; Kitoh, Kyosuke published an article.Computed Properties of 636-73-7 The title of the article was Synthesis and biological evaluation of N-(7-indolyl)-3-pyridinesulfonamide derivatives as potent antitumor agents. And the article contained the following:

The synthesis and antitumor activity of E7070 analogs containing a 3-pyridinesulfonamide moiety is reported. E7070 was selected from our sulfonamide-based compound collections, currently undergoing Phase II clin. trials because of its tolerable toxicity profile and some antitumor responses in the Phase I setting. Of the analogs examined, ER-35745 (I), a 6-amino-3-pyridinesulfonamide derivative, demonstrated significant oral efficacy against the HCT116 human colon carcinoma xenograft in nude mice. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Computed Properties of 636-73-7

The Article related to pyridinesulfonamide indolyl derivative preparation antitumor, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Computed Properties of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 10, 2008, Minter, Aaron; Stokes, Berlin published a patent.Application of 51566-22-4 The title of the patent was Preparation of diaminopyridines from glutaronitriles. And the patent contained the following:

I is prepared by contacting II with a chem. oxidant and/or a dehydrogenation catalyst in liquid ammonia neat, or in a mixture of liquid ammonia and a polar, aprotic solvent, to form a reaction mixture; and heating the reaction mixture to produce I; wherein R1 and R2 are each independently selected from (a) H; (b) a hydrocarbyl group; (c) NR3R4 wherein R3 and R4 are each independently selected from H and a hydrocarbyl group; (d) -CO-R5wherein R5 is a hydrocarbyl group; and (e) YR6 wherein Y is selected from O and S and R6 is selected from H , a hydrocarbyl group, and -COR5 wherein R5 is a hydrocarbyl group. Thus, glutaronitrile (3.0 g, 31.9 mmol) was combined with Pd-C (3.39 g, 3.19 mmol, 10 mol% of 10% Pd on carbon) and mixed with liquid NH3 (1.0 g, 58.7 mmol), then heated at 200° for 45 h and a pressure of approx. 90 psi to give 2.43 mmol of 2,6-diaminopyridine in 7.6 % net yield. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Application of 51566-22-4

The Article related to glutaronitrile amination dehydrogenation diaminopyridine preparation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Application of 51566-22-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 20, 2011, Minter, Aaron; Stokes, Berlin published a patent.Name: 3-Methylpyridine-2,6-diamine The title of the patent was Process for the synthesis of diaminopyridines from glutaronitriles. And the patent contained the following:

A liquid-phase process is provided for the manufacture from glutaronitriles and related compounds of 2,6-diaminopyridine and related compounds, which are used industrially as compounds and as components in the synthesis of a variety of useful materials. The synthesis proceeds by means of a dehydrogenative aromatization process. The experimental process involved the reaction of 3-Methylpyridine-2,6-diamine(cas: 51566-22-4).Name: 3-Methylpyridine-2,6-diamine

The Article related to glutaronitrile amination dehydrogenation diaminopyridine preparation, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Name: 3-Methylpyridine-2,6-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 18, 2021, Lee, Jong Ho published a patent.Name: 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine The title of the patent was Transparent polyimide prepared using single-port synthesis. And the patent contained the following:

Title polymer is prepared by dissolving a tetracarboxylic dianhydride, a diamine, and a catalyst and it has excellent properties such as optical transparency, hydrophobicity, water absorption, dielec. constant, thermal-mech. stability, and short production time. The experimental process involved the reaction of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine(cas: 1349171-28-3).Name: 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine

The Article related to transparent polyimide single port tetracarboxylic dianhydride diamine catalyst, Industrial Organic Chemicals, Leather, Fats, and Waxes: Manufacture Of Industrial Organic Chemicals and other aspects.Name: 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 15, 2021, Oderinde, Martins S.; Ramirez, Antonio; Dhar, T. G. Murali; Cornelius, Lyndon A. M.; Jorge, Christine; Aulakh, Darpandeep; Sandhu, Bhupinder; Pawluczyk, Joseph; Sarjeant, Amy A.; Meanwell, Nicholas A.; Mathur, Arvind; Kempson, James published an article.Recommanded Product: Methyl 5-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate The title of the article was Photocatalytic Dearomative Intermolecular [2 + 2] Cycloaddition of Heterocycles for Building Molecular Complexity. And the article contained the following:

Indole and indoline rings are important pharmacophoric scaffolds found in marketed drugs, agrochems., and biol. active mols. The [2 + 2] cycloaddition reaction is a versatile strategy for constructing architecturally interesting, sp3-rich cyclobutane-fused scaffolds with potential applications in drug discovery programs. A general platform for visible-light mediated intermol. [2 + 2] cycloaddition of indoles with alkenes has been realized. A substrate-based screening approach led to the discovery of tert-butyloxycarbonyl (Boc)-protected indole-2-carboxyesters as suitable motifs for the intermol. [2 + 2] cycloaddition reaction. Significantly, the reaction proceeds in good yield with a wide variety of both activated and unactivated alkenes, including those containing free amines and alcs., and the transformation exhibits excellent regio- and diastereoselectivity. Moreover, the scope of the indole substrate is very broad, extending to previously unexplored azaindole heterocycles that collectively afford fused cyclobutane containing scaffolds that offer unique properties with functional handles and vectors suitable for further derivatization. DFT computational studies provide insights into the mechanism of this [2 + 2] cycloaddition, which is initiated by a triplet-triplet energy transfer process. The photocatalytic reaction was successfully performed on a 100 g scale to provide the dihydroindole analog. The experimental process involved the reaction of Methyl 5-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate(cas: 1234616-83-1).Recommanded Product: Methyl 5-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

The Article related to regioselective diastereoselective photocatalytic dearomative intermol cycloaddition indole alkene, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Recommanded Product: Methyl 5-bromo-1H-pyrrolo[2,3-b]pyridine-2-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 7, 1995, Dobrusin, Ellen M.; Showalter, Howard D. H.; Denny, William A.; Palmer, Brian D.; Rewcastle, Gordon W.; Tercel, Moana; Thompson, Andrew M. published a patent.Related Products of 156267-13-9 The title of the patent was Preparation of 2-indolyldisulfides and analogs as protein tyrosine kinase inhibitors and antitumor agents. And the patent contained the following:

Title compounds [I; R1 = H, halo, alkyl, alkoxy, etc.; R2 = (acyl)alkyl, acyl, CH:CHCO2H, etc.; R3 = H, alkyl, CH2Ph; R4 = SH, SnR, SeH, SenR, etc.; R = H, alkyl, (hetero)aryl, I in which R4 = bond, etc.; R4R5 = S, Se; R5R6 = bond; R6 = H; n = 1-3] were prepared 2Hus, 1-methyl-2-indolinone was treated with P2S5 and the product condensed with PhNCO to give, after oxidation, title compound II which had IC50 of 3-4μM against growth factor mediated mitogenesis in vitro. The experimental process involved the reaction of N,3-Dimethylpyridin-2-amine(cas: 156267-13-9).Related Products of 156267-13-9

The Article related to indolyldisulfide preparation protein tyrosine kinase inhibitor, antitumor indolyldisulfide preparation, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Related Products of 156267-13-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 3, 1994, Rewcastle, Gordon W.; Denny, William A. published an article.Quality Control of N,3-Dimethylpyridin-2-amine The title of the article was Lithiation routes to oxindoles and 2-indolinethiones: precursors to 2,2′-dithiobisindoles with tyrosine kinase inhibitory properties. And the article contained the following:

N-Substituted oxindoles, e.g. I, and 2-indolinethiones can be prepared by lithiation of carboxyl protected N,2-dimethylanilines followed by quenching with CO2 or CS2 resp. 2-Indolinethione derivatives are also available via demethylation of 2-methylthioindoles, which are prepared by lithiation of N-substituted indoles and treatment with di-Me disulfide. The experimental process involved the reaction of N,3-Dimethylpyridin-2-amine(cas: 156267-13-9).Quality Control of N,3-Dimethylpyridin-2-amine

The Article related to dithiobisindole preparation tyrosine kinase inhibitory, oxindole substituted, indolinethione substituted, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Quality Control of N,3-Dimethylpyridin-2-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem