Day: November 4, 2022

On July 9, 1998, Kanno, Hisashi; Kanda, Yoichi; Sunagawa, Kazuhiko; Eizuka, Takayoshi published a patent.SDS of cas: 170235-18-4 The title of the patent was Preparation of phenoxypicolinic acid derivatives as agrochemical fungicides. And the patent contained the following:

The title compounds [I; R = halo, C1-4 alkyl, haloalkyl, alkoxy, haloalkoxy, alkylthio, or alkylamino, etc.; n1 = 1-3; Y = C1-4 alkyl, haloalkyl, alkoxy, or haloalkoxy, etc.; m = 0-5] are prepared I are useful as active ingredients contained in agricultural or horticultural fungicides. Thus, 2-bromo-4-methoxy-6-[3-(trifluoromethyl)phenoxy]pyridine (preparation given) was treated with n-BuLi, reacted with CO2, and treated with 1N HCl to give 30% I (Rn1 = 4-OMe, Ym = 3-CF3), which at 1 kg/ha showed > 70% fungicidal effect for Botrytis cinerea. The experimental process involved the reaction of Methyl 6-bromo-5-methoxypicolinate(cas: 170235-18-4).SDS of cas: 170235-18-4

The Article related to phenoxypicolinic acid preparation agrochem fungicide, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.SDS of cas: 170235-18-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 9, 1980, Chen, Min-Feng published a patent.Electric Literature of 52243-87-5 The title of the patent was 1,1′-Dialkyl-4,4′-bipyridinium dihalides and their herbicidal use. And the patent contained the following:

The title compounds I (R = alkyl, X = halogen) were prepared by treating 4,4′-bipyridine (II) with a haloalkanoic acid and H2O at pH <4. Thus II was treated with saturated aqueous ClCH2CO2H to give I (R = Me, X = Cl) in 99% yield. The experimental process involved the reaction of 1,1'-Dipropyl-[4,4'-bipyridine]-1,1'-diium bromide(cas: 52243-87-5).Electric Literature of 52243-87-5

The Article related to dialkylbipyridinium dihalide, bipyridinium dialkyl dihalide, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Electric Literature of 52243-87-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Weglinski, Zbigniew; Talik, Tadeusz published an article in 1982, the title of the article was Synthesis of some derivatives of nicotinic acid.Application In Synthesis of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate And the article contains the following content:

Hydroxynicotinic acids I (R = 4-Me, 5-Me; R1 = HO) and II (R = 5-Me, 6-Me; R1 = HO) were esterified in EtOH containing H2SO4 to give I and II (R1 = EtO) which were autoclaved with (NH4)2CO3 at 373°K to give I and II (R1 = H2N). Treatment of the Et esters with N2H4 in EtOH gave I and II (R1 = NHNH2). The experimental process involved the reaction of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate(cas: 85614-89-7).Application In Synthesis of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

The Article related to nicotinate methylhydroxy amidation, nicotinamide methylhydroxy, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Application In Synthesis of Ethyl 5-methyl-6-oxo-1,6-dihydropyridine-3-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 7, 1999, Kanno, Hisashi; Yoshida, Kazuo; Sato, Tsutomu; Sato, Kobi; Kanda, Yoichi published a patent.Category: pyridine-derivatives The title of the patent was Preparation of 6-phenoxypicolinic acid alkylidenehydrazide derivatives as herbicides. And the patent contained the following:

Claimed are 6-Phenoxypicolinic acid alkylidenehydrazide derivatives [I; R1 = halo, C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkylthio, C1-4 alkylamino, C1-4 dialkylamino, (C1-4 alkyl)(C7-8aralkyl)amino; m = 0-3; R2, R3 = H, C1-10 C2-6 alkenyl, C2-6 alkynyl, C3-6 cycloalkyl, Ph, or aryl-C1-3 alkyl each optionally substituted with Xa or Xb; ; X1, Xb = halo, C1-4 alkoxy, C1-4 alkylthio, C1-4 alkyl, C3-6 cycloalkyl, or cyano; na = nb = 0 or integer selected from number of H atoms substitutable with Xa and Xb in R2 and R3; or when R2 and R3 are an alkyl chain, R2 and R3 are directly linked together to form a ring optionally interposed with O, S, or optionally C1-4 alkyl-substituted NH; Y = C1-4 alkyl, C1-4 haloalkyl, C1-4 alkoxy, C1-4 haloalkoxy, C1-4 alkylthio, or halo; p = 0-5; when m, n, na, nb, and p are ≥2, R1, R2, Xa, Xb, and Y are same or different groups], a process for producing these, and a herbicide containing any of the derivatives as the active ingredient. These compounds exhibit excellent herbicidal activity with high selectivity at low dosage and does not inflict damage to the subsequent crops in double-cropping. Thus, 6-methoxy-6-[3-(trifluoromethyl)phenoxy]picolinic acid was stirred with chloroacetaldehyde in a mixture of 40% aqueous NaOH and EtOH at room temperature for ∼4 h to give 88% 6-methoxy-6-[3-(trifluoromethyl)phenoxy]picolinic acid (2-chloroethylidene)hydrazide (II). II 100 g/10 post emergence are controlled ≥50% Amaranthus retroflexus, Brassica kaber, Solanum nigrum, and Galium spurium. The experimental process involved the reaction of Methyl 6-bromo-5-methoxypicolinate(cas: 170235-18-4).Category: pyridine-derivatives

The Article related to phenoxypicolinic acid alkylidenehydrazide preparation herbicide, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On February 29, 2008, Costero, Ana M.; Gil, Salvador; Parra, Margarita; Huguet, Nuria; Allouni, Zouhir; Lakmiri, Rajae; Atlamsani, Ahmed published an article.Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine The title of the article was 3,3′-Disubstituted 2,2′-bipyridines as carboxylate receptors: conformational regulation of the bipyridine moiety. And the article contained the following:

Two bipyridine derivates were synthesized and characterized and their ability to act as sensors for carboxylates was evaluated by UV/Vis and fluorescence studies. The influence of the substituents of the thiourea groups on the stoichiometry of the resulting dicarboxylate complexes was established. Conformational changes in the bipyridine moiety under different conditions were evaluated. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine

The Article related to bipyridinedithiourea preparation complexation nickel dicarboxylate, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: [2,2′-Bipyridine]-3,3′-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 30, 1980, Chen, Ming-Feng published a patent.HPLC of Formula: 52243-87-5 The title of the patent was 1,1′-Dialkyl-4,4′-bipyridylium dihalide. And the patent contained the following:

The title compounds I (R = C1-3 alkyl; X = Cl, Br) were obtained by quaternizing 4,4′-bipyridine (II) with haloalkanoic acid. Thus II was treated with ClCH2CO2H at 120° to give 99% I (R = Me, X = Cl). The experimental process involved the reaction of 1,1′-Dipropyl-[4,4′-bipyridine]-1,1′-diium bromide(cas: 52243-87-5).HPLC of Formula: 52243-87-5

The Article related to bipyridine quaternization haloalkanoate, dialkylbipyridinium halide, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.HPLC of Formula: 52243-87-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 15, 2013, Qian, Guodong; Rao, Xingtang; Cai, Jianfeng; Cui, Yuanjing; Yang, Yu; Wang, Zhiyu published a patent.COA of Formula: C21H13NO8 The title of the patent was Preparation of metal organic frame material for adsorbing and storing methane. And the patent contained the following:

The title metal organic frame material has a three-dimensional network structure consisting of transitional metal ion and organic ligand through coordination bonds or intermol. force, and is prepared by dissolving nitrate, acetate, chloride, carbonate, sulfate or perchlorate of Cu, Zn, Cd, Co, Ni or Mn and I (R1-3 =H, F, Me, NH2, MeO, HO, NO2) in water and/or organic solvent, reacting at 40-120°C to give the metal organic frame material, allowing exchange of the metal organic frame material with acetone, and activating at 0°C under vacuum condition for 36 h and then at 100°C for 12 h. The three-dimensional network structure has sp. surface area 2000-3000 m2/g and pore volume 1-2 cm3/g. Preferably, the transitional metal ion is divalent Cu, Zn, Co, Ni, Cd, and Mn ion. The organic ligand contains pyridine, F, Me, amino, methoxy, hydroxy, nitro, etc., which do not participate in coordination. The metal organic frame material has high sp. surface area, pore volume, and thermal stability, large methane adsorption and storage capacity under variable temperature and variable pressure, simple preparation process, low cost, and repeated use. The experimental process involved the reaction of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid(cas: 1431292-15-7).COA of Formula: C21H13NO8

The Article related to metal organic frame material preparation methane adsorption storage, Unit Operations and Processes: Separation Processes and other aspects.COA of Formula: C21H13NO8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On April 17, 2013, Qian, Guodong; Rao, Xingtang; Cai, Jianfeng; Yu, Jiancan; Cui, Yuanjing; Yang, Yu; Wang, Zhiyu; Fan, Xianping; Wang, Minquan published a patent.Safety of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid The title of the patent was Metal organic framework substance for acetylene adsorption and storage and its preparation method. And the patent contained the following:

The metal organic framework substance material uses transition metal ions and a multi-dentate organic ligand 5,5′-(pyridine-2,5-diyl)-isophthalic acid to form three-dimensional network structure through coordination bonds or intermol. forces. Transition metal ions are preferably divalent copper, zinc, cobalt, nickel, cadmium ion. The metal organic framework substance material, has simple manufacture process, has high sp. surface area 2,000-2,200 m2/g and high pore volume 1.0-1.3 cm3/g. The method includes (1) dissolving di-Me 5-amino-m-phthalate in 15 weight% hydrobromic acid solution, stirring and cooling to 0-5°C, dripping 2.5mol/L sodium nitrite solution, diazotizing to obtain diazo salt solution; (2) dissolving cuprous bromide in 15 weight% hydrobromic acid solution, cooling to 0°C, dripping diazo salt solution under stirring, reacting at 0°C for 20-30 min, reacting at room temperature for ≥5 h, filtering to sep. organic layer, water washing, dissolving organic layer in dichloromethane, drying with anhydrous MgSO4, filtering, purifying by column chromatog. to obtain di-Me 5-bromo-m-phthalate; (3) dissolving di-Me 5-bromo-m-phthalate and bis(pinacolato)diboron in dried dioxane, adding potassium acetate and bis(triphenylphosphine) palladium dichloride, reacting at 65-70°C for 12 h, extracting with Et acetate, drying organic layer with anhydrous magnesium sulfate, removing organic solvent, purifying by column chromatog. to obtain di-Me pinacol 5-borate-1,3-phthalate. The method further includes (4) dissolving di-Me pinacol 5-borate-1,3-phthalate and 2,5-dibromopyridine in dioxane solution, adding potassium carbonate and catalyst bis(triphenylphosphine) palladium dichloride, reflux stirring under Ar protection at 70-90°C for 8-24 h, extracting with chloroform, collecting organic phase, evaporating solvent off, re-crystallizing with toluene to obtain product di-Me 5,5′-(pyridin-2,5-diyl)-m-phthalate; (5) dissolving in 3.0 mol/L NaOH solution, refluxing at 100°C for 12 h, cooling to room temperature, regulating pH to 1-2, ageing for 12 h, filtering, water washing, drying to obtain 5,5′-(pyridin-2,5-diyl)-m-phthalic acid; and (6) dissolving Cu, Zn, Cd, Co or Ni nitrate, acetate, chloride, carbonate, sulfate or perchlorate with 5,5′-(pyridin-2,5-diyl)-m-phthalic acid in water or/and organic solvent, reacting at 40-120°C to obtain title product. The material introduces pyridine-containing basic unit to multi-dentate organic ligand, and can effectively improve adsorption and storage amount of acetylene. The material is provided with relatively high acetylene adsorption amounts under 273 K and 298 K temperature condition, may be used at low pressure, and is expected to be used as a novel effective acetylene adsorbing and storing material. The experimental process involved the reaction of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid(cas: 1431292-15-7).Safety of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid

The Article related to metal pyridin diyl phthalic acid framework acetylene adsorption storage, Unit Operations and Processes: Separation Processes and other aspects.Safety of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 23, 1974, Bowden, Roy D.; Seaton, Thomas published a patent.Safety of 4-Chloro-2,6-difluoropyridine The title of the patent was Chlorofluoropyridines. And the patent contained the following:

Chlorofluoropyridines were prepared by vaporization of CCl4, CCl3F, or F2ClCCFCl2 solutions of fluoropyridines at 290-350° with solvent and reactant feed rates 0.18-0.6 and 0.025-0.125 mole/hr, resp., and contacting the vapor with Cl feed rate 0.5-1.10 mole/hr at 335-695° for 9.0-25.0 sec. Thus, CCl4 solution of 2-fluoropyridine, feed rates 0.3 and 0.025 mole/hr, resp., was vaporized at 290° and the vapor contacted with Cl feed rate 0.52 mole/hr at 375° for 23.5 sec to give 70% 6-chloro-2-fluoropyridine and traces of 5,6-, 4,6-, and 3,6-dichloro-2-fluoropyridines. The experimental process involved the reaction of 4-Chloro-2,6-difluoropyridine(cas: 34968-33-7).Safety of 4-Chloro-2,6-difluoropyridine

The Article related to chlorofluoropyridine, pyridine chlorofluoro, chlorination fluoropyridine, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Safety of 4-Chloro-2,6-difluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 21, 2022, Fasching, Bernhard; Ryckmans, Thomas; Flohr, Alexander; Ritzen, Andreas; Harvey, Freya; McAllister, Laura published a patent.Recommanded Product: 6-(tert-Butyl)pyridin-3-amine The title of the patent was Preparation of isoindolinone compounds as modulators of cereblon. And the patent contained the following:

This invention relates to the title compounds I [X1 = (un)substituted alkyl, cycloalkyl, aryl, etc.; or X1 together with the N atom of the carbamate forms (un)substituted 4-8 membered heterocycloalkyl; X2 = H, (un)substituted cycloalkyl, aryl, etc.; L1 = a covalent bond, alkyl; L2 = a covalent bond, alkyl; L3 = a covalent bond, alkyl, O, etc.] or pharmaceutically acceptable salts or stereoisomers thereof, useful as modulators of cereblon, in particular in the treatment of abnormal cell growth in mammals, especially humans. E.g., a multi-step synthesis of II, starting from Me 5-bromo-2-methylbenzoate, was described. Exemplified compounds I were tested for their ability for cereblon binding (data given for representative compounds I). Pharmaceutical composition comprising compound I was disclosed. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Recommanded Product: 6-(tert-Butyl)pyridin-3-amine

The Article related to isoindolinone dioxopiperidinyl preparation cereblon modulator anticancer, Heterocyclic Compounds (One Hetero Atom): Pyridines and other aspects.Recommanded Product: 6-(tert-Butyl)pyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem