Day: December 2, 2022

Mohan, M. published the artcileSynthesis, characterization and antitumor properties of some metal(II) complexes of 2-pyridinecarboxaldehyde 2′-pyridylhydrazone and related compounds, Application of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Inorganica Chimica Acta (1988), 151(1), 61-8, database is CAplus.

MLX₂ (M = Mn, Fe, Co, Ni, Cu, Pt, X = Cl; M = Zn, X = OAc; L = 2-pyridinecarboxaldehyde 2′-quinolylhydrazone and 2′-pyridylhydrazone (PCPH) and the 6-, 3′-, 4′-, 5′-, and 6′-Me derivatives of PCPH) were prepared and characterized by magnetic susceptibility measurements down to liquid N temperature and also by electronic, IR, ESR and Moessbauer spectra. All MLX₂ are monomeric, high-spin, 5-coordinate (square-pyramidal) except for Ni(PCPH)Cl₂ which is polymeric, high-spin, 6-coordinate. Each ligand behaves as a tridentate NNN donor, via the pyridine N, azomethine N, and pyridine or quinoline N. One of the most active agents of this series, Cu(PCPH)Cl₂, showed antitumor activity against a variety of transplanted tumors, including Sarcoma 180, Ehrlich carcinoma and L1210 leukemia sensitive to α-(N)-heterocyclic carboxaldehyde thiosemicarbazones. This agent caused inhibition of ³H-thymidine and ³H-uridine incorporation into DNA and RNA, resp., of Sarcoma 180 ascites cells; protein biosynthesis was relatively insensitive to the action of this agent.

Inorganica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Application of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bhar, Kishalay published the artcileHigh temperature spin crossover behaviour of mononuclear bis-(thiocyanato)iron(II) complexes with judiciously designed bidentate N-donor Schiff bases with varying substituents, Safety of Phenyl(pyridin-2-yl)methanone, the publication is Dalton Transactions (2022), 51(24), 9302-9313, database is CAplus and MEDLINE.

THe authors present herein a family of mol. cis-[Fe^II(X-PPMA)₂(NCS)₂]·H₂O [4-X-N-(phenyl(pyridin-2-yl)methylene)aniline; X-PPMA; X = Cl (1), Br (2), and CH₃ (3)] complexes that exhibit spin crossover behavior above room temperature Judiciously designed bidentate N-donor Schiff bases of 2-benzoylpyridine and para-substituted anilines in combination with Fe(NCS)₂ were used for the synthesis of complexes 1–3. The relatively strong ligand field of the Schiff bases stabilizes the low spin state of iron(II) up to 300 K which is evident from magnetic measurements, room temperature Mossbauer spectra and crystallog. bond/angle distortion parameters. Interestingly, complexes 1–3 crystallize in a tetragonal system with either a P4₃2₁2 or P4₁2₁2 chiral space group from achiral building units due to the supramol. helical arrangements of mols. through intermol. (pyridine)C-H···C(NCS) interactions in the crystalline state. Complexes 1 and 2 exhibit complete, gradual and slightly irreversible spin crossover behavior in the temperature range of 300-500 K with equilibrium temperatures (T_1/2) 375 K (1) and 380 K (2). The spin state evolution of iron(II) in complexes 1 and 2 is monitored between 150 K and 450 K through variable temperature crystallog. studies in the warming mode. The structural data are in good agreement with the 94% (1) and 87% (2) high spin conversion of iron(II) at 450 K. At a high temperature (450 K), some minor irreversible ligand motion is noticed in complexes 1 and 2, in addition to a complete solvent loss that may induce the slight irreversibility of the spin crossover. On the other hand, complex 3 shows a complete and gradual spin crossover in the temperature range of 10-475 K with strong irreversible features. The equilibrium temperatures obtained upon first warming (T_1/2↑) and second cooling (T_1/2↓) are 375 K and 200 K, resp. In complex 3, the loss of a water mol. triggers strong deviations in the spin crossover behavior. Moreover, dehydrated complex 3 exhibits photoswitching LIESST effect with a relaxation temperature T(LIESST) = 60 K.

Dalton Transactions published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Safety of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Luo, Dexia published the artcileDesign, Synthesis, and Bioactivity of α-Ketoamide Derivatives Bearing a Vanillin Skeleton for Crop Diseases, Quality Control of 18437-58-6, the publication is Journal of Agricultural and Food Chemistry (2020), 68(27), 7226-7234, database is CAplus and MEDLINE.

A series of novel α-ketoamide derivatives bearing a vanillin skeleton were designed and synthesized. Bioactivity tests on virus and bacteria were performed. The results indicated that some compounds exhibited excellent antitobacco mosaic virus (TMV) activities, such as compound I exhibited an inactivation activity of 90.1% and curative activity of 51.8% and compound II exhibited a curative activity of 54.8% at 500μg mL^-1, which is equivalent to that of the com. ningnanmycin (inactivation of 91.9% and curative of 51.9%). Moreover, the in vitro antibacterial activity test illustrated that compounds showed much higher activities than com. thiodiazole copper, which could be used as lead compounds or potential candidates. The findings of transmission electron microscopy and mol. docking indicated that the synthesized compounds exhibited strong and significant binding affinity to the TMV coat protein and could obstruct the self-assembly and increment of TMV particles. This study revealed that α-ketoamide derivatives bearing a vanillin skeleton could be used as a novel potential pesticide for controlling the plant diseases.

Journal of Agricultural and Food Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Quality Control of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liao, Lihao published the artcileOrganoselenium-Catalyzed Regioselective C-H Pyridination of 1,3-Dienes and Alkenes, HPLC of Formula: 107263-95-6, the publication is Angewandte Chemie, International Edition (2017), 56(12), 3201-3205, database is CAplus and MEDLINE.

An efficient approach for organoselenium-catalyzed regioselective C-H pyridination of 1,3-dienes to form pyridinium salts has been developed. This method was also successfully applied to direct C-H pyridination of alkenes. Fluoropyridinium reagents, or initially loaded pyridine derivatives, acted as pyridine sources in the pyridination reactions. The obtained pyridinium salts could be further converted under different conditions. This work is the first example of catalytic C-2 direct C-H functionalization of 1,3-dienes and the first case of organoselenium-catalyzed C-H pyridination.

Angewandte Chemie, International Edition published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, HPLC of Formula: 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Shengqiang published the artcileEfficient synthesis of 3-aryl-1H-indazol-5-amine by Pd-catalyzed Suzuki-Miyaura cross-coupling reaction under microwave-assisted conditions, COA of Formula: C7H10BNO3, the publication is Tetrahedron Letters (2015), 56(24), 3750-3753, database is CAplus.

Various 3-aryl-1H-indazol-5-amine derivatives were synthesized by Pd-catalyzed Suzuki-Miyaura cross-coupling reaction of (NH) free 3-bromo-indazol-5-amine with arylboronic acids under microwave-assisted conditions. The coupling reaction can be carried out under the conditions with dioxane/H₂O as solvent, Pd(OAc)₂ and RuPhos as catalyst system, and K₃PO₄ as a base in good to excellent yields.

Tetrahedron Letters published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C13H19N5OS, COA of Formula: C7H10BNO3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yu, Tao published the artcilePoly(ethylene glycol) dimethyl ether mediated oxidative scission of aromatic olefins to carbonyl compounds by molecular oxygen, Recommanded Product: Phenyl(pyridin-2-yl)methanone, the publication is RSC Advances (2021), 11(23), 13848-13852, database is CAplus and MEDLINE.

A simple and practical oxidative scission of aromatic olefins to carbonyl compounds R¹C(O)R₂ [R¹ = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc., R² = Ph, 4-MeOC₆H₄, 4-ClC₆H₄, ect.] using O₂ as the sole oxidant with poly(ethylene glycol) di-Me ether as a benign solvent was developed. A wide range of monosubstituted, gem-disubstituted, 1,2-disubstituted, trisubstituted and tetrasubstituted aromatic olefins was successfully converted into the corresponding aldehydes and ketones in excellent yields even with gram-scale reaction. Some control experiments were also conducted to support a possible reaction pathway.

RSC Advances published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C6H5NO, Recommanded Product: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Feng, Yufei published the artcileRelative bioavailability of betahistine mesylate tablet in healthy volunteers, Related Products of pyridine-derivatives, the publication is Zhongguo Linchuang Yaolixue Zazhi (2006), 22(3), 188-191, database is CAplus.

The bioavailability of domestic and imported betahistine mesylate and its bioequivalence in healthy volunteers were studied. A single oral dose of 24 mg domestic and imported betahistine mesylate tablets were given to 20 healthy male volunteers according to an open randomized 2 way crossover design. Plasma concentration of betahistine mesylate was determined by HPLC-MS-MS method. The pharmacokinetic parameter of the two products were as follow: t_max were (1.1 ± 0.5) and (1.0 ± 0.4) h; C_max were (358.88 ± 93.44) and (360.99 ± 62.88) ng/mL^-1; AUC_0-t were (1687.01 ± 400.51) and (1591.43 ± 352.05) ng/h/mL^-1, resp. The relative bioavailability of domestic product was (108.3 ± 24.1)%. The result demonstrated that two formations were bioequivalence by anal. of variance, two-one side test and 90% confidential internal.

Zhongguo Linchuang Yaolixue Zazhi published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gawali, Suhas Shahaji published the artcileIron-catalyzed regioselective cyclotrimerization of alkynes to benzenes, Application of 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, the publication is Journal of Organometallic Chemistry (2019), 139-149, database is CAplus.

We report the synthesis and characterization of simple di(aminomethyl)pyridine ligated iron-pincer complexes, which catalyzed the regioselective [2+2+2]-cyclotrimerization of terminal aryl and alkyl alkynes to provide the 1,2,4-trisubstituted benzene mols. Interestingly, internal alkynes also exhibited similar cyclization and resulted in hexa-substituted benzene compounds Increased steric bulk on pincer ligands diminished the selectivity for cycloaddition Cyclotrimerization reactions proceeded at room temperature upon activation of catalyst by a Grignard reagent. EPR studies indicated thermally induced spin crossover effect in catalyst.

Journal of Organometallic Chemistry published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Application of 2,6-Bis((di-tert-butylphosphino)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Romano, Sonia published the artcileDrug shortages in community pharmacies: Impact on patients and on the health system, Quality Control of 21829-25-4, the publication is Journal of the American Pharmacists Association (2022), 62(3), 791-799.e2, database is CAplus and MEDLINE.

Worldwide, drug shortages are a critical public health concern. Consequences range from inconvenience and distress to more serious concerns related to neg. clin., humanistic and economic outcomes. This study aimed to investigate the impact of drug shortages at the community pharmacies on patients and on the health system in Portugal. A national, cross-sectional, multicenter study was conducted in Portuguese community pharmacies during Apr. 2019. The proportion of patients reporting drug shortages, types of drugs affected and consequent economic burden to patients and the health system were estimated Regional and urban setting stratification was performed.A total of 71.1% of pharmacies participated in the study and 22,830 patient surveys were retrieved. About 52.2% of patients experienced a drug shortage in the past 12 mo; 21.5% had to see a physician to change the prescription and 5.7% declared treatment discontinuation because of this shortage. The estimated economic impact of shortages related to addnl. physician appointments varied between euro2.1-euro4.4 million for patients and euro35.3-euro43.8 million for the National Health Service. Drug shortages were mostly felt in rural and inner regions and least felt in the islands. This national study showed that community pharmacy drug shortages are a national problem with neg. consequences on patients and the health system, which need to be tackled and mitigated.

Journal of the American Pharmacists Association published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Quality Control of 21829-25-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mahmoudi, Malek published the artcileOrnamenting of Blue Thermally Activated Delayed Fluorescence Emitters by Anchor Groups for the Minimization of Solid-State Solvation and Conformation Disorder Corollaries in Non-Doped and Doped Organic Light-Emitting Diodes, Name: 2-Pyridinylboronic acid, the publication is ACS Applied Materials & Interfaces (2022), 14(35), 40158-40172, database is CAplus and MEDLINE.

Motivated to minimize the effects of solid-state solvation and conformation disorder on emission properties of donor-acceptor-type emitters, we developed five new asym. multiple donor-acceptor type derivatives of tert-Bu carbazole and trifluoromethyl benzene exploiting different electron-accepting anchoring groups. Using this design strategy, for a compound containing four di-tert-Bu carbazole units as donors as well as 5-Me pyrimidine and trifluoromethyl acceptor moieties, small singlet-triplet splitting of ca. 0.03 eV, reverse intersystem crossing rate of 1 x 10⁶ s^-1, and high photoluminescence quantum yield of neat film of ca. 75% were achieved. This compound was also characterized by the high value of hole and electron mobilities of 8.9 x 10^-4 and 5.8 x 10^-4 cm² V^-1 s^-1 at an elec. field of 4.7 x 10⁵ V/cm, showing relatively good hole/electron balance, resp. Due to the lowest conformational disorder and solid-state solvation effects, this compound demonstrated very similar emission properties (emission colors) in non-doped and differently doped organic light-emitting diodes (OLEDs). The lowest conformational disorder was observed for the compound with the addnl. accepting moiety inducing steric hindrance, limiting donor-acceptor dihedral rotational freedom. It can be exploited in the multi-donor-acceptor approach, increasing the efficiency. Using an emitter exhibiting the minimized solid-state solvation and conformation disorder effects, the sky blue OLED with the emitting layer of this compound dispersed in host 1,3-bis(N-carbazolyl)benzene displayed an emission peak at 477 nm, high brightness over 39 000 cd/m², and external quantum efficiency up to 15.9% along with a maximum current efficiency of 42.6 cd/A and a maximum power efficiency of 24.1 lm/W.

ACS Applied Materials & Interfaces published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Name: 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem