Day: November 8, 2022

Computed Properties of C7H7NOIn 2021 ,《Co-Catalyzed Synthesis of Primary Amines via Reductive Amination employing Hydrogen under very mild Conditions》 appeared in ChemSusChem. The author of the article were Elfinger, Matthias; Schoenauer, Timon; Thomae, Sabrina L. J.; Staeglich, Robert; Drechsler, Markus; Zobel, Mirijam; Senker, Juergen; Kempe, Rhett. The article conveys some information:

Nanostructured and reusable 3d-metal catalysts that operate with high activity and selectivity in important chem. reactions are highly desirable. Here, a cobalt catalyst was developed for the synthesis of primary amines via reductive amination employing hydrogen as the reducing agent and easy-to-handle ammonia, dissolved in water, as the nitrogen source. The catalyst operates under very mild conditions (1.5 mol% catalyst loading, 50°C and 10 bar H2 pressure) and outperforms com. available noble metal catalysts (Pd, Pt, Ru, Rh, Ir). A broad scope and a very good functional group tolerance were observed The key for the high activity seemed to be the used support: an N-doped amorphous carbon material with small and turbostratically disordered graphitic domains, which is microporous with a bimodal size distribution and with basic NH functionalities in the pores. After reading the article, we found that the author used 4-Acetylpyridine(cas: 1122-54-9Computed Properties of C7H7NO)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Computed Properties of C7H7NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H7N3In 2019 ,《A new class of meta-pyridine-urea oligomers for selective identification of mercury(II) ions》 appeared in Tetrahedron Letters. The author of the article were Liu, Yajing; Chi, Chenjing; Wu, Renbo; Huang, Yong; Liu, Song; Sun, Mingyue; Sun, Yuli; Yang, Zequn; Chen, HuaLong; Wu, Zehui. The article conveys some information:

A series of new pyridine-urea oligomers were synthesized and tested for their ability to recognize ions in PBS or Ac buffer solution by fluorescence. The ability of oligourea urea to selectively recognize Hg2+ was gradually enhanced with the increase of chain, which was further proved by DFT calculation The 1:2 stoichiometry was established for the L7-Hg2+ complex on the basis of Job’s plot. The binding constant (KB) and the lowest detection limit for Hg2+ were also determined DFT calculations were used to optimize the structures of L2-7 and its Hg2+ complexes. Highly sensitive and selective probes for the recognition of Hg2+ based on this report are expected to be developed and used for in vivo detection. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6COA of Formula: C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.COA of Formula: C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Application of 2510-22-7In 2020 ,《Synthesis and Optical Properties of Quadrupolar Pyridinium Salt and Its Application as Bioimaging Agent》 appeared in Chemistry Letters. The author of the article were Hoshi, Keita; Sanagawa, Yohei; Umebayashi, Ryuta; Tabata, Atsushi; Nagamune, Hideaki; Hase, Eiji; Minamikawa, Takeo; Yasui, Takeshi; Yoshida, Yasushi; Minagawa, Keiji; Kawamura, Yasuhiko; Imada, Yasushi; Yagishita, Fumitoshi. The article conveys some information:

We have synthesized and characterized an acceptor-π-donor-π-acceptor type pyridinium salt. The salt exhibited yellow emission with large Stokes shift in solution and was successfully excited by NIR irradiation via two-photon absorption process. In addition, it was found that the usage of the salt as a bioimaging agent for HeLa cells visualizes cell death. The combined use of the salt and a com. available green fluorescent dye for the detection of live cell viability realized the one-shot fluorescence imaging of live and dead HeLa cells under the single blue excitation. In the experiment, the researchers used many compounds, for example, 4-Ethynylpyridine(cas: 2510-22-7Application of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Application of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reference of Methyl 5-bromopicolinateIn 2021 ,《Synthesis and characterization of new pyridine-based chiral calamitic liquid crystals》 appeared in Liquid Crystals. The author of the article were Vardar, Deniz; Ocak, Hale; Akdas Kilic, Huriye; Jeannin, Olivier; Camerel, Franck; Eran, Belkiz Bilgin. The article conveys some information:

In this paper, novel chiral calamitic compounds, consisting of n-dodecyloxyphenyl substituted pyridine carboxylate core linked to one or two benzene rings through ester linkers was synthesized by multi-step procedures. The other end was varied by introducing a flexible (S)-2-methylbutyloxy or (S)-3,7-dimethyloctyloxy chiral chain. The liquid crystal properties of new compounds were investigated by various exptl. techniques such as DSC, POM and SAXS. The pyridine-based calamitic compounds exhibited enantiotropic chiral smectic mesophases such as SmC*, SmA or uncharacteristic mesophase depending on hetero aromatic rings such as nicotinate or picolinate cores, number of aromatic rings and the type of chiral-branched chain. In the experimental materials used by the author, we found Methyl 5-bromopicolinate(cas: 29682-15-3Reference of Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Reference of Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of 2,5-DibromopyridineIn 2020 ,《Synthesis of Pyridoclax Analogues: Insight into Their Druggability by Investigating Their Physicochemical Properties and Interactions with Membranes》 appeared in ChemMedChem. The author of the article were De Pascale, Martina; Iacopetta, Domenico; Since, Marc; Corvaisier, Sophie; Vie, Veronique; Paboeuf, Gilles; Hennequin, Didier; Perato, Serge; De Giorgi, Marcella; Sinicropi, Maria Stefania; Sopkova-De Oliveira Santos, Jana; Voisin-Chiret, Anne-Sophie; Malzert-Freon, Aurelie. The article conveys some information:

Pyridoclax is considered a promising anticancer drug, acting as a protein-protein interaction disruptor, with potential applications in the treatment of ovarian, lung, and mesothelioma cancers. Eighteen sensibly selected structural analogs of Pyridoclax were synthesized, and their physicochem. properties were systematically assessed and analyzed. Moreover, considering that drug-membrane interactions play an essential role in understanding the mode of action of a given drug and its eventual toxic effects, membrane models were used to investigate such interactions in bulk (liposomes) and at the air-water interface. The measured exptl. data on all original oligopyridines allowed the assessment of relative differences in terms of physicochem. properties, which could be determinant for their druggability, and hence for drug development. In the experiment, the researchers used 2,5-Dibromopyridine(cas: 624-28-2Quality Control of 2,5-Dibromopyridine)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Quality Control of 2,5-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Computed Properties of C5H3Br2NIn 2019 ,《Extended π-conjugated quinazolinone derivatives with enhanced third-order nonlinear optical response》 appeared in Dyes and Pigments. The author of the article were Jia, Jianhong; Zhang, Jiuming; Zhou, Chunsong; Zheng, Mingming; Feng, Dong; Liang, Guanqiu; She, Yuanbin. The article conveys some information:

Quinazolinone derivatives were designed and synthesized based to the structure of donor-π-acceptor-π-donor (D-π-A-π-D). To obtain materials with good third-order nonlinear optical response that the authors have introduced some electron-donating groups such as triarylamine, cumene, and N,N-dimethylaniline into the 8- or 2,8- position of the quinazolinone. Compared with the parent QZ-1, the target compounds showed a significant red shift. Electrochem. data and theor. calculation showed that the introduction of the donor group that extended the conjugation length of the mol. and reduced the HOMO/LOMO band gap which promoted the intramol. charge transfer (ICT). Z-scan results demonstrated that as the electron-donating ability of the donor group increased, the synthetic materials exhibit stronger nonlinear optical response. Among them, QZB-1 incorporating with 2 triarylamine groups has a γ value of 34.616 × 10-32 esu, which is up to 38 times of the parent structure. The results of this study have guiding significance for the mol. design of nonlinear optical materials. The results came from multiple reactions, including the reaction of 2,5-Dibromopyridine(cas: 624-28-2Computed Properties of C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. Computed Properties of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 1539-42-0In 2020 ,《A red-emitting luminescent probe for sequentially detecting Cu2+ and cysteine/histidine in aqueous solution and its imaging application in living zebrafish》 appeared in Dyes and Pigments. The author of the article were Yang, Yutong; Li, Yibin; Zhi, Xiaomin; Xu, Yingjun; Li, Minna. The article conveys some information:

A unique red-emissive luminescent probe based on dipicolyl amine (DPA) tethered ruthenium(II) tris(bipyridine) derivative (Ru-DPA) has been developed for the sequential and specific detection of Cu2+ and cysteine (Cys)/histidine (His) in pure aqueous medium. The probe Ru-DPA displayed an ′on-off′ luminescence response at 610 nm specifically toward Cu2+, accompanied by a distinct naked-eye luminescence color change from orange-red to colorless. Also, Ru-DPA enabled anal. of Cu2+ with a detection of limit as low as 0.04 μM. Addnl., the in situ generated Ru-DPA-Cu ensemble detected specifically Cys/His based on the strong affinity for Cu2+ to Cys and His, giving rise to a significant increase in the MLCT-based luminescence of Ru(II) complex and a relevant chromogenic change from colorless to orange-red. This copper (II) ion competitive-displacement detection strategy offered a good linearity with a low detection limit for Cys at 0.24 μM and His at 1.4 μM under pure aqueous medium. Moreover, Ru-DPA exhibited extremely low cytotoxicity (>90% viability at a concentration range from 20 to 100 μM), excellent membrane permeability and was successfully applied to the luminescence imaging of Cu2+ and Cys/His both in living bone mesenchymal stem cells (BMSCs) and zebrafish. The results demonstrated the great potential of Ru-DPA for monitoring Cu2+ and Cys/His in environmental and biol. systems. In the experimental materials used by the author, we found Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0SDS of cas: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.SDS of cas: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 94928-86-6In 2019 ,《Regioselective and Stereoselective Difluoromethylation of Enamides with Difluoromethyltriphenylphosphonium Bromide via Photoredox Catalysis》 appeared in Organic Letters. The author of the article were Zhu, Tong-Hao; Zhang, Ze-Yu; Tao, Ji-Yu; Zhao, Kai; Loh, Teck-Peng. The article conveys some information:

A regioselective and stereoselective difluoromethylation of enamides with bench-stable and easily accessible difluoromethyltriphenylphosphonium bromide is described. A broad array of synthetically important and geometrically defined β-difluoromethylated enamides bearing various functional groups are obtained with up to 91% yield. In the experiment, the researchers used fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6HPLC of Formula: 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. HPLC of Formula: 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: Picolinic acidIn 2020 ,《Characterization of a Mixed-Valence Ru(II)/Ru(III) Ion-Pair Complex. Unexpected High-Frequency Electron Paramagnetic Resonance Evidence for Ru(III)-Ru(III) Dimer Coupling》 was published in Inorganic Chemistry. The article was written by Impert, Olga; Kozakiewicz, Anna; Wrzeszcz, Grzegorz; Katafias, Anna; Bienko, Alina; van Eldik, Rudi; Ozarowski, Andrew. The article contains the following contents:

In this contribution, we report the synthesis and full characterization of the first mixed-valence Ru(II)/Ru(III) ion-pair complex, [RuII(bipy)2(pic)]+[cis-RuIIICl2(pic)2]-, in the solid state and in aqueous solution, where bipy = 2,2′-bipyridine and pic- = picolinate. In addition, unexpected high-frequency ESR evidence for interactions between two neighboring Ru(III) ions, resulting in a triplet state, S = 1, was found.Picolinic acid(cas: 98-98-6Recommanded Product: Picolinic acid) was used in this study.

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Recommanded Product: Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Recommanded Product: 1539-42-0In 2019 ,《Ruthenium(II)-Polypyridyl-Based Sensor Bearing a DPA Unit for Selective Detection of Cu(II) Ion in Aqueous Medium》 was published in ChemistrySelect. The article was written by Arora, Aayushi; Kaushal, Jolly; Kumar, Arun; Kumar, Pramod; Kumar, Sushil. The article contains the following contents:

Ruthenium(II) polypyridyl linked di-(2-picolyl)amine (DPA) based chemosensor [Ru(bpy)2(bpmpip)](PF6)2 (Ru-L) has been developed for the selective detection of Cu(II) ion in purely aqueous medium. The change in absorbance and emission spectra of chemosensor Ru-L was observable upon addition of Cu2+ ion. Competitive binding studies, detection limit (18.9 nM) and binding constants illustrate significant sensing ability of chemosensor Ru-L. Spectral behavior of chemosensor Ru-L at different pH was also investigated in absence and presence of Cu2+ ion. Binding of Cu2+ to Ru-L occurs in 1:1 stoichiometry, in good agreement with the results obatined from ESI-mass spectrometry, Job’s plot experiment and spectroscopic titrations The emission intensity of Ru-L was selectively quenched by Cu2+ ion and an obvious color change from red orange to yellow in aqueous solution as well as on paper strips was observed under UV light. The reversibility cycles for the detection of Cu2+ ion were achieved by EDTA and corresponding logic gate was also developed. The water solubility, reversibility and optical visualization of the present chemosensor make it ideal for practical applications on real samples. After reading the article, we found that the author used Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0Recommanded Product: 1539-42-0)

Bis(pyridin-2-ylmethyl)amine(cas: 1539-42-0) is a secondary amine with two picolyl substituents. The compound is a tridentate ligand in coordination chemistry and commonly used to produce Zn-based chemosensors/probes, such as Zinpry.Recommanded Product: 1539-42-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem