Month: November 2022

On July 13, 1999, Cheng, Jianjun; Deming, Timothy J. published an article.COA of Formula: C10H12N2O The title of the article was Screening of Optically Active Nickel Initiators for Enantioasymmetric Polymerization of γ-Benzyl Glutamate-N-Carboxyanhydride. And the article contained the following:

The use of chiral pyridinyl oxazoline ligands in nickel initiators to enantioasym. polymerize γ-benzyl glutamate N-carboxyanhydride (I) was studied. Catalysts prepared from 4,4-dimethyl-(2-pyridinyl)-2-oxazoline and Ni(COD) displayed I polymerization activity which was virtually identical to that of bipyridine-Ni(COD). The kinetic selectivity for the D-antipode displayed by catalyst prepared from (4S)-4-tert-butyl-(2-pyridinyl)-2-oxazoline in homopolymerization was also displayed in polymerization of the racemate. The selectivity of the catalysts was highly sensitive to substitution on the 4 position of the oxazoline ring. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).COA of Formula: C10H12N2O

The Article related to oxazoline nickel catalyst polymerization benzyl glutamate, enantioasym polymerization benzyl glutamate nickel catalyst, polybenzyl glutamate preparation catalyst nickel, pyridine nickel catalyst polymerization benzyl glutamate and other aspects.COA of Formula: C10H12N2O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 31, 1987, Dondoni, Alessandro; Fantin, Giancarlo; Fogagnolo, Marco; Medici, Alessandro; Pedrini, Paola published an article.Synthetic Route of 109660-12-0 The title of the article was Palladium-catalyzed coupling of oxazol-2-yl- and 2-oxazolin-2-yltrimethylstannanes with aromatic halides. A new entry to 2-aryl and 2-heteroaryl oxazoles and oxazolines. And the article contained the following:

Coupling of lithiated 4-methyloxazole and 4,4-dimethyl-2-oxazoline with RX (R = Ph, p-FC6H4, p-tolyl, p-MeSC6H4, o-CNC6H4, thienyl, pyridyl, 2-thiazolyl, 3-furyl, naphthyl, quinolyl, X = Cl, Br, iodo) in benzene in the presence of (Ph3P)4P gave 70-100% 4 oxazoles I and 16 oxazolines II. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Synthetic Route of 109660-12-0

The Article related to safety toxic chlorotrimethylstannane, oxazole aryl, oxazoline aryl, coupling oxazolylstannane aryl halide, arylation oxazoline oxazole, stannane oxazolyl coupling aryl halide, palladium catalyst coupling oxazolylstannanehaloarene and other aspects.Synthetic Route of 109660-12-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On March 14, 2005, Munoz, M. Paz; Adrio, Javier; Carretero, Juan Carlos; Echavarren, Antonio M. published an article.Recommanded Product: 109660-12-0 The title of the article was Ligand Effects in Gold- and Platinum-Catalyzed Cyclization of Enynes: Chiral Gold Complexes for Enantioselective Alkoxycyclization. And the article contained the following:

Phosphine and bidentate N-N ligands inhibit the Alder-ene-type cycloisomerization of enynes catalyzed by Pt(II) and favor the alkoxycyclization process. The enantioselective Pt(II)-catalyzed alkoxycyclization has been studied in the presence of chiral mono- and bidentate phosphines, as well as chiral bidentate N-N ligands. Modest levels of enantioselection (up to 50% ee) have been obtained with Tol-BINAP as ligand. The alkoxycyclizations with a catalyst formed from [Au(L)Cl]/AgX proceed more readily, and up to 94% ee’s have been obtained using [(AuCl)2(Tol-BINAP)] (1) as the precatalyst. X-ray crystal structures of Au(I) complexes 1 and chloro-(R)-2-(tert-butylsulfenyl)-1-(diphenylphosphino)ferrocene gold(I) show the AuCl fragments monocoordinated with the P centers of the chiral phosphine ligands. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Recommanded Product: 109660-12-0

The Article related to enyne phosphine platinum gold complex catalyzed stereoselective alkoxycyclization alc, platinum chiral phosphine complex preparation methoxycyclization catalyst, gold chiral phosphine complex preparation alkoxycyclization catalyst and other aspects.Recommanded Product: 109660-12-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On May 27, 2005, Toele, P.; Glasbeek, M. published an article.Electric Literature of 75449-26-2 The title of the article was Ultrafast excited-state intramolecular double proton transfer dynamics of [2,2′-bipyridyl]-3,3′-diamine. And the article contained the following:

A femtosecond fluorescence upconversion study of [2,2′-bipyridyl]-3,3′-diamine (BP(NH2)2), in liquid solution, is reported. It is concluded that photoexcited BP(NH2)2 undergoes a branched intramol. double proton transfer reaction comprising two trajectories: (a) ultrafast double proton transfer (<100 fs) followed by twisting (∼250 fs); (b) a combined process of double proton transfer and twisting, with an overall reaction time of ∼250 fs. Picosecond transient fluorescence is attributed to vibrational cooling in the excited product state. The lifetime of ∼10 ps of the tautomer product state is indicative of conical intersection of the product- and ground-state potential energy surfaces. The experimental process involved the reaction of [2,2'-Bipyridine]-3,3'-diamine(cas: 75449-26-2).Electric Literature of 75449-26-2

The Article related to fluorescence upconversion study bipyridyldiamine photoinduced intramol double proton transfer, excited state intramol double proton transfer dynamics bipyridyldiamine, photoinduced tautomerization photophys photochem bipyridyldiamine and other aspects.Electric Literature of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 30, 2009, Li, Hong Liang published an article.Computed Properties of 75449-26-2 The title of the article was 2,2′-[(2,2′-Bipyridine-3,3′-diyl)bis(nitrilomethylidyne)]diphenol. And the article contained the following:

The title mol., C24H18N4O2, lies on a 2-fold rotation axis with a dihedral angle of 73.7(1)° between the mean planes of the symmetry-related pyridine rings. The dihedral angle between unique benzene and pyridine rings is 8.0(1)°. An intramol. O-H…N H bond may influence the mol. conformation. In the crystal structure, there are weak π-π stacking interactions with a centroid-centroid distance of 3.7838(15) Å. Crystallog. data and at. coordinates are given. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Computed Properties of 75449-26-2

The Article related to mol structure bipyridinediyl nitrilomethylidyne phenol, crystal structure bipyridinediyl nitrilomethylidyne phenol, hydrogen bond bipyridinediylnitrilomethylidynediphenol, pi stacking interaction bipyridinediylnitrilomethylidynediphenol and other aspects.Computed Properties of 75449-26-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On September 15, 2014, Gouda, Ayman A.; Hashem, Hisham; Jira, Thomas published an article.Recommanded Product: 132-20-7 The title of the article was Development and validation of a rapid stability indicating HPLC-method using monolithic stationary phase and two spectrophotometric methods for determination of antihistaminic acrivastine in capsules. And the article contained the following:

Simple, rapid and accurate high performance liquid chromatog. (HPLC) and spectrophotometric methods are described for determination of antihistaminic acrivastine in capsules. The first method (method A) is based on accurate, sensitive and stability indicating chromatog. separation method. Chromolith Performance RP-18e column, a relatively new packing material consisting of monolithic rods of highly porous silica, was used as stationary phase applying isocratic binary mobile phase of ACN and 25 mM NaH2PO4 pH 4.0 in the ratio of 22.5:77.5 at flow rate of 5.0 mL/min and 40 °C. A diode array detector was used at 254 nm for detection. The elution time of acrivastine was found to be 2.080 ± 0.032. The second and third methods (methods B and C) are based on the oxidation of acrivastine with excess N-bromosuccinimide (NBS) and determination of the unconsumed NBS with, metol-sulfanilic acid (λmax: 520 nm) or amaranth dye (λmax: 530 nm). The reacted oxidant corresponds to the drug content. Beer’s law is obeyed over the concentration range 1.563-50, 2.0-20 and 1.0-10 μg mL-1 for methods A, B and C, resp. The limits of detection and quantitation were 0.40, 0.292 and 0.113 μg mL-1 and 0.782, 0.973 and 0.376 μg mL-1 for methods A, B and C, resp. The HPLC method was validated for system suitability, linearity, precision, limits of detection and quantitation, specificity, stability and robustness. Stability tests were done through exposure of the analyte solution for four different stress conditions and the results indicate no interference of degradants with HPLC-method. The proposed methods was favorably applied for determination of acrivastine in capsules formulation. Statistical comparison of the obtained results from the anal. of the studied drug to those of the reported method using t- and F-tests showed no significant difference between them. The experimental process involved the reaction of N,N-Dimethyl-3-phenyl-3-(pyridin-2-yl)propan-1-amine maleate(cas: 132-20-7).Recommanded Product: 132-20-7

The Article related to chromatog monolithic stationary phase spectrophotometry antihistaminic acrivastine capsule, acrivastine, capsules, monolithic columns, n-bromosuccinimide, spectrophotometry, stability indicating lc-method and other aspects.Recommanded Product: 132-20-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 12, 2000, Ankersen, Michael; Stidsen, Carsten Enggaard; Crider, Michael Albert published a patent.Quality Control of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine The title of the patent was Use of pyridinylaminoalkyl- and imidazolylalkyl-substituted thioureas, isothioureas, and guanidines as somatostatin agonists and antagonists, for treating diseases related to the eye. And the patent contained the following:

The invention relates to the use of somatostatin receptor ligands of nonpeptide origin, e.g., I or II, or a pharmaceutically acceptable salt thereof [wherein: m = 2, 3, 4, 5 or 6; n = 1, 2 or 3; p = 1, 2, 3, 4, 5 or 6; R1, R2 = independently H or C1-6 alkyl optionally substituted with halo, amino, OH, alkoxy, or aryl; X = S, O, NH, NCOPh or N(CN); A = (hetero)aryl optionally substituted with halo, amino, OH, NO2, C1-6 alkyl, C1-6 alkoxy, or aryl, B = (hetero)aryl optionally substituted with halo, amino, OH, C1-6 alkyl, C1-6 alkoxy, or aryl; D = (hetero)aryl or amino, optionally substituted with halo, amino, OH, C1-6 alkyl, C1-6 alkoxy, or aryl]. The compounds have high and/or selective affinity to the somatostatin receptor protein designated SSTR4, and are useful for the preparation of medicaments for treatment of diseases associated with adverse conditions of the retina and/or iris-ciliary body in mammals (no data). Such conditions include high intraocular pressure (IOP) and/or deep ocular infections. The diseases which may be treated are, e.g. glaucoma, stromal keratitis, iritis, retinitis, cataract, and conjunctivitis. Over 40 compounds are claimed for usage, and 27 synthetic examples are given. For instance, propane-1,3-diamine underwent a sequence of: (1) N-arylation with 2-bromopyridine (76%); (2) N-benzylation with NaH and 4-bromobenzyl bromide in DMSO (70%); (3) conversion of the N’-amine to an isothiocyanate using DCC and CS2 (88%); (4) amination of the isothiocyanate with 3-[1-(triphenylmethyl)imidazol-4-yl]propylamine (80%); and (5) deprotection of the trityl group with aqueous HCl in EtOH (99%), to give title compound III.2HCl. The experimental process involved the reaction of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine(cas: 199522-66-2).Quality Control of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine

The Article related to thiourea isothiourea guanidine pyridinylaminoalkyl imidazolylalkyl preparation somatostatin agonist antagonist, antiglaucoma somatostatin receptor agonist antagonist thiourea isothiourea guanidine preparation and other aspects.Quality Control of N1-(5-Bromopyrid-2-yl)ethane-1,2-diamine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 30, 1999, Franco, D.; Panyella, D.; Rocamora, M.; Gomez, M.; Clinet, J. C.; Muller, G.; Dunach, E. published an article.Recommanded Product: 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine The title of the article was Electrochemical cleavage of allyl aryl ethers and allylation of carbonyl compounds: umpolung of allyl-palladium species. And the article contained the following:

The electrochem., Pd-catalyzed cleavage of the carbon-oxygen bond of allyl aryl ethers has been examined; the method constitutes a new alternative for allyl ether deprotection. The allyl transfer from the allyl ether to the carbonyl group in 2-allyloxy benzaldehyde is reported and is an example of allyl-Pd reactivity umpolung. Pd(II) complexes, associated to several nitrogen ligands are efficient catalyst precursors for these electrochem. reactions. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Recommanded Product: 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine

The Article related to allyl aryl ether electrochem cleavage, electrochem ether cleavage catalyst palladium complex, aryl allyl ether deprotection electrochem cleavage, allylsalicylaldehyde allyl transfer palladium chloride catalyst and other aspects.Recommanded Product: 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 6, 2007, Baysal, Akin; Aydemir, Murat; Durap, Feyyaz; Guemguem, Bahattin; Oezkar, Saim; Yildirim, Leyla Tatar published an article.Formula: C10H10N4 The title of the article was Synthesis and characterizations of 3,3′-bis(diphenylphosphinoamine)-2,2′-bipyridine and 3,3′-bis(diphenylphosphinite)-2,2′-bipyridine and their chalcogenides. And the article contained the following:

New bis(phosphinoamine) and bis(phosphinite) derivatives of 2,2′-bipyridine were prepared through a single step reaction of 3,3′-diamino-2,2′-bipyridine or 3,3′-dihydroxy-2,2′-bipyridine with diphenylchlorophosphine, resp. Their P = E chalcogenide phosphinates (E = O, S, Se) were also prepared All the new compounds were characterized by elemental anal., IR and NMR spectroscopies. The mol. structure of 3,3′-bis(diphenylthiophosphinate)-2,2′-bipyridine was elucidated by single-crystal x-ray crystallog. The experimental process involved the reaction of [2,2′-Bipyridine]-3,3′-diamine(cas: 75449-26-2).Formula: C10H10N4

The Article related to crystal structure bipyridinediyl bisthiophosphinate, mol structure bipyridinediyl bisthiophosphinate, bipyridine phosphinoamino phosphinite preparation oxidation, chalcogenide phosphinate bipyridine preparation and other aspects.Formula: C10H10N4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem