Day: December 7, 2022

Nevskaya, Alisa A. published the artcileSynthesis and cytotoxicity of novel 1-arylindolizines and 1-arylpyrrolo[2,1-a]isoquinolines, Product Details of C12H9NO, the publication is Tetrahedron Letters (2021), 153552, database is CAplus.

An efficient approach to the synthesis of indolizines and pyrrolo[2,1-a]isoquinolines based on a domino reaction was described. The reactivity of the derivatives and the structure-activity anal. are carried out in a number of the obtained compounds A hit was found showing high cytotoxicity on tumor cells whose cytotoxic effect was comparable to that of the known topoisomerase I inhibitor camptothecin.

Tetrahedron Letters published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Product Details of C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Krow, Grant published the artcileReinvestigation of 1,2-dihydropyridine formation by condensation of aldehydes with aniline. Revision of a structural assignment, Formula: C18H25N, the publication is Tetrahedron Letters (1971), 3653-6, database is CAplus.

The product of the HOAc catalyzed condensation of 3:1 PrCHO-PhNH2 was established by uv and NMR spectra as I. The reaction of I with maleic anhydride gave II, via a concerted π2s+π4s addition The structure and stereochemistry of II was determined by its NMR spectrum in the presence of Eu(DPM)3. In this abstract DPM=(tert-BuCO)2C-H.

Tetrahedron Letters published new progress about 34562-31-7. 34562-31-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 3,5-Diethyl-1-phenyl-2-propyl-1,2-dihydropyridine, and the molecular formula is C18H25N, Formula: C18H25N.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yin, Xiaojun published the artcileStar-Shaped Macromolecules with the Core of Hexakis-(fluoren-2-yl)benzene and the Periphery of Pyridine: Synthesis and Application as Solution-Processable Electron-Transport Materials, COA of Formula: C5H6BNO2, the publication is Macromolecular Rapid Communications (2015), 36(18), 1658-1663, database is CAplus and MEDLINE.

Three new star-shaped macromols. with hexakis(fluoren-2-yl)benzene as the core and pyridine as the periphery (2Py-HFB, 3Py-HFB, and 4Py-HFB) are synthesized and characterized. The synthetic conditions of octacarbonyldicobat-catalyzed cycloaddition reaction for different alkyne precursors are investigated. The coordination interaction between the pyridine ring of alkyne precursor and the cobalt catalyst may result in very low yield of the cyclotrimerization product. However, with the increase of the catalyst loading, the yields of the intermediates of cyclopentadienone are enhanced. Then, the desired cyclotrimerization products can be obtained by the Diels-Alder reactions of cyclopentadienone with acetylene in good yield. These new compounds exhibit good thermal stability and favorable electron affinity. By using the new compounds as electron-transporting materials, all-solution-processed phosphorescent organic light-emitting devices (OLEDs) show good performance with a maximum current efficiency of 5.6 cd A^-1 and maximum external quantum efficiency of 4.68%.

Macromolecular Rapid Communications published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C14H10N2O, COA of Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Galli, Ubaldina published the artcileIdentification of a sirtuin 3 inhibitor that displays selectivity over sirtuin 1 and 2, Application of Pyridine-3-sulfonic acid, the publication is European Journal of Medicinal Chemistry (2012), 58-66, database is CAplus and MEDLINE.

As part of an effort to identify novel selective modulators of sirtuins, we synthesized and tested several isosteres and constrained analogs of nicotinamide. Biol. data suggest that compound 2 is selective for Sirt3 over Sirt1 and Sirt2.

European Journal of Medicinal Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Application of Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Hoepping, Alexander published the artcileAn alternative synthesis of sodium cyanodithioformate and the disodium salt of cis-1,2-dicyanoethylene-1,2-dithiol, Category: pyridine-derivatives, the publication is Journal fuer Praktische Chemie/Chemiker-Zeitung (1998), 340(3), 269-270, database is CAplus.

A new synthesis of Na cyanodithioformate and the disodium salt of cis-1,2-dicyanoethylene-1,2-dithiol is reported. The key step involves a nucleophilic thiolation with elemental S starting from a substituted acetonitrile. This method may serve as a cyanide- and CS₂-free alternative in the preparation of the title compounds

Journal fuer Praktische Chemie/Chemiker-Zeitung published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Souza de Araujo, Guilherme Rodolfo published the artcileMicroemulsions formed by PPG-5-CETETH-20 at low concentrations for transdermal delivery of nifedipine: Structural and in vitro study, Application In Synthesis of 21829-25-4, the publication is Colloids and Surfaces, B: Biointerfaces (2022), 112474, database is CAplus and MEDLINE.

Nifedipine is a potent anti-hypertensive, which is poorly orally bioavailable on account of first-pass metabolism, short half-life, and low water solubility This study aimed to develop a microemulsified system with low surfactant concentration and to evaluate the influence of microemulsion (ME) phase behavior on skin permeation of nifedipine, as drug model. Thereafter, MEs were obtained using PPG-5-CETETH-20, oleic acid, and phosphate buffer at pH 5.0. The selected MEs were isotropic, with droplet diameters less than 10 nm, polydispersity index < 0.25, and pH between 5.0 and 5.2. MEs presented low viscosity and Newtonian behavior. SAXS results confirmed bicontinuous and oil-in-water (o/w) MEs formation. The presence of the drug promoted only very slight modifications in the ME structure. The MEs presented ability to deliver nifedipine via the transdermal route when in comparison with the control. Nevertheless, the skin permeated and retained amounts from the o/w and bicontinuous formulations did not differ significantly. The ATR-FTIR demonstrated that both formulations promoted fluidization and disorganization of lipids and increased the drug diffusion and partition coefficients in the skin. In conclusion, PPG-5-CETETH-20 MEs obtained proved to be effective skin permeation enhancers, acting by rising the coefficients of partition and diffusion of the nifedipine in the skin.

Colloids and Surfaces, B: Biointerfaces published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C15H14N2, Application In Synthesis of 21829-25-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Lei published the artcilePalladium(0)-catalyzed asymmetric C(sp³)-H arylation using a chiral binol-derived phosphate and an achiral ligand, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Chemical Science (2017), 8(2), 1344-1349, database is CAplus and MEDLINE.

The first efficient palladium(0)-catalyzed enantioselective C(sp³)-H activation reaction using a catalytic chiral base and an achiral phosphine ligand was reported. Fine-tuning the binol-derived phosphoric acid pre-catalyst and the reaction conditions was found to be crucial to achieve high levels of enantioselectivity for a variety of indoline products containing both tri- and tetrasubstituted stereocenters.

Chemical Science published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C16H20N2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Makinen, Silja K. published the artcileHighly selective guest uptake in a silver sulfonate network imparted by a tetragonal to triclinic shift in the solid state, Formula: C5H5NO3S, the publication is Chemistry – A European Journal (2001), 7(23), 5176-5182, database is CAplus and MEDLINE.

The Ag sulfonate network presented herein, Ag 3-pyridinesulfonate, reversibly and selectively absorbs MeCN while undergoing a major structural rearrangement. The origin of this structural flexibility is a coupling of the weak coordinating ability of the SO₃ group with the geometrically pliant Ag(I) center. Single crystal and powder x-ray structures of both the desolvated and solvated forms are presented in addition to the mechanism of their reversible interconversion. A heterogeneous gas chromatog. study showing selective extraction of the MeCN is also presented. Extended solid frameworks which reorder to any extent are not common but the structure presented herein transforms from a tetragonal to a triclinic crystal system. The results indicate that cooperative interactions in systems based on supposedly weaker interactions can yield softer yet functional networks with behavior unlike that observed in more rigid inorganic frameworks.

Chemistry – A European Journal published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Formula: C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yin, Jinjin published the artcileNifedipine or amlodipine? The choice for hypertension during pregnancy: a systematic review and meta-analysis, Safety of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Archives of Gynecology and Obstetrics, database is CAplus and MEDLINE.

There is a lack of sufficient evidence regarding efficacy and safety of amlodipine on treating hypertension during pregnancy. To compare antihypertensive efficacy, pregnancy outcome and safety of amlodipine with nifedipine on hypertension during pregnancy. A systematic search of PubMed, Embase, Cochrane Library, clinicaltrials.gov, Chinese National Knowledge Infrastructure, Wanfang Database and China Biol. Medicine disk of randomized controlled trials (RCTs) up to Apr. l5, 2021 was conducted on RCTs comparing amlodipine to nifedipine for the treatment of hypertension during pregnancy. Screening, data extraction, and quality assessment were done by two independent reviewers. To estimate relative effects from all available evidence, a meta-anal. was conducted. Seventeen RCTs were included. Amlodipine was found the efficacy is slightly superior to nifedipine on treating hypertension during pregnancy (RR 1.06, 95% CI 1.01 to 1.10) with a decreased risk for maternal side effects (RR 0.42, 95% CI 0.29 to 0.61). Subgroup anal. found amlodipine can get a better control on SBP (RR – 11.68, 95% CI – 17.98 to – 5.37) and DBP (RR – 7.44, 95% CI – 13.81 to – 1.06) compared with intermediate-/long-acting nifedipine. In addition, there was no difference between amlodipine and nifedipine on pregnancy outcomes including caesarean section, premature labour, placental abruption, FGR, fetal distress, neonatal asphyxia. Given the results of this systematic review and meta-anal., amlodipine can be effectively and safely used for hypertension during pregnancy.

Archives of Gynecology and Obstetrics published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C5H10O, Safety of Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zeng, Kui published the artcileDirect nitrogen interception from chitin/chitosan for imidazo[1,5-a]pyridines, Name: Phenyl(pyridin-2-yl)methanone, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(41), 6068-6071, database is CAplus and MEDLINE.

A catalyst-free one-pot methodol. that enable direct nitrogen interception of chitosan/chitin for imidazo[1,5-a]pyridines was developed. This strategy features direct synthesis of important deuterated imidazo[1,5-a]pyridines and tridentate ligands. In particular, a broad group of previously inaccessible products including saturated 1-alkylimidazo[1,5-a]pyridines were unprecedentedly synthesized by this protocol.

Chemical Communications (Cambridge, United Kingdom) published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C15H24S, Name: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem