Day: November 10, 2022

Formula: C7H9NOIn 2018 ,《Palladium-Catalyzed C-O Cross-Coupling of Primary Alcohols》 appeared in Organic Letters. The author of the article were Zhang, Hong; Ruiz-Castillo, Paula; Buchwald, Stephen L.. The article conveys some information:

Two catalyst systems are described, which together provide mild and general conditions for the Pd-catalyzed C-O cross-coupling of primary alcs. For activated substrates, such as electron-deficient aryl halides, the com. available ligand I [R = R’ = Bu-t] promotes efficient coupling for a variety of alc. nucleophiles. In the case of unactivated electrophiles, such as electron-rich aryl halides, the new ligand I [R = adamantyl, R’ = cyclohexyl] was developed to improve these challenging C-O bond-forming reactions. In the experiment, the researchers used 2-(2-Hydroxyethyl)pyridine(cas: 103-74-2Formula: C7H9NO)

2-(2-Hydroxyethyl)pyridine(cas: 103-74-2) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

HPLC of Formula: 128071-75-0In 2022 ,《Iodine-Mediated C=C Double Bond Cleavage toward Pyrido[2,1-b]quinazolinones》 appeared in Organic Letters. The author of the article were Hao, Wei; Li, Kailu; Ye, Chenyang; Yu, Wenquan; Chang, Junbiao. The article conveys some information:

A transition-metal-free C=C double bond cleavage reaction employing mol. iodine is described. In the presence of K2CO3 as the base, I2-mediated C = C bond cleavage followed by intramol. annulation of N-(2-vinylaryl)pyridin-2-amine substrates, e.g., N-(2-vinylnaphthalen-1-yl)pyridin-2-amine produces pyrido[2,1-b]quinazolinones, e.g., 7H-benzo[h]pyrido[2,1-b] quinazolin-7-one and related heterocyclic compounds This reaction can be completed on a gram scale and has been successfully applied to the synthesis of compounds with important biol. properties such as 11H-pyrido[2,1-b]quinazolin-11-one and 2-methyl-11-oxo-11H-pyrido[2,1-b]quinazoline-8-carboxylic acid, including efflux pump inhibitory and antiallergic activities. In the experimental materials used by the author, we found 2-Bromonicotinaldehyde(cas: 128071-75-0HPLC of Formula: 128071-75-0)

2-Bromonicotinaldehyde(cas: 128071-75-0) belongs to pyridine. The basicity and metallophilic high donor number of these π-deficient systems has long favored them as ligands in metal catalysis. The last decade saw pyridine assume a stronger role as functional group for directed C–H oxidation/activation.HPLC of Formula: 128071-75-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

SDS of cas: 98-98-6In 2019 ,《Palladium-Catalyzed C8-H Acylation of 1-Naphthylamines with Acyl Chlorides》 appeared in Organic Letters. The author of the article were Yu, Xiaomeng; Yang, Fan; Wu, Yusheng; Wu, Yangjie. The article conveys some information:

A facile and efficient protocol for palladium-catalyzed regioselective C8-H acylation of 1-naphthylamine derivatives with acyl chlorides has been developed. The reaction exhibits broad functional group tolerance, and both aromatic and α,β-unsaturated acyl chlorides can be effectively coupled with 1-naphthylamines. Moreover, the picolinamide moiety as a bidentate directing group likely plays a key role in this regioselective transformation. In the part of experimental materials, we found many familiar compounds, such as Picolinic acid(cas: 98-98-6SDS of cas: 98-98-6)

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.SDS of cas: 98-98-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H3Br2NIn 2020 ,《Regioselective, stereoselective, and living polymerization of divinyl pyridine monomers using rare earth catalysts》 appeared in Polymer Chemistry. The author of the article were Yan, Chao; Liu, Zhao-Xuan; Xu, Tie-Qi. The article conveys some information:

The first regioselective, stereoselective, and living polymerization of divinyl pyridine monomers, mediated by simple rare earth catalysts, is reported. The polymerization by Ln(CH2SiMe3)3(L)2 (Ln = Sc, Y, Lu, Dy; L = THF, Py) is perfectly regioselective for a 2,5-divinylpyridine (DVP) monomer, and the process only concerned the double bond at the 2-position of DVP and the C=C bond at the 5-position selectively remained unreacted. In contrast, the polymerization of DVP by La(CH2SiMe3)3(THF)2 is not regioselective, producing a crosslinking network. The polymerization by Lu(CH2SiMe3)3(Py)2/B(C6F5)3 is most stereoselective, yielding perfect isotactic PDVP with mmmm >99%. The isoselectivity (mm) of the polymers could be controlled in a range of 31% to 99% by adjusting the amount of THF added. The DVP polymerization is controlled by Lu[CH(C5H4N)CH2CH2SiMe3]3 (formed via in situ mixing of Lu(CH2SiMe3)3(THF)2 and 2-vinylpyridine), with the mol. weight (Mn) matching the theor. value of monomer conversion and a narrow dispersity. The stereoblock polymerization of DVP with 2-vinylpyridine was achieved by adding the monomer sequentially. The post-functionalization of stereoblock polymers containing vinyl groups has been achieved by the thiol-ene “”click”” reaction in which all the C=C double bonds are quant. converted to thioether bonds. The experimental process involved the reaction of 2,5-Dibromopyridine(cas: 624-28-2COA of Formula: C5H3Br2N)

2,5-Dibromopyridine(cas: 624-28-2) belongs to pyridine. Pyridine and pyridine-derived structures are privileged pharmacophores in medicinal chemistry and an essential functionality for organic chemists. As the prototypical π-deficient heterocycle, pyridine illustrates distinctive chemistry as both substrate and reagent. COA of Formula: C5H3Br2N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

COA of Formula: C5H5BrN2In 2014 ,《Several human cyclin-dependent kinase inhibitors, structurally related to roscovitine, as new anti-malarial agents》 was published in Molecules. The article was written by Houze, Sandrine; Hoang, Nha-Thu; Lozach, Olivier; Le Bras, Jacques; Meijer, Laurent; Galons, Herve; Demange, Luc. The article contains the following contents:

In Africa, malaria kills one child each minute. It is also responsible for about one million deaths worldwide each year. Plasmodium falciparum, is the protozoan responsible for the most lethal form of the disease, with resistance developing against the available anti-malarial drugs. Among newly proposed anti-malaria targets, are the P. falciparum cyclin-dependent kinases (PfCDKs). There are involved in different stages of the protozoan growth and development but share high sequence homol. with human cyclin-dependent kinases (CDKs). We previously reported the synthesis of CDKs inhibitors that are structurally-related to (R)-roscovitine, a 2,6,9-trisubstituted purine, and they showed activity against neuronal diseases and cancers. In this report, we describe the synthesis and the characterization of new CDK inhibitors, active in reducing the in vitro growth of P. falciparum (3D7 and 7G8 strains). Six compounds are more potent inhibitors than roscovitine, and three exhibited IC50 values close to 1 μM for both 3D7 and 7G8 strains. Although, such mols. do inhibit P. falciparum growth, they require further studies to improve their selectivity for PfCDKs. In addition to this study using 6-Bromopyridin-3-amine, there are many other studies that have used 6-Bromopyridin-3-amine(cas: 13534-97-9COA of Formula: C5H5BrN2) was used in this study.

6-Bromopyridin-3-amine(cas: 13534-97-9) belongs to anime. Milder oxidation, using reagents such as NaOCl, can remove four hydrogen atoms from primary amines of the type RCH2NH2 to form nitriles (R―C≡N), and oxidation with reagents such as MnO2 can remove two hydrogen atoms from secondary amines (R2CH―NHR′) to form imines (R2C=NR′). Tertiary amines can be oxidized to enamines (R2C=CHNR2) by a variety of reagents.COA of Formula: C5H5BrN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Quality Control of Picolinic acidIn 2020 ,《Tailoring In Situ Healing and Stabilizing Post-Treatment Agent for High-Performance Inverted CsPbI3 Perovskite Solar Cells with Efficiency of 16.67%》 was published in ACS Energy Letters. The article was written by Fu, Sheng; Wan, Li; Zhang, Wenxiao; Li, Xiaodong; Song, Weijie; Fang, Junfeng. The article contains the following contents:

CsPbI3 perovskite solar cells (PSCs) have revealed promising applications for high-performance photovoltaic devices. Despite the high efficiency for regular CsPbI3 PSCs, poor stability for adverse dopants reflects the importance of the inverted. However, the inverted lag far for a phase transition and inferior CsPbI3 films. Here, we report an effective post-treatment agent, methylammonium pyridine-2-carboxylic (MAPyA), to heal and stabilize CsPbI3 films. MAPyA on CsPbI3 can decompose into methylamine (MA) gas and pyridine-2-carboxylate (PyA-) at 100°C, and MA could remove pinholes, while PyA- gifts effective passivation. In addition, oriented PyA- hinders phase transition and isolates external erosions for long-term stability. The optimized devices show the highest efficiency among the inverted CsPbI3 PSCs of 16.67%. Besides, the phase stability and robustness against external erosions get considerable promotion. More importantly, unpackaged I-rich inorganic PSCs are rarely reported with long-term maximum power point in ambient condition, and our unencapsulated device still retains 81.31% of the initial efficiency after 1800 min of outdoor operation (relative humidity 30%).Picolinic acid(cas: 98-98-6Quality Control of Picolinic acid) was used in this study.

Picolinic acid(cas: 98-98-6) is used as a chelate for alkaline earth metals. Used to prepare picolinato ligated transition metal complexes. In synthetic organic chemistry, has been used as a substrate in the Mitsunobu reaction and in the Hammick reaction.Quality Control of Picolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Chromism, positional, conformational and structural isomerism in a series of Zn(II) and Cd(II) coordination polymers based on methylated azine N,N’-donor linkers》 was written by Lozovan, Vasile; Kravtsov, Victor Ch.; Gorincioi, Elena; Rotaru, Andrei; Coropceanu, Eduard B.; Siminel, Nikita; Fonari, Marina S.. Reference of 4-AcetylpyridineThis research focused onzinc cadmium pyridinylethylidenehydrazine iodide nitrate polymer preparation luminescence; thermal stability zinc cadmium pyridinylethylidenehydrazine iodide nitrate polymer; crystal structure zinc cadmium pyridinylethylidenehydrazine iodide nitrate polymer. The article conveys some information:

Seven new coordination polymers [Zn(I)2(4-bpmhz)]n (1), [Cd(I)2(4-bpmhz)]n (2), [Zn(I)2(3-bpmhz)]n (3), [Cd(I)2(3-bpmhz)2]n (4), [Zn(NO3)2(H2O)2(4-bpmhz)]n·0.5n(EtOH) (5), [Cd(NO3)2(4-bpmhz)3/2(MeOH)]n·0.5nH2O (6) and [Zn(NO3)2(3-bpmhz)2]n (7) were prepared following the reactions of the zinc and cadmium iodide or nitrate salts with the methylated azine ligands of the bis-monodentate N,N’-donor type, 1,2-bis(1-(pyridin-4-yl)ethylidene)hydrazine (4-bpmhz) and 1,2-bis(1-(pyridin-3-yl)ethylidene)hydrazine (3-bpmhz). The single-crystal X-ray diffraction studies show that compounds 1-5, and 7 display 1D chain structures, while compound 6 shows a 2D coordination network, and both 4-bpmhz and 3-bpmhz act as bidentate bridging ligands. The crystals 1 and 2 are isomorphous, and differ by the metal cation only. The single coordination chains in 1-3 have zigzag structures; they are linear in 5, while 4 and 7 display similar double-chain structures. The crystal packing in 5 and 6 provides cavities occupied by solvent mols., ethanol and water. The compounds were characterized in the solid state and in solution by spectroscopic (FTIR, UV-Vis, NMR) methods; the solid state emissive properties were studied for all compounds, while their thermal stability and behavior were investigated by thermogravimetry under inert atm., while the thermochromism for several compounds was registered and discussed. In the part of experimental materials, we found many familiar compounds, such as 4-Acetylpyridine(cas: 1122-54-9Reference of 4-Acetylpyridine)

4-Acetylpyridine(cas: 1122-54-9) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Reference of 4-Acetylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Sodium Sulfite-Involved Photocatalytic Radical Cascade Cyclization of 2-Isocyanoaryl Thioethers: Access to 2-CF2/CF3-Containing Benzothiazoles》 was written by Yuan, Yao; Dong, Wuheng; Gao, Xiaoshuang; Xie, Xiaomin; Zhang, Zhaoguo. Formula: C33H24IrN3This research focused ontrifluoromethyl benzothiazole preparation photocatalytic radical cascade cyclization isocyanoaryl thioether. The article conveys some information:

A visible-light-induced radical cascade cyclization of 2-isocyanoaryl thioethers for the synthesis of 2-CF2/CF3-containing benzothiazoles has been developed. Sodium sulfite can participate in the photocatalytic cycle as a reductant that efficiently transforms Ir4+ into Ir3+ to promote the fluoroalkylation under mild reaction conditions. The experimental part of the paper was very detailed, including the reaction process of fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6Formula: C33H24IrN3)

fac-Tris(2-phenylpyridine)iridium(cas: 94928-86-6) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Formula: C33H24IrN3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

《Synthesis of α-Heteroaryl Propionic Esters by Palladium-Catalyzed α-Heteroarylation of Silyl Ketene Acetals》 was written by Li, Bowen; Luo, Bangke; Blakemore, Caroline A.; Smith, Aaron C.; Widlicka, Daniel W.; Berritt, Simon; Tang, Wenjun. Recommanded Product: Methyl 5-bromopicolinateThis research focused ontrimethylsiloxy propene tertiary butoxy heteroaryl bromide palladium catalyst heteroarylation; tertiary butyl pyridinyl propanoate preparation. The article conveys some information:

A practical and efficient synthesis of α-heteroaryl propionic esters was developed by employing palladium-catalyzed α-heteroarylation of silyl ketene acetals, forming a wide variety of α-heteroaryl propionic esters with various substituents and functionalities in high yields. The success of this transformation was credited to the development of the bulky P,P=O ligand. This method provided an efficient synthesis of α-heteroaryl propionic acids. In the experiment, the researchers used many compounds, for example, Methyl 5-bromopicolinate(cas: 29682-15-3Recommanded Product: Methyl 5-bromopicolinate)

Methyl 5-bromopicolinate(cas: 29682-15-3) belongs to pyridine. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Additionally, pyridine-based natural products continue to be discovered and studied for their properties and to understand their biosynthesis.Recommanded Product: Methyl 5-bromopicolinate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ye, Bihai; Yao, Jian; Wu, Changhui; Zhu, Huilong; Yao, Weijun; Jin, Lili; Dou, Xiaowei published an article on February 18 ,2022. The article was titled 《Rhodium-Catalyzed Asymmetric Conjugate Pyridylation with Pyridylboronic Acids》, and you may find the article in ACS Catalysis.HPLC of Formula: 1003043-40-0 The information in the text is summarized as follows:

In this study, the rhodium-catalyzed asym. conjugate pyridylation of α,β-unsaturated carbonyl compounds with pyridylboronic acids was reported. The bifunctional chiral amide-diene ligand, which dramatically accelerated the reaction via possible H-bonding activation, and alc. solvent, which significantly inhibited the competing protodeboronation of pyridylboronic acids under rhodium catalysis, worked in concert to promote the reaction, thus enabling production of the pyridylation products in high yields (up to 99%) with good enantioselectivities (up to >99% ee). The experimental process involved the reaction of (6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0HPLC of Formula: 1003043-40-0)

(6-Chloro-5-methylpyridin-3-yl)boronic acid(cas: 1003043-40-0) belongs to pyridine. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. As ligands, solvents, and catalysts they facilitate reactions; thus descriptions of these new ligands and their applications abound each year.HPLC of Formula: 1003043-40-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem