Day: December 7, 2022

Bos, Pieter H. published the artcileDevelopment of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents, Formula: C7H10BNO3, the publication is Cell Chemical Biology (2019), 26(12), 1703-1715.e37, database is CAplus and MEDLINE.

Disease-causing mutations in many neurodegenerative disorders lead to proteinopathies that trigger endoplasmic reticulum (ER) stress. However, few therapeutic options exist for patients with these diseases. Using an in vitro screening platform to identify compounds that protect human motor neurons from ER stress-mediated degeneration, we discovered that compounds targeting the mitogen-activated protein kinase kinase kinase kinase (MAP4K) family are neuroprotective. The kinase inhibitor URMC-099 (compound 1) stood out as a promising lead compound for further optimization. We coupled structure-based compound design with functional activity testing in neurons subjected to ER stress to develop a series of analogs with improved MAP4K inhibition and concomitant increases in potency and efficacy. Further structural modifications were performed to enhance the pharmacokinetic profiles of the compound 1 derivatives Prostetin/12k emerged as an exceptionally potent, metabolically stable, and blood-brain barrier-penetrant compound that is well suited for future testing in animal models of neurodegeneration.

Cell Chemical Biology published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Formula: C7H10BNO3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Scarry, Sarah M. published the artcileSynthesis of Kappa Opioid Antagonists Based On Pyrrolo[1,2-α]quinoxalinones Using an N-Arylation/Condensation/Oxidation Reaction Sequence, Application of 2-Bromopyridin-3-amine, the publication is Journal of Organic Chemistry (2016), 81(21), 10538-10550, database is CAplus and MEDLINE.

The quinoxaline and quinoxalinone family of N heterocycles is present in mols. of therapeutic relevance for diverse applications ranging from infectious diseases to neuroscience targets. Here, the authors describe a general synthetic sequence to afford pyrrolo[1,2-α]pyrazinones from com. available starting materials and their use in preparing potential kappa opioid receptor antagonists. The biol. data obtained from the latter set of compounds is briefly presented and discussed.

Journal of Organic Chemistry published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Application of 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Figueiredo, Joana published the artcileHazard of novel anti-fouling nanomaterials and biocides DCOIT and silver to marine organisms, SDS of cas: 971-66-4, the publication is Environmental Science: Nano (2020), 7(6), 1670-1680, database is CAplus.

Biocide-based coatings have been applied for several years to tackle marine biofouling. Recently, engineered nanomaterials, such as silica mesoporous nanocapsules (SiNCs), were used to encapsulate DCOIT, an anti-fouling booster biocide, and Ag, a broad-spectrum bactericidal agent, in order to control their release with time. This study aims to assess the environmental hazard of three novel anti-fouling nanomaterials (SiNC-DCOIT, SiNC-Ag and SiNC-DCOIT-Ag) and their free counterparts (DCOIT, Ag and SiNCs) to marine ecosystems. In order to accomplish this goal, marine toxicity data (L/E/IC₅₀ or NOEC) were compiled to derive PNEC values for each compound based on statistical and deterministic approaches. The first approach relies on the hazardous concentration for 5% of the species (HC₅ using species sensitivity distribution curves) and the second relies on the lowest L/E/IC₅₀ or NOEC value, considering the appropriate assessment factors. In both approaches, PNEC values were lower for the encapsulated biocides than for their free forms. Thus, biocide encapsulation appears to be a promising solution to develop a new generation of efficient anti-fouling additives for maritime coatings with lower environmental hazard than the current state-of-the-art biocides.

Environmental Science: Nano published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, SDS of cas: 971-66-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Tite, Tony published the artcileThe synthesis of 6-deazaformycin A, HPLC of Formula: 18437-58-6, the publication is Synlett (2009), 2927-2930, database is CAplus.

The synthesis of the new C-nucleoside 6-deazaformycin A was achieved through: the condensation of a suitably substituted lithiated 2-picoline with 2,3,5-tri-O-benzyl-D-ribonolactone; borohydride reduction of the resulting hemiacetals; followed by intramol. Mitsunobu cyclization of the carbinols; manipulation of the protecting groups, and subsequent ring closure to result in the formation of 7-amino-3-(β-D-ribofuranosyl)pyrazolo[4,3-b]pyridine.

Synlett published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C14H18BNO2S, HPLC of Formula: 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Baudequin, Christine published the artcileEnantioselective electrophilic fluorination: a study of the fluorine-transfer from achiral N-F reagents to cinchona alkaloids, Application In Synthesis of 107263-95-6, the publication is Journal of Fluorine Chemistry (2003), 122(2), 189-193, database is CAplus.

A transfer fluorination on cinchona alkaloids with the aid of achiral N-F fluorine-transfer reagents is described. Ten com. available reagents were evaluated. Selectfluors, Accufluor, N-fluorobenzenesulfonimide (NFSi), and N-fluoro-2,6-dichloropyridinium tetrafluoroborate are effective fluorine-transfer reagents. The N-fluoroammonium salts of cinchona alkaloids thus prepared were employed in the construction of stereogenic fluorinated carbon centers with enantioselectivity as high as 85%. Ionic liquids are effective “green” solvents for the development of this methodol.

Journal of Fluorine Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Application In Synthesis of 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Dan-Yang published the artcileElectronic Effect-Guided Rational Design of Candida antarctica Lipase B for Kinetic Resolution Towards Diarylmethanols, SDS of cas: 91-02-1, the publication is Advanced Synthesis & Catalysis (2021), 363(7), 1867-1872, database is CAplus.

Herein, we developed an electronic effect-guided rational design strategy to enhance the enantioselectivity of Candida antarctica lipase B (CALB) mutants towards bulky pyridyl(phenyl)methanols. Compared to W104A mutant previously reported with reversed S-stereoselectivity toward sec-alcs., three mutants (W104C, W104S and W104T) displayed significant improvement of S-enantioselectivity in the kinetic resolution (KR) of various Ph pyridyl Me acetates due to the increased electronic effects between pyridyl and polar residues. The electronic effects were also observed when mutating other residues surrounding the stereospecificity pocket of CALB, such as T42A, S47A, A281S or A281C, and can be used to manipulate the stereoselectivity. A series of bulky pyridyl(phenyl) methanols, including S-(4-chlorophenyl)(pyridin-2-yl) methanol (S-CPMA), the intermediate of bepotastine, were obtained in good yields and ee values.

Advanced Synthesis & Catalysis published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, SDS of cas: 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kramberger, L. published the artcileHeterocycles. CXXVII. Action of sulfur on some heterocyclic compounds. Formation of thioamides, oxidative cyclization and thiation, Quality Control of 2215-33-0, the publication is Journal of Heterocyclic Chemistry (1975), 12(2), 337-42, database is CAplus.

The formation of heterocyclic thioamides from alkylpyridines, heteroaromatic amines and sulfur was investigated. Oxidative cyclization of these thioamides afforded the corresponding thiazoloazines. Attempted thiation of some hydrazones gave triazolopyridines and some examples of direct thiation of heterocycles are given. Thus, 2-methylpyridine, 5, and RNH2 gave 10 I (R = 3-pyridyl, 4-pyridyl, 4-methyl-2-pyridyl, 5-methyl-2-pyridyl, 2-pyridazyl, 2-pyrazyl, 2-triazolyl, 5-tetrazolyl, 2-benzothiazolyl, anilino). Oxidative cyclization of I (R = 5-methyl-2-pyridyl) gave II. Attempted thiation of III gave IV and thiation of 2-(N-2-pyridylformimidoyl)pyridine gave I (R = 2-pyridyl).

Journal of Heterocyclic Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Quality Control of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Motz, Rachel N. published the artcileHigh-Throughput Screening of Earth-Abundant Water Reduction Catalysts toward Photocatalytic Hydrogen Evolution, Computed Properties of 91-02-1, the publication is Inorganic Chemistry (2021), 60(2), 774-781, database is CAplus and MEDLINE.

Cobalt(II) glyoxime and heterocycle complexes [Co(LL)₂pyCl]ⁿ⁺ (LL – α-dioxime, 8-quinolinols, α-diketone dihydrazides, bipyridines, phenanthrolines, pyridyltetrazoles, etc.; n = 0-2) were generated in situ and screened for cocatalytic activity in Eosin Y-catalyzed photoreduction of water in the presence of triethylamine as sacrificial reductant. Noble-metal photosensitizers and water reduction co-catalysts (WRCs) still present the highest activity in homogeneous photocatalytic hydrogen production The search for earth-abundant alternatives is usually limited by the time required to screen new catalyst combinations; however, here, we utilize newly designed and developed high-throughput photoreactors for the parallel synthesis of novel WRCs and colorimetric screening of hydrogen evolution. This unique approach allowed rapid optimization of photocatalytic water reduction using the organic photosensitizer Eosin Y and the archetypal cobaloxime WRC [Co(GL1)₂pyCl], where GL1 is dimethylglyoxime and py is pyridine. Subsequent combinatorial synthesis generated 646 unique cobalt complexes of the type [Co(LL)₂pyCl], where LL is a bidentate ligand, that identified promising new WRC candidates for hydrogen production D. functional theory (DFT) calculations performed on such cobaloxime derivative complexes demonstrated that reactivity depends on hydride affinity. Alkyl-substituted glyoximes were necessary for hydrogen production and showed increased activity when paired with ligands containing strong hydrogen-bond donors. Using a newly developed method of H₂ detection using colorimetric tape, we screened a massive parallel library of cobaloxime water reduction catalysts. This noble-metal-free system of photocatalytic water reduction was optimized using Eosin Y as a photosensitizer. Screening identified a series of intriguing heteroleptic species with high activity, while DFT calculations of potential reaction intermediates correlated the activity of homoleptic cobaloximes to their hydride binding affinity.

Inorganic Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Computed Properties of 91-02-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Madura, J. D. published the artcilePhysical and structural properties of taurine and taurine analogs, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Amino Acids (1997), 13(2), 131-139, database is CAplus.

The inhibition of the phosphorylation of an ∼20kDa protein present in the mitochondrial fraction of the rat retina by taurine and taurine analogs was investigated using computational methods. Correlations between mol. weight, mol. volume, and calculated pKa values vs. IC₅₀ values are reported. These data appear to support the hypotheses according to Lombardini and Props that the inhibition of the phosphorylation of an ∼20 kDa protein by taurine and taurine analogs dependent on (i) the critical distance between the N and S atoms in the taurine moiety (S-C-C-N) of the analog, (ii) the environment of the N atom in the taurine analog (saturated ring vs. unsaturated ring), and (iii) the placement of both the S and N atoms not being present simultaneously in the ring structure. Using computational methods results supporting hypotheses (i) and (ii) are presented.

Amino Acids published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Pavia, Michael R. published the artcileN-Phenyl-N’-pyridinylureas as anticonvulsant agents, Recommanded Product: 4-Amino-2-picoline, the publication is Journal of Medicinal Chemistry (1990), 33(2), 854-61, database is CAplus and MEDLINE.

A series of N-phenyl-N‘-pyridinylureas, e.g., I (R, R¹, R², R³ = H, Cl, Br, F, CF₃, Me, Et, CHMe₂, NO₂, NH₂, OMe, etc.) was prepared by the reaction of aryl isocyanates with 2-, 3-, of 4-aminopyridine. They were examined for anticonvulsant activity. Extensive structure/activity investigations revealed optimal activity in the N-(2,6-disubstituted-phenyl)-N‘-(4-pyridinyl)urea series, with I (R = Cl, R¹ = R² = H, R³ = Me) (II) exhibiting the best overall anticonvulsant profile. II was effective against seizures induced by maximal electroshock but did not protect mice from clonic seizures produced by the convulsant pentylenetetrazol. The overall pharmacol. profile suggests that II would be of therapeutic use in the treatment of generalized tonic-clonic and partial seizures. II was selected for Phase 1 clin. trials.

Journal of Medicinal Chemistry published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Recommanded Product: 4-Amino-2-picoline.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem