Day: December 7, 2022

Purificacao, Sara I. published the artcileOne-Pot Synthesis of 1,2-Disubstituted 4-, 5-, 6-, and 7-Azaindoles from Amino-o-halopyridines via N-Arylation/Sonogashira/Cyclization Reaction, SDS of cas: 39856-58-1, the publication is Organic Letters (2017), 19(19), 5118-5121, database is CAplus and MEDLINE.

A direct synthesis of several 1,2-disubstituted 4-, 5-, 6-, and 7-azaindoles from available amino-o-halopyridines is described. This procedure involves a palladium-catalyzed N-arylation followed by a Sonogashira reaction and subsequent cyclization in a one-pot manner, exhibiting a wide scope and compatibility with electron-withdrawing and electron-donating groups. The strategy represents an advancement in azaindole chem. with a straightforward approach toward 1,2-disubstituted azaindoles, while avoiding complex N-arylations of hindered 2-substituted azaindoles and difficult purification steps of intermediates.

Organic Letters published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, SDS of cas: 39856-58-1.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Fernandez, M. A. published the artcileNew approaches for monitoring the marine environment: the case of antifouling paints, Related Products of pyridine-derivatives, the publication is International Journal of Environment and Health (2007), 1(3), 427-448, database is CAplus.

A review. Protection of ships hulls against biofouling has been a problem since man began sailing the seas. The most common protections are specially produced antifouling paints. These paints could be broadly classified in three main groups, or generations, depending on the technol. applied: first generation copper-based, second generation organotin-based, and the new, third generation, organotin-free antifouling paints. Most of these new paints contain biocides, and consequently are also toxic. To further complicate risk evaluations, synergistic effects occurred when mixtures were tested. Some researchers have pointed out the risk of employing these compounds without a deep knowledge of their environmental behavior and their effects on marine communities. However, the transition from second to third generation antifoulings is now a reality. Therefore, in this paper, considerations on the chem. and ecotoxicol. information required and proposals for approaches to deal with the new antifouling problems are discussed.

International Journal of Environment and Health published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

van der Vlugt, Jarl Ivar published the artcileT-Shaped Cationic Cu^I Complexes with Hemilabile PNP-Type Ligands, Quality Control of 338800-13-8, the publication is Inorganic Chemistry (2008), 47(11), 4442-4444, database is CAplus and MEDLINE.

The versatile coordination behavior of the PNP ligands 1A (2,6-bis[(di-tert-butylphosphino)methyl]pyridine) and 1B (2,6-bis[(diphenylphosphino)methyl]pyridine) to Cu^I is described. A hemilabile interaction of the pyridine N-donor atom to the Cu center resulted in a rare T-shaped complex with 1A, while with 1B also a tetracoordinated species could be isolated. Theor. calculations support the weak interaction of the pyridine N donor in 1A with the Cu center.

Inorganic Chemistry published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C4Br2N2O4S, Quality Control of 338800-13-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

van der Vlugt, Jarl Ivar published the artcileCu^I Complexes with a Non-innocent PNP Ligand: Selective Dearomatization and Electrophilic Addition Reactivity, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, the publication is Inorganic Chemistry (2009), 48(16), 7513-7515, database is CAplus and MEDLINE.

The neutral, T-shaped complex Cu^I(PN^–P^tBu) (2)featuring a de-aromatized 2,6-bis[(di-tert-butylphosphino)methyl]pyridine (PN^–P^tBu) PNP-pincer ligand, is shown to interact rapidly with electrophiles. Furthermore, C-C bond formation onto the deprotonated methylene-bridgehead carbon is observed with MeOTf as the electrophile. The mol. structure of the methylated derivatives were determined by X-ray crystallog. This represents the first case of selective modification of the lutidine-based backbone of such non-innocent PNP ligands. Theor. calculations support the formation of monomeric complex 2 and indicate the high reactivity of the methylene fragment in this Cu^I complex.

Inorganic Chemistry published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C10H11NO4, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

van der Vlugt, Jarl Ivar published the artcileDinuclear Copper(I) Thiolate Complexes with a Bridging Noninnocent PNP Ligand, Application of 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, the publication is Chemistry – A European Journal (2011), 17(14), 3850-3854, database is CAplus and MEDLINE.

The synthesis and crystal structures of dinuclear copper(I) complexes [Cu₂(μ-SR)(μ-PNP)Br] [R = Ph (4), CH₂Ph (5); PNP = 2,6-bis(di-tert-butylphosphinomethyl)pyridine] in which both the thiolate and PNP act as bridging ligands are described. The PNP ligand bridges in an unprecedented κ²-P,N-κ¹-P mode. The Cu…Cu distance of 2.7 Å, DFT calculations for optimized mol. structure, topol. anal. of electron d. in the framework of quantum theory of atoms in mols. (QT AIM) and natural-bond-order (NBO) anal. all indicate the absence of metallophilic interactions. These dinuclear complexes were prepared by treating a coordination polymer [Cu₂(μ-PNP)(μ-Br)₂]_n (3Br) with NaN(TMS)₂ followed by the thiol (HSR). The synthesis of the precursor 3Br from PNP and [CuBr(SMe₂)] is also described. The crystal structure of the related μ-chloro complex (3Cl) was determined since the μ-bromo complex formed poor quality crystals. Preliminary reactivity studies showed that the bromide ligand in complex 5 can be substituted with NCS or SPh.

Chemistry – A European Journal published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C15H14Cl2S2, Application of 2,6-Bis((di-tert-butylphosphino)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Khajondetchairit, Patcharaporn published the artcileDesign, synthesis, and evaluation of the anticancer activity of 2-amino-aryl-7-aryl-benzoxazole compounds, Product Details of C6H8N2, the publication is Chemical Biology & Drug Design (2017), 90(5), 987-994, database is CAplus and MEDLINE.

A series of 2-amino-aryl-7-aryl-benzoxazole derivatives have been designed, synthesized, and evaluated as anticancer agents. Fourteen of the compounds exhibited cytotoxic effects toward human A549 lung cancer cells. We found 12l was the most potent with an EC₅₀ of 0.4 μm, equivalent to the anticancer drug doxorubicin, but had low selectivity following cross screening in monkey kidney Vero cells. Eight of the most potent or most selective compounds were further profiled in addnl. cell lines (MCF7, NCI-H187, and KB) to better understand their cytotoxic activity. Only compound 12l had a measurable EC₅₀ in a single cell line (3.3 μm in the KB cell line). Taken together, this data suggest the series as a whole display specific cytotoxicity toward A549 cells. Cheminformatics searches pointed to JAK2 as a possible target. A subset of compounds assayed at this target showed IC₅₀s ranging from 10 to 0.08 μm; however, no clear correlation between JAK2 potency and A549 cytotoxicity was observed

Chemical Biology & Drug Design published new progress about 18437-58-6. 18437-58-6 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 4-Amino-2-picoline, and the molecular formula is C6H8N2, Product Details of C6H8N2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Beier, Markus published the artcileNucleotides. Part 62. Pyridinium salts. An effective class of catalysts for oligonucleotide synthesis, Related Products of pyridine-derivatives, the publication is Helvetica Chimica Acta (1999), 82(6), 879-887, database is CAplus.

Various pyridinium salts were tested as catalysts for the condensation step in the phosphoramidite approach of oligonucleotide synthesis. Pyridinium chloride turned out to be the most effective activator, speeding up the condensation tremendously. Pyridinium bromide and tosylate can also he regarded as powerful substitutes for the commonly used 1H-tetrazole. The acidic pK_a of the pyridinium cation provides an optimal range for phosphoramidite activation, which is followed by a nucleophilic attack of the pyridine ring to give a P-pyridinio intermediate as the most likely precursor of phosphite ester formation. ³¹P-NMR studies indirectly support this proposal.

Helvetica Chimica Acta published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Barlin, G. B. published the artcileIonization constants of heterocyclic substances. IX. Protonation of aminopyridines and aminopyrimidinones, HPLC of Formula: 33631-04-8, the publication is Journal of the Chemical Society [Section] B: Physical Organic (1971), 1425-32, database is CAplus.

Ionization constants and uv spectra are reported for amino-2-hydroxypyridines (amino-2-pyridones), amino-4-hydroxypyridines(amino-4-pyridones), and amino-2,4-di-hydroxypryimidines (amino-2,4-pyrimidinediones) and their O-and ring N-Me derivatives Protonation of 3- and 5-amino-2-hydroxypyridines and 3,4-diamino-2-hydroxypyridine (I) occurs first at the amino group (the 3-NH2 of I), but 4- and 6-amino-2-hydroxypyridines and 2- and 3-amino-4-hydroxypyridines are protonated first at O. The most basic center of 4,5-diamino-2,6-dihydroxypyrimidine is the 5-NH2 group.

Journal of the Chemical Society [Section] B: Physical Organic published new progress about 33631-04-8. 33631-04-8 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine,Ether, name is 2-Methoxypyridine-3,4-diamine, and the molecular formula is C6H9N3O, HPLC of Formula: 33631-04-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Gilicinski, Andrew G. published the artcileOn the relative power of electrophilic fluorinating reagents of the nitrogen-fluorine (N-F) class, Formula: C6H5F4NO3S, the publication is Journal of Fluorine Chemistry (1992), 59(1), 157-62, database is CAplus.

Electrochem. measurements have been employed as a measure of the relative chem. reactivity of a series of N-F class electrophilic fluorinating reagents. A correlation has been found between the potential for the first one-electron reduction of the reagents and their observed reactivity in synthetic fluorination reactions. Comparative electrochem. data in acetonitrile and DMF are reported.

Journal of Fluorine Chemistry published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Formula: C6H5F4NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Dumitru, Florina published the artcileHomo- and heteroduplex complexes containing terpyridine-type ligands and Zn²⁺, Synthetic Route of 2215-33-0, the publication is European Journal of Inorganic Chemistry (2005), 4255-4262, database is CAplus.

We describe a study of the equilibrium binding of Zn²⁺ to binary mixtures of tridentate ligands terpyridine (1), 2,5-(CHNC₆H₅)₂pyridine (2) and (2-pyridyl)NHNCH(2-pyridyl) (3) which leads to the formation of a dynamic mixture of homo ([Zn(1)₂](CF₃SO₃)₂ 4, [Zn(2)₂](CF₃SO₃)₂ 5, [Zn(3)₂](CF₃SO₃)₂ 6) and hetero ([Zn(1)(3)](CF₃SO₃)₂ 7, [Zn(1)(2)](CF₃SO₃)₂ 8, [Zn(2)(3)](CF₃SO₃)₂ 9) coordination compounds We report the crystal structures of five such complexes (4, 5, 7–9) which assemble into complementary duplex compounds that further self-organize into double helical- or lamellar-type architectures in the solid state. The ligand exchange between homo-duplex complexes in solution leads to the preferential formation of the heteroduplex complexes. As might be expected these processes display a statistical distribution of homo-duplex:heteroduplex:homo-duplex complexes of 1:2:1 for the mixtures resulting from 4:6 and 5:6 ligands. However, complex 8 is preferred in a 4:5 mixture which presents a composition of 1:4:1 (amplification factor of about 33%). The X-ray structural determinations of selected single crystals resulting from the stoichiometric mixtures of homo-duplex complexes show unique heteroduplex superstructures 7–9 in the solid state. The present results present the solid-state structures of homo- and hetero-complexes resulting from terpyridine-type ligands 1–3 and Zn²⁺ metal ions. The heteroduplex Zn²⁺ complexes 7–9 are quant. crystallized in the solid state by statistical (7, 9) and structural (8) driven selection in solution from a binary mixture of the terpyridine-type complexes and then trapped by crystallization in the solid state.

European Journal of Inorganic Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Synthetic Route of 2215-33-0.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem