Day: December 7, 2022

Abinaya, R. published the artcileVisible light mediated selective oxidation of alcohols and oxidative dehydrogenation of N-heterocycles using scalable and reusable La-doped NiWO₄ nanoparticles, Computed Properties of 91-02-1, the publication is Green Chemistry (2021), 23(16), 5990-6007, database is CAplus.

Visible light-mediated selective and efficient oxidation of various primary benzyl alcs. RCH₂OH (R = Ph, 2-bromophenyl, pyridin-2-yl, etc.)/secondary benzyl alcs. such as 1-(phenyl)-ethanol, diphenylmethanol, 1-phenylethane-1,2-diol, etc. to aldehydes RCHO/ketones such as acetophenone, benzophenone, chalcone, etc. and oxidative dehydrogenation (ODH) of partially saturated heterocycles using a scalable and reusable heterogeneous photoredox catalyst in aqueous medium are described. A systematic study led to a selective synthesis of aldehydes under an argon atm. while the ODH of partially saturated heterocycles under an oxygen atm. resulted in very good to excellent yields. The methodol. is atom economical and exhibits excellent tolerance towards various functional groups, and broad substrate scope. Furthermore, a one-pot procedure was developed for the sequential oxidation of benzyl alcs. and heteroaryl carbinols I (R¹ = H, C(O)OMe) followed by the Pictet-Spengler cyclization and then aromatization to obtain the β-carbolines II in high isolated yields. This methodol. was found to be suitable for scale up and reusability. To the best of our knowledge, this is the first report on the oxidation of structurally diverse aryl carbinols and ODH of partially saturated N-heterocycles e.g., III using a recyclable and heterogeneous photoredox catalyst under environmentally friendly conditions.

Green Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Computed Properties of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Fathi, Ahlam M. published the artcileCharacteristics of multidentate Schiff base ligand and its complexes using cyclic voltammetry, fluorescence, antimicrobial behavior and DFT-calculations, Recommanded Product: Phenyl(pyridin-2-yl)methanone, the publication is Journal of Molecular Structure (2021), 129263, database is CAplus.

The electrochem. behavior of a series of the metal complexes [Fe(III), Ni(II), Ru(III),Pd(II) and Hf(IV)] derived from the Schiff base ligand (E)-5-((phenyl(-pyridin-2-yl)methylene)amino)pyrimidine-2,4(1H,3H)-dione (H₂L) which was previously prepared from condensation of 5-aminouracil and 2-benzoylpyridine was studied by using cyclic voltammetric technique. The Schiff base ligand H₂L and its metal complexes exhibited quasi-reversible oxidation-reduction with three electron transfer and it was suggested that their reactions on the platinum surface electrode are not purely diffusion controlled but also under adsorption control. The redox reactive sites of the H₂L and its complexes were located via the geometry optimization and frequency calculations using d. functional theory (DFT) at the B3LYP/LanL2DZ level of theory. In addition, the Schiff base ligand and its metal complexes exhibit fluorescent properties. The antimicrobial activity of the Schiff base ligand H₂L and its metal complexes was tested against Gram-pos. bacteria (Staphylococcus aureus and Bacillus cereus), Gram-neg. bacteria (E. coli and Pseudomonas aeruginosa) and fungal strain (Aspergillus niger) by using agar well-diffusion method. The microbial testes of the ligand (H₂L) and its metal complexes exhibited good inhibition efficiency to prevent growth of bacteria.

Journal of Molecular Structure published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Recommanded Product: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Shkurko, O. P. published the artcileSubstituent effects on the amino-group chemical shifts in NMR spectra of substituted aminopyridines, Formula: C6H8N2, the publication is Khimiya Geterotsiklicheskikh Soedinenii (1990), 54-9, database is CAplus.

Correlation analyses are presented for amino-group proton chem. shifts in m– and p-substituted (with respect to the amino group) 2-, 3-, and 4-aminopyridines (6 series altogether) using inductive and resonant substituent constants

Khimiya Geterotsiklicheskikh Soedinenii published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C7H5ClN2S, Formula: C6H8N2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Matralis, Alexios N. published the artcileDevelopment of Chemical Entities Endowed with Potent Fast-Killing Properties against Plasmodium falciparum Malaria Parasites, Related Products of pyridine-derivatives, the publication is Journal of Medicinal Chemistry (2019), 62(20), 9217-9235, database is CAplus and MEDLINE.

One of the attractive properties of artemisinins is their extremely fast-killing capability, quickly relieving malaria symptoms. Nevertheless, the unique benefits of these medicines are now compromised by the prolonged parasite clearance times and the increasing frequency of treatment failures, attributed to the increased tolerance of Plasmodium falciparum to artemisinin. This emerging artemisinin resistance threatens to undermine the effectiveness of antimalarial combination therapies. Herein, we describe the medicinal chem. efforts focused on a cGMP-dependent protein kinase (PKG) inhibitor scaffold, leading to the identification of novel chem. entities with very potent, similar to artemisinins, fast-killing potency against asexual blood stages that cause disease, and activity against gametocyte activation that is required for transmission. Furthermore, we confirm that selective PKG inhibitors have a slow speed of kill, while chemoproteomic anal. suggests for the first time serine/arginine protein kinase 2 (SRPK2) targeting as a novel strategy for developing antimalarial compounds with extremely fast-killing properties.

Journal of Medicinal Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chowdhury, Santanu published the artcileA new luminescent sulfate bridged dimeric copper(II) complex with DNA binding and SO₂ fixation ability: Synthesis and structure, Computed Properties of 2215-33-0, the publication is Polyhedron (2009), 28(17), 3863-3871, database is CAplus.

New luminescent mononuclear and dinuclear Cu(II) (S = 1/2) complexes [Cu(HL)(H₂O)₂](ClO₄)₂ (1a) and [Cu₂(HL)₂(μ-SO₄)₂]·2H₂O (1b) were synthesized with the acyclic tridentate pyridine-2-carboxaldehyde-2-pyridylhydrazone ligand, HL (1). The mononuclear complex 1a can be converted into the disulfate bridged dimeric Cu(II) complex 1b by passing freshly prepared SO₂ through the basic medium. On excitation at 290 nm, the ligand fluoresces at 364 nm due to an intraligand ¹(π-π^_*) transition. Upon complexation with Cu(II), the emission peak is slightly blue shifted (356 nm, F/F ₀ 0.76 for 1a and 354 nm, F/F ₀ 0.89 for 1b) with a little quenching in the emission intensity. The association constants (K_ass (5.06 ± 0.004) × 10⁴ for 1a and K_ass (5.46 ± 0.006) × 10⁴ for 1b at 298 K) and the thermodn. parameters were determined by UV-visible spectroscopy. The mol. structure of the complex 1b (Cu···Cu 4.456 Å) was determined by single crystal x-ray diffraction studies. The complex 1b exhibits a strong interaction towards DNA as revealed from the K_b (intrinsic binding constant) 6.3 × 10⁴ M^-1 and K_sv (Stern-Volmer quenching constant) 2.93 values.

Polyhedron published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Computed Properties of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Neudeck, Sven published the artcileNew Powerful and Oxidatively Rugged Dinuclear Ru Water Oxidation Catalyst: Control of Mechanistic Pathways by Tailored Ligand Design, Name: Pyridine-3-sulfonic acid, the publication is Journal of the American Chemical Society (2014), 136(1), 24-27, database is CAplus and MEDLINE.

A new powerful and oxidatively rugged pyrazolate-based water oxidation catalyst of formula {[Ru^II(py-SO₃)₂(H₂O)]₂(μ-Mebbp)}^–, 1(H₂O)₂^–, has been prepared and thoroughly characterized spectroscopically and electrochem. This new catalyst has been conceived based on a specific ligand tailoring design, so that its performance has been systematically improved. It was also demonstrated how subtle ligand modifications cause a change in the O-O bond formation mechanism, thus revealing the close activation energy barriers associated with each pathway.

Journal of the American Chemical Society published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Name: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lee, Yao published the artcileViral replication and innate immunity of feline herpesvirus-1 virulence-associated genes in feline respiratory epithelial cells, Category: pyridine-derivatives, the publication is Virus Research (2019), 56-67, database is CAplus and MEDLINE.

Feline herpesvirus-1 (FHV-1) infection occurs worldwide and is a leading cause of respiratory and ocular diseases in cats. Current vaccines reduce the severity of symptoms but do not prevent infection and, therefore, do not provide defense against an establishment of latency and reactivation. We hypothesize that immunomodulation of FHV-1 is the cause of lack in protection and that deletion of virulence/immune modulatory genes of FHV-1 will enhance safety and immunogenicity. Our objective was to use feline respiratory epithelial cell (FREC) cultures to define in vitro growth characteristics and immunomodulation resulting from infection of FRECs with the virulent FHV-1 strain C27 (WT) and glycoprotein C-deletion (gC-), glycoprotein E-deletion (gE-), serine/threonine protein kinase-deletion (PK-), as well as gE and thymidine kinase-double-deletion (gE-TK-) mutants generated by bacterial artificial chromosome mutagenesis. Differentiated FRECs were mock inoculated or inoculated with WT, gC-, gE-, PK-, or gE-TK- mutants. Virus titration and real-time quant. PCR assays were performed on samples collected at 1 hpi followed by 24 h intervals between 24 and 96 hpi to determine growth kinetics. Real-time PCR was used to quantitate IFNa, TNFa, IL-1β, IL-10, and TGFβ-specific mRNA levels. Immunoassays were performed to measure the protein levels of subsets of cytokines/chemokines secreted by FRECs. Inoculation of FRECs with gE-TK- resulted in significantly lower end-point titers than inoculation with WT or gE-. Both PK- and gC- inoculated FRECs also produced significantly lower end-point titers at 96 hpi than WT. Overall, intracellular virus titers were higher than those of extracellular virus. PCR results for viral DNA paralleled the virus titration results. Further, in contrast to WT inoculation, an increase in IFNa and IL-10 mRNA expression was not observed following inoculation with gE-TK- and PK-, but inoculation with gE-TK- and PK- did result in increased TGFβ expression in FRECs compared to responses following infection with WT. Moreover, gE-TK- and PK- blocked the inhibition of IL-8 and neutrophil chemoattractant (KC), which was observed following inoculation with WT. In summary, the results obtained in FRECs may be used to predict the safety and immunogenicity characteristics of these mutants in vivo. Our study highlights the value of the FREC system for studying replication kinetics/immune modulation factors of FHV-1 and screening prospective vaccine candidates before their use in exptl. cats.

Virus Research published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Michiba, Kazuyoshi published the artcileUsefulness of human jejunal spheroid-derived differentiated intestinal epithelial cells for the prediction of intestinal drug absorption in humans, Product Details of C17H18N2O6, the publication is Drug Metabolism & Disposition (2022), 50(3), 204-213, database is CAplus and MEDLINE.

This study aimed to demonstrate the usefulness of human jejunal spheroid-derived differentiated intestinal epithelial cells as a novel in vitro model for clarifying the impact of intestinal drug-metabolizing enzymes and transporters on the intestinal absorption of substrate drugs in humans. Three-dimensional human intestinal spheroids were successfully established from surgical human jejunal specimens and expanded for a long period using L-WRN-conditioned medium, which contains Wnt3a, R-spondin 3, and noggin. The mRNA expression levels of intestinal pharmacokinetics-related genes in the human jejunal spheroid-derived differentiated intestinal epithelial cells were drastically increased over a 5-day period after seeding compared with those in human jejunal spheroids and were approx. the same as those in human jejunal tissue over a culture period of at least 13 days. Activities of typical drug-metabolizing enzymes [cytochrome P 450 (CYP) 3A, CYP2C9, uridine 5-diphospho-glucuronosyltransferase 1A, and carboxylesterase 2] and uptake/efflux transporters [peptide transporter 1/solute carrier 15A1], P-glycoprotein, and breast cancer resistance protein) in the differentiated cells were confirmed. Furthermore, intestinal availability (Fg) values estimated from the apical-to-basolateral permeation clearance across cell monolayer showed a good correlation with the in vivo Fg values in humans for five CYP3A substrate drugs (Fg range, 0.35-0.98). In conclusion, the functions of major intestinal drug-metabolizing enzymes and transporters could be maintained in human jejunal spheroid-derived differentiated intestinal epithelial cells. This model would be useful for the quant. evaluation of the impact of intestinal drug-metabolizing enzymes and transporters on the intestinal absorption of substrate drugs in humans.

Drug Metabolism & Disposition published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Product Details of C17H18N2O6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Rana, Surjyakanta published the artcileOrgano functionalized graphene with Pd nanoparticles and its excellent catalytic activity for Suzuki coupling reaction, Category: pyridine-derivatives, the publication is Applied Catalysis, A: General (2015), 539-547, database is CAplus.

Synthesis of well distributed palladium nanoparticles (3-7 nm) on organo di-amine functionalized graphene is reported, which demonstrated excellent catalytic activity for Suzuki coupling reaction. Organo functionalized graphene support acted as an excellent host which helped in avoiding “Ostwald ripening” i.e., preventing palladium nanoparticle sintering and because of which the catalyst as a whole showed excellent catalytic activity for Suzuki coupling reaction. The catalytic material was characterized by X-ray diffraction (XRD), Fourier-transfer IR spectroscopy (FTIR), Raman spectra, X-ray photoelectron spectra (XPS), and Scanning electron microscope (SEM), Transmittance electron microscopy (TEM) anal. FT-IR revealed that the organic amine functional group was successfully grafted onto the graphene oxide surface. The formation of palladium nanoparticles was confirmed by XPS techniques. The catalytic activity in the coupling reaction using idobenzene was superb with 100% conversion and 98% yield and also activity remained almost unaltered up to six cycles. Typically, an extremely high turnover frequency of 185,078 h-1 or 3,084.64 min-1 is observed in the C-C Suzuki coupling reaction using organo di-amine functionalized graphene as catalyst. Experiments were also conducted under identical conditions to prove heterogeneity of the catalyst.

Applied Catalysis, A: General published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Culp, Jeffrey T. published the artcileScreening Hofmann Compounds as CO₂ Sorbents: Nontraditional Synthetic Route to Over 40 Different Pore-Functionalized and Flexible Pillared Cyanonickelates, SDS of cas: 1008506-24-8, the publication is Inorganic Chemistry (2013), 52(8), 4205-4216, database is CAplus and MEDLINE.

A simple reaction scheme based on the heterogeneous intercalation of pillaring ligands (HIPLs) provides a convenient method for systematically tuning pore size, pore functionality, and network flexibility in an extended series of pillared cyanonickelates (PICNICs), commonly named Hofmann compounds The versatility of the approach is demonstrated through the preparation of over 40 different PICNICs containing pillar ligands ranging from âˆ? to âˆ?5 Å in length and modified with a wide range of functional groups, including fluoro, aldehyde, alkylamine, alkyl, aryl, trifluoromethyl, ester, nitro, ether, and non-metalated 4,4′-bipyrimidine. The HIPL method involves reaction of a suspension of preformed polymeric sheets of powd. anhydrous Ni cyanide with an appropriate pillar ligand in refluxing organic solvent, converting the planar [Ni₂(CN)₄]_n networks into polycrystalline three-dimensional porous frameworks containing the organic pillar ligand. Preliminary studies indicate that the HIPL reaction is also amenable to forming Co(L)Ni(CN)₄, Fe(L)Ni(CN)₄, and Fe(L)Pd(CN)₄ networks. The materials show variable adsorption behavior for CO₂ depending on the pillar length and pillar functionalization. Several compounds show structurally flexible behavior during the adsorption and desorption of CO₂. The newly discovered flexible compounds include two flexible Fe(L)Ni(CN)₄ derivatives that are structurally related to previously reported porous spin-crossover compounds The preparations of 20 pillar ligands based on ring-functionalized 4,4′-dipyridyls, 1,4-bis(4-pyridyl)benzenes, and N-(4-pyridyl)isonicotinamides are also described.

Inorganic Chemistry published new progress about 1008506-24-8. 1008506-24-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Pyridine,Boronic Acids,Boronic acid and ester, name is 3-Methoxypyridine-4-boronic acid, and the molecular formula is C6H8BNO3, SDS of cas: 1008506-24-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem