Day: December 9, 2022

Yu, Xiao-Qiang published the artcileAryl triolborates: Novel reagent for copper-catalyzed N-arylation of amines, anilines, and imidazoles, Recommanded Product: 2-Pyridinylboronic acid, the publication is Chemistry – An Asian Journal (2008), 3(8-9), 1517-1522, database is CAplus and MEDLINE.

The N-arylation of primary and secondary aliphatic amines, anilines, and imidazoles with novel potassium aryl triolborates was carried out in the presence of a reoxidant and a catalytic amount of Cu(OAc)₂ (10 mol %). Aryl triolborates were found to be better reagents than arylboronic acids or potassium aryl trifluoroborates as the former achieved high yields under mild conditions. Coupling of primary and secondary aliphatic amines to give N-arylamines in excellent yields was performed under oxygen atm. The reactions of anilines and imidazoles to provide N-arylanilines and N-arylimidazoles in good yields proceeded smoothly when trimethylamine N-oxide was used as an oxidant.

Chemistry – An Asian Journal published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is Al2H32O28S3, Recommanded Product: 2-Pyridinylboronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Mikami, Eiichi published the artcileRapid determination of drugs in pharmaceutical preparations by liquid chromatography. (III). Determination of todralazine hydrochloride, trimetoquinol hydrochloride, nicardipine hydrochloride, sulpiride, furosemide and betahistine mesilate in pharmaceutical preparations, Formula: C10H20N2O6S2, the publication is Iyakuhin Kenkyu (1992), 23(6), 896-901, database is CAplus.

Liquid chromatog. methods using UV detection are described for determination of the title drugs in pharmaceutical preparations Stationary phase was Wakosil 5C18. Internal standards were p-hydroxybenzoic acid (for todralazine hydrochloride and sulpiride), Me p-aminobenzoate (for trimetoquinol hydrochloride and betahistidine mesilate), Pr p-hydroxybenzoate (for nicardipine hydrochloride), and Pr p-aminobenzoate (for furosemide). These rapid methods are useful for anal. for com. pharmaceutical preparations

Iyakuhin Kenkyu published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, Formula: C10H20N2O6S2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kaewchuay, Netnapit published the artcileA novel hybrid mode of sample injection to enhance CZE sensitivity for simultaneous determination of a pyridine-triphenylborane anti-fouling agent and its degradation products, Synthetic Route of 971-66-4, the publication is Electrophoresis (2011), 32(12), 1486-1491, database is CAplus and MEDLINE.

We developed a novel hybrid sample injection mode (HSIM) that presents the combination of electrokinetic injection and vacuum injection to enhance detection sensitivity in CZE. Samples were introduced using both vacuum and electrokinetic injections simultaneously, with a water plug injected into the capillary prior to sample introduction (i.e. similarly to field-amplified sample injection, FASI). Using a sample mixture containing an anti-fouling agent applied to ship hulls, pyridine-triphenylborane and its degradation products (diphenylborinic acid, phenylboronic acid, and phenol) dissolved in ACN, the length of water plug, time, and voltage for sample introduction were optimized. The signal intensity (peak height) was found to be up to a 30-fold increased using HSIM by applying 4 kV for 4 s at the inlet end of the capillary as the cathode with supplementary vacuum in comparison with only vacuum injection for 4 s. The LODs (at a S/N of 3) for pyridine-triphenylborane, diphenylborinic acid, phenylboronic acid, and phenol were 0.88, 1.0, 21, and 23 μg/L, resp. At the level of 0.04 mg/L, the RSDs (n=4, intra-day) for the above analytes were in the ranges of 1.9-11, 4.3-9.2, and 0.34-0.66% for peak area, peak height, and migration time, resp. The HSIM is a simple and promising procedure useful for enhancing the sensitivity for both low-and high-mobility ions in CZE.

Electrophoresis published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Synthetic Route of 971-66-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Fukushi, Keiichi published the artcileSimultaneous determination of a pyridine-triphenylborane anti-fouling agent and its estimated degradation products using capillary zone electrophoresis, Application of Triphenyl(pyridin-1-ium-1-yl)borate, the publication is Journal of Chromatography A (2010), 1217(14), 2187-2190, database is CAplus and MEDLINE.

A com. organoborane compound, pyridine-triphenylborane (PTPB), is often applied to ship hulls as an anti-fouling agent. The authors developed capillary zone electrophoresis (CZE) with direct UV detection for the simultaneous determination of PTPB and its estimated degradation products: diphenylborinic acid (DPB), phenylboronic acid (MPB), and phenol. The limits of detection (LODs) for PTPB, DPB, MPB, and phenol were, resp., 25, 30, 50, and 29 μg/L at a signal-to-noise ratio of three. At concentrations of 0.5 mg/L, values of the relative standard deviation (relative standard deviation, n = 6, intra-day) of peak area were obtained, resp., for PTPB, DPB, MPB, and phenol, as 4.1%, 4.1%, 4.7%, and 3.4% for peak heights 3.6%, 3.2%, 1.7%, and 1.4%, and for migration times 1.1%, 1.1%, 1.0%, and 0.73%. The analytes were detected within 14 min. Simple photodegradation experiments were conducted to verify the usefulness of the proposed method for addnl. PTPB degradation studies.

Journal of Chromatography A published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, Application of Triphenyl(pyridin-1-ium-1-yl)borate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kuznetsov, V. V. published the artcileSpectrophotometric titrimetry of nitrogen-containing heteroaromatic sulfonates in organo-aqueous solutions, Computed Properties of 636-73-7, the publication is Zhurnal Analiticheskoi Khimii (1990), 45(11), 2204-10, database is CAplus.

The formation constants and free energy of transfer of Ba complexes with 8-quinolinol-2-, 8-quinolinol-5-, and 3-pyridinesulfonates in H₂O-Me₂CO were examined by potentiometry and a method was developed for determining the sulfonates in the presence of sulfates. The method involves titration with BaCl₂ vs. Orthanilic B.

Zhurnal Analiticheskoi Khimii published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Computed Properties of 636-73-7.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Sreedhar, B. published the artcileNanocrystalline Titania-Supported Palladium(0) Nanoparticles for Suzuki-Miyaura Cross-Coupling of Aryl and Heteroaryl Halides, Computed Properties of 197958-29-5, the publication is Advanced Synthesis & Catalysis (2011), 353(14-15), 2823-2836, database is CAplus.

The Suzuki cross-coupling reaction of various aryl and heteroaryl halides with arylboronic and heteroarylboronic acids was studied using a titania-supported palladium(0) catalyst at room temperature under air. The conversion and selectivity results obtained for many substrates were excellent and similar to those provided by more active or even homogeneous catalysts. The methodol. was similarly effective using 2-bromo-3,4,5-trimethoxybenzaldehyde as the coupling partner. Furthermore, it has been shown that it is useful for the synthesis of terphenyls and tetraphenyls. The catalyst is quant. recovered from the reaction by simple filtration and reused for a number of cycles without significant loss of activity. Inductively coupled plasma (ICP) mass-spectrometric anal. of the filtrate from the reaction mixture demonstrated that the palladium metal hardly leached into the solution within the limits of the detector (1 ppm), thus suggesting that the present Suzuki-Miyaura reaction proceeded by heterogeneous catalysis.

Advanced Synthesis & Catalysis published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C12H9N3O4, Computed Properties of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Kawada, Takuma published the artcileAsymmetric Transfer Hydrogenative Amination of Benzylic Ketones Catalyzed by Cp*Ir(III) Complexes Bearing a Chiral N-(2-Picolyl)sulfonamidato Ligand, Category: pyridine-derivatives, the publication is Journal of Organic Chemistry (2022), 87(13), 8458-8468, database is CAplus and MEDLINE.

A convenient asym. reductive amination of benzylic ketones (α-arylated ketones) catalyzed by newly designed Cp*Ir complexes bearing a chiral N-(2-picolyl)sulfonamidato ligand was developed. Using readily available β-amino alcs. as chiral aminating agents, a range of benzo-fused and acyclic ketones were successfully reduced with formic acid in methanol at 40°C to afford amines with favorable chemo- and diastereoselectivities. The amino alc.-derived chiral auxiliary was easily removed by mild periodic oxidants, leading to optically active primary β-arylamines without erosion of the optical purity (up to 97% ee). The excellent catalytic performance was retained even upon lowering the amount of catalyst to a substrate/catalyst (S/C) ratio of 20,000, and the amination could be performed on a large scale exceeding 100 g. The precise hydride transfer to iminium species generated from the ketonic substrate and the chiral amine counterpart was suggested by the mechanistic studies on stoichiometric reactions of isolable hydridoiridium complexes and model intermediates such as N,O-acetal, enamine, and iminium compounds

Journal of Organic Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Category: pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Xie, Pan published the artcilePhoto-induced oxidative cleavage of C-C double bonds for the synthesis of biaryl methanone via CeCl₃ catalysis, Recommanded Product: Phenyl(pyridin-2-yl)methanone, the publication is Organic & Biomolecular Chemistry (2021), 19(31), 6781-6785, database is CAplus and MEDLINE.

A Ce-catalyzed strategy is developed to produce biaryl methanones via photooxidative cleavage of C-C double bonds at room temperature This reaction is performed under air and demonstrates high activity as well as functional group tolerance. A synergistic Ce/ROH catalytic mechanism is also proposed based on the exptl. observations. This protocol should be the first successful Ce-catalyzed photooxidation reaction of olefins with air as the oxidant, which would provide inspiration for the development of novel Ce-catalyzed photochem. synthesis processes.

Organic & Biomolecular Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C8H7ClO3, Recommanded Product: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Yu published the artcileSelective approach to N-substituted tertiary 2-pyridones, Product Details of C5H6BNO2, the publication is New Journal of Chemistry (2022), 46(23), 11138-11142, database is CAplus.

The regio- and enantioselective amination of readily available vinyl cyclic carbonates with ambivalent 2-hydroxypyridines was achieved using a Pd(0)/DACH-naphthyl catalyst system. The reaction proceeded under simple conditions, providing access to chiral N-substituted 2-pyridones that bear elusive tertiary carbon centers. A significant drawback previously related to making these products via transition metal-catalyzed allylic substitution procedures was overcome by this catalytic method.

New Journal of Chemistry published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C10H9ClN2O, Product Details of C5H6BNO2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Jin, Hongwei published the artcileCopper-Catalyzed One-Pot Synthesis of Substituted Benzimidazoles, Recommanded Product: 2-Bromopyridin-3-amine, the publication is Advanced Synthesis & Catalysis (2010), 352(2+3), 347-350, database is CAplus.

A copper-catalyzed one-pot synthesis of functionalized benzimidazoles has been developed. The procedure combines the copper-catalyzed three-component cascade reaction of sulfonyl azides R¹SO₂N₃ (R¹ = Ph, 4-MeC₆H₄, etc.), alkynes R²CCH (R² = Ph, 4-MeC₆H₄, etc.) and 2-X-4-R³-aniline (R³ = H, Me, Cl; X = Br, I) and the copper-catalyzed intramol. N-arylation of sulfonamides in one sequence, which afforded the products I in moderate to good yields.

Advanced Synthesis & Catalysis published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C5H5BrN2, Recommanded Product: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem