Day: November 24, 2022

Syntheses, crystal structures and Hirshfeld surface analyses of (3aR,4S,7R,7aS)-2-(perfluoropyridin-4-yl)-3a,4,7,7a-tetrahydro-4,7-methanoisoindole-1,3-dione and (3aR,4S,7R,7aS)-2-[(perfluoropyridin-4-yl)oxy]-3a,4,7,7a-tetrahydro-4,7-methanoisoindole-1,3-dione was written by Peloquin, Andrew J.;Balaich, Gary J.;Iacono, Scott T.. And the article was included in Acta Crystallographica in 2019.Application of 700-16-3 The following contents are mentioned in the article:

The syntheses and crystal structures of the title compounds, C₁₄H₈F₄N₂O₂ and C₁₄H₈F₄N₂O₃, are reported. In each crystal, the packing is driven by C-H路路路F intertactions, along with a variety of C-H路路路O, C-O路路路蟺, and C-F路路路蟺 contacts. Hirshfeld surface anal. was conducted to aid in the visualization of these various influences on the packing: they showed that the largest contributions to the surface contacts arise from H路路路F/F路路路H interactions, followed by H路路路H and O路路路H/H路路路O. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Application of 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application of 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reactions of Fluoroalkanes with Mg-Mg Bonds: Scope, sp³C-F/sp²C-F Coupling and Mechanism was written by Coates, Greg;Ward, Bryan J.;Bakewell, Clare;White, Andrew J. P.;Crimmin, Mark R.. And the article was included in Chemistry – A European Journal in 2018.Product Details of 700-16-3 The following contents are mentioned in the article:

Sp³C-F Bonds of fluoroalkanes (7 examples; 1æŽ? 2æŽ?and 3æŽ? undergo addition to a low-valent Mg-Mg species generating reactive organomagnesium reagents. Further reactions with a series of electrophiles results in a net C-F to C-B, C-Si, C-Sn or C-C bond transformation (11 examples, diversity). The new reactivity was exploited in an unprecedented one-pot magnesium-mediated coupling of sp³C-F and sp²C-F bonds. Calculations suggest that the sp³C-F bond activation step occurs by frontside nucleophilic attack of the Mg-Mg reagent on the fluoroalkane. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Product Details of 700-16-3).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Product Details of 700-16-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reactions of pyridin-2-ol, pyridin-3-ol, and pyridin-4-ol with pentafluoro- and pentachloropyridine was written by Ranjbar-Karimi, Reza;Davodian, Tayebeh;Mehrabi, Hossein. And the article was included in Chemistry of Heterocyclic Compounds in 2017.Electric Literature of C5F5N The following contents are mentioned in the article:

Reactions of pentafluoro- and pentachloropyridines with pyridin-2-ol, pyridin-3-ol and pyridin-4-ol are reported. Pyridin-4-ol yields product of attack at the nitrogen atom, while pyridin-3-ol reacts at the oxygen atom. Pyridin-2-ol reacts as an ambident nucleophile, providing a mixture of products I (X = F, Cl) and II arising from attack at both the oxygen and the nitrogen atoms. The structures of compounds were confirmed by IR spectroscopy, ¹H, ¹³C and ¹⁹F NMR spectroscopy, as well as elemental anal. and X-ray crystallog. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Electric Literature of C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule ä¼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Catalyst-Free Hydrodefluorination of Perfluoroarenes with NaBH₄ was written by Schoch, Timothy D.;Mondal, Mukulesh;Weaver, Jimmie D.. And the article was included in Organic Letters in 2021.Recommanded Product: 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

An economical means of removing fluorine from various highly fluorinated arenes using NaBH₄ for synthesis of partially fluorinated arenes was presented. The procedure was adapted for different classes of perfluoroarenes. A novel isomer of an emerging class of organic dyes based on the carbazole phthalonitrile motif was succinctly synthesized in two steps from tetrafluorophthalonitrile, demonstrating the utility of the hydrodefluorination procedure. Initial exploration of the dye showed it to be photoactive and capable of facilitating contrathermodynamic styrenoid E/Z isomerization. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Recommanded Product: 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of diheteroaryl sulfides via chemoselective reaction of 4,6-diaminopyrimidine-2(1H)-thione with haloheteroaryl compounds was written by Davodian, Tayebeh;Ranjbar-Karimi, Reza;Mehrabi, Hossein. And the article was included in Chemistry of Heterocyclic Compounds in 2017.Recommanded Product: 2,3,4,5,6-Perfluoropyridine The following contents are mentioned in the article:

A series of substituted diheteroaryl sulfides was synthesized by the reaction of 4,6-diaminopyrimidine-2(1H)-thione with fluoro- and chloroheteroarom. compounds in the presence of Na₂CO₃ in acetonitrile under reflux conditions. The study indicated that 4,6-diaminopyrimidine-2(1H)-thione reacts with fluoro- and chloroheteroarom. compounds chemoselectively as S- rather than N-nucleophile. The structures of the synthesized compounds were confirmed by IR, ¹H, ¹⁹F, and ¹³C NMR spectroscopy, as well as elemental anal. and X-ray structural anal. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Recommanded Product: 2,3,4,5,6-Perfluoropyridine).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJè·¯moléˆ? in pyridine vs. 150 kJè·¯moléˆ? in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C鈥揌 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 2,3,4,5,6-Perfluoropyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ruthenium-Catalyzed Straightforward Synthesis of 1,2,3,4-Tetrahydronaphthyridines via Selective Transfer Hydrogenation of Pyridyl Ring with Alcohols was written by Xiong, Biao;Li, Ya;Lv, Wan;Tan, Zhenda;Jiang, Huanfeng;Zhang, Min. And the article was included in Organic Letters in 2015.Name: (3-Aminopyridin-2-yl)methanol The following contents are mentioned in the article:

Through a ruthenium-catalyzed selective hydrogen transfer coupling reaction, a novel straightforward synthesis of 1,2,3,4-tetrahydronaphthyridines e. g., I, from o-aminopyridyl methanols and alcs. has been developed. The synthetic protocol proceeds in an atom- and step-economic fashion together with the advantages of operational simplicity, broad substrate scope, production of water as the only byproduct, and no need for external reducing reagents such as high pressure H₂ gas, offering a highly practical approach for accessing this type of structurally unique products. This study involved multiple reactions and reactants, such as (3-Aminopyridin-2-yl)methanol (cas: 52378-63-9Name: (3-Aminopyridin-2-yl)methanol).

(3-Aminopyridin-2-yl)methanol (cas: 52378-63-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six èŸ?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H眉ckel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Name: (3-Aminopyridin-2-yl)methanol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Light-Mediated Sulfur-Boron Exchange was written by Panferova, Liubov I.;Dilman, Alexander D.. And the article was included in Organic Letters in 2021.Synthetic Route of C5F5N The following contents are mentioned in the article:

Photochem. organocatalytic substitution of pyridylthio group in alkyl tetrafluoropyridinyl thioethers RS-4-C₅F₄N with bis(catecholato)diboron followed by treatment with pinacol and triethylamine affording pinacol boronic esters RBpin is described. The reaction is promoted by an organic photocatalyst, 2,4,6-tris(diphenylamino)-3,5-difluorobenzonitrile (3DPA2FBN) under irradiation with 400 nm light, and works with primary, secondary, and tertiary sulfides. The electron depleting character of the fluorinated pyridine fragment plays an important role in generating alkyl radicals. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Synthetic Route of C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule ä¼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nucleophilic aromatic substitution of polyfluoroarenes to access highly functionalized 10-phenylphenothiazine derivatives was written by Kikushima, Kotaro;Koyama, Haruka;Kodama, Kazuki;Dohi, Toshifumi. And the article was included in Molecules in 2021.Synthetic Route of C5F5N The following contents are mentioned in the article:

Nucleophilic aromatic substitution (S_NAr) reactions can provide metal-free access to synthesize monosubstituted aromatic compounds An efficient S_NAr conditions for para-selective substitution of polyfluoroarenes with phenothiazine in the presence of a mild base to afford the corresponding 10-arylphenothiazine derivatives have been developed. The resulting polyfluoroarene-bearing phenothiazines were subjected to a second S_NAr reaction to generate highly functionalized derivatives with potential applicability as photocatalysts for the reduction of carbon-halogen bonds. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Synthetic Route of C5F5N).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule ä¼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Synthetic Route of C5F5N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Novel syntheses of camptothecin alkaloids. Part I. Intramolecular [4+2] cycloadditions of N-arylimidates and 4H-3,1-benzoxazin-4-ones as 2-aza-1,3-dienes was written by Fortunak, Joseph M. D.;Mastrocola, Antonietta R.;Mellinger, Mark;Sisti, Nicolas J.;Wood, Jeffery L.;Zhuang, Zhi-Ping. And the article was included in Tetrahedron Letters in 1996.Safety of Ethyl 5-cyano-4-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate The following contents are mentioned in the article:

Intramol. [4+2] cycloadditions of both N-arylimidates and (4H)-3,1-benzoxazin-4-ones acting as 2-aza-1,3-dienes were described. Reaction with unactivated alkynes lead to pyrrolo[3,4-b]quinolines containing the ABC ring system of camptothecin. E.g., 10-methoxycamptothecin precursor I was prepared by intramol. [4+2] cycloaddition of a 4:1 isomeric mixture of O-methylimidate II (R = 4-MeOC₆H₄), which had been prepared by Me₃OBF₄ O-methylation of the corresponding N-(4-methoxyphenyl)-amide, followed by elimination of methanol. This study involved multiple reactions and reactants, such as Ethyl 5-cyano-4-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate (cas: 58610-61-0Safety of Ethyl 5-cyano-4-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate).

Ethyl 5-cyano-4-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate (cas: 58610-61-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ路mol� in pyridine vs. 150 kJ路mol� in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Safety of Ethyl 5-cyano-4-methyl-6-oxo-1,6-dihydropyridine-2-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fluorinated Aminopyridines: Synthesis, Structure, and Rare Liquid-Liquid Cocrystal Formation Driven by Unusually Short N-H路路路F-C Hydrogen Bonding was written by Peloquin, Andrew J.;Kure, Daniel A.;Jennings, Abby R.;McMillen, Colin D.;Iacono, Scott T.;Pennington, William T.. And the article was included in Crystal Growth & Design in 2020.Category: pyridine-derivatives The following contents are mentioned in the article:

Perfluoropyridine underwent nucleophilic aromatic substitution with excesses of unhindered primary and secondary amines to yield tetrafluoro-4-pyridinamines. The structures for twelve of the products were determined by X-ray crystallog. Perfluoropyridine formed solid cocrystals with dicyclohexylamine and 2-methylpiperidine; the complexes were stable to approx. 100掳C above the normal b.p. of perfluoropyridine. The solid state packing in the cocrystals of perfluoropyridine with dicyclohexylamine and 2-methylpiperidine was dominated by hydrogen bonding between pyridine C-F bonds and the amine N-H bonds. This study involved multiple reactions and reactants, such as 2,3,4,5,6-Perfluoropyridine (cas: 700-16-3Category: pyridine-derivatives).

2,3,4,5,6-Perfluoropyridine (cas: 700-16-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ路mol� in pyridine vs. 150 kJ路mol� in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem