Day: November 9, 2022

《Infrared Spectroscopic Detection of Biosignatures at Lake Tirez, Spain: Implications for Marsã€?was published in Astrobiology in 2020. These research results belong to Preston, Louisa J.; Barcenilla, Rebeca; Dartnell, Lewis R.; Kucukkilic-Stephens, Ezgi; Olsson-Francis, Karen. Computed Properties of C6H5NO2 The article mentions the following:

The detection of potential biosignatures with mineral matrixes is part of a multifaceted approach in the search for life on other planetary bodies. The 2020 ExoMars Rosalind Franklin rover includes within its payload three IR spectrometers in the form of ISEM (IR Spectrometer for ExoMars), MicrOmega, and Ma-MISS (Mars Multispectral Imager for Subsurface Studies). The use of this technique in the detection and characterization of biosignatures is of great value. Organic materials are often co-deposited in terrestrial evaporites and as such have been proposed as relevant analogs in the search for life on Mars. This study focuses on Ca-sulfates collected from the hypersaline Tirez Lake in Spain. Mid IR and visible near IR anal. of soils, salt crusts, and crystals with green and red layering indicative of microbial colonization of the samples was acquired from across the lake and identified the main mineral to be gypsum with inputs of carbonate and silica. Organic functional groups that could be attributed to amides and carboxylic acids were identified as well as chlorophyll; however, due to the strong mineralogical absorptions observed, these were hard to unambiguously discern. Taxonomical assignment demonstrated that the archaeal community within the samples was dominated by the halophilic extremophile Halobacteriaceae while the bacterial community was dominated by the class Nocardiaceae. The results of this research highlight that sulfates on Mars are a mixed blessing, acting as an effective host for organic matter preservation but also a material that masks the presence of organic functional groups when analyzed with spectroscopic tools similar to those due to fly on the 2020 ExoMars rover. A suite of complementary anal. techniques therefore should be used to support the spectral identification of any candidate extraterrestrial biosignatures. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6Computed Properties of C6H5NO2)

Picolinic acid(cas: 98-98-6) is used in the preparation of 2-Aminodihydro[1,3]thiazines as BACE 2 inhibitors and their preparation and use in the treatment of diabetes.Computed Properties of C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Addressing Multiple Ions Using Single Optical Probe: Multi-Color Response via Mutually Independent Sensing Pathwaysã€?was written by Dey, Nilanjan; Bhattacharjee, Subham; Bhattacharya, Santanu. Formula: C6H6BrN And the article was included in ChemistrySelect in 2020. The article conveys some information:

Multiresponsive smart optical probe based on p-phenylene vinylene backbone is designed for simultaneous sensing of multiple ions, such as Cu2+, Zn2+ and F- at pH 7.4. A rapid color change from colorless to deep yellow is observed upon addition of both Cu2+ and Zn2+ ion. However, under long UV lamp, the green-colored emission of the probe is specifically quenched in the presence of Cu2+, while Zn2+ induces change in the emission color from green to yellow. On the contrary, F-, unlike Cu2+ and Zn2+, does not render any change in visible color, however, an emission quenching, similar to that of Cu2+ addition, was noticed. The binding of metal ions to the central bipyridine core diminishes the ′conformational flexibilityâ€?and facilitates ′ligand to metal ionâ€?charge transfer. On the contrary, addition of fluoride triggers the cleavage of silyl ether groups and results in the photo-induced electron transfer from free hydroxyl groups to the core aromatic unit. Thus, we can detect as well as discriminate these three ions (Cu2+, Zn2+ and F-) simultaneously by comparing the resp. output signals. Further, a sustainable strategy has been developed for on-site detection of toxic ions using reusable, low-cost paper strips.2-Bromo-5-methylpyridine(cas: 3510-66-5Formula: C6H6BrN) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Formula: C6H6BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Direct Suzuki-Miyaura Coupling with Naphthalene-1,8-diaminato (dan)-Substituted Organoboronsã€?was written by Yoshida, Hiroto; Seki, Michinari; Kamio, Shintaro; Tanaka, Hideya; Izumi, Yuki; Li, Jialun; Osaka, Itaru; Abe, Manabu; Andoh, Hiroki; Yajima, Tomoki; Tani, Tomohiro; Tsuchimoto, Teruhisa. Quality Control of 2-Bromo-5-methylpyridine And the article was included in ACS Catalysis in 2020. The article conveys some information:

The direct Suzuki-Miyaura coupling with “”protected”” R-B(dan) (dan = naphthalene-1,8-diaminato) (R = Ph, 4-MeOC6H4, 2-pyridyl) was demonstrated to smoothly occur without in situ deprotection of the B(dan) moiety. The use of KOt-Bu (Ba(OH)2 in some cases) as a base under anhydrous conditions is the key to the successful cross-coupling, where R-B(dan) is readily converted into a transmetalation-active borate-form, regardless of the well-accepted diminished boron-Lewis acidity. In addition to this study using 2-Bromo-5-methylpyridine, there are many other studies that have used 2-Bromo-5-methylpyridine(cas: 3510-66-5Quality Control of 2-Bromo-5-methylpyridine) was used in this study.

2-Bromo-5-methylpyridine(cas: 3510-66-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Quality Control of 2-Bromo-5-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Organo-photoredox-Catalyzed Atom-Transfer Radical Substitution of Alkenes with α-Carbonyl Alkyl Halidesã€?was written by Hirata, Goki; Shimada, Taisei; Nishikata, Takashi. Recommanded Product: 94928-86-6 And the article was included in Organic Letters in 2020. The article conveys some information:

A light-driven atom-transfer radical substitution (ATRS) and carboesterification reaction of alkenes with alkyl halides has been developed using PTH (N-phenylphenothiazine) as the organo-photoredox catalyst. Two types of products were obtained, depending on the additive and solvent used during the reaction. Primary, secondary, and tertiary alkyl halides reacted to give the ATRS products. This protocol has several advantages: it requires mild reaction conditions and a low catalyst loading and exhibits a broad substrate scope and good functional group tolerance. Mechanistic studies indicate that alkyl radicals might be generated as the key intermediates via photocatalysis, providing a new direction for ATRS reactions. In the part of experimental materials, we found many familiar compounds, such as fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Recommanded Product: 94928-86-6)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Recommanded Product: 94928-86-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Rapid Access to Diverse Potassium Acyltrifluoroborates (KATs) through Late-Stage Chemoselective Cross-Coupling Reactionsã€?was written by Deng, Xingwang; Zhou, Guan; Han, Xiao; Ullah, Khadim; Srinivasan, Rajavel. Computed Properties of C5H3Br2N And the article was included in Organic Letters in 2021. The article conveys some information:

Functionalization of acyltrifluoroborates K[BrArCOBF3] (Ar = arylene, 2,5-thiophenediyl) was achieved by late-stage cross-coupling with arylboronic acids, arylacetylenes and aromatic amines, providing access to substituted trifluoroborates K[RArCOBF3] (R = aryl, alkynyl, arylamino). Potassium acyltrifluoroborates (KATs) are opening up new avenues in chem. biol., materials science, and synthetic organic chem. due to their intriguing reactivities. However, the synthesis of these compounds remains mostly complicated and time-consuming. Herein, we have developed chemoselective Pd-catalyzed approaches for the late-stage diversification of arenes bearing prefunctionalized KATs. These approaches feature chemoselective cross-coupling, rapid diversification, functional group tolerance, mild reaction conditions, simple operation, and high yields. In the experimental materials used by the author, we found 2,5-Dibromopyridine(cas: 624-28-2Computed Properties of C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Computed Properties of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Xiaoyu; Liu, Bo; Pei, Congcong; Li, Jingya; Zou, Dapeng; Wu, Yangjie; Wu, Yusheng published their research in Organic Letters in 2021. The article was titled 《Visible-Light-Induced Radical Difluoromethylation/Cyclization of Unactivated Alkenes: Access to CF2H-Substituted Quinazolinonesã€?COA of Formula: C33H24IrN3 The article contains the following contents:

A mild and efficient visible-light-induced radical difluoromethylation/cyclization of unactivated alkenes towards the synthesis of substituted quinazolinones with easily accessible difluoromethyltriphenylphosphonium bromide was developed. The transformation has the advantages of wide functional group compatibility, a broad substrate scope and operational simplicity. The benign protocol offered a facile access to pharmaceutically valuable difluoromethylated polycyclic quinazolinones. The experimental process involved the reaction of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6COA of Formula: C33H24IrN3)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.COA of Formula: C33H24IrN3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Song, Ruichong; Tago, Tetsuro; Tatsuta, Maho; Shiraishi, Nana; Iwai, Kumiko; Hirano, Keiichi; Toyohara, Jun; Tanaka, Hiroshi published their research in ChemistrySelect in 2021. The article was titled 《N-Alkyl 3-aminobut-2-enenitrile as a Non-radioactive Side Product in Nucleophilic 18F-Fluorinationã€?Computed Properties of C5H3Br2N The article contains the following contents:

Acetonitrile acted as a reactant under the conventional reaction conditions for aliphatic nucleophilic 18F-fluorination in acetonitrile to provide the N-alkyl 3-aminobut-2-enenitrile (E)-I as one of the side products was found. Dimerization of acetonitrile promoted by a complex of K2CO3 and K222 provided 3-aminobut-2-enenitrile, which acted as nucleophile to provide N-alkyl amino derivatives (E)-I. Based on the finding, avoiding acetonitrile in the drying of [18F]fluoride as well as 18F-labeling enabled the preparation of 18F-labeled compounds II (X = 18F) containing only a small amount of the corresponding alc. II (X = OH). Finally, usage of an automated synthesizer to achieve an efficient phase-tag-assisted synthesis of 18F-labeled stilbene derivative as a 18F-labeled amyloid-β ligand (X = 18F) is described. The experimental part of the paper was very detailed, including the reaction process of 2,5-Dibromopyridine(cas: 624-28-2Computed Properties of C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine is widely used in the precursor to agrochemicals and pharmaceuticals. Also, it is used as an important reagent and organic solvent.Computed Properties of C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zwergel, Clemens; Di Bello, Elisabetta; Fioravanti, Rossella; Conte, Mariarosaria; Nebbioso, Angela; Mazzone, Roberta; Brosch, Gerald; Mercurio, Ciro; Varasi, Mario; Altucci, Lucia; Valente, Sergio; Mai, Antonello published their research in ChemMedChem in 2021. The article was titled 《Novel Pyridine-Based Hydroxamates and 2-Aminoanilides as Histone Deacetylase Inhibitors: Biochemical Profile and Anticancer Activityã€?Reference of 6-Bromopyridin-3-amine The article contains the following contents:

Starting from the N-hydroxy-3-((4-(2-phenylbutanoyl)amino)phenyl)acrylamide (5 b) previously described by us as a HDAC inhibitor, we prepared four aza-analogs, 6-8, 9 b, as regioisomers containing the pyridine nucleus. Preliminary screening against mHDAC1 highlighted the N-hydroxy-5-((2-(2-phenylbutanoyl)amino)pyridyl)acrylamide (9 b) as the most potent inhibitor. Thus, we further developed both pyridylacrylic- and nicotinic-based hydroxamates (9 a, 9 c-f, and 11 a-f) and 2-aminoanilides (10 a-f and 12 a-f), related to 9 b, to be tested against HDACs. Among them, the nicotinic hydroxamate 11 d displayed sub-nanomolar potency (IC50: 0.5 nM) and selectivity up to 34 000 times that of HDAC4 and from 100 to 1300 times that of all the other tested HDAC isoforms. The 2-aminoanilides were class I-selective HDAC inhibitors, generally more potent against HDAC3, with the nicotinic anilide 12 d being the most effective (IC50HDAC3=0.113μM). When tested in U937 leukemia cells, the hydroxamates 9 e, 11 c, and 11 d blocked over 80% of cells in G2/M phase, whereas the anilides did not alter cell-cycle progress. In the same cell line, the hydroxamate 11 c and the anilide 10 b induced about 30% apoptosis, and the anilide 12 c displayed about 40% cytodifferentiation. Finally, the most potent compounds in leukemia cells 9 b, 11 c, 10 b, 10 e, and 12 c were also tested in K562, HCT116, and A549 cancer cells, displaying antiproliferative IC50 values at single-digit to sub-micromolar level.6-Bromopyridin-3-amine(cas: 13534-97-9Reference of 6-Bromopyridin-3-amine) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Reference of 6-Bromopyridin-3-amine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chen, Xiaoxi; Fan, Shuai; Zhang, Meng; Gao, Yuzhen; Li, Shangda; Li, Gang published their research in Chemical Science in 2021. The article was titled 《Palladium-catalyzed remote para-C-H activation of arenes assisted by a recyclable pyridine-based templateã€?Name: Pyridin-3-ylboronic acid The article contains the following contents:

An unprecedented pyridine-based para-directing template (DT) assisted, Pd-catalyzed para-C-H alkenylation of three classes of arenes, i.e. phenylpropanoic acids, 2-Ph benzoic acids and benzyl alcs., with a series of alkenes included perfluoroalkenes was reported. Notably, the pyridine-based para-DT could be easily synthesized and readily recycled under mild conditions. These results may find application in rapid construction of para-substituted arenes and stimulated the exploration of novel methods for para-C-H functionalization of arenes. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Name: Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Name: Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Weber, Stefan; Bruenig, Julian; Veiros, Luis F.; Kirchner, Karl published their research in Organometallics in 2021. The article was titled 《Manganese-Catalyzed Hydrogenation of Ketones under Mild and Base-free Conditionsã€?Category: pyridine-derivatives The article contains the following contents:

In this paper, several Mn(I) complexes were applied as catalysts for the homogeneous hydrogenation of ketones. The most active precatalyst is the bench-stable alkyl bisphosphine Mn(I) complex fac-[Mn(dippe)(CO)3(CH2CH2CH3)]. The reaction proceeds at room temperature under base-free conditions with a catalyst loading of 3 mol % and a hydrogen pressure of 10 bar. A temperature-dependent selectivity for the reduction of α,β-unsaturated carbonyls was observed At room temperature, the carbonyl group was selectively hydrogenated, while the C:C bond stayed intact. At 60°, fully saturated systems were obtained. A plausible mechanism based on DFT calculations which involves an inner-sphere hydride transfer is proposed. In the experiment, the researchers used many compounds, for example, 4-Acetylpyridine(cas: 1122-54-9Category: pyridine-derivatives)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem