Day: November 10, 2022

《Efficient synthesis of highly dispersed ultrafine Pd nanoparticles on a porous organic polymer for hydrogenation of CO2 to formate》 was published in RSC Advances in 2020. These research results belong to Shao, Xianzhao; Miao, Xinyi; Yu, Xiaohu; Wang, Wei; Ji, Xiaohui. Electric Literature of C5H7N3 The article mentions the following:

Precise design of catalytic supports is an encouraging technique for simultaneously improving the activity and stability of the catalyst. However, development of efficient heterogeneous catalysts for transforming CO2 into formic acid (FA) is still a big challenge. Herein, we report that Pd nanoparticles (NPs) based on a porous organic polymeric support containing amide and pyridine functional groups (AP-POP) can be an efficient catalyst for selective hydrogenation of CO2 to form formate with high efficiency even under mild reaction conditions (6.0 MPa, 80°C). Electron d. of the active Pd species modulated via the interaction between pyridine nitrogen and Pd play important roles in dramatic enhancement of catalytic activity and was indicated by XPS along with CO chemisorption. This work provides an interesting and effective strategy for precise support design to improve the catalytic performance of nanoparticles. The results came from multiple reactions, including the reaction of 2,6-Diaminopyridine(cas: 141-86-6Electric Literature of C5H7N3)

2,6-Diaminopyridine(cas: 141-86-6) belongs to pyridine. Pyridine and its simple derivatives are stable and relatively unreactive liquids, with strong penetrating odours that are unpleasant.Electric Literature of C5H7N3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《The Active Center of Co-N-C Electrocatalysts for the Selective Reduction of CO2 to CO Using a Nafion-H Electrolyte in the Gas Phase》 was published in ACS Omega in 2020. These research results belong to Ogihara, Hitoshi; Maezuru, Tomomi; Ogishima, Yuji; Inami, Yuta; Saito, Mayuko; Iguchi, Shoji; Yamanaka, Ichiro. Formula: C12H12N2 The article mentions the following:

To contribute a solution for the global warming problem, the selective electrochem. reduction of CO2 to CO was studied in the gas phase using a [CO2(g), Co-N-C cathode | Nafion-H | Pt/C anode, H2/water] system without using carbonate solutions The Co-N-C electrocatalysts were synthesized by partial pyrolysis of precursors in inert gas, which were prepared from various N-bidentate ligands, Co(NO3)2, and Ketjenblack (KB). The most active electrocatalyst was Co-(4,4′-dimethyl-2,2′-bipyridine)/KB pyrolyzed at 673 K, denoted Co-4,4′-dmbpy/KB(673K). A high performance of CO formation (331 μmol h-1 cm-2, 217 TOF h-1) at 0.020 A cm-2 with 78% current efficiency was obtained at -0.75 V (SHE) and 273 K under strong acidic conditions of Nafion-H. Characterization studies using extended X-ray absorption fine structure (EXAFS), XPS, transmission electron microscopy-energy-dispersive X-ray (TEM-EDX), X-ray diffraction (XRD), and temperature-programmed desorption with mass spectrometry (TPD-MS) indicated the active site as Co coordinated with four N atoms bonding the surface of KB, abbreviated Co-N4-Cx structure. A model of the reduction mechanism of CO2 on the active site was proposed. In the experiment, the researchers used 4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6Formula: C12H12N2)

4,4′-Dimethyl-2,2′-bipyridine(cas: 1134-35-6) is used as a chemical Intermediate. It can be used for the determination of ferrous and cyanide compounds.Formula: C12H12N2 Furthermore, 4,4′-Dimethyl-2,2′-bipyridine is used in the synthesis of a series of o-phenanthroline-substituted ruthenium(II) complexes.

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Fluorination as a route towards unlocking the hydrogen bond donor ability of phenolic compounds in self-assembled monolayers》 was published in CrystEngComm in 2020. These research results belong to Pinfold, Harry; Pattison, Graham; Costantini, Giovanni. HPLC of Formula: 100-48-1 The article mentions the following:

We report on the comparative performance of a simple diphenol and its fluorinated analog as hydrogen-bond-donating building blocks for the formation of multicomponent self-assembled monolayers. The fluorinated mol. is found to be a significantly more effective building block than its unfluorinated counterpart. In the part of experimental materials, we found many familiar compounds, such as 4-Cyanopyridine(cas: 100-48-1HPLC of Formula: 100-48-1)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridine is very deactivated towards electrophilic substitution with respect to benzene. For this reason classical formylation, using methods such as the Gattermann or Vilsmeier reactions, are not generally successful. HPLC of Formula: 100-48-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Continuous Flow as Enabling Technology: Synthesis of Heteroaromatic Sulfinates as Bench Stable Cross-Coupling Partners》 was written by Lima, Fabio; Andre, Jerome; Marziale, Alexander; Greb, Andreas; Glowienke, Susanne; Meisenbach, Mark; Schenkel, Berthold; Martin, Benjamin; Sedelmeier, Joerg. Quality Control of 2,6-Dibromopyridine And the article was included in Organic Letters in 2020. The article conveys some information:

An enabling continuous flow setup for handling of unstable organolithium intermediates and synthesis of heteroaryl sulfinates on a multigram scale is described. The developed continuous flow process allows for the synthesis and simple isolation of heteroaryl sulfinates which are otherwise challenging to access in classical batch mode. The lithium sulfinate salts prepared by this method were shown to be efficient reaction partners in palladium catalyzed C(sp2)-C(sp2) cross-coupling to access medicinally relevant bis-heteroaryl motifs. In addition to this study using 2,6-Dibromopyridine, there are many other studies that have used 2,6-Dibromopyridine(cas: 626-05-1Quality Control of 2,6-Dibromopyridine) was used in this study.

2,6-Dibromopyridine(cas: 626-05-1) belongs to pyridine. Pyridines form stable salts with strong acids. Pyridine itself is often used to neutralize acid formed in a reaction and as a basic solvent. Quality Control of 2,6-Dibromopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Discovery of the Potent Phosphoinositide 3-Kinase d (PI3 K d) Inhibitors》 was written by Lei, Tao; Hong, Yongwei; Chang, Xinyue; Zhang, Zhimin; Liu, Xingguo; Hu, Miao; Huang, Wenhai; Yang, Haiyan. Application In Synthesis of 2-Pyridinylboronic acid And the article was included in ChemistrySelect in 2020. The article conveys some information:

The PI3Kd plays a pivotal role in regulating immune cell function and has recently emerged as a promising therapeutic target in treating various diseases, which draw more and more attention to discover potent PI3Kd inhibitors in recent years. Starting from structure-based drug design, a series of derivatives were designed and synthesized as new chemotypes of PI3Kd inhibitors. The potential compounds were structurally optimized by interaction showed in docking study. In cell-free kinase activity assays, Homogeneous Time-Resolved Fluorescence Assay (HTRF) method was performed for evaluating the inhibitory activities against PI3Kd. Interestingly, the representative compound 4 exhibited potent PI3Kd activity (IC50=72 nM), which is comparable to that of pos. compound TGR1202. Furthermore, compound 4 showed 15-fold water solubility than TGR1202. In addition, the tests of compound 4 on anti-cancer activity against jeko-1 cancer cell line and cytotoxicity against peripheral blood mononuclear cell (PBMC) suggested high inhibition activity and low toxicity resp. A series of experiments indicated that compound 4 possessed novel chem. structure and high-efficiency PI3Kd inhibition activity, deserving further structural optimization to develop highly potent PI3Kd inhibitors. The results came from multiple reactions, including the reaction of 2-Pyridinylboronic acid(cas: 197958-29-5Application In Synthesis of 2-Pyridinylboronic acid)

2-Pyridinylboronic acid(cas: 197958-29-5) belongs to pyridine. When pyridine is adsorbed on oxide surfaces or in porous materials, the following species are commonly observed: (i) pyridine coordinated to Lewis acid sites, (ii) pyridine H-bonded to weakly acidic hydroxyls, and (iii) protonated pyridine. At high coverage, physisorbed pyridine and protonated dimers can also be observed.Application In Synthesis of 2-Pyridinylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《A novel, robust method for quantification of multiple kynurenine pathway metabolites in the cerebrospinal fluid》 was written by Schwieler, Lilly; Trepci, Ada; Krzyzanowski, Stanislaw; Hermansson, Sigurd; Granqvist, Mathias; Piehl, Fredrik; Venckunas, Tomas; Brazaitis, Marius; Kamandulis, Sigitas; Lindqvist, Daniel; Jones, Arthur Daniel; Erhardt, Sophie; Brundin, Lena. COA of Formula: C6H5NO2 And the article was included in Bioanalysis in 2020. The article conveys some information:

Kynurenine metabolites are potential modulators of psychiatric disease. We aimed to develop a highly sensitive biochem. anal. of cerebrospinal fluid (CSF) tryptophan (TRP) metabolites, to investigate the stability of metabolites and to confirm our previous findings of aberrant CSF quinolinic acid (QUIN) and picolinic acid (PIC) in suicide attempters using this method. Ten CSF TRP metabolites were analyzed with ultraperformance LC-MS/MS. The method showed small intra- and interassay variation. Metabolites were stable following freeze-thaw cycles. A decreased CSF PIC/QUIN ratio was found in suicide attempters. The feasibility of reliably determining CSF TRP metabolites were demonstrated, including separation of the two isomers PIC and nicotinic acid (NA) and the finding of a reduced PIC/QUIN ratio replicated in suicide attempters. The experimental process involved the reaction of Picolinic acid(cas: 98-98-6COA of Formula: C6H5NO2)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.COA of Formula: C6H5NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Di, Jia-Qi; Zhang, Mo; Chen, Yu-Xuan; Wang, Jin-Xin; Geng, Shan-Shan; Tang, Jia-Qi; Zhang, Zhan-Hui published their research in Green Chemistry in 2021. The article was titled 《Copper anchored on phosphorus g-C3N4 as a highly efficient photocatalyst for the synthesis of N-arylpyridin-2-amines》.Safety of Pyridin-3-ylboronic acid The article contains the following contents:

A heterogeneous photocatalyst based on copper modified phosphorus doped g-C3N4 (Cu/P-CN) has been prepared and characterized. This recyclable catalyst exhibited high photocatalytic activity for the synthesis of N-arylpyridin-2-amine derivatives I (Ar = Ph, naphthalen-1-yl, thiophen-3-yl, dibenzo[b,d]furan-3-yl, etc.; R = H, Me; R1 = H, Cl, Br, Me, NO2; R2 = H, Cl, Br, Me; R3 = H, Cl, Br) by the reaction of 2-aminopyridines II and aryl boronic acids ArB(OH)2 at room temperature under the irradiation of blue light. Importantly, the range of substrates for this coupling reaction has been expanded to include aryl boronic acids with strong electron-withdrawing groups as viable raw materials. In addition, this heterogeneous catalyst can be used at least 6 times while maintaining its catalytic activity. In the part of experimental materials, we found many familiar compounds, such as Pyridin-3-ylboronic acid(cas: 1692-25-7Safety of Pyridin-3-ylboronic acid)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Safety of Pyridin-3-ylboronic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Bollenbach, Maud; Nemska, Simona; Wagner, Patrick; Camelin, Guillaume; Daubeuf, Francois; Obrecht, Adeline; Villa, Pascal; Rognan, Didier; Bihel, Frederic; Bourguignon, Jean-Jacques; Schmitt, Martine; Frossard, Nelly published their research in Molecules in 2021. The article was titled 《Design, synthesis and biological evaluation of arylpyridin-2-yl guanidine derivatives and cyclic mimetics as novel MSK1 inhibitors. An application in an asthma model》.Electric Literature of C5H6BNO2 The article contains the following contents:

In order to identify new MSK1 inhibitors, a screening of a library of low mol. weight compounds was performed, and the results highlighted the I [R = phenyl] ( IC50~18μM) as a starting hit for structure-activity relationship study. Derivatives, homologues and rigid mimetics of I [R = Ph, 2-furanyl, 3-pyridine, etc.] were designed, and all synthesized compounds were evaluated for their inhibitory activity towards MSK1. Among them, the non-cytotoxic 2-aminobenzimidazole was the most potent at inhibiting significantly: (i) MSK1 activity, (ii) the release of IL-6 in inflammatory conditions in vitro (IC50~2μM) and (iii) the inflammatory cell recruitment to the airways in a mouse model of asthma. In the experimental materials used by the author, we found Pyridin-3-ylboronic acid(cas: 1692-25-7Electric Literature of C5H6BNO2)

Pyridin-3-ylboronic acid(cas: 1692-25-7) belongs to pyridine. In industry and in the lab, pyridine is used as a reaction solvent, particularly when its basicity is useful, and as a starting material for synthesizing some herbicides, fungicides, and antiseptics.Electric Literature of C5H6BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Lai, Yin-Long; Yan, Shaoxi; He, Dan; Zhou, Li-Zhen; Chen, Zi-Shen; Du, Yu-Long; Li, Jianxiao published their research in RSC Advances in 2021. The article was titled 《Palladium-catalyzed bisthiolation of terminal alkynes for the assembly of diverse (Z)-1,2-bis(arylthio)alkene derivatives》.Application of 2510-22-7 The article contains the following contents:

An efficient and straightforward palladium-catalyzed three-component cascade bisthiolation of terminal alkynes RCCH (R = n-Pr, Ph, cyclohexyl, 2-thienyl, etc.) and arylhydrazines ArNH2NH2.HCl (Ar = Ph, 4-fluorophenyl, 3-thienyl, etc.) with sodium thiosulfate (Na2S2O3) as the sulfur source for the assembly of functionalized (Z)-1,2-bis(arylthio)alkene derivatives RC(SAr)=CH(SAr) is described. Using 0.5 mol% IPr-Pd-Im-Cl2 as the catalyst, a wide range of terminal alkynes and arylhydrazines are well tolerated, thus producing the desired products in good yields with good functional group tolerance and excellent regioselectivity. Moreover, this protocol could be readily scaled up, showing potential applications in organic synthesis and material science. In the experiment, the researchers used 4-Ethynylpyridine(cas: 2510-22-7Application of 2510-22-7)

4-Ethynylpyridine(cas: 2510-22-7) belongs to pyridine. Pyridine’s structure is isoelectronic with that of benzene, but its properties are quite different. Pyridine is completely miscible with water, whereas benzene is only slightly soluble. Like all hydrocarbons, benzene is neutral (in the acid–base sense), but because of its nitrogen atom, pyridine is a weak base.Application of 2510-22-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhang, Xiao; Yang, Chao; Gao, Han; Wang, Lei; Guo, Lin; Xia, Wujiong published their research in Organic Letters in 2021. The article was titled 《Reductive Arylation of Aliphatic and Aromatic Aldehydes with Cyanoarenes by Electrolysis for the Synthesis of Alcohols》.Application In Synthesis of 4-Cyanopyridine The article contains the following contents:

An electroreductive arylation reaction of aliphatic and aromatic aldehydes as well as ketones with electro-deficient (hetero)arenes is described. A variety of cyano(hetero)arenes and carbonyl compounds, especially aliphatic aldehydes, have been examined, providing secondary and tertiary alcs. in moderate to good yields. Mechanistic studies, including cyclic voltammetry (CV), ESR (EPR), and divided-cell experiments, support the generation of aliphatic ketyl radicals and persistent heteroaryl radical anions via cathodic reduction followed by radical-radical cross-coupling. In the experimental materials used by the author, we found 4-Cyanopyridine(cas: 100-48-1Application In Synthesis of 4-Cyanopyridine)

4-Cyanopyridine(cas: 100-48-1) belongs to pyridine. Pyridines are often used as catalysts or reagents; particular notice has been paid recently to how pyridine coordinates to metal centers enabling a wide range of valuable reactions. Application In Synthesis of 4-Cyanopyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem