Day: December 8, 2022

Warr, Rebecca J. published the artcileInorganic asymmetric synthesis: asymmetric synthesis of a two-bladed propeller, octahedral metal complex, Related Products of pyridine-derivatives, the publication is Inorganic Chemistry (2006), 45(21), 8618-8627, database is CAplus and MEDLINE.

A C₂ hexadentate, in which two pyridine-2-aldehyde 2′-pyridylhydrazone (PAPHY) groups are linked to a chiral auxiliary derived from (R,R)-tartaric acid, (R,R)-I, reacts with Fe(II) benzenesulfonate to give the two-bladed propeller, octahedral complex (P_Fe)-[Fe{(R,R)-I}](PhSO₃)₂ with complete diastereoselectivity, as determined by ¹H NMR spectroscopy and x-ray crystallog. Saponification of the ester linkages and deprotonation of the hydrazone-NH groups in the configurationally pure diastereomer affords (P_Fe)-[Fe(5-HOCH₂PAPY)₂] with 85% retention of configuration at the Fe stereocenter, as determined by reprotonation of the neutral complex with enantiomerically pure (aR)-binaphthyl H₃PO₄ and anal. of the ¹H NMR spectrum of the mixture of diastereomeric salts produced. This is the 1st asym. synthesis of a two-bladed propeller, octahedral metal complex by the classical organic methodol. of chiral auxiliary-directed, asym. synthesis.

Inorganic Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C5H5BO4S, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

East, Stephen P. published the artcileDNA gyrase (GyrB)/topoisomerase IV (ParE) inhibitors: Synthesis and antibacterial activity, Application of 2-Pyridinylboronic acid, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(3), 894-899, database is CAplus and MEDLINE.

The synthesis and antibacterial activities of three chemotypes of DNA supercoiling inhibitors based on imidazo[1,2-a]pyridine and [1,2,4]triazolo[1,5-a]pyridine scaffolds, e.g. I (R = H, Ph, 2-HOC₆H₄, 2-pyridyl, 5-pyrimidyl, 1-imidazolyl, CO₂Me, CONHEt, etc.), that target the ATPase subunits of DNA gyrase and topoisomerase IV (GyrB/ParE) is reported. The most potent scaffold was selected for optimization leading to a series with potent Gram-pos. antibacterial activity and a low resistance frequency.

Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Application of 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liu, Xin published the artcileSelective Construction of C-C and C=C Bonds by Manganese Catalyzed Coupling of Alcohols with Phosphorus Ylides, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, the publication is Advanced Synthesis & Catalysis (2021), 363(4), 1096-1104, database is CAplus.

The manganese complex e.g., I catalyzed coupling of alcs. ROH (R = benzyl, cyclohexyl, furan-2-ylmethyl, etc.) with phosphorus ylides R¹ = P(C₆H₅)₃ (I) [R¹ = H, C(O)OEt, (morpholin-4-yl)carbonyl, benzoyl, etc.] were reported. The selectivity in the coupling of primary alcs. with phosphorus ylides (I) to form carbon-carbon single (C-C) and carbon-carbon double (C=C) bonds can be controlled by the ligands. In the conversion of more challenging secondary alcs. with phosphorus ylides (I), the selectivity towards the formation of C-C vs is obtained. C=C bonds can be controlled by the reaction conditions, namely the amount of base. The scope and limitations of the coupling reactions were thoroughly evaluated by the conversion of 21 alcs. and 15 ylides. Notably, compared to existing methods, which are based on precious metal complexes as catalysts, the present catalytic system is based on earth abundant manganese catalysts e.g., I. The reaction can also be performed in a sequential one-pot reaction generating the phosphorus ylide in situ followed manganese catalyzed C-C and C=C bond formation. Mechanistic studies suggest that the C-C bond was generated via a borrowing hydrogen pathway and the C=C bond formation followed an acceptorless dehydrogenative coupling pathway.

Advanced Synthesis & Catalysis published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chaplin, Adrian B. published the artcile[Rh{NC₅H₃-2,6-(CH₂PtBu₂)₂}(PCy₃)][BArF₄]: A Latent Low-Coordinate Rhodium(I) PNP Pincer Compound, Application In Synthesis of 338800-13-8, the publication is Organometallics (2011), 30(16), 4466-4469, database is CAplus.

An expedient new route to the cationic [(PNP^tBu)Rh(L)]⁺ metal fragments (PNP^tBu = κ³-NC₅H₃-2,6-(CH₂P ^tBu₂)₂; L = CO, acetone, ethene, MeCN, N₂) by the synthesis of, then substitution of PCy₃ in, [(PNP^tBu)Rh(PCy₃)][BAr^F₄] is reported. This synthetic route also allows for the synthesis of the new dihydrogen complex [(PNP^tBu)Rh(H₂)][BAr^F₄]. [(PNP^R)Rh(PCy₃)][BAr^F₄] (R = Ph, Cy, Mes) are also reported, in which the PCy₃ ligand is more tightly bound to the metal center.

Organometallics published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Application In Synthesis of 338800-13-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Lee, Kyounghoon published the artcileLigand K-edge XAS, DFT, and TDDFT analysis of pincer linker variations in Rh(I) PNP complexes: reactivity insights from electronic structure, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, the publication is Dalton Transactions (2016), 45(24), 9774-9785, database is CAplus and MEDLINE.

Here we report P K-edge, Cl K-edge, and Rh L₃-edge X-ray absorption spectroscopy (XAS) data for Rh[C₅H₃N-2,6-(XP^tBu₂)₂]Cl, where X = O (^tBuPONOP; 1) or CH₂ (^tBuPNP; 2), I and II, resp. Solid-state XAS data for 1 and 2 were compared to d. functional theory (DFT) and time-dependent d. functional theory (TDDFT) calculations to identify how changing the PNP pincer linker from O to CH₂ affected electronic structure and bonding at Rh(I). Pronounced differences in XAS peak intensities and energies were observed The P K-edge XAS data revealed a large increase in Rh 4d_x2_-y2 and P 3p orbital-mixing (Rh-P σ*) in 1 compared to 2, and pronounced transition energy variations reflected marked differences in orbital energies and compositions By comparison, the Cl K-edge XAS data revealed only subtle differences in Rh-Cl covalency, although larger splitting between the Rh-Cl π* and σ* transitions was observed in 2. Anal. of the occupied MOs from DFT (HOMO, HOMO-1, HOMO-2, and HOMO-3) and comparison to the unoccupied MOs involved in XAS revealed a relatively uniform energy increase (ca. 0.3-0.5 eV) for all five 4d-derived MOs in Rh(^tBuPNP)Cl (2) compared to Rh(^tBuPONOP)Cl (1). The energy shift was relatively invariant with respect to differences in orbital symmetry, bonding type (σ or π), and orbital mixing, which suggested that the increase could be attributed to electrostatic effects. The change in d-orbital energies are consistent with known reactivity differences of Rh(^tBuPONOP)⁺ and Rh(^tBuPNP)⁺ towards CO, H₂, and CH₂Cl₂, and are explained here by considering how d-orbital energies affect covalent L â†?M σ bonding and M â†?L π backbonding.

Dalton Transactions published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, Recommanded Product: 2,6-Bis((di-tert-butylphosphino)methyl)pyridine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Johns, Brian A. published the artcile1,3,4-Oxadiazole substituted naphthyridines as HIV-1 integrase inhibitors. Part 2: SAR of the C5 position, Application In Synthesis of 197958-29-5, the publication is Bioorganic & Medicinal Chemistry Letters (2009), 19(6), 1807-1810, database is CAplus and MEDLINE.

The use of a 1,3,4-oxadiazole in combination with an 8-hydroxy-1,6-naphthyridine ring system has been shown to deliver potent enzyme and antiviral activity through inhibition of viral DNA integration. This report presents a detailed structure-activity investigation of the C5 position resulting in low nM potency for several analogs with an excellent therapeutic index.

Bioorganic & Medicinal Chemistry Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Application In Synthesis of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Nelson, Shawn D. Jr. published the artcileDivergent Synthesis and Real-Time Biological Annotation of Optically Active Tetrahydrocyclopenta[c]pyranone Derivatives, Quality Control of 197958-29-5, the publication is Organic Letters (2016), 18(24), 6280-6283, database is CAplus and MEDLINE.

Sp³-rich compounds are underrepresented in libraries for probe- and drug-discovery, despite their promise of extending the range of accessible mol. shapes beyond planar geometries. With this in mind, a collection of single-enantiomer bicyclic, fused cyclopentenones underpinned by a complexity-generating Pauson-Khand cyclization was synthesized. A fingerprint of biol. actions of these compounds was determined immediately after synthesis using real-time annotation-a process relying on multiplexed measurements of alterations in cell morphol. features.

Organic Letters published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Quality Control of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cappello, Daniela published the artcileA Boron Difluoride Hydrazone (BODIHY) Polymer Exhibits Aggregation-Induced Emission, COA of Formula: C12H9NO, the publication is Macromolecular Rapid Communications (2021), 42(8), 2000553, database is CAplus and MEDLINE.

Polymers that exhibit aggregation-induced emission (AIE) find use, for example, as cell-imaging agents and as fluorometric sensors due to their unique optical properties. However, the structural diversity of AIE-active polymers has not necessarily advanced at the same rate as their applications. In this work, ring-opening metathesis polymerization is used to synthesize the first example of a polymer (M_n = 61,600 g mol^-1, Dj = 1.32) containing boron difluoride hydrazone (BODIHY) heterocycles in its repeating unit. The BODIHY monomer and polymer described absorb and emit in the visible region in solution (λ_abs = 428 and 429 nm, λ_em = 528 and 526 nm) and as thin films (λ_abs = 443 and 440 nm, λ_em = 535 and 534 nm). Monomer (Φ_Film = 10%) and polymer (Φ_Film = 6%) exhibit enhanced emission as thin films compared to solution (Φ_Soln â‰?1%) as well as AIE upon the addition of water to DMF solutions as a result of restriction of intramol. motion. Enhancement factors for the monomer and polymer are determined to be 58 and 15, resp. The title BODIHY polymer exhibited an earlier onset of AIE and enhanced sensitivity to solution viscosity when compared to the parent monomer.

Macromolecular Rapid Communications published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, COA of Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Okamura, H. published the artcileToxicity evaluation of new antifouling compounds using suspension-cultured fish cells, Category: pyridine-derivatives, the publication is Chemosphere (2002), 46(7), 945-951, database is CAplus and MEDLINE.

A simple, rapid toxicity test was developed using the suspension-cultured fish cell line CHSE-sp derived from chinook salmon Oncorhynchus tshawytscha embryos to assess the toxicity of new marine antifouling compounds The compounds tested were copper pyrithione, Diuron, Irgarol 1051, KH101, Sea-Nine 211, and zinc pyrithione, all of which have been nominated in Japan as possible replacements for organotin compounds The in vitro acute toxicity (24-h EC₅₀) of the six compounds to these fish cells was evaluated using the dye Alamar Blue to determine cell viability, and then correlated with the results of in vivo chronic toxicities (28-day LC₅₀) to juvenile rainbow trout Oncorhynchus mykiss. The suspension-cultured fish cells were found to be suitable for the screening of such chems. before performing an in vivo test. The toxicities of the test compounds obtained from both tests, shown in decreasing order, were as follows: copper pyrithione > zinc pyrithione > KH101 â‰?Sea-Nine 211 > Diuron > Irgarol 1051. The herbicides Diuron and Irgarol 1051 showed the least toxicity, while the pyrithiones had the greatest toxicity.

Chemosphere published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Xu, Chen published the artcileSynthesis and Structural Characterization of Palladacycles with Polydentate Ligands by a Stepwise Coupling Route – Palladacycles Containing Halides as Efficient Catalysts and Substrates, Related Products of pyridine-derivatives, the publication is European Journal of Inorganic Chemistry (2011), 2011(31), 4878-4888, database is CAplus.

A series of ferrocenyl palladacycles with polydentate ligands were conveniently prepared by the Suzuki coupling reactions of a halide-containing ferrocenyl palladacycle [PdCl({(η⁵-C₅H₅)}Fe{(η⁵-C₅H₃)N₂C₄H₂Cl})(PPh₃)] (1) and arylboronic acids without addnl. palladium catalysis. In the absence of addnl. base, amination also occurred in high yield. This new protocol was successfully applied to the Suzuki coupling reactions of the analogous halide-containing palladacycle [PdCl({(η⁵-C₅H₅)}Fe{(η⁵-C₅H₃)NC₅H₃Br})(PPh₃)] (15) and Buchwald-Hartwig amination of the analogous complex [PdCl({(η⁵-C₅H₅)}Fe{(η⁵-C₅H₃)NC₅H₃Br})(DCPAB)] (32), where DCPAB = 2-dicyclohexylphosphanyl-2′-(N,N-dimethylamino)biphenyl. The halide-containing palladacycles act as efficient catalysts and substrates in the coupling reactions. 37 New examples have been fully characterized by elemental anal., IR and ¹H NMR spectroscopy, and ESI-MS. Addnl., the mol. structures of eight compounds were determined by single-crystal x-ray diffraction, and many types of intermol. C-H···Cl (O, N, π) interactions and π-π interactions were found in the crystal structures of these palladacycles.

European Journal of Inorganic Chemistry published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C20H19NO4, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem