Month: November 2022

On November 20, 1997, Ankersen, Michael; Stidsen, Carsten Enggaard; Andersen, Henrik Sune published a patent.HPLC of Formula: 199522-66-2 The title of the patent was Preparation of thioureas and guanidines as somatostatin agonists and antagonists. And the patent contained the following:

The title compounds [I and II; m = 2-6; n = 1-3; p = 1-6; R1, R2 = H, (un)substituted C1-6 alkyl; X = S, O, NH, NC(O)Ph, N(CN); A, B, D = (un)substituted aryl, heteroaryl] and their salts, useful for treating medical disorders related to binding to human somatostatin receptor subtypes, were prepared and formulated. Thus, reaction of N-(4-bromobenzyl)-N-(3-isothiocyanatopropyl)-N-(pyridin-2-yl)amine and 3-(1-triphenylmethylimidazol-4-yl)propylamine in CHCl3 followed by treatment of the triphenylmethyl intermediate with HCl afforded 80% III.2HCl. Compounds I are effective at 0.001-50 mg/kg/day. The experimental process involved the reaction of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine(cas: 199522-66-2).HPLC of Formula: 199522-66-2

The Article related to somatostatin agonist antagonist thiourea guanidine preparation, thiourea preparation formulation somatostatin agonist antagonist, guanidine preparation formulation somatostatin agonist antagonist and other aspects.HPLC of Formula: 199522-66-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 5, 2012, Akiri, Kalyanachakravarthi; Cherukuvada, Suryanarayan; Rana, Soumendra; Nangia, Ashwini published an article.Related Products of 636-73-7 The title of the article was Crystal Structures of Pyridine Sulfonamides and Sulfonic Acids. And the article contained the following:

Despite the widespread occurrence of pyridinesulfonic acid and pyridinesulfonamide functional groups in drugs and pharmaceuticals, and their use as ligands in metal-organic frameworks, a systematic structural study of their H bonding and mol. packing is lacking. Crystal structures of 2-, 3-, and 4-pyridinesulfonic acids/amides in terms of N+-H···O- H bonds, N-H···O dimer/catemer synthons, and graph set notations are discussed. This model study provides a background for polymorph screening and solid form hunting of pharmacol. active sulfonamides. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Related Products of 636-73-7

The Article related to crystal structure pyridinesulfonamide pyridinesulfonic acid, mol structure pyridinesulfonamide pyridinesulfonic acid, hydrogen bond dimer catemer synthon pyridinesulfonamide pyridinesulfonic acid and other aspects.Related Products of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 1, 2003, El Ali, Bassam published an article.Application of 636-73-7 The title of the article was Rh6(CO)16-H3PW12O40-catalyzed one pot hydroformylation-cyclotrimerization of cyclohexene and cyclopentene to 2,4,6-trisubstituted 1,3,5-trioxanes. And the article contained the following:

One-pot hydroformylation-cyclotrimerization of cyclopentene and cyclohexene was selectively catalyzed by Rh6(CO)16 and H3PW12O40·xH2O (HPA-W12) in THF at 40 atm (CO/H2 = 1/1) and afforded 2,4,6-tris(cycloalkyl)-1,3,5-trioxanes as major products along with the corresponding aldehydes. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Application of 636-73-7

The Article related to hydroformylation cyclotrimerization cyclohexene cyclopentene rhodium tungstophosphoric acid catalyst, trioxane tricycloalkyl preparation hexarhodium hexadecacarbonyl tungstophosphoric acid catalyst and other aspects.Application of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Sarkar, Suman De; Kumar, N. Y. Phani; Ackermann, Lutz published an article in 2017, the title of the article was Ruthenium(II) Biscarboxylate-Catalyzed Borylations of C(sp2)-H and C(sp3)-H Bonds.Quality Control of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine And the article contains the following content:

Versatile borylations of C(sp2)-H and C(sp3)-H were achieved with Ru(II) biscarboxylate complexes as catalysts. The robust nature of the Ru(II) catalyst enabled C(sp3)-H borylation on pyrrolidines, piperidines, aromatic compounds and azepanes with ample scope and excellent positional selectivity control. The experimental process involved the reaction of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine(cas: 1349171-28-3).Quality Control of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine

The Article related to ruthenium catalyzed borylation benzene pyrrolidine piperidine azepane, monoborylated arene heterocycle pyrrolidine piperidine azepane preparation, c−h activation, alkanes, boron, mechanism, ruthenium and other aspects.Quality Control of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Maity, Ayan; Anderson, Bryce Lane; Deligonul, Nihal; Gray, Thomas G. published an article in 2013, the title of the article was Room-temperature synthesis of cyclometalated iridium(III) complexes: kinetic isomers and reactive functionalities.Reference of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine And the article contains the following content:

Cyclometalated iridium(III) complexes have been prepared in high yields from base-assisted transmetalation reactions of cis-bis(aquo)iridium(III) complexes with boronated aromatic proligands. Reactions proceed at room temperature Potassium hydroxide and potassium phosphate are effective supporting bases. Kinetic, meridional isomers are isolated because of the mildness of the new technique. Syntheses are faster with KOH, but the gentler base K3PO4 broadens the reaction’s scope. Complexes of chelated ketone, aldehyde, and alc. complexes are reported that bind iridium through formally neutral oxygen and formally anionic carbon. The new complexes luminesce with microsecond-scale(coating) lifetimes at 77 K and nanosecond-scale lifetimes at room temperature; emission quenches in air. Two complexes, an aldehyde and its reduced (alc.) derivative, are crystallog. characterized. Their bonding is examined with d.-functional theory calculations Time-dependent computations suggest that the Franck-Condon triplet states of these complexes have mixed orbital parentage, arising from one-particle transitions that mingle through CI. The experimental process involved the reaction of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine(cas: 1349171-28-3).Reference of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine

The Article related to phenylpyridine phenylpyrazole phenylquinoline benzothienylpyridine cyclometalated iridium preparation luminesce, crystal mol structure difluorophenylpyridine cyclometalated iridium formyltolyl complex and other aspects.Reference of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On June 30, 2008, Qiu, Zhi-Hui; Liang, Fu-Pei; Ruan, Qing-Feng; Zhao, Shan-Rong published an article.Electric Literature of 636-73-7 The title of the article was catena-Poly[[diaquamanganese(II)]-di-μ-pyridine-3-sulfonato-κ2N:O;κ2O:N]. And the article contained the following:

In the title polymeric complex, [Mn(C5H4NO3S)2(H2O)2]n, the Mn atom is located on a center of inversion and is coordinated by two O atoms and two N atoms derived from four different pyridine-3-sulfonate (pySO3) ligands, and two O atoms derived from two H2O mols. in a distorted trans-N2O4 octahedral geometry. The metal atoms are bridged by the pySO3 ligands to form a 1-dimensional chain. The chains are further connected into a three-dimensional architecture via H bonds. Crystallog. data and at. coordinates are given. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Electric Literature of 636-73-7

The Article related to mol structure manganese aqua pyridinesulfonato polymeric complex, crystal structure manganese aqua pyridinesulfonato polymeric complex, hydrogen bond manganese aqua pyridinesulfonato polymeric complex and other aspects.Electric Literature of 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ghorai, Debasish; Mueller, Valentin; Keil, Helena; Stalke, Dietmar; Zanoni, Giuseppe; Tkachenko, Boryslav A.; Schreiner, Peter R.; Ackermann, Lutz published an article in 2017, the title of the article was Secondary Phosphine Oxide Preligands for Palladium-Catalyzed C-H (Hetero)Arylations: Efficient Access to Pybox Ligands.Related Products of 109660-12-0 And the article contains the following content:

C-H arylations of oxazolines were accomplished with a well-defined palladium catalyst derived from a secondary bisdiamantyl phosphine oxide. The single-component secondary phosphine oxide (SPO)-palladium complex enabled C-H activations with aryl bromides and challenging aryl chlorides in the absence of directing groups, setting the stage for the step-economical synthesis of pybox ligands under racemization-free reaction conditions. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Related Products of 109660-12-0

The Article related to bisdiamantyl phosphine oxide palladium complex catalyst preparation crystal structure, oxazoline aryl halide phosphine oxide palladium complex catalyst arylation, aryloxazoline regioselective preparation and other aspects.Related Products of 109660-12-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On January 20, 1989, Corey, E. J.; Posner, Gary H.; Atkinson, Richard F.; Wingard, Astrid K.; Halloran, Daniel J.; Radzik, Donna M.; Nash, John J. published an article.Safety of Pyridine-3-sulfonic acid The title of the article was Formation of olefins via pyrolysis of sulfonate esters. And the article contained the following:

Esters, e.g., I and II, of 8-quinolinesulfonic acid and 2-pyridinesulfonic acid were synthesized from alcs. and the acid chlorides. The secondary esters decomposed cleanly at moderate temperatures to give olefins in high yields. Thus, I was heated at 150° to give 92% cyclohexene. Product studies were consistent with carbocation formation and abstraction by a ring nitrogen to give the olefin. The importance of a basic group was confirmed by pyrolysis of a series of para-substituted cyclohexyl benzenesulfonates III (R = NHAc, NHEt, NO2, Br, Me, MeO, Me2N). Thermolysis of III (R = NHEt, NHAc) cleanly gave cyclohexene in good yield; however, thermolysis of III (R = NO2, Br, Me Me) gave cyclohexene in low yield along with considerable amounts of tar. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Safety of Pyridine-3-sulfonic acid

The Article related to olefin preparation sulfonate pyrolysis, pyrolysis sulfonate ester, alkyl quinolinesulfonate preparation thermolysis, pyridinesulfonate preparation thermolysis, thermal elimination alkyl quinolinesulfonate and other aspects.Safety of Pyridine-3-sulfonic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 15, 2014, Gouda, Ayman A.; Hashem, Hisham; Jira, Thomas published an article.Recommanded Product: 132-20-7 The title of the article was Development and validation of a rapid stability indicating HPLC-method using monolithic stationary phase and two spectrophotometric methods for determination of antihistaminic acrivastine in capsules. And the article contained the following:

Simple, rapid and accurate high performance liquid chromatog. (HPLC) and spectrophotometric methods are described for determination of antihistaminic acrivastine in capsules. The first method (method A) is based on accurate, sensitive and stability indicating chromatog. separation method. Chromolith Performance RP-18e column, a relatively new packing material consisting of monolithic rods of highly porous silica, was used as stationary phase applying isocratic binary mobile phase of ACN and 25 mM NaH2PO4 pH 4.0 in the ratio of 22.5:77.5 at flow rate of 5.0 mL/min and 40 °C. A diode array detector was used at 254 nm for detection. The elution time of acrivastine was found to be 2.080 ± 0.032. The second and third methods (methods B and C) are based on the oxidation of acrivastine with excess N-bromosuccinimide (NBS) and determination of the unconsumed NBS with, metol-sulfanilic acid (λmax: 520 nm) or amaranth dye (λmax: 530 nm). The reacted oxidant corresponds to the drug content. Beer’s law is obeyed over the concentration range 1.563-50, 2.0-20 and 1.0-10 μg mL-1 for methods A, B and C, resp. The limits of detection and quantitation were 0.40, 0.292 and 0.113 μg mL-1 and 0.782, 0.973 and 0.376 μg mL-1 for methods A, B and C, resp. The HPLC method was validated for system suitability, linearity, precision, limits of detection and quantitation, specificity, stability and robustness. Stability tests were done through exposure of the analyte solution for four different stress conditions and the results indicate no interference of degradants with HPLC-method. The proposed methods was favorably applied for determination of acrivastine in capsules formulation. Statistical comparison of the obtained results from the anal. of the studied drug to those of the reported method using t- and F-tests showed no significant difference between them. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Recommanded Product: 132-20-7

The Article related to chromatog monolithic stationary phase spectrophotometry antihistaminic acrivastine capsule, acrivastine, capsules, monolithic columns, n-bromosuccinimide, spectrophotometry, stability indicating lc-method and other aspects.Recommanded Product: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 12, 2000, Ankersen, Michael; Stidsen, Carsten Enggaard; Crider, Michael Albert published a patent.Quality Control of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine The title of the patent was Use of pyridinylaminoalkyl- and imidazolylalkyl-substituted thioureas, isothioureas, and guanidines as somatostatin agonists and antagonists, for treating diseases related to the eye. And the patent contained the following:

The invention relates to the use of somatostatin receptor ligands of nonpeptide origin, e.g., I or II, or a pharmaceutically acceptable salt thereof [wherein: m = 2, 3, 4, 5 or 6; n = 1, 2 or 3; p = 1, 2, 3, 4, 5 or 6; R1, R2 = independently H or C1-6 alkyl optionally substituted with halo, amino, OH, alkoxy, or aryl; X = S, O, NH, NCOPh or N(CN); A = (hetero)aryl optionally substituted with halo, amino, OH, NO2, C1-6 alkyl, C1-6 alkoxy, or aryl, B = (hetero)aryl optionally substituted with halo, amino, OH, C1-6 alkyl, C1-6 alkoxy, or aryl; D = (hetero)aryl or amino, optionally substituted with halo, amino, OH, C1-6 alkyl, C1-6 alkoxy, or aryl]. The compounds have high and/or selective affinity to the somatostatin receptor protein designated SSTR4, and are useful for the preparation of medicaments for treatment of diseases associated with adverse conditions of the retina and/or iris-ciliary body in mammals (no data). Such conditions include high intraocular pressure (IOP) and/or deep ocular infections. The diseases which may be treated are, e.g. glaucoma, stromal keratitis, iritis, retinitis, cataract, and conjunctivitis. Over 40 compounds are claimed for usage, and 27 synthetic examples are given. For instance, propane-1,3-diamine underwent a sequence of: (1) N-arylation with 2-bromopyridine (76%); (2) N-benzylation with NaH and 4-bromobenzyl bromide in DMSO (70%); (3) conversion of the N’-amine to an isothiocyanate using DCC and CS2 (88%); (4) amination of the isothiocyanate with 3-[1-(triphenylmethyl)imidazol-4-yl]propylamine (80%); and (5) deprotection of the trityl group with aqueous HCl in EtOH (99%), to give title compound III.2HCl. The experimental process involved the reaction of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine(cas: 199522-66-2).Quality Control of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine

The Article related to thiourea isothiourea guanidine pyridinylaminoalkyl imidazolylalkyl preparation somatostatin agonist antagonist, antiglaucoma somatostatin receptor agonist antagonist thiourea isothiourea guanidine preparation and other aspects.Quality Control of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem