Day: December 9, 2022

Lan, Lixin published the artcileUltrasonic-assisted synthesis of 2-sulfonyl nitrogen heterocyclic compounds, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Youji Huaxue (2018), 38(2), 492-497, database is CAplus.

A facile and convenient ultrasonic-assisted method for the synthesis of 2-sulfonyl nitrogen heterocyclics has been developed. Using bromo-tris-pyrrolidino-phosphonium hexafluorophosphate (PyBroP) as catalyst, the reactions were carried out under ultrasound irradiation condition at room temperature for 1.0 h, and the 2-sulfonyl nitrogen heterocyclics were obtained in good yields with nitrogen heterocyclic N-oxides and sulfinic acid as raw materials. The reaction has the advantages of good substrate suitability, short reaction times and high yields, which provides a efficient approach for the synthesis of 2-sulfonyl nitrogen heterocyclics and their derivatives

Youji Huaxue published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Yan, Fangyou published the artcilePredicting Toxicity of Ionic Liquids in Acetylcholinesterase Enzyme by the Quantitative Structure-Activity Relationship Method Using Topological Indexes, Safety of 1-(Cyanomethyl)pyridin-1-ium chloride, the publication is Journal of Chemical & Engineering Data (2012), 57(8), 2252-2257, database is CAplus.

A new topol. index (TI) was proposed based on atom characters (e.g., atom radius, atom electronegativity, etc.) and atom positions in the hydrogen-suppressed mol. structure in our previous work. In this work, the TI was used for predicting the toxicity of ILs in acetylcholin esterase (log EC₅₀ AChE) by the multiple linear regression (MLR) method. For ILs composed entirely of cations and anions, the TIs are calculated from cations and anions, resp. The 221 ILs used in the MLR model are based on imidazolium (Im), pyridinium (Pyi), pyrrolidinium (Pyo), ammonium (Am), phosphonium (Ph), quinolinium (Qu), piperidinium (Pi), and morpholinium (Mo). The regression coefficient (R²) and the overall average absolute error (AAE) are 0.877 and 0.153, resp.

Journal of Chemical & Engineering Data published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C20H19NO4, Safety of 1-(Cyanomethyl)pyridin-1-ium chloride.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cao, Dawei published the artcileLight-driven MPV-type reduction of aryl ketones/aldehydes to alcohols with isopropanol under mild conditions, Name: Phenyl(pyridin-2-yl)methanone, the publication is Green Chemistry (2021), 23(19), 7539-7543, database is CAplus.

Herein, a direct light-driven strategy for reducing ketones R¹C(O)R² (R¹ = Ph, pyridin-2-yl, Bu, 1-benzofuran-2-yl, etc.; R² = Ph, pyridin-2-yl, Me, pentyl, etc.) /aldehydes R³CHO (R³ = Ph, 4-(trifluoromethyl)phenyl, 1-benzofuran-2-yl, naphthalen-2-yl, etc.) to alcs. R¹CH(OH)R²/R³OH using isopropanol as the reducing agent and solvent, in the presence of t-BuOLi, under an air atm. at room temperature is developed. This operationally simple light-promoted Meerwein-Ponndorf-Verley (MPV) type reduction can be used to produce various benzylic alc. derivatives as well as applied to bioactive mols. and PEEK model compounds, demonstrating its application potential.

Green Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Name: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Luise, Nicola published the artcileDiversity-oriented synthesis of bicyclic fragments containing privileged azines, Safety of Ethyl 2-(2-chloropyridin-3-yl)acetate, the publication is Bioorganic & Medicinal Chemistry Letters (2019), 29(2), 248-251, database is CAplus and MEDLINE.

An innovative and efficient reagent- and scaffold-based diversity oriented synthesis (DOS) of a fragment set was developed for fragment-based drug discovery (FBDD) programs. Twelve diverse, functionalized and bicyclic scaffolds were rapidly accessed by adopting a convenient synthetic toolkit around three privileged azine cores in order to effectively modulate biomols. These structures are characterized by both key motifs for interacting with diverse biol. targets via hydrogen bonds and useful points of growth for subsequent fragment optimization.

Bioorganic & Medicinal Chemistry Letters published new progress about 164464-60-2. 164464-60-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Chloride,Ester, name is Ethyl 2-(2-chloropyridin-3-yl)acetate, and the molecular formula is C9H10ClNO2, Safety of Ethyl 2-(2-chloropyridin-3-yl)acetate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Fang, Xiang published the artcileSynthesis of monofluorinated indolizines and their derivatives by the 1,3-dipolar reaction of N-ylides with fluorinated vinyl tosylates, COA of Formula: C7H7ClN2, the publication is Tetrahedron (2004), 60(25), 5487-5493, database is CAplus.

Monofluorinated indolizines, benzo[d]indolizines and 4H-pyrrolo[1,2-a]benzimidazoles were synthesized in moderate yields by 1,3-dipolar cycloaddition reaction between fluorinated vinyl tosylates and N-ylides of pyridinium, isoquinolinium and benzimidazolium, generated in situ from their halide salts. When the same N-ylides were allowed to react with 2,3,3-trifluoro-1-propenyl tosylate, the unexpected product formylated indolizines and their derivatives, e.g., I, were obtained. A reaction mechanism is also proposed.

Tetrahedron published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, COA of Formula: C7H7ClN2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Ye, Hao published the artcilePalladium-catalyzed Heck cyclization/carbonylation with formates: synthesis of azaindoline-3-acetates and furoazaindolines, Name: 2-Bromopyridin-3-amine, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(48), 6825-6828, database is CAplus and MEDLINE.

Herein a palladium-catalyzed domino cyclization/carbonylation to access ester-functionalized azaindolines, e.g., I applying formates, e.g., phenylformate as a convenient carbonyl source was reported. All four azaindoline isomers were constructed, exhibiting good functional group compatibility. On this basis, modifying the starting tether on the aminopyridine led to furoazaindolines, e.g., II via an intramol. reductive cyclization after the palladium-catalyzed process.

Chemical Communications (Cambridge, United Kingdom) published new progress about 39856-58-1. 39856-58-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Bromide,Amine, name is 2-Bromopyridin-3-amine, and the molecular formula is C10H16Br3N, Name: 2-Bromopyridin-3-amine.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem