Day: December 7, 2022

Zhang, Guobao published the artcileDiscovery of pyrimidine benzimidazoles as Src-family selective Lck inhibitors. Part II, Quality Control of 18437-58-6, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(23), 6691-6695, database is CAplus and MEDLINE.

A series of 4-amino-6-benzimidazole-pyrimidines was designed to target lymphocyte-specific tyrosine kinase (Lck), a member of the Src-family kinases (SFKs). These type II inhibitors were optimized using a cellular Lck-dependent proliferation assay and are capable of inhibiting Lck at single-digit nanomolar concentrations This scaffold is likely to serve a valuable template for developing potent inhibitors of a number of SFKs.

Bioorganic & Medicinal Chemistry Letters published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C10H9ClN2O, Quality Control of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Niu, Luyao published the artcileSynthesis, structure and anticancer activity of three platinum(II) complexes with 2-phenylpyridine derivatives, Category: pyridine-derivatives, the publication is Inorganic Chemistry Communications (2021), 108737, database is CAplus.

Three luminescent Pt(II) complexes, [Pt(5-NO₂-ppy)(H-5-NO₂-ppy)(Cl)] (1), [Pt(2-(2′,4′-dF)-ppy)(H-2-(2′,4′-dF)-ppy)(Cl)] (2), [Pt(2-(3′,5′-dF)-ppy)(H-2-(3′,5′-dF)-ppy)(Cl)] (3) with 2-phenyl-5-nitropyridyl (5-NO₂-ppy), 2-(2,4-difluorophenyl)pyridine (2-(2′,4′-dF)-ppy) and 2-(3,5-difluorophenyl)pyridine(2-(3′,5′-dF)-ppy) were synthesized. FTIR spectroscopy, multinuclear NMR spectroscopy and single-crystal x-ray crystallog. were used to determine their structures. The UV-visible absorption and photoluminescence (PL) spectra of 1–3 were measured. 1–3 Displayed rich photophys. properties with the maximum emission wavelengths at 403-527 nm in the photoluminescence spectra, which demonstrated 1–3 have the potential to become the DNA luminescent probes in living cells. The anticancer activities of these complexes were tested in vitro by MTT assay against four tumor cell lines BGC823, MGC803 (human gastric cancer cell lines), HepG2 (human hepatocellular carcinoma), A549 (human non-small-cell lung cancer cell lines), HL-7702(human normal liver cell line). Moreover, 3 displayed highest cytotoxicity against human gastric cancer cell lines with the values of IC₅₀ at 13.036-26.594μM.

Inorganic Chemistry Communications published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Fischer, Eberhard published the artcilePreparation and reactions of pyridinium betaines, HPLC of Formula: 17281-59-3, the publication is Zeitschrift fuer Chemie (1978), 18(4), 137-8, database is CAplus.

Reaction of the pyridinium compounds I (R = H, Me) with R¹NCS (R¹ = Et, Ph, 4-ClC₆H₄) gave the betaines II, which reacted with R²COCl (R² = Ph, 2-, 3-O₂NC₆H₄, 3,4-Cl₂C₆H₃, CH₂Cl, OMe, COCl) to give the pyridinum chlorides III.

Zeitschrift fuer Chemie published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, HPLC of Formula: 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sivudu, K. Samba published the artcileHighly efficient and reusable hydrogel-supported nano-palladium catalyst: Evaluation for Suzuki-Miyaura reaction in water, Application of 2-Pyridinylboronic acid, the publication is Journal of Molecular Catalysis A: Chemical (2008), 295(1-2), 10-17, database is CAplus.

Ligand-free, palladium-supported, poly(N-isopropylacrylamide-co-potassium methacrylate) [poly(NIPA-co-PMA)] hydrogel nanocomposite with different comonomer ratios were synthesized. The developed hydrogel-palladium composites were characterized by SEM, TEM, UV-vis DRS and x-ray diffraction. The catalytic performance of these hydrogel-palladium nanocomposites was examined for Suzuki-Miyaura cross-coupling reaction of aryl halides with arylboronic acids in an aqueous medium. The hydrogel with comonomer ratio of 8.8:1.6 mmol of NIPA:PMA exhibited optimum catalytic activity, which can be effectively reused 5-6 times without loss of catalytic activity.

Journal of Molecular Catalysis A: Chemical published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C7H5Cl2NO, Application of 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sundar, Ch. Syama published the artcileThe synthesis and bioactivity of dimethyl (2,3-dihydrobenzo[b][1,4]dioxin-6-yl)(arylamino)methylphosphonates, Synthetic Route of 18437-58-6, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2014), 189(4), 551-557, database is CAplus.

A new series of α-amino phosphonates I (R = aryl) were synthesized by a one-pot, three-component reaction of 2,3-dihydrobenzo[b][1,4]dioxine-6-carboxaldehyde, primary aromatic amines, and HP(O)(OMe)₂ by using nano-TiO₂ as a catalyst under solvent-free conditions at 50°. Major advantages of the method are high yields, short reaction times, recyclable catalyst, and solvent-free reaction conditions. Among these novel α-amino phosphonates, I (R = 3-O₂NC₆H₄, 4-FC₆H₃-3-NO₂) showed higher antioxidant activity in DPPH scavenging, reducing power assay, and lipid peroxidation

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C9H17NO, Synthetic Route of 18437-58-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gunaratne, Gihan S. published the artcileIdentification of a dihydropyridine scaffold that blocks ryanodine receptors, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is iScience (2022), 25(1), 103706, database is CAplus and MEDLINE.

Ryanodine receptors (RyRs) are large, intracellular ion channels that control Ca²⁺ release from the sarco/endoplasmic reticulum. Dysregulation of RyRs in skeletal muscle, heart, and brain has been implicated in various muscle pathologies, arrhythmia, heart failure, and Alzheimer′s disease. Therefore, there is considerable interest in therapeutically targeting RyRs to normalize Ca²⁺ homeostasis in scenarios involving RyR dysfunction. Here, a simple invertebrate screening platform was used to discover new chemotypes targeting RyRs. The approach measured Ca²⁺ signals evoked by cyclic ADP ribose, a second messenger that sensitizes RyRs. From a 1,534-compound screen, FLI-06 (currently described as a Notch “inhibitor”) was identified as a potent blocker of RyR activity. Two closely related tyrosine kinase inhibitors that stimulate and inhibit Ca²⁺ release through RyRs were also resolved. Therefore, this simple screen yielded RyR scaffolds tractable for development and revealed an unexpected linkage between RyRs and trafficking events in the early secretory pathway.

iScience published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Zhehui published the artcileAperture-Opening Encapsulation of a Transition Metal Catalyst in a Metal-Organic Framework for CO₂ Hydrogenation, HPLC of Formula: 338800-13-8, the publication is Journal of the American Chemical Society (2018), 140(26), 8082-8085, database is CAplus and MEDLINE.

The aperture-opening process resulting from dissociative linker exchange in zirconium-based metal-organic framework (MOF) UiO-66 was used to encapsulate the ruthenium complex (^tBuPNP)Ru(CO)HCl in the framework (^tBuPNP = 2,6-bis((di-tert-butyl-phosphino)methyl)pyridine). The resulting encapsulated complex, [Ru]@UiO-66, was a very active catalyst for the hydrogenation of CO₂ to formate. Unlike the analogous homogeneous catalyst, [Ru]@UiO-66 could be recycled five times, showed no evidence for bimol. catalyst decomposition, and was less prone to catalyst poisoning. These results demonstrated for the first time how the aperture-opening process in MOFs can be used to synthesize host-guest materials useful for chem. catalysis.

Journal of the American Chemical Society published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, HPLC of Formula: 338800-13-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Rao, H. Surya Prakash published the artcileCopper-catalyzed C(sp³)-C(sp²) cross-coupling. Synthesis of 4-aryl-2-alkyl-amino-3-nitro-4H-chromenes, COA of Formula: C5H6BNO2, the publication is European Journal of Organic Chemistry (2014), 2014(17), 3646-3655, database is CAplus.

Inexpensive copper(II) acetate effectively catalyzes cross-coupling of electron-deficient as well as electron-rich arylboronic acids with 4-methylsulfanyl-2-alkylamino-3-nitro-4H-chromenes under near neutral conditions at room temperature to furnish a range of 4-aryl-4H-chromenes. This new strategy enabled substitution of the C(4)SMe group present on a sp³ hybridized carbon of the 4H-chromenes with aryl/heteroaryl groups. Mechanistic probing revealed that the Cu(I)-Cu(III) cycle is involved in catalysis. One-pot sequential substitution of C(4)SMe followed by C(6)Br with aryl groups was achieved through Cu(OAc)₂ and Pd₂(dba)₃ (Suzuki coupling) catalysis. © 2014 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.

European Journal of Organic Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, COA of Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ramakrishna, Visannagari published the artcileA Zwitterionic Palladium(II) Complex as a Precatalyst for Neat-Water-Mediated Cross-Coupling Reactions of Heteroaryl, Benzyl, and Aryl Acid Chlorides with Organoboron Reagents, Application of 5-Nitro-2-phenylpyridine, the publication is European Journal of Organic Chemistry (2017), 2017(48), 7238-7255, database is CAplus.

In the presence of an (arylimidazoliumquinazolinyl)palladium dichloride complex, arylboronic acids and potassium aryltrifluoroborates underwent Suzuki-Miyaura coupling reactions with aryl, benzylic, and aroyl chlorides in water to yield biaryls, diarylmethanes, and diaryl ketones. Heterocycle-containing biaryls were prepared using either PPh₃ or X-Phos as addnl. ligands.

European Journal of Organic Chemistry published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Application of 5-Nitro-2-phenylpyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sindhuja, Elangovan published the artcilePalladium(II) thiocarboxamide complexes: synthesis, characterisation and application to catalytic Suzuki coupling reactions, Product Details of C13H13N, the publication is Dalton Transactions (2012), 41(17), 5351-5361, database is CAplus and MEDLINE.

A simple route to synthesize palladium(II) complexes from the reaction of N-substituted pyridine-2-thiocarboxamide ligands and PdCl₂(PPh₃)₂ has been developed. The new complexes are very soluble in common solvents and have been fully characterized (elemental anal., FTIR, ¹H, ³¹P, ¹³C-NMR), including an x-ray diffraction anal. The mol. structures of all the complexes were determined and reveal square planar geometry around Pd with little distortion. The complexes were tested in the Suzuki coupling of electronically deactivated aryl and heteroaryl bromides and have much greater activity, without using any promoting additives or phase transfer agent under aerobic conditions. Higher reaction rates were obtained by varying R substituents on the aromatic ring of pyridine-2-thiocarboxamide. The effect of other variables on the cross-coupling reaction, such as temperature, solvent and base, is also reported.

Dalton Transactions published new progress about 85237-71-4. 85237-71-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is 5-Methyl-2-(p-tolyl)pyridine, and the molecular formula is C17H20ClN3, Product Details of C13H13N.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem