Day: November 7, 2022

On July 31, 2012, Hutti, Jessica E.; Porter, Melissa A.; Cheely, Adam W.; Cantley, Lewis C.; Wang, Xiaodong; Kireev, Dmitri; Baldwin, Albert S.; Janzen, William P. published an article.COA of Formula: C20H24N2O4 The title of the article was Development of a high-throughput assay for identifying inhibitors of TBK1 and IKKε. And the article contained the following:

IKKε and TBK1 are noncanonical IKK family members which regulate inflammatory signaling pathways and also play important roles in oncogenesis. However, few inhibitors of these kinases have been identified. While the substrate specificity of IKKε has recently been described, the substrate specificity of TBK1 is unknown, hindering the development of high-throughput screening technologies for inhibitor identification. Here, we describe the optimal substrate phosphorylation motif for TBK1, and show that it is identical to the phosphorylation motif previously described for IKKε. This information enabled the design of an optimal TBK1/IKKε substrate peptide amenable to high-throughput screening and we assayed a 6,006 compound library that included 4,727 kinase-focused compounds to discover in vitro inhibitors of TBK1 and IKKε. 227 Compounds in this library inhibited TBK1 at a concentration of 10 μM, while 57 compounds inhibited IKKε. Together, these data describe a new high-throughput screening assay which will facilitate the discovery of small mol. TBK1/IKKε inhibitors possessing therapeutic potential for both inflammatory diseases and cancer. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).COA of Formula: C20H24N2O4

The Article related to high throughput screening tbk1 ikk inhibitor, Pharmacology: Methods and other aspects.COA of Formula: C20H24N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On February 28, 2010, Cox, Geoffrey B.; Maier, Norbert M.; Zhang, Tong; Franco, Pilar published an article.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate The title of the article was Enantioselective reversed-phase chromatography with protein-based columns. And the article contained the following:

Excellent reversed-phase separations using a protein-based column, CHIRAL-AGP, with volatile LC-MS compatible buffer systems have been obtained for a range of basic solutes. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

The Article related to reversed phase chromatog chiral agp ammonium acetate, Pharmacology: Methods and other aspects.Name: N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 31, 2011, Hu, Le-Le; Chen, Chen; Huang, Tao; Cai, Yu-Dong; Chou, Kuo-Chen published an article.HPLC of Formula: 132-20-7 The title of the article was Predicting biological functions of compounds based on chemical-chemical interactions. And the article contained the following:

Given a compound, how can we effectively predict its biol. function. It is a fundamentally important problem because the information thus obtained may benefit the understanding of many basic biol. processes and provide useful clues for drug design. In this study, based on the information of chem.-chem. interactions, a novel method was developed that can be used to identify which of the following eleven metabolic pathway classes a query compound may be involved with: (1) Carbohydrate Metabolism, (2) Energy Metabolism, (3) Lipid Metabolism, (4) Nucleotide Metabolism, (5) Amino Acid Metabolism, (6) Metabolism of Other Amino Acids, (7) Glycan Biosynthesis and Metabolism, (8) Metabolism of Cofactors and Vitamins, (9) Metabolism of Terpenoids and Polyketides, (10) Biosynthesis of Other Secondary Metabolites, (11) Xenobiotics Biodegradation and Metabolism It was observed that the overall success rate obtained by the method via the 5-fold cross-validation test on a benchmark dataset consisting of 3,137 compounds was 77.97%, which is much higher than 10.45%, the corresponding success rate obtained by the random guesses. Besides, to deal with the situation that some compounds may be involved with more than one metabolic pathway class, the method presented here is featured by the capacity able to provide a series of potential metabolic pathway classes ranked according to the descending order of their likelihood for each of the query compounds concerned. Furthermore, our method was also applied to predict 5,549 compounds whose metabolic pathway classes are unknown. Interestingly, the results thus obtained are quite consistent with the deductions from the reports by other investigators. It is anticipated that, with the continuous increase of the chem.-chem. interaction data, the current method will be further enhanced in its power and accuracy, so as to become a useful complementary vehicle in annotating uncharacterized compounds for their biol. functions. A dissertation. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).HPLC of Formula: 132-20-7

The Article related to carbohydrate energy lipid biol function, metabolic pathway chem interaction, Pharmacology: Methods and other aspects.HPLC of Formula: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 9, 2003, Hoegberg, Thomas; Rist, Oystein; Hjelmencrantz, Anders; Moldt, Peter; Elling, Christian E.; Schwartz, Thue W.; Gerlach, Lars Ole; Holst Lange, Birgitte published a patent.Recommanded Product: 75449-26-2 The title of the patent was Metal ion binding-based chemical libraries useful for drug discovery processes. And the patent contained the following:

The invention discloses the use of chem. compounds or selections of chem. compounds (libraries) of the general formula R1XFY(R1)GZR1 [F, G = N, O, S, Se, P; X, Y, Z = (un)branched C1-12 alkyl, (hetero)aryl, etc.; R1 = H, ABC; A = coupling or connecting moiety; B = spacer moiety; C = functional group] for in vivo methods for testing or validating the physiol. importance and/or the therapeutic or pharmacol. potential of biol. target mols., notably proteins such as, e.g., receptors and especially 7TM receptors in test animals expressing the biol. target mol. with, notably, a silent, engineered metal ion site. Use of specific metal ion binding sites of a generic nature in specific biol. target mols. such as, e.g. transmembrane proteins wherein the metal-ion binding site is capable of forming a complex with a metal ion is also described. The invention provides chem. compounds or libraries suitable for use in methods for improving the in vivo pharmacokinetic behavior of metal-ion chelates (e.g. the absorption pattern, the plasma half-life, the distribution, the metabolism and/or the elimination of the metal ion chelates). In order to improve the efficacy of the metal ion chelates impact on the biol. target mol. after administration of the metal ion chelate in vivo to a test animal, it is advantageous e.g. to increase the time period during which the metal ion chelate is in the circulatory system and/or localized at the target. Metal ion chelating compounds, which are designed to be suitable for use in a target validation process according to the invention and to libraries of at least two or more of such metal-ion chelating compounds are disclosed. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Recommanded Product: 75449-26-2

The Article related to metal chelate library drug discovery, target protein drug discovery metal chelate library, receptor target drug discovery metal chelate library, Pharmacology: Methods and other aspects.Recommanded Product: 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Yanru; Miyamoto, Shoto; Torigoe, Takeru; Kuninobu, Yoichiro published an article in 2021, the title of the article was Regioselective C(sp3)-H alkylation of a fructopyranose derivative by 1,6-HAT.Formula: C36H22F16IrN4P And the article contains the following content:

Regioselective C(sp3)-H alkylation of a fructopyranose derivative using electron-deficient alkenes as alkylation reagents was achieved. The reaction proceeded via 1,6-hydrogen atom transfer under photoredox iridium catalysis. Several functional groups were introduced into the fructopyranose derivative The experimental process involved the reaction of 4,4′-Bis(trifluoromethyl)-2,2′-bipyridinebis[3,5-difluoro-2-[5-methyl-2-pyridinyl)phenyl] iridium(III) hexafluorophosphate(cas: 2229858-27-7).Formula: C36H22F16IrN4P

The Article related to regioselective alkylation catalyst alkene fructopyranose glycoside preparation, photoredox iridium catalysis hydrogen transfer alkylation, Carbohydrates: Glycosides and other aspects.Formula: C36H22F16IrN4P

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 31, 2004, Panchaud, Philippe; Renaud, Philippe published an article.Name: Pyridine-3-sulfonic acid The title of the article was 3-Pyridinesulfonyl azide: A useful reagent for radical azidation. And the article contained the following:

Radical azidations and carboazidations have been achieved using 3-pyridinesulfonyl azide as azidating agent. Due to its base properties and its polarity, the excess of reagent is readily removed at the end of the reaction by filtration through silica gel or by extraction with either aqueous 1M HCl or 1M CuSO4. The use of this reagent greatly facilitates the tedious purifications of the final azides frequently encountered when reactions are run according to the original procedure involving benzenesulfonyl azide. Thus, reaction of Et 2-iodoacetate with 1-octene in presence of Bu6Sn2/di-tert-Bu hyponitrite/3-pyridinesulfonyl azide in C6H6 gave 80% Et 4-azidodecanoate. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Name: Pyridine-3-sulfonic acid

The Article related to pyridinesulfonyl azide preparation reagent radical azidation, Aliphatic Compounds: Other and other aspects.Name: Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Shi, Peiying; Lin, Xinhua; Yao, Hong published an article in 2015, the title of the article was Metabolism and plasma pharmacokinetics of isoorientin, a natural active ingredient, in Sprague-Dawley male rats after oral and intravenous administration.Product Details of 132-20-7 And the article contains the following content:

Several pharmacol. effects have been revealed on isoorientin, suggesting its potential medicinal prospects. The metabolic and plasma pharmacokinetic profiles of isoorientin were investigated in rats. For intra-gastric gavage, parent drug and three metabolites were detected in urine and feces by HPLC-MS/MS, but only one metabolite was found in plasma and identified as isoorientin 3′- or 4′-O-sulfate (M1) according to MS and UV absorbance spectra. After a single i.v. administration of isoorientin (5, 10, or 15 mg/kg B.W.) in rats, linear pharmacokinetic property was observed with favorable terminal half-lives (1.67 ± 1.32-2.07 ± 0.50 h). After a single p.o. administration of isoorientin (150 mg/kg B.W.) in rats, plasma isoorientin concentration was low, but the concentration of M1 was comparatively high. Low systemic exposure of oral isoorientin in rats could result from its low aqueous solubility and extensive first-pass metabolism, and plasma concentration of M1 can be used as a biomarker of isoorientin intake. Isoorientin showed low oral bioavailability (8.98 ± 1.07%), and had about 6% or 45% dose recovery in urine or feces, resp., 72 h after intra-gastric gavage. These studies are the first to describe the pharmacokinetics of isoorientin via i.v. or p.o. dosing, providing important information for understanding its process in vivo. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Product Details of 132-20-7

The Article related to isoorientin metabolite pharmacokinetics oral intravenous drug delivery, isoorientin, metabolism, pharmacokinetics, Pharmacology: Drug Metabolism and other aspects.Product Details of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Banda, Jagadeesh; Lakshmanan, Ramalingam; Vvs, Shiva Prasad; Gudla, Srinibas Patro; Prudhivi, Rosaiah published an article in 2015, the title of the article was A highly sensitive method for the quantification of fludrocortisone in human plasma using ultra-high-performance liquid chromatography tandem mass spectrometry and its pharmacokinetic application.Application of 132-20-7 And the article contains the following content:

A simple and high sensitive ultra-high-performance liquid chromatog. tandem mass spectrometry method for the determination of fludrocortisone in human plasma was developed and validated as per guidelines. The analyte and internal standard (IS), fludrocortisone-d5, were extracted from human plasma via liquid-liquid extraction using tert-Bu Me ether. The chromatog. separation was achieved on a Chromolith RP18e column using a mixture of acetonitrile and 2 mM ammonium formate (70:30, volume/volume) as the mobile phase at a flow rate of 0.7 mL/min. Quantitation was performed on a triple quadrupole mass spectrometer employing electrospray ionization technique, operating in multiple reaction monitoring and pos. ion mode. The precursors to product ion transitions monitored for fludrocortisone and IS were m/z 381.2 → 343.2 and 386.2 → 348.4, resp. The assay was validated with linear range of 40-3000 pg/mL. The intra- and inter-day precisions (relative standard deviation) were within 0.49-7.13 and 0.83-5.87%, resp. The proposed method was successfully applied to pharmacokinetic studies in humans. Copyright © 2015 John Wiley & Sons, Ltd. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Application of 132-20-7

The Article related to fludrocortisone acetate plasma pharmacokinetics uhplc tandem mass spectrometry, uhplc-ms/ms, fludrocortisone, human plasma, method validation, pharmacokinetics, Pharmacology: Drug Metabolism and other aspects.Application of 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 31, 2019, Kobayashi, Yuka; Cordonier, Christopher E. J.; Noda, Yohei; Nagase, Fuminori; Enomoto, Junko; Kageyama, Tatsuto; Honma, Hideo; Maruo, Shoji; Fukuda, Junji published an article.SDS of cas: 636-73-7 The title of the article was Tailored cell sheet engineering using microstereolithography and electrochemical cell transfer. And the article contained the following:

Postoperative adhesion and occlusion remain a serious issue associated with various surgeries, including endoscopic surgery, in which proliferated fibrous tissues stick to adjacent tissues and often cause severe complications. Cell sheet engineering has emerged as an effective approach not only for cell transplantation but also for the treatment of postoperative adhesion and occlusion. However, as the tissues in the body, such as middle ear and small intestine, and typical operative sites are non-flat and spatially complicated, tailored cell sheets with three-dimensional (3D) configurations may lead to widespread use of this approach. In the present study, we used microstereolithog., biocompatible gold plating, and electrochem. cell detachment to achieve this purpose. Various objects with dimensions ranging from millimeter- to micrometer-scale were fabricated with photocurable resin using lab-made equipment for microstereolithog. To coat the fabricated objects with a thin gold layer, conventional cyanide-based gold plating was unusable because it severely damaged almost all cells. Electroless non-cyanide gold plating we prepared was cytocompatible and suitable for electrochem. cell detachment. Cell sheets on the gold-plated substrate could be directly transplanted into a mouse i.p. using electrochem. cell detachment. We further demonstrated that cell sheets grown on gold-coated 3D objects were rapidly detached along with the desorption of electroactive-oligopeptide monolayer and transferred to a surrounding hydrogel. This approach may provide a promising strategy to prepare and directly transplant tailor-made cell sheets with suitable configurations. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).SDS of cas: 636-73-7

The Article related to cell sheet engineering microstereolithog gold plating electrochem detachment, Pharmaceuticals: Pharmaceutics and other aspects.SDS of cas: 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 31, 2015, Kiraz, Hasan Ali; Oemuer, Dilek; Ekin, Serpil; Toman, Hueseyin; Uyan, Berna; Yurtlu, Buelent Serhan; Hanci, Volkan published an article.Formula: C20H24N2O4 The title of the article was Evaluation of precipitation characteristics of commonly used non-steroidal anti-inflammatory analgesic drugs. And the article contained the following:

Postoperative pain is a major problem in clin. practice. Non-steroidal anti-inflammatory drugs have traditionally been used to relieve postoperative pain. Administration of i.v. products together can result incompatibility problems and this is clin. hazardous. Reference texts, published reports can provide information about drugs’ incompatibility characteristics but there have been limited data for new drugs such as lornoxicam, tenoxicam and dexketoprofen, commonly used non-steroidal antiinflammatory drugs. In this study, it was aimed to investigate whether there is precipitation between lornoxicam, tenoxicam and dexketoprofen with other commonly used drugs in anesthesiol. practice. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Formula: C20H24N2O4

The Article related to tenoxicam dexketoprofen lornoxicam nonsteroidal antiinflammatory analgesic precipitation, Pharmaceuticals: Pharmaceutics and other aspects.Formula: C20H24N2O4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem