Month: November 2022

Dang, Qin-Qin; Zhan, Yu-Fen; Duan, Li-Na; Zhang, Xian-Ming published an article in 2015, the title of the article was A pyridyl-decorated MOF-505 analogue exhibiting hierarchical porosity, selective CO2 capture and catalytic capacity.HPLC of Formula: 1431292-15-7 And the article contains the following content:

An expanded pyridyl-decorated MOF-505 analog [Cu2(L)(H2O)2]·Gx (H4L = 5,5′-(pyridine-2,5-diyl)diisophthalic acid, G = solvent mol.) was solvothermally synthesized and reported. It exhibited rare hierarchical meso- and microporosity. With exposed unsaturated CuII sites and Lewis basic pyridyl sites, the material shows both large CO2-uptake capacity (123.4 cm3 g-1 at 273 K, 1 bar) and high selectivity for CO2 over N2 (55.7) at 273 K. Also, for the first time the compound was exploited for its heterogeneous catalytic performance toward the cyanosilylation reaction under solvent-free conditions. The compound can be recycled up to five times with only a minor loss of activity. The experimental process involved the reaction of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid(cas: 1431292-15-7).HPLC of Formula: 1431292-15-7

The Article related to copper pyridinediyldiisophthalate mof solvothermal preparation crystal structure, gas adsorption copper pyridinediyldiisophthalate mof, aryl aldehyde cyanosilylation catalyst copper pyridinediyldiisophthalate mof and other aspects.HPLC of Formula: 1431292-15-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yang, Bing; Jiang, Xin; Guo, Qing; Lei, Tao; Zhang, Li-Ping; Chen, Bin; Tung, Chen-Ho; Wu, Li-Zhu published an article in 2016, the title of the article was Self-Assembled Amphiphilic Water Oxidation Catalysts: Control of O-O Bond Formation Pathways by Different Aggregation Patterns.Formula: C5H5NO3S And the article contains the following content:

The oxidation of water to mol. oxygen is the key step to realize water splitting from both biol. and chem. perspective. In an effort to understand how water oxidation occurs on a mol. level, a large number of mol. catalysts have been synthesized to find an easy access to higher oxidation states as well as their capacity to make O-O bond. However, most of them function in a mixture of organic solvent and water and the O-O bond formation pathway is still a subject of intense debate. Herein, we design the first amphiphilic Ru-bda (H2bda=2,2′-bipyridine-6,6′-dicarboxylic acid) water oxidation catalysts (WOCs) of formula [RuII(bda)(4-OTEG-pyridine)2] (1, OTEG=OCH2CH2OCH2CH2OCH3) and [RuII(bda)(PySO3Na)2] (2, PySO3-=pyridine-3-sulfonate), which possess good solubility in water. Dynamic light scattering (DLS), scanning electron microscope (SEM), critical aggregation concentration (CAC) experiments and product anal. demonstrate that they enable to self-assemble in water and form the O-O bond through different routes even though they have the same bda2- backbone. This work illustrates for the first time that the O-O bond formation pathway can be regulated by the interaction of ancillary ligands at supramol. level. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).Formula: C5H5NO3S

The Article related to self assembled amphiphilic water oxidation catalyst, control oxygen oxygen bond formation pathway different aggregation pattern, amphiphilic complexes, catalysis, ruthenium complex, self-assembly, water oxidation and other aspects.Formula: C5H5NO3S

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 9, 2000, Dow, Robert Lee; Liu, Kevin Kun-Chin; Morgan, Bradley Paul; Swick, Andrew Gordon published a patent.Reference of 4-(Chloromethyl)-2-methoxy-6-methylpyridine The title of the patent was Preparation of nonracemic octahydrophenanthrene and other tricyclic derivatives as selective modulators of glucocorticoid receptors. And the patent contained the following:

Title compounds [e.g., I; D = CR7, CR7R16, N, NR7, O’ E = C, CR6, N; F = CR4, CR4R5, O; R = XR1; R1 = H, alkyl, acylalkyl, arylalkyl, etc.; R2 = H, halo, alkyl, alkoxy, etc.; R3 = H, alkyl, arylalkyl, etc.; 1 of R2,R3 = null when adjacent dashed line = bond; R4,R5 = H, cyano, alkyl, alkoxy, etc.; R4R5 = O; R6 = H, cyano, alkyl, alkoxy, OH, etc.; R7,R16 = H, halo, cyano, alkyl, etc.; R7R16 = O; R8R9 = atoms to complete a substituted heteroaromatic ring; R14,R15 = H, halo, alkyl, alkoxy, etc.; R14R15 = O when adjacent dashed lines = null; X = bond, CH2, CH(OH), CO; Z = (un)substituted CH2, -CH2CH2, -CH2CO, CO, etc.; dashed lines = optional bonds] were prepared as glucocorticoid receptor modulators (no data). E.g., 6-methoxy-2-tetralone was alkylated by formation of the pyrrolidine enamine and alkylation with benzyl bromide; the benzylated ketone then undergoes asym. Michael addition with Me vinyl ketone in the presence of (S)-(-)-α-methylbenzylamine followed by cyclocondensation with sodium methoxide to give a nonracemic methoxytetrahydrophenanthrenone derivative E.g., demethylation of the methoxytetrahydrophenanthrenone with boron trichloride, reduction of the enone with lithium and ammonia, addition of 1-lithiopropyne to the ketone, formation of the aryl triflate with triflic anhydride and carbonylation with carbon monoxide in the presence in the presence of palladium acetate and bis(diphenylphosphino)propanol gives an hydroxyoctahydrophenanthrenecarboxylic acid derivative which is coupled with 4-(aminomethyl)pyridine in the presence of trimethylaluminum to give the octahydrophenanthrenecarboxamide II as one of the title compounds The experimental process involved the reaction of 4-(Chloromethyl)-2-methoxy-6-methylpyridine(cas: 1227595-34-7).Reference of 4-(Chloromethyl)-2-methoxy-6-methylpyridine

The Article related to nonsteroidal glucocorticoid receptor selective agonist antagonist preparation, treatment obesity diabetes inflammation nonsteroidal glucocorticoid receptor modulator, glucocorticoid receptor modulator preparation and other aspects.Reference of 4-(Chloromethyl)-2-methoxy-6-methylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 4, 2021, Tanaka, Jin; Nagashima, Yuki; Araujo Dias, Antonio Junio; Tanaka, Ken published an article.Formula: C17H20BNO2 The title of the article was Photo-Induced ortho-C-H Borylation of Arenes through In Situ Generation of Rhodium(II) Ate Complexes. And the article contained the following:

Photoinduced in situ “oxidation” of half-sandwich metal complexes to “high-valent” cationic metal complexes has been used to accelerate catalytic reactions. Here, we report the unprecedented photoinduced in situ “reduction” of half-sandwich metal [Rh(III)] complexes to “low-valent” anionic metal [Rh(II)] ate complexes, which facilitate ligand exchange with electron-deficient elements (diboron). This strategy was realized by using a functionalized cyclopentadienyl (CpA3) Rh(III) catalyst we developed, which enabled the basic group-directed room temperature ortho-C-H borylation of arenes. The experimental process involved the reaction of 2-(2-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)pyridine(cas: 1349171-28-3).Formula: C17H20BNO2

The Article related to photocatalyzed regioselective borylation arene rhodium ate in situ catalyst, mol structure optimized rhodium complex transition state potential energy, half sandwich rhodium ate complex in situ catalyst borylation and other aspects.Formula: C17H20BNO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On October 21, 2021, Arnold, Lee D.; Lopatin, Uri; Keung, Walter published a patent.Synthetic Route of 39919-70-5 The title of the patent was Preparation of peptidomimetics as inhibitors of cysteine proteases for treatment of viral infections including COVID-19. And the patent contained the following:

The invention is related to the preparation of broad spectrum, viral protease inhibitor compounds, e.g., I, comprising a warhead covalently bound to a 3CL protease inhibitor, wherein the inhibitor compound covalently binds to Cys on the protease, and wherein the inhibitor compound is active against multiple such as viruses caliciviruses, picornaviruses and coronaviruses. The compounds are contemplated to inhibit proteases, such as the 3C, CL- or 3CL-like protease. Thus, I was prepared by Ugi reaction between pyridine-3-carbaldehyde, 4-tert-butylaniline, (2R,4S)-1-tert-butoxycarbonyl-4-hydroxypyrrolidine-2-carboxylic acid and isocyanocyclohexane followed by cleavage of the tert-butoxycarbonyl group in II and treatment with BrCN. Select compounds of the invention were evaluated for their antiviral activity against COVID-19 (nCoV-2019, SARS-CoV2) Mpro in an enzymic assay and against human coronavirus 229E and OC43 in the cytopathic effect assays. The experimental process involved the reaction of 6-(tert-Butyl)pyridin-3-amine(cas: 39919-70-5).Synthetic Route of 39919-70-5

The Article related to peptidomimetic preparation viral cysteine protease inhibitor viral infection treatment, cysteine protease inhibitor antiviral sarscov2 covid19 mpro peptidomimetic preparation, covid19 treatment peptidomimetic preparation and other aspects.Synthetic Route of 39919-70-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 31, 2021, Si, Xue-Jian; Jia, Jing; Bao, Yu-Liang; Wu, Ya-Pan; Liu, Yunling; Dong, Wen-Wen; Zhao, Jun; Li, Dong-Sheng published an article.Safety of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid The title of the article was Superprotonic conductivity of a 3D anionic metal-organic framework by synergistic effect of guest [Me2NH2]+ cations, water molecules and host carboxylates. And the article contained the following:

A new 3D anionic metal-organic framework material, namely, [Me2NH2]2[Cd3(L)]·2H2O (1, H4L = 2,5′-di(3′,5′-dicarboxylphenyl)pyridine) has been synthesized under solvothermal conditions and characterized by single crystal x-ray diffraction, PXRD, thermogravimetric anal. and proton conduction investigation. In 1, the adjacent Cd(II) ions are joined to form a trinuclear [Cd3(COO)8] secondary building unit (SBU) by eight bridging carboxylate groups of L4- ligands. The trinuclear [Cd3(COO)8] SBUs are connected by L4- ligands into a 3D (4,8)-connected framework with 1D channels. Most interestingly, due to the guest [Me2NH2]+ cations, water mols. and carboxylates sites are lined the pore channels, 1 possesses a remarkable proton conductivity of 1.12 x 10-1 S cm-1 at 60° and 98% RH, which is comparable to com. available Nafion. The mechanism of proton conduction was also well discussed. The experimental process involved the reaction of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid(cas: 1431292-15-7).Safety of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid

The Article related to dicarboxylphenylpyridine cadmium metal organic framework preparation crystal mol structure, superprotonic conductivity three dimensional anionic metal organic framework, synergistic guest cation water mol host carboxylate and other aspects.Safety of 5,5′-(Pyridine-2,5-diyl)diisophthalic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On December 3, 2001, Makinen, Silja K.; Melcer, Natalia J.; Parvez, Masood; Shimizu, George K. H. published an article.SDS of cas: 636-73-7 The title of the article was Highly selective guest uptake in a silver sulfonate network imparted by a tetragonal to triclinic shift in the solid state. And the article contained the following:

The Ag sulfonate network presented herein, Ag 3-pyridinesulfonate, reversibly and selectively absorbs MeCN while undergoing a major structural rearrangement. The origin of this structural flexibility is a coupling of the weak coordinating ability of the SO3 group with the geometrically pliant Ag(I) center. Single crystal and powder x-ray structures of both the desolvated and solvated forms are presented in addition to the mechanism of their reversible interconversion. A heterogeneous gas chromatog. study showing selective extraction of the MeCN is also presented. Extended solid frameworks which reorder to any extent are not common but the structure presented herein transforms from a tetragonal to a triclinic crystal system. The results indicate that cooperative interactions in systems based on supposedly weaker interactions can yield softer yet functional networks with behavior unlike that observed in more rigid inorganic frameworks. The experimental process involved the reaction of Pyridine-3-sulfonic acid(cas: 636-73-7).SDS of cas: 636-73-7

The Article related to silver pyridinesulfonic acid supramol network complex preparation, acetonitrile reversible sorption silver pyridinesulfonic acid supramol network complex, crystal structure silver pyridinesulfonic acid supramol network complex and other aspects.SDS of cas: 636-73-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On November 27, 2008, Soll, Mark David; Le Hir De Fallois, Loic Patrick; Huber, Scot Kevin; Lee, Hyoung Ik; Wilkinson, Douglas Edward; Jacobs, Robert Toms published a patent.Recommanded Product: 1086838-13-2 The title of the patent was Preparation of aryl-fused triazole and pyrazole derivatives and their use as antiparasitic agents against endo- and ectoparasites. And the patent contained the following:

Title compounds I [P = CR1 or N; Q = CR2 or N; V = CR8 or N; W = CR9 or N; X = CR10 or N; Y = CR11 or N; R1, R2, R8, R9, R10 and R11 independently = H, NH2, amido, CN, NO2, halo. etc.; R3, R4 and R5 independently = H, halo, alkyl, hydroxyalkyl, alkylthioalkyl, etc.; R4 and R5 together with the carbon to which they are attached formed a cycloalkyl ring; R6 = H, alkyl, alkoxyalkyl, alkylcarbonyl, alkylthiocarbonyl or (un)substituted benzyl; R7 = H, alkyl, alkoxyalkyl, alkylcarbonyl, alkylthiocarbonyl or (un)substituted phenyl; Z = direct bond, CO, CS or S(O)p; m = 1-3; p = 0-2], and pesticidally acceptable salts, are prepared Thus, e.g., II was prepared by amidation of 4-trifluoromethoxybenzoyl chloride with 2-amino-2-methyl-3-(4,5,7-trichloro-2H-benzotriazol-2-yl)propionitrile which was prepared starting from 4,5,7-trichloro-1H-benzotriazole in a multi-step. I are antiparasitic agents, e.g., II gave at least 90% motility inhibition against Haemonchus contortus at a test concentration of 0.0025 ppm at the 4 days assessment. Therefore, I and pesticidal compositions are particularly useful for controlling endo- and ectoparasites which parasitize animals. The experimental process involved the reaction of 5-Chloro-3-nitropicolinaldehyde(cas: 1086838-13-2).Recommanded Product: 1086838-13-2

The Article related to benzotriazole cyanoethylamino preparation antiparasitic endoparasite ectoparasite, indazole cyanoethylamino preparation parasiticidal infection, endoparasite ectoparasite pesticidal pyrazolopyridine cyanoethylamino preparation and other aspects.Recommanded Product: 1086838-13-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On July 13, 1999, Cheng, Jianjun; Deming, Timothy J. published an article.COA of Formula: C10H12N2O The title of the article was Screening of Optically Active Nickel Initiators for Enantioasymmetric Polymerization of γ-Benzyl Glutamate-N-Carboxyanhydride. And the article contained the following:

The use of chiral pyridinyl oxazoline ligands in nickel initiators to enantioasym. polymerize γ-benzyl glutamate N-carboxyanhydride (I) was studied. Catalysts prepared from 4,4-dimethyl-(2-pyridinyl)-2-oxazoline and Ni(COD) displayed I polymerization activity which was virtually identical to that of bipyridine-Ni(COD). The kinetic selectivity for the D-antipode displayed by catalyst prepared from (4S)-4-tert-butyl-(2-pyridinyl)-2-oxazoline in homopolymerization was also displayed in polymerization of the racemate. The selectivity of the catalysts was highly sensitive to substitution on the 4 position of the oxazoline ring. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).COA of Formula: C10H12N2O

The Article related to oxazoline nickel catalyst polymerization benzyl glutamate, enantioasym polymerization benzyl glutamate nickel catalyst, polybenzyl glutamate preparation catalyst nickel, pyridine nickel catalyst polymerization benzyl glutamate and other aspects.COA of Formula: C10H12N2O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

On August 31, 1987, Dondoni, Alessandro; Fantin, Giancarlo; Fogagnolo, Marco; Medici, Alessandro; Pedrini, Paola published an article.Synthetic Route of 109660-12-0 The title of the article was Palladium-catalyzed coupling of oxazol-2-yl- and 2-oxazolin-2-yltrimethylstannanes with aromatic halides. A new entry to 2-aryl and 2-heteroaryl oxazoles and oxazolines. And the article contained the following:

Coupling of lithiated 4-methyloxazole and 4,4-dimethyl-2-oxazoline with RX (R = Ph, p-FC6H4, p-tolyl, p-MeSC6H4, o-CNC6H4, thienyl, pyridyl, 2-thiazolyl, 3-furyl, naphthyl, quinolyl, X = Cl, Br, iodo) in benzene in the presence of (Ph3P)4P gave 70-100% 4 oxazoles I and 16 oxazolines II. The experimental process involved the reaction of 2-(4,5-Dihydro-4,4-dimethyl-2-oxazolyl)pyridine(cas: 109660-12-0).Synthetic Route of 109660-12-0

The Article related to safety toxic chlorotrimethylstannane, oxazole aryl, oxazoline aryl, coupling oxazolylstannane aryl halide, arylation oxazoline oxazole, stannane oxazolyl coupling aryl halide, palladium catalyst coupling oxazolylstannanehaloarene and other aspects.Synthetic Route of 109660-12-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem