Day: December 9, 2022

Kiselyov, Alexander S. published the artcileA novel three-component reaction of N-fluoropyridinium salts: a facile approach to imidazo[1,2-a]pyridines, Formula: C6H5F4NO3S, the publication is Tetrahedron Letters (2005), 46(26), 4487-4490, database is CAplus.

The reaction of N-fluoropyridinium triflates I (R¹ = H, 2-Me, 4-Me₂CH, 2-Ph, 3-Cl, etc.) with isonitriles R²NC (R² = Me₂CH, Me₃C, EtO₂CH₂, cyclohexyl, Ph, PhCH₂, etc.) in acetonitrile or propionitrile in the presence of NaBH(OAc)₃ led to the formation of the corresponding imidazo[1,2-a]pyridines II (R³ = Me, Et) in 44-73% yields. The proposed reaction mechanism involves the intermediate formation of a highly reactive carbene species and apparent reduction of the pyridinium intermediate with NaBH(OAc)₃ to yield the targeted heterocycles.

Tetrahedron Letters published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Formula: C6H5F4NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Guven, Alaattin published the artcileAcidity study on 3-substituted pyridines, Recommanded Product: Pyridine-3-sulfonic acid, the publication is International Journal of Molecular Sciences (2005), 6(11), 257-275, database is CAplus.

A comprehensive theor. study for the protonation of some 3-substituted pyridines has been carried out in aqueous solution (ε=78.4) by semi empirical AM1 method in MOPAC2000 and PM5 method in MOPAC2002. Solvent effect was accounted for implicitly by means of the conductor like screening model (COSMO). The acidity constants of these pyridine derivatives have been calculated The tautomeric and/or conformational equilibrium for these compounds, where available, were also taken into account to find out the mol fractions of the species in aqueous media. The results obtained from the calculations were compared with the available exptl. values, and the results indicate a considerable agreement with available exptl. data.

International Journal of Molecular Sciences published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Feibelman, Peter J. published the artcileWhat Limits Turnover Number in NH₃ Synthesis on a PNP Pincer Molecule?, SDS of cas: 338800-13-8, the publication is Comments on Inorganic Chemistry (2014), 34(1-2), 3-16, database is CAplus.

Abiol. NH₃ synthesis under mild conditions on a PNP [=2,6-bis(di-tert-butyl-phosphinomethyl)pyridine] pincer chelating an Mo(N₂)₃ group has been reported and attributed to a catalytic cycle wherein only the equatorial N₂ is reduced. The present calculations suggest that reduction of axial N₂ ligands was the reason the cycle ended after production of 23 equivalent of NH₃. NH₃ detachment from axial NNH₃ initiates a terminal reaction pathway by leaving an axial nitrido N behind on the Mo. The trans influence of the strong axial nitride bond causes the second axial N₂ to detach from the Mo, with N-Mo-N₂ remaining as a non-catalytic, pincer-chelated group.

Comments on Inorganic Chemistry published new progress about 338800-13-8. 338800-13-8 belongs to pyridine-derivatives, auxiliary class Bis-phosphine Ligands, name is 2,6-Bis((di-tert-butylphosphino)methyl)pyridine, and the molecular formula is C23H43NP2, SDS of cas: 338800-13-8.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

El-Assal, Mona Ibrahim published the artcileNano-sponge novel drug delivery system as carrier of anti-hypertensive drug, Computed Properties of 89076-64-2, the publication is International Journal of Pharmacy and Pharmaceutical Sciences (2019), 11(10), 47-63, database is CAplus.

The study was designed to prepare Nano-sponge formulation loaded with nifedipine. Studying parameters which affecting the formulas in addition to pharmacokinetics and toxicity tests. Nine Nano-sponge formulations were prepared by the solvent evaporation technique. Different ratios of polymer ethylcellulose, COpolymers β-cyclodextrin and hydroxypropyl β-cyclodextrin in addition to solubilizing agent polyvinyl alc. were used. Thermal anal., X-ray powder diffraction (XRPD), shape and surface morphol., particle size, %production yield, %porosity, % swelling, and % drug entrapment efficiency of Nano-sponge were examined Release kinetic also studied beside comparison of pharmacokinetic parameters of the optimum choice formula and marketed one in addition to Toxicol. consideration. Particle size in the range of 119.1 nm to 529 nm which were increased due to the increase in the concentration of polymer to the drug. Nano-sponge revealed porous, spherical nature. Increased in the drug/polymer molar ratios (1:1 to 1:3) may increase their % production yield ranged from 62.1% to 92.4%. The drug content of different formulations was in the range of 77.9% to 94.7%, and entrapment efficiency was in the range of 82.72 % to 96.63%. Drug released in controlled sustained pattern and followed Higuchi, s diffusion mechanism. Pharmacokinetic parameters of optimized formula showed significant higher maximum plasma drug concentration, area under plasma concentration-time curve, volume of distribution and mean residence time. Nano-sponge loaded drug proved biol. safety at low concentrations Nano-sponge drug delivery system has showed small Nano size, porous with controlled drug release and significant-high plasma drug concentration that improved solubility, drug bioavailability and proved safety.

International Journal of Pharmacy and Pharmaceutical Sciences published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Computed Properties of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

El Ali, Bassam published the artcileRh₆(CO)₁₆-H₃PW₁₂O₄₀-catalyzed one pot hydroformylation-cyclotrimerization of cyclohexene and cyclopentene to 2,4,6-trisubstituted 1,3,5-trioxanes, Recommanded Product: Pyridine-3-sulfonic acid, the publication is Journal of Molecular Catalysis A: Chemical (2003), 203(1-2), 53-58, database is CAplus.

One-pot hydroformylation-cyclotrimerization of cyclopentene and cyclohexene was selectively catalyzed by Rh₆(CO)₁₆ and H₃PW₁₂O₄₀·xH₂O (HPA-W₁₂) in THF at 40 atm (CO/H₂ = 1/1) and afforded 2,4,6-tris(cycloalkyl)-1,3,5-trioxanes as major products along with the corresponding aldehydes.

Journal of Molecular Catalysis A: Chemical published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Recommanded Product: Pyridine-3-sulfonic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Christophe, Bernard published the artcileOccurrence of early after depolarization under healthy or hypertrophic cardiomyopathy conditions in the human ventricular endocardial myocyte: In silico study using 109 torsadogenic or non-torsadogenic compounds, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, the publication is Toxicology and Applied Pharmacology (2022), 115914, database is CAplus and MEDLINE.

The goal of the CiPA initiative (Comprehensive in vitro Proarrhythmia Assay) was to assess a more accurate prediction of new drug candidate proarrhythmic severe liabilities such as torsades de pointes, for example. This new CiPA paradigm was partly based on in silico reconstruction of human ventricular cardiomyocyte action potential useful to identify repolarization abnormalities such early afterdepolarization (EAD), for example. Using the ToR-ORd algorithm (Tomek-Rodriguez-O’Hara-Rudy dynamic model), the aim of the present work was (i) to identify intracellular parameters leading to EAD occurrence under healthy and hypertrophic cardiomyopathy (HCM) conditions and (ii) to evaluate the prediction accuracy of compound torsadogenic risk based on EAD occurrence using a large set of 109 torsadogenic and non-torsadogenic compounds under both exptl. conditions. In silico results highlighted the crucial involvement of Ca++ handling in the ventricular cardiomyocyte intracellular subspace compartment for the initiation of EAD, demonstrated by a higher amplitude of Ca++ release from junctional sarcoplasmic reticulum to subspace compartments (Jrel) measured at EAD take-off voltage in the presence vs. the absence of EAD initiated either by high IKr inhibition or by high enough concentration of a torsadogenic compound under both exptl. conditions. Under healthy or HCM conditions, the prediction accuracy of the torsadogenic risk of compound based on EAD occurrence was observed to be 61 or 92%, resp. This high accuracy under HCM conditions was discussed regarding its usefulness for cardiac safety pharmacol. at least at early drug screening/preclin. stage of the drug development process.

Toxicology and Applied Pharmacology published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C17H18N2O6, Recommanded Product: Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chiswell, B. published the artcilePlatinum complexes of some deprotonatable tridentate ligands, Related Products of pyridine-derivatives, the publication is Australian Journal of Chemistry (1968), 21(8), 1997-2001, database is CAplus.

Pt(II) and Pt(IV) complexes of 1,3-bis(2-pyridyl)-1,2-diazaprop-2-ene and ligands of similar structure, but with Me “blocking groups” adjacent to the pyridine N atoms, were studied. In neutral solution, these ligands lose a proton upon interaction with either Pt(II) or Pt(IV) salts to yield highly colored complexes soluble in organic solvents. Protonated compounds of both oxidation states can be obtained, but such compounds are unstable in neutral solution and readily yield deprotonated complexes.

Australian Journal of Chemistry published new progress about 2215-33-0. 2215-33-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Amine, name is 2-((2-(Pyridin-2-yl)hydrazono)methyl)pyridine, and the molecular formula is C11H10N4, Related Products of pyridine-derivatives.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Chen, Hong-hua published the artcileEfficacy of manual reduction combined with betahistine mesylate in treatment of benign paroxysmal positional vertigo, SDS of cas: 54856-23-4, the publication is Xiandai Zhenduan Yu Zhiliao (2017), 28(7), 1235-1236, database is CAplus.

To explore the efficacy of manual reduction combined with drugs in the treatment of 60 cases of benign paroxysmal positional vertigo. Patients who were diagnosed with benign paroxysmal positional vertigo in our hospital from Feb. 2013 to Jan. 2015 were collected and randomly divided into a study group and a control group. The basic treatment of the two groups was manual reduction, and the study group was treated with betahistine mesylate tablets. The therapeutic effects of the two groups were compared for benign paroxysmal positional vertigo. The two groups were scored by the Vertigo Disorder Rating Scale before and after treatment. The therapeutic effects of the study group and the control group for benign paroxysmal positional vertigo were 100% and 66.7%, resp., and there was a difference (P < 0.05). The study group and the control group had no difference in the scores of the Vertigo Disorder Rating Scale before treatment (P > 0.05). There was a difference in the scores of the vertigo disorder rating scale between the study group and the control group after treatment (P < 0.05). This article believes that manual reduction combined with drugs has a definite effect in the treatment of benign paroxysmal positional vertigo and can significantly improve the symptoms of patients.

Xiandai Zhenduan Yu Zhiliao published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, SDS of cas: 54856-23-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Asahara, Haruyasu published the artcileSubstituent Diversity-directed Synthesis of Nitropyridines and Nitroanilines by Three-component Ring Transformation, Quality Control of 89076-64-2, the publication is Procedia Engineering (2017), 1046-1057, database is CAplus.

A novel method for synthesis of various kinds of nitroarenes by using a three-component ring transformation (TCRT) of dinitropyridone with ketones in the presence of ammonium acetate as nitrogen source is developed. This method requires only simple manipulations and mild reaction conditions. Furthermore, the modification of obtained nitropyridine or nitroaniline frameworks can be easily obtained only changing a com. available substrates.

Procedia Engineering published new progress about 89076-64-2. 89076-64-2 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitro Compound,Benzene, name is 5-Nitro-2-phenylpyridine, and the molecular formula is C11H8N2O2, Quality Control of 89076-64-2.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Anonymous published the artcilePreparation of new nitrogen-bridged heterocycles. 72. A new approach to 1-acyl-3-(substituted methylthio)thieno[3′,4′:4,5]imidazo[1,5-a]pyridine derivatives [Erratum to document cited in CA154:284193], Application In Synthesis of 17281-59-3, the publication is Chemical & Pharmaceutical Bulletin (2010), 58(12), 1672, database is CAplus.

On page 1502 the title contains an error; the correct title is given. On page 1509 in the right column, lines 3,8 and 7 and in the left column, lines 8 and 7, imidazo[1,5-α]pyridine is incorrect; the correction is given. On page 1510 in the left column, lines 3 and 17, imidazo[1,5-α]pyridine is incorrect; the correction is given. On page 1510, a reference should be added; the reference is given.

Chemical & Pharmaceutical Bulletin published new progress about 17281-59-3. 17281-59-3 belongs to pyridine-derivatives, auxiliary class Pyridine,Nitrile,Salt, name is 1-(Cyanomethyl)pyridin-1-ium chloride, and the molecular formula is C7H7ClN2, Application In Synthesis of 17281-59-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem