Day: December 2, 2022

Gao, Zongming published the artcileAn In Vitro Dissolution Method for Testing Extended-Release Tablets Under Mechanical Compression and Sample Friction, SDS of cas: 21829-25-4, the publication is Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) (2022), 111(6), 1652-1658, database is CAplus and MEDLINE.

The release and dissolution of an active pharmaceutical ingredient (API) from the solid oral formulation into the gastrointestinal (GI) tract is critical for the drug′s absorption into systemic circulation. Extended-release (ER) solid oral dosage forms are normally subjected to phys. shear and grinding forces as well as pressure exerted by peristaltic movements when passing through the GI tract. The complex phys. contraction and sample friction exerted by the GI tract are not simulated well by compendial dissolution methods. These limitations render traditional in vitro dissolution testing unable to discriminate and predict a product′s in vivo performance. The objective of this study was to develop a dissolution method that better simulates the GI environment that products are subject to when taken by patients. A newly designed Mech. Apparatus under GI Conditions (MAGIC) was assembled with a dissolution platform and mech. capabilities to allow in vitro dissolution testing under sample contractions and friction. The dissolution platform, with medium flow-through configuration, was manufactured by 3D printing. A 60 mg polymer matrix-based ER nifedipine product was tested. To simulate GI physiol. conditions during the dissolution testing, the flow rate of the medium, and a combination of mech. compression with rotation induced sample friction at various rotation frequencies were explored. The polymer matrix-based nifedipine ER formulation used here failed its controlled release functionality in the simulated GI environment under mech. compression and sample friction. The results showed that the MAGIC system, with flow-through configuration under compression and sample friction, has advantages over compendial methods in testing ER solid oral formulations.

Journal of Pharmaceutical Sciences (Philadelphia, PA, United States) published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, SDS of cas: 21829-25-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

van Veldhoven, Jacobus P. D. published the artcileTargeting the K_v11.1 (hERG) channel with allosteric modulators. Synthesis and biological evaluation of three novel series of LUF7346 derivatives, Computed Properties of 18437-58-6, the publication is European Journal of Medicinal Chemistry (2021), 113033, database is CAplus and MEDLINE.

Three novel series of substituted benzophenones for their allosteric modulation of the human Kv11.1 (hERG) channel were synthesized and evaluated. Effects of this is compared with reference compound LUF7346 previously shown to shorten the action potential of cardiomyocytes derived from human stem cells. Most compounds behaved as neg. allosteric modulators (NAMs) of [3H]dofetilide binding to the channel. Compound III [R = 2-Cl; R¹ = CH₂cPr; X= Y = C] was the most potent amongst all ligands, remarkably reducing the affinity of dofetilide in competitive displacement assays. One of the other II [R = H; X = N] tested in a second radioligand binding set-up, displayed unusual displacement characteristics with a pseudo-Hill coefficient significantly distinct from unity, further indicative of its allosteric effects on the channel. Some compounds were evaluated in a more physiol. relevant context in beating cardiomyocytes derived from human induced pluripotent stem cells. Surprisingly, the compounds tested showed effects quite different from the reference NAM LUF7346. For instance, compound I [R = 3-Me] prolonged, rather than shortened, the field potential duration, while it did not influence this parameter when the field potential was already prolonged by dofetilide. In subsequent patch clamp studies on HEK293 cells expressing the hERG channel the compounds behaved as channel blockers. In conclusion, new allosteric modulators of the hERG channel were successfully synthesized and identified . Unexpectedly, their effects differed from the reference compound in functional assays on hERG-HEK293 cells and human cardiomyocytes, to the extent that the compounds behaved as stand-alone channel blockers.

European Journal of Medicinal Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C7H8BClO2, Computed Properties of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Duffaut, N. published the artcilePreparation of some organosilicon compounds derived from ω-undecylenic alcohol, Recommanded Product: Triphenyl(pyridin-1-ium-1-yl)borate, the publication is Revue Francaise des Corps Gras (1957), 69-73, database is CAplus.

Reduction of Me 10-undecenoate gave the corresponding alc. which with SOCl₂ in presence of PhNMe₂ gave 80% Cl(CH₂)₉CH:CH₂ (I). I added HSiCl₃ quantitatively to give Cl(CH₂)₁₁SiCl₃ (II), b₁₆ 189°, n_D²⁰ 1.4688, d₂₀ 1.1204. With C₆H₆ and AlCl₃ II furnishes 1-phenyl-11-trichlorosilylundecane, b₁₆ 216-18°, n_D²⁰ 1.4955 d₂₀ 1.0788, and further, by methylation, 1-phenyl-11-trimethylsilylundecane, b₃ 176-7, n_D²⁰ 1.4822, d₂₀ 0.8618, ν 698 and 759 cm.^-1 II in ether gave with MeOH 1-chloro-11-trimethoxysilylundecane (III), b₁₆ 187°, n_D²⁰ 1.4426, d₂₀ 0.9855. The Br analog (IV) was obtained, b₁₆ 196°, n_D²⁰ 1.4559, d₂₀ 1.1192. III and IV gave very small amounts of amine by replacing the halogen by NEt₂. From I Me₃Si(CH₂)₉CH: CH₂ (V) was prepared, b₁₆ 131-2°, n_D²⁰ 1.4417, d₂₀ 0.8021, which with Cl₃CCO₂Et gave about 30% addition product, C₁₈H₃₅O₂Cl₃Si, b_2.5 215-16°, n_D²⁰ 1.4700, d₂₀ 1.0521.

Revue Francaise des Corps Gras published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Recommanded Product: Triphenyl(pyridin-1-ium-1-yl)borate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wu, Ping published the artcileMicrowave irradiation induced synthesis of 2-amino-4,6-diarylpyridines, HPLC of Formula: 17281-59-3, the publication is Youji Huaxue (2006), 26(12), 1673-1676, database is CAplus.

Under microwave irradiation, N-cyanomethylpyridinium chloride reacted with chalcones in the presence of ammonium acetate and acetic acid to give 2-amino-4,6-diarylpyridines in high yields. 2-Aminoduiarylpyridines can also be prepared from one-pot reactions of N-cyanomethylpyridinium chloride with aromatic aldehydes and substituted acetophones. The structures of the products were characterized with ¹H NMR, IR and HPLC-MS spectra.

Youji Huaxue published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C25H34N4O2S, HPLC of Formula: 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wu, Wen-Lian published the artcileDesign and synthesis of orally efficacious benzimidazoles as melanin-concentrating hormone receptor 1 antagonists, Safety of (6-Hydroxypyridin-3-yl)boronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(14), 3674-3678, database is CAplus and MEDLINE.

Biaryl urea lead compound I was discovered earlier in an MCH antagonist program. Novel benzimidazole analogs with increased chem. stability, devoid of the potential carcinogenic liability associated with a biarylamine moiety, were synthesized and evaluated to be potent MCH R1 antagonists. Two compounds in this series have demonstrated in vivo efficacy in a rodent obesity model.

Bioorganic & Medicinal Chemistry Letters published new progress about 903899-13-8. 903899-13-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Alcohol,Boronic Acids,Boronic acid and ester, name is (6-Hydroxypyridin-3-yl)boronic acid, and the molecular formula is C2H8Cl2N4S2, Safety of (6-Hydroxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Vincent, Stephane P. published the artcileElectrophilic Fluorination-Nucleophilic Addition Reaction Mediated by Selectfluor: Mechanistic Studies and New Applications, Application of 1-Fluoropyridiniumtriflate, the publication is Journal of Organic Chemistry (1999), 64(14), 5264-5279, database is CAplus and MEDLINE.

The electrophilic fluorination-nucleophilic addition reaction with Selectfluor-type reagents upon glycals has been studied and optimized. This reaction leads to selective fluorination at the 2-position with concomitant nucleophilic addition to the anomeric center. To understand the stereochem. outcome of this process, a mechanistic study has led to the discovery that, in the fucose series, Selectfluor adds specifically in a syn manner, yielding a 1-[TEDA-CH₂Cl]-2-fluoro saccharide that anomerizes slowly to a more stable intermediate. The anomeric α/β distribution was studied as a function of reactants and conditions, and it was found that a judicious choice of protective group strategy can improve the stereoselectivity of both fluorination and nucleophilic addition Furthermore, a hypersensitive radical probe was used to probe the reaction, and no product characteristic of a radical process was isolated, suggesting that no single electron transfer occurs during the attack of the glycal on Selectfluor. The importance of solvent effect, Selectfluor counterion, and stepwise procedure has also been discussed. This study has brought an important improvement of yields and a broader range of allowed nucleophiles such as secondary alcs. of carbohydrates, amino acids, phosphates, or phosphonates. This optimized process was further applied to the modification of important bioactive mols., including the synthesis of fluorinated daunomycin and oleandrin analogs and the oxidation of thio glycosides to the corresponding sulfoxides.

Journal of Organic Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C11H11BFNO4, Application of 1-Fluoropyridiniumtriflate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Blake, James F. published the artcileDiscovery of (S)-1-(1-(4-Chloro-3-fluorophenyl)-2-hydroxyethyl)-4-(2-((1-methyl-1H-pyrazol-5-yl)amino)pyrimidin-4-yl)pyridin-2(1H)-one (GDC-0994), an Extracellular Signal-Regulated Kinase 1/2 (ERK1/2) Inhibitor in Early Clinical Development, HPLC of Formula: 18437-58-6, the publication is Journal of Medicinal Chemistry (2016), 59(12), 5650-5660, database is CAplus and MEDLINE.

The extracellular signal-regulated kinases ERK1/2 represent an essential node within the RAS/RAF/MEK/ERK signaling cascade that is commonly activated by oncogenic mutations in BRAF or RAS or by upstream oncogenic signaling. While targeting upstream nodes with RAF and MEK inhibitors has proven effective clin., resistance frequently develops through reactivation of the pathway. Simultaneous targeting of multiple nodes in the pathway, such as MEK and ERK, offers the prospect of enhanced efficacy as well as reduced potential for acquired resistance. Described herein is the discovery and characterization of GDC-0994 (22), an orally bioavailable small mol. inhibitor selective for ERK kinase activity.

Journal of Medicinal Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, HPLC of Formula: 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Urtaeva, Zh. Kh. published the artcileElectrochemical behavior of organoboron compounds, Category: pyridine-derivatives, the publication is Zhurnal Obshchei Khimii (1986), 56(6), 1294-9, database is CAplus.

The electrochem. oxidation of R₃B (I; R = Me, Bu, Ph, 1-naphthyl, mesityl) was difficult, and the anodic peak potentials did not reflect the reactivity of I toward O₂. Complexation with NH₃ or pyridine facilitated the electrochem. oxidation of I. Polarog. reduction of I (R = Ph, 1-naphthyl, mesityl) gave the anion radicals, which dimerized at a rate governed by the solvating ability of the solvent.

Zhurnal Obshchei Khimii published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C7H12ClNO, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Urtaeva, Zh. Kh. published the artcileElectrochemical properties of organoboron compounds, Recommanded Product: Triphenyl(pyridin-1-ium-1-yl)borate, the publication is Doklady Akademii Nauk SSSR (1986), 286(3), 671-4 [Phys. Chem.], database is CAplus.

The electrochem. properties were studied of trimethyl-, tri-n-butyl-, triphenyl-, tri-α-naphthyl-, and trimesitylborons, as well as their complexes with NH₃ and pyridine. Cyclic voltammograms of the oxidation of trimethylboron in a supporting electrolyte of 0.1M NaBF₄ in MeCN at 25° are shown. The electrochem. oxidation of several organoboron compounds and their complexes on a Pt disk electrode by cyclic voltammetry is also shown, using a supporting electrolyte of Bu₄NBF₄ in MeCN. The polarog. reduction of 10^-3M triarylborons and their complexes in 0.1M Et₄NClO₄ is also described. The simplest organoboron compounds are electrochem. oxidized with difficulty, and the value of their half-wave oxidation potentials cannot be used for evaluating their reactivities with respect to O and other chem. oxidizing agents; the formation of complexes with NH₃ and pyridine rarely increases the capability of the organoboron compounds to be electrochem. oxidized.

Doklady Akademii Nauk SSSR published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C7H5Br2F, Recommanded Product: Triphenyl(pyridin-1-ium-1-yl)borate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Potkin, V. I. published the artcile5-(Naphth-1-yl)- and 5-[(1,1′-biphenyl)-4-yl]isoxazole-3-carbaldehyde oximes: Synthesis, complexes with palladium, and application in catalysis, Safety of 2-Bromopyridin-3-amine, the publication is Russian Journal of General Chemistry (2014), 84(9), 1782-1792, database is CAplus.

1-(Naphth-1-yl)- and 1-(1,1′-biphenyl)-4-yl-3,4,4-trichloro-3-buten-1-ones were synthesized by acylation of naphthalene and biphenyl with 3,4,4-trichloro-3-butenoyl chloride. Further reaction with hydroxylamine led to 5-(naphth-1-yl)- and 5-[(1,1′-biphenyl)-4-yl]isoxazole-3-carbaldehyde oximes. The latter form complexes with palladium, which possess high catalytic activity in the Suzuki reaction in aqueous and aqueous-alc. media.

Russian Journal of General Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Safety of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem