Day: December 7, 2022

Lakshmidevi, Jangam published the artcileA quick and low E-factor waste valorization procedure for CuCl-catalyzed oxidative self-coupling of (hetero)arylboronic acid in pomegranate peel ash extract, Category: pyridine-derivatives, the publication is Green Chemistry Letters and Reviews (2022), 15(3), 538-545, database is CAplus.

The application of waste biomass-derived materials to synthetic chem. is a remarkable achievement, and the use of aqueous media is further advancement. The switch towards earth’s abundant metals like cobalt/copper/iron/nickel from precious palladium in C-C coupling reactions is also a high throughput in the global sustainability perspective. Herein, we describe a CuCl-catalyzed homocoupling of (hetero)arylboronic acids (HABAs) in water extract of pomegranate ash (WEPA) with low E-factor of 1.25 without including the column chromatog. separation of products, which helped in understanding the effectiveness of this method on comparison to reported protocols lacking amounts of silica gel and eluents, however, it was 171.64 by including column purification The reactions are conducted at room temperature to deliver self-coupling products with 90-99% yields in 10-45 min under precious metal, ligand, non-renewable base, toxic/problematic organic solvent and added oxidant-free conditions. A wide range of substrates were screened with aryl and heteroaryl moieties containing diversified functional groups. The substitution of earth’s rare metals-based catalysts by abundant copper, exploration of waste to state-of-the-art C-C coupling, use of biorenewable base, aqueous media, ambient conditions, operational simplicity, excellent yields of biaryls and quick reactions are the noteworthy advantages of this protocol.

Green Chemistry Letters and Reviews published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Goriya, Yogesh published the artcileRuthenium-Catalyzed C6-Propenylation Reactions of Substituted Pyridine Derivatives: Directed and Direct C-H Activation, Synthetic Route of 89076-64-2, the publication is Chemistry – A European Journal (2012), 18(42), 13288-13292, S13288/1-S13288/158, database is CAplus and MEDLINE.

The complex [(Ru(p-cymene)Cl₂)₂] effects direct C6 propenylation of pyridine derivatives Allyl bromide was found to be optimum for the direct propenylation. E.g., in presence of adamantane-1-carboxylic acid, K₂CO₃, and [(Ru(p-cymene)Cl₂)₂], propenylation of 2-phenylpyridine with allyl bromide gave 67% (E)-I. The expected directed allylation/propenylation of the Ph ring was found to be the predominant pathway with allyl acetate. A one-pot propenylation and arylation (by aryl halides) of 2-arylpyridines was also catalyzed by [(Ru(p-cymene)Cl₂)₂].

Chemistry – A European Journal published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Synthetic Route of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kale, Manoj G. published the artcileThiazolopyridine Ureas as Novel Antitubercular Agents Acting through Inhibition of DNA Gyrase B, Category: pyridine-derivatives, the publication is Journal of Medicinal Chemistry (2013), 56(21), 8834-8848, database is CAplus and MEDLINE.

A pharmacophore-based search led to the identification of thiazolopyridine ureas, e.g., I, as a novel scaffold with antitubercular activity acting through inhibition of DNA Gyrase B (GyrB) ATPase. Evaluation of the binding mode of thiazolopyridines in a Mycobacterium tuberculosis (Mtb) GyrB homol. model prompted exploration of the side chains at the thiazolopyridine ring C-5 position to access the ribose/solvent pocket. Potent compounds with GyrB IC₅₀ â‰?1 nM and Mtb MIC â‰?0.1 μM were obtained with certain combinations of side chains at the C-5 position and heterocycles at the C-6 position of the thiazolopyridine core. Substitutions at C-5 also enabled optimization of the physicochem. properties. Representative compounds were cocrystd. with Streptococcus pneumoniae (Spn) ParE; these confirmed the binding modes predicted by the homol. model. The target link to GyrB was confirmed by genetic mapping of the mutations conferring resistance to thiazolopyridine ureas. The compounds are bactericidal in vitro and efficacious in vivo in an acute murine model of tuberculosis.

Journal of Medicinal Chemistry published new progress about 1351413-50-7. 1351413-50-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Amide,Pyridine,Boronic Acids,Boronic acid and ester, name is (1-Methyl-2-oxo-1,2-dihydropyridin-4-yl)boronic acid, and the molecular formula is C6H8BNO3, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bhaskar, Boyapally published the artcileTamarindus indica seed ash extract for C-C coupling under added organics and volatile organic solvent-free conditions: a waste repurposing technique for Suzuki-Miyaura reaction, COA of Formula: C5H6BNO2, the publication is Environmental Science and Pollution Research, database is CAplus and MEDLINE.

A tremendous research has been appeared on Pd-catalyzed Suzuki-Miyaura cross-coupling (SMC) during the last four decades due to its high prominence in constructing biaryl motifs of several complexes as well as simple organic compounds of high biol. and com. significance. The use of organic solid waste-derived materials for SMC in benign solvents like water/aqueous media is a very good achievement in these cases. We report in this article the usability of water extract of Tamarindus indica seeds ash (WETS) as a renewable base and reaction medium for Pd(OAc)₂-catalyzed SMC reaction at room temperature (RT). The WETS has been characterized using powder XRD, EDAX, SEM, and FTIR anal. Furthermore, this process is highly environmentally beneficial by the waste repurposing to prominent chem. transformation along with the advantages such as ambient condition and avoids non-renewable chems. like volatile organic solvents, ligands, promoters, and bases. Based on these merits and the quick reactions with high yields of products, this method can attain the interest of the scientific community in exploring the waste-derived ashes to significant chem. transformations.

Environmental Science and Pollution Research published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, COA of Formula: C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Alvarez-Builla, Julio published the artcileUse of dipolar species under phase-transfer catalysis. Part 1. 1,3-Dipolar cycloaddition in a two-phase system, Application In Synthesis of 17281-59-3, the publication is Journal of Chemical Research, Synopses (1984), 202-3, database is CAplus.

Eleven indolizines were prepared in 18-82% yield by 1,3-dipolar cycloaddition of pyridinium ylides with RCCCO₂Me (R = MeO₂C, Ph) in a 2-phase system. Addition of MeO₂CCCCO₂Me to N-(methoxycarbonylmethyl)pyridinium chloride and KOH, supported on alumina (1:1) suspended in MeCN, at room temperature for >18 h, followed by dehydrogenation with 5% Pd-C at reflux for 4 h gave 44% indolizine I. Phase-transfer catalysts did not significantly improve the yields.

Journal of Chemical Research, Synopses published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Application In Synthesis of 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zurwerra, Didier published the artcileSynthesis and Stability of Boratriazaroles, Safety of 2-Pyridinylboronic acid, the publication is Organic Letters (2015), 17(1), 74-77, database is CAplus and MEDLINE.

We describe the synthesis and stability anal. of novel boratriazaroles that can be viewed as bioisosteres of imidazoles or pyrazoles. These heterocycles could conveniently be obtained by condensing a boronic acid and amidrazone 1 in various solvents. A detailed stability anal. of selected compounds at different pH values as a function of time led to the identification of steric hindrance around the boron atom as a key element for stabilization.

Organic Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C10H9ClN2O, Safety of 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Bell, Colin Frank published the artcileNephelometric determination of silver and mercury with bis(I,3-di-(2′-pyridyl)-I,2-diaza-2-propenato) cobalt(III) perchlorate, Safety of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, the publication is Analytica Chimica Acta (1970), 52(2), 313-21, database is CAplus.

Procedures are described for the nephelometric determination of Ag and Hg, based on adduct-formation with the Co(III) complex of 1,3-di(2-pyridyl)-1,2-diaza-2-propene (PAPHY). The procedures are rapid, sensitive, and reproducible and compare favorably with other nephelometric methods for these metals. The nature of the adducts is discussed.

Analytica Chimica Acta published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Safety of 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Latini, Alessandro published the artcileA novel water-resistant and thermally stable black lead halide perovskite, phenyl viologen lead iodide C₂₂H₁₈N₂(PbI₃)₂, Safety of 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, the publication is Dalton Transactions (2020), 49(8), 2616-2627, database is CAplus and MEDLINE.

A novel black organoammonium iodoplumbate semiconductor, namely Ph viologen lead iodide C₂₂H₁₈N₂(PbI₃)₂ (PhVPI), was successfully synthesized and characterized. This material showed phys. and chem. properties suitable for photovoltaic applications. Indeed, low direct allowed band gap energy (E_g = 1.32 eV) and high thermal stability (up to at least 300°) compared to methylammonium lead iodide CH₃NH₃PbI₃ (MAPI, E_g = 1.5 eV) render PhVPI potentially attractive for solar cell fabrication. The compound was extensively characterized by x-ray diffraction (performed on both powder and single crystals), UV-visible diffuse reflectance spectroscopy (UV-visible DRS), UV-photoelectron spectroscopy (UPS), FTIR spectroscopy, TG-DTA, and CHNS anal. Reactivity towards water was monitored through x-ray powder diffraction carried out after prolonged immersion of the material in water at room temperature Unlike its Me ammonium counterpart, PhVPI proved to be unaffected by water exposure. The lack of reactivity towards water is to be attributed to the quaternary nature of the nitrogen atoms of the Ph viologen units that prevents the formation of acid-base equilibrium when in contact with water. However, PhVPI’s thermal stability was evaluated by temperature-controlled powder XRD measurements following an hour-long isothermal treatment at 250 and 300°. In both cases no signs of decomposition could be detected. However, the compound melted incongruently at 332° producing, upon cooling, a mostly amorphous material. PhVPI is slightly soluble in DMF (âˆ? mM) and highly soluble in DMSO. Nevertheless, its solubility in DMF can be dramatically increased by adding an equimolar amount of DMSO. Therefore, Ph viologen lead iodide can be amenable for the fabrication of solar devices by spin coating as actually done for MAPI-based cells. The crystal structure, determined by single crystal x-ray diffraction using synchrotron radiation, turned out to be triclinic and consequently differs from the prototypal perovskite structure. In fact, it comprises infinite double chains of corner-sharing PbI₆ octahedra along the a-axis direction with Ph viologen cations positioned between the columns. Finally, the present determination of PhVPI’s electronic band structure achieved through UPS and UV-visible DRS is instrumental in using the material for solar cells.

Dalton Transactions published new progress about 47369-00-6. 47369-00-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Benzene,Organic ligands for MOF materials,Nitrogen containing MOF ligands,Nitrogen containing MOF ligands, name is 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride, and the molecular formula is C22H18Cl2N2, Safety of 1,1′-Diphenyl-[4,4′-bipyridine]-1,1′-diium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yang, Quanlu published the artcileRecyclable palladium catalyst on graphene oxide for the C-C/C-N cross-coupling reactions of heteroaromatic sulfonates, Safety of 5-Nitro-2-phenylpyridine, the publication is Tetrahedron (2015), 71(36), 6124-6134, database is CAplus.

A well-defined heterogeneous palladium catalyst, graphene oxide grafted with palladium chloride (PdCl₂), was prepared and found to be an effective catalyst for a carbon-carbon coupling (C-C bond formation), carbon-nitrogen coupling (C-N bond formation) of heteroaryl sulfonates with aryl boronic acids, terminal alkynes, amines, resp., leading to the desired coupling products in moderate to excellent yields. The catalyst was characterized by XRD, IR, SEM, TEM, XPS and ICP. It is worth noting that this catalyst offers a number of advantages such as high stability and negligible metal leaching. It also retains good activity for at least five successive runs without any addnl. activation treatment, showing a better performance than the well-known com. Pd/C catalysts. This approach would be very useful from a practical viewpoint.

Tetrahedron published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Safety of 5-Nitro-2-phenylpyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Xie, Long-Yong published the artcileSelectfluor-mediated regioselective nucleophilic functionalization of N-heterocycles under metal- and base-free conditions, Recommanded Product: 1-Fluoropyridiniumtriflate, the publication is Green Chemistry (2018), 20(3), 760-764, database is CAplus.

A practical and environmentally attractive methodol. for the direct diversification of N-heterocycles at ambient temperature under open-air conditions was developed. The obvious advantage of the process is that no toxic reagent, transition metal, base or other additive was employed, thus greatly reducing costs, facilitating post-reaction neutralization and purification and minimizing the environmental impact.

Green Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C4H12ClNO, Recommanded Product: 1-Fluoropyridiniumtriflate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem