Day: December 1, 2022

Bohme, Horst published the artcileAddition compounds of triphenylboron and thioethers or tertiary amines, Product Details of C23H20BN, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (1957), 160-3, database is CAplus.

cf. C.A. 51, 13739e. NaBPh₄ in MeOH with Me₂SBr₂ at 5-10° precipitated Me₂SBPh₃ (I), m. 180°; with (iso-Pr)₂S and Br at 0° (iso-Pr)₂SBPh₃, m. 165° (decomposition); with tetrahydrothiophene dibromide at -5-0° unstable (C₄H₈S)₂BPh₃, m. 132-3°; and with PhCH₂SBr₂ at -70° in a closed system, PhCH₂SBPh₃, decomposed at room temperature With pyridine dibromide at 0° and with Et₃NBr₂, the products were colorless C₅H₅NBPh₃, m. 214° (decomposition), and Et₃NBPh₃, m. 177-8°, resp. Ph₂SBPh₃ could not be prepared in this way, nor could the thioether addition compounds be prepared by direct combination. I was insoluble in H₂O and most organic solvents and was not attacked in the cold by dilute acids or alkalies.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Product Details of C23H20BN.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Glinkerman, Christopher M. published the artcileSynthesis, Characterization, and Rapid Cycloadditions of 5-Nitro-1,2,3-triazine, COA of Formula: C11H8N2O2, the publication is Organic Letters (2018), 20(9), 2628-2631, database is CAplus and MEDLINE.

The synthesis, characterization, and a study of the cycloaddition reactions of 5-nitro-1,2,3-triazine (I) are reported. The electron-deficient nature of I permits rapid cycloaddition with a variety of electron-rich dienophiles, including amidines, enamines, enol ethers, ynamines, and ketene acetals in high to moderate yields. ¹H NMR studies of a representative cycloaddition reaction between I and an amidine revealed a remarkable reaction rate and efficiency (1 mM, <60 s, CD₃CN, 23°, >95%).

Organic Letters published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, COA of Formula: C11H8N2O2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Jimenez Plaza, J. published the artcile2-Pyridylaldehyde-2-pyridylhydrazone as an analytical reagent. V. Spectrophotometric determination of copper(II), Application of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Boletin de la Sociedad Quimica del Peru (1980), 46(1), 94-102, database is CAplus.

2-Pyridylaldehyde-2-pyridylhydrazone reacts with Cu(II) in pH 5 buffer solution (HOAc-NaOAc) to form a 1:1 complex. The reaction can be used to determine Cu(II) by measuring the absorbance of the complex at 350-370 nm. Beer’s law is obeyed for 1-6.5 ppm Cu. Tolerance levels are given for 30 ions.

Boletin de la Sociedad Quimica del Peru published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Application of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gimenez Plaza, J. published the artcile2-Pyridylaldehyde-2-pyridylhydrazone as an analysis reagent. II. Spectrophotometric determination of nickel(II), COA of Formula: C11H10N4, the publication is Revista de la Sociedad Quimica de Mexico (1981), 25(4), 488-91, database is CAplus.

Ni²⁺ reacts with 2-pyridylaldehyde-2-pyridylhydrazide to form a yellow 1:1 complex which has maximum absorbance at 355 nm and pH 7.5. The color is stable up to 3 h when the order of addition is reagent + cation + buffer. Beer’s law is obeyed for 1-7 ppm Ni. Ag, Hg(II), Sb(III), Sn(II), Fe(II), Fe(III), Al, Co(II), Zn, Mn(II), Pd(II), Be, Cu(II), Cd, Au(III), Bi, Ce(IV), Ca, Sr, Ba, and Mg 2 ppm interfere.

Revista de la Sociedad Quimica de Mexico published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, COA of Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gimenez Plaza, J. published the artcile2-Pyridinecarboxaldehyde 2-pyridylhydrazone as analytical agent. IV. Spectrophotometric determination of palladium(II), Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Afinidad (1980), 37(367), 237-9, database is CAplus.

Pd(II) was determined spectrophotometrically as its 1:1 complex with 2-pyridinecarboxaldehyde 2-pyridylhydrazone. Approx. 5 mL 0.002M 2-pyridinecarboxaldehyde 2-pyridylhydrazone and 5 mL HOAc/NaOAc buffer (pH5) were added to the sample in a total volume of 25 mL. The absorbance of the solution was measured at 360-390 nm after 1 h. The relative error in the determination of 2.5-7 ppm Pd was 0.3-0.5%. Significant interference was caused by � ppm Ag(I), Cu(II), Co(II), Sn(II), Ni(II), Fe(II), Fe(III), V(V), and Au(III).

Afinidad published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gimenez Plaza, J. published the artcile2-Pyridylaldehyde 2-pyridylhydrazone as an analytical reagent. VI. Spectrophotometric determination of iron(II), Formula: C11H10N4, the publication is Boletin de la Sociedad Quimica del Peru (1980), 46(3), 278-8, database is CAplus.

Fe(II) 3-10 ppm in aqueous solution was determined spectrophotometrically by reaction with 10 mL 2 × 10^-3M 2-pyridylaldehyde 2-pyridylhydrazone in the presence of 5mL pH 9 NH₄Cl-NH₄OH buffer. The order of reagent addition is not important. The maximum absorption of the violet solution is at 550 nm. The complex is stable for at least 3 h. Stoichiometry of the complex is 2:1 (reagent/cation). Beer’s law is obeyed for 2-16 ppm Fe(II). Zr(IV) and Be(II) >50 ppm and Sn(II), Co(II), and Ce(II) >2 ppm interfere.

Boletin de la Sociedad Quimica del Peru published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Formula: C11H10N4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gimenez Plaza, J. published the artcile2-Pyridinecarboxaldehyde 2-pyridylhydrazone as analytical reagent. III. Spectrophotometric determination of cobalt(II), Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Afinidad (1980), 37(367), 243-6, database is CAplus.

A method for the spectrophotometric determination of Co(II) is based on the formation of a 1:1 complex of Co(II) with 2-pyridinecarboxaldehyde 2-pyridylhydrazone (I). Approx. 10 mL EtOH was added to the sample with 3 mL HOAc/NaOAc buffer (pH 6) and 5 mL 0.002M I and the total volume was adjusted to 25 mL. The absorbance was measured at 350-90 nm after 15 min. The relative error was 0.3-0.5% for determining 2-5 ppm Co. Significant interference was observed from � ppm Hg(II), Cu(II), Sn(II), Fe(III), Ni(II), Zn(II), Fe(II), Pd(II), Au(III), Mo(VI), V(V), Os(VIII), and Ce(IV). The logarithm of the stability constant of the Cr-I complex is 6.88.

Afinidad published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Recommanded Product: 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Karaman, Rafik published the artcileSymmetrical and unsymmetrical quadruply aza-bridged, closely interspaced, cofacial bis(5,10,15,20-tetraphenylporphyrin)s. 2. Synthesis, characterization, and conformational effects of solvents, Formula: C5H5NO3S, the publication is Journal of the American Chemical Society (1992), 114(12), 4889-98, database is CAplus.

Title compounds I [X = NR, R = 3-pyridylsulfonyl (R¹), 1-methylpyridinium-3-sulfonyl (R²), CONH₂, cyano, tosyl; X = OCO₂, R = R¹, cyano] have been synthesized and fully characterized by 2-dimensional ¹H-¹H NMR (COSY), 2-dimensional ¹³C-¹H NMR, fast-atom-bombardment mass spectrometry, UV/vis, IR, and fluorescence spectral techniques. It was established, on the basis of ¹H NMR, UV/vis, and emission spectrophotometries, that I (X = NR, R = R¹, R², tosyl) exist in more than one conformational in DMSO and in only one sym. conformation in CHCl₃. Their biszinc complexes and tetraprotonated derivatives exist in one conformation regardless of the solvent. These observations have been attributed to an interaction between DMSO and the pyrrolic N-H protons of the porphyrin cores which is inhibited by metalation or protonation. Mol. dynamics calculations reveal that the intracavity interactions of I (X = NR, R = R¹) with DMSO are more important than the intercavity interactions which result in discrete, unsym. conformations of the dimer. In contrast, I (X = OCO₂, R = R¹, cyano; X = NR, R = cyano, CONH₂) do not show any conformational changes upon switching from CHCl₃ to DMSO. This is attributed to the long interplanar distances calculated for the porphyrin dimers which prevent intracavity coordination of DMSO with both porphyrin moieties. ¹H NMR variable-temperature experiments of I (X = NR, R = R¹) in DMSO show that the conformation of the dimer is greatly affected by temperature While at room temperature I (X = NR, R = R¹) exists in more than one conformation, at higher temperatures (150°) only one conformation is populated. It is proposed that at room temperature, the existence of a H-bonding network between DMSO and the dimer results in more than one conformation, while at higher temperatures the network is destroyed to furnish an average conformation.

Journal of the American Chemical Society published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Formula: C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sutherland, Hamish S. published the artcileSynthesis and Structure-activity Relationships of Antitubercular 2-Nitroimidazooxazines Bearing Heterocyclic Side Chains, HPLC of Formula: 870459-90-8, the publication is Journal of Medicinal Chemistry (2010), 53(2), 855-866, database is CAplus and MEDLINE.

Previously, biphenyl analogs of the antituberculosis drug PA-824 were found to display improved potencies against M. tuberculosis but were poorly soluble Heterobiaryl analogs of these, e.g., I (X = 2,5-thiophenediyl, R = 4-F), in which the first Ph ring was replaced with various 5-membered ring heterocycles, were prepared with the aim of identifying potent new candidates with improved aqueous solubility The compounds were constructed by coupling the chiral 2-nitroimidazooxazine II with various halomethyl-substituted arylheterocycles, by cycloadditions to a propargyl ether derivative of this alc., or by Suzuki couplings on haloheterocyclic Me ether derivatives The arylheterocyclic compounds were all more hydrophilic than their corresponding biphenyl analogs, and several showed solubility improvements. 1-Methylpyrazole, e.g., I (X = 1-methyl-3,5-pyrazolediyl, R = 4-F₃C), 1,3-linked-pyrazole, e.g., I (X = 1,3-pyrazolediyl, R = 4-F), 2,4-linked-triazole, e.g., I [X = 1,2,3-triazole-2,4-diyl, R = 4-(CF₃O)] and tetrazole analogs, e.g., I (X = 2,5-tetrazolediyl, R = H) had 3- to 7-fold higher MIC potencies against replicating M. tuberculosis than predicted by their lipophilicities. Two pyrazole analogs were >10-fold more efficacious than the parent drug in a mouse model of acute M. tuberculosis infection, and one displayed a 2-fold higher solubility

Journal of Medicinal Chemistry published new progress about 870459-90-8. 870459-90-8 belongs to pyridine-derivatives, auxiliary class Trifluoromethyl,Pyridine,Fluoride,Boronic acid and ester,Boronic Acids,Boronic acid and ester, name is (4-(Trifluoromethyl)pyridin-2-yl)boronic acid, and the molecular formula is C4HN5, HPLC of Formula: 870459-90-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

McConnell, Danielle L. published the artcileSynthesis of Bench-Stable N-Quaternized Ketene N,O-Acetals and Preliminary Evaluation as Reagents in Organic Synthesis, Recommanded Product: Phenyl(pyridin-2-yl)methanone, the publication is Journal of Organic Chemistry (2021), 86(18), 13025-13040, database is CAplus and MEDLINE.

In this report, a general synthetic approach to a variety of bench-stable N-quaternized ketene N,O-acetals I (R = H, 2-Ph, 4-Me, 2,6-Cl₂, etc.; X = OTf, NTf₂) via treatment of pyridine II or aniline bases with acetylenic ethers R¹CC (R¹ = OEt, 4-methoxyphenyl) and an appropriate Bronsted or Lewis acid (triflic acid, triflimide, or scandium(III) triflate) have been described. The resulting pyridinium I and anilinium salts C₆H₅N⁺((CH₃)CH₂)C(=CH₂)R¹ X^– can be used as reagents or synthetic intermediates in multiple reaction types. For example, N-(1-ethoxyvinyl)pyridinium or anilinium salts can thermally release highly reactive O-Et ketenium ions for use in acid catalyst-free electrophilic aromatic substitutions. N-(1-ethoxyvinyl)-2-halopyridinium salts I (R = 2-Cl, 2-Br) can be employed in peptide couplings as a derivative of Mukaiyama reagent (2-chloro-1-methylpyridinium iodide) or react with phenylmethanamine in nucleophilic aromatic substitutions under mild conditions. These preliminary reactions illustrate the broad potential of these currently understudied compounds in organic synthesis.

Journal of Organic Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Recommanded Product: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem