Day: December 7, 2022

Ivanov, Sergei V. published the artcileFluorination of deltahedral closo-borane and -carborane anions with N-fluoro reagents, Quality Control of 107263-95-6, the publication is Journal of Fluorine Chemistry (1998), 89(1), 65-72, database is CAplus.

The treatment of cesium salts of CB₁₁H₁₂^–, CB₉H₁₀^–, B₁₂H₂^–, and B₁₀H₁₀^2- with the com. available N-fluoro reagent 1-chloromethyl-4-fluoro-1,4-diazoniabicyclo[2.2.2]octane bis(tetrafluoroborate) (F-TEDA) resulted in the formation of fluorinated derivatives of these 10- and 12-vertex borane and carborane anions. This is the first reported use of an N-fluoro reagent to fluorinate B-H bonds of any type. The effects of changing the solvent, temperature, and reagent stoichiometry were studied. The derivatives 1-B₁₀H₉F²-, 2-B₁₀H₉F^2-, and 1,10-B₁₀H₈F₂^2- are the first fluorinated derivatives of the parent B₁₀H₁₀^2- cluster. For the other three parent anions, reactions with F-TEDA resulted in a higher degree of fluorination than reactions with liquid anhydrous hydrogen fluoride (LAHF) at the same temperature However, F-TEDA was less regioselective than LAHF for B-H B-F transformations.

Journal of Fluorine Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Quality Control of 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Feng published the artcileHydrogen bonding effects on topological structures of two supramolecular transition metal coordination complexes based on organosulphonate ligands, Formula: C5H5NO3S, the publication is Inorganic Chemistry Communications (2010), 13(5), 656-658, database is CAplus.

The syntheses, x-ray crystal structures and topol. analyses of two supramol. coordination complexes, [Co(H₂O)₄(ps)₂] 1 and [Cu(H₂O)₂(ps)₂] 2 (ps^– = pyridine-3-sulfonic anion), are reported. Although the basic coordination environments and patterns around the metal centers of 1 and 2 are similar, the overall topologies of the two complexes are very different due to the formation of distinct hydrogen bonding interactions resulting from organosulfonate ligands.

Inorganic Chemistry Communications published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Formula: C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pu, Chunlan published the artcileDesign, synthesis and biological evaluation of indole derivatives as Vif inhibitors, Application of 2-Bromopyridin-3-amine, the publication is Bioorganic & Medicinal Chemistry Letters (2017), 27(17), 4150-4155, database is CAplus and MEDLINE.

In this article, design, synthesis and biol. evaluation of indole derivatives as viral infectivity factor (Vif) inhibitors is reported. Fragment-based virtual screening (FBVS) was conducted and a series of fragments was obtained, among which, 5-(pyridin-2-yl)-1H-indole can form H-bonds with Tyr148 and Ile155 and based on this fragment other indole derivatives were synthesized. Through the immune-fluorescence staining and Western blot assays, 3-(1H-indol-5-yl)pyridin-6-amine (I) shows potent activity in inhibiting Vif-mediated A3G degradation Further docking experiment shows that compound I form H-bond interactions with residues His139, Tyr148 and Ile155. Therefore, I is a promising lead compound against Vif that can be used to treat AIDS.

Bioorganic & Medicinal Chemistry Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Application of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pruschinski, Lucas published the artcileSuzuki-Miyaura Cross-Couplings under Acidic Conditions, Safety of 5-Nitro-2-phenylpyridine, the publication is Synthesis (2020), 52(6), 882-892, database is CAplus.

Suzuki-Miyaura reactions with Pd(PPh₃)₄ had carried out using lithium N-phenylsydnone-4-carboxylate as additive, which gave best yields at pH 5.7 in a mixture of acetic acid, water, and sodium carbonate. Reaction parameters such as the Pd source, the solvent, reaction time and temperature, acid, base and carboxylate have been varied and some representative examples of the Suzuki-Miyaura reaction have been examined

Synthesis published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Safety of 5-Nitro-2-phenylpyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Hong-hong published the artcileSynthesis and catalytic esterification of a novel solid acid catalyst 3-pyridine sulfonic acid-phosphomolybdic acid, Category: pyridine-derivatives, the publication is Huaxue Shiji (2016), 38(6), 506-510, database is CAplus.

A novel solid acid was synthesized by the reaction of 12-molybdophosphoric acid (HPM) with 3-pyridine sulfonic acid (PSA) and confirmed by X-ray powder diffraction, FT-IR, TG and potentiometric titration Then the solid acid was employed for esterification to evaluate its acid-catalytic activity. Various reaction parameters, including methanol/oleic acid molar ratio, catalyst dosage, reaction temperature and time were systematically examined These results indicated that the prepared catalyst maintained the Keggin structure of the raw HPM, and exhibited good thermal stability and higher acidity. The catalyst exhibited excellent catalytic activity in esterification and good reusability. 96.5% Conversion of oleic acid was obtained under the following conditions: mole ratio of alc. to acid 7:1, the reaction temperature 80°C, catalyst amount 10 wt% of the weight of oleic acid and the reaction time 5 h. After the fourth recycling, there was no obvious change in phase and Keggin structure for the catalysts.

Huaxue Shiji published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C9H22OSi, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Morin, Marie S. T. published the artcileCopper-Catalyzed Petasis-Type Reaction: A General Route to α-Substituted Amides From Imines, Acid Chlorides, and Organoboron Reagents, Quality Control of 971-66-4, the publication is Journal of Organic Chemistry (2012), 77(4), 2013-2017, database is CAplus and MEDLINE.

A copper-catalyzed Petasis-type reaction of imines, acid chlorides, and organoboranes to form α-substituted amides is described. This reaction does not require the use of activated imines or the transfer of special units from the organoboranes and represent a useful generalization of the Petasis reaction.

Journal of Organic Chemistry published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Quality Control of 971-66-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chen, Jiayan published the artcilePalladium(II)-catalyzed enantioselective arylation of α-imino esters, Category: pyridine-derivatives, the publication is Journal of Organic Chemistry (2012), 77(19), 8541-8548, database is CAplus and MEDLINE.

A protocol for Pd(II)-catalyzed asym. arylation of N-aryl imino esters has been developed. The method affords a practical and direct access to chiral arylglycine derivatives in good yields and with high enantioselectivities.

Journal of Organic Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Shaomei published the artcileDetermination of betahistine mesylate in tablets by ion chromatography, Formula: C10H20N2O6S2, the publication is Huagong Jishu Yu Kaifa (2011), 40(4), 27-29, database is CAplus.

The sulfur in the mol. structure of betahistine mesylate sample was converted into its oxides via combustion and further absorption by an absorbing solution to become sulfate. The sulfate in the solution was determined by ion chromatog. The amount of betahistine mesylate was derived from its stoichiometric relationship with sulfur. The calibration curve of sulfur was linear in the concentration range of 0.02-60 μg/mL. The average recovery was 98.8% with RSD of 0.15%. The method was simple, accurate and reproducible, and it could be used for the quality control of betahistine mesylate tablets.

Huagong Jishu Yu Kaifa published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C7H12ClNO, Formula: C10H20N2O6S2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Shi, Zhaojiang published the artcileElectrochemical oxidative dearomatization of 2-arylthiophenes, Application In Synthesis of 197958-29-5, the publication is Organic Chemistry Frontiers (2022), 9(11), 2921-2925, database is CAplus.

A green and sustainable electrochem. oxidative dearomatization of 2-arylthiophenes was reported. The variation of substitution patterns afforded easy access to both C2/C3 and C2/C5 difunctionalized dearomative dihydrothiophenes such as I [R = Ph, 3-FC₆H₄, 2-pyridyl, etc.; R¹ = OAc, OC(O)Et]. The synthetic utility of the resulting dihydrothiophenes was further demonstrated by the concise synthesis of a pyridazinone analog with interesting vasodilator activity.

Organic Chemistry Frontiers published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C18H28B2O4, Application In Synthesis of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Shaoning published the artcileDesign, synthesis and evaluation of substituted piperidine based KCNQ openers as novel antiepileptic agents, Computed Properties of 197958-29-5, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(10), 1731-1735, database is CAplus and MEDLINE.

Epilepsy is a kind of disease with complicated pathogenesis. KCNQ (Kv7) is a voltage dependent potassium channel that is mostly associated with epilepsy and thus becomes an important target in the treatment of epilepsy. In this paper, a series of substituted piperidine derivatives targeting KCNQ were designed and synthesized by using scaffold hopping and active substructure hybridization. Compounds were evaluated by fluorescence-based thallium influx assay, Rb⁺ flow assay and electrophysiol. patch-clamp assay. Results showed that some compounds possessed more potent potassium channel opening activity than Retigabine. More significantly, compound I was found to have good pharmacokinetic profiles in vivo.

Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C8H11NO, Computed Properties of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem