Day: December 9, 2022

Liao, Jun published the artcileEfficacy of vestibular rehabilitation training combined with medication in treatment of vestibular neuritis, Computed Properties of 54856-23-4, the publication is Sichuan Yixue (2017), 38(3), 332-334, database is CAplus.

Objective: To observe and evaluate the clin. effect of vestibular rehabilitation training combined with drug therapy in the treatment of vestibular neuritis. Methods: 30 cases of vestibular neuritis diagnosed during hospital stay between Sept. 2014 and Sept. 2015 in our department were included. 15 patients in exptl. group received vestibular rehabilitation training combined with drug therapy and 15 patients in control group only received drug therapy. Dizziness Handicap Inventory (DHI) scores on admission and 4 wk after onset of exptl. group and control group were compared. Results: Difference of DHI scores on admission between the two groups was not statistically significant (P>0.05). Both in two groups, differences of DHI scores before and after treatment were statistically significant (P<0.05). After 1 mo of treatment, comparing the differences of DHI scores in the two groups, the difference being statistically significant (P<0.05). Conclusion: Vestibular rehabilitation training combined with drug therapy can improve the prognosis of patients with vestibular neuritis.

Sichuan Yixue published new progress about 54856-23-4. 54856-23-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Salt,Amine,Inhibitor,Inhibitor, name is N-Methyl-2-(pyridin-2-yl)ethan-1-amine dimethanesulfonate, and the molecular formula is C10H20N2O6S2, Computed Properties of 54856-23-4.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Li, Zhibin published the artcileSelective electrochemical oxidation of aromatic hydrocarbons and preparation of mono/multi-carbonyl compounds, Recommanded Product: Phenyl(pyridin-2-yl)methanone, the publication is Science China: Chemistry (2021), 64(12), 2134-2141, database is CAplus.

A selective electrochem. oxidation was developed under mild condition. Various mono-carbonyl and multi-carbonyl compounds can be prepared from different aromatic hydrocarbons with moderate to excellent yield and selectivity by virtue of this electrochem. oxidation The produced carbonyl compounds can be further transformed into α-ketoamides, homoallylic alcs. and oximes in a one-pot reaction. In particular, a series of α-ketoamides were prepared in a one-pot continuous electrolysis. Mechanistic studies showed that 2,2,2-trifluoroethan-1-ol (TFE) can interact with catalyst species and generate the corresponding hydrogen-bonding complex to enhance the electrochem. oxidation performance.

Science China: Chemistry published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C12H9NO, Recommanded Product: Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhao, Bing published the artcileDiscovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates, Formula: C12H9NO, the publication is Acta Pharmaceutica Sinica B (2021), 11(1), 203-221, database is CAplus and MEDLINE.

In this study, structure-activity relationship based on thiosemicarbazone derivatives (E)-R¹C(S)NHN=C(R²)(R³) (I) (R¹ = phenylamino, Ph, cyclohexylamino, morpholin-4-yl, etc.; R² = H, Me; R³ = Ph, pyridin-2-yl, 3,4,5-trimethoxyphenyl, etc.) was systematically characterized and their potential activities combined with meropenem (MEM) were evaluated. Compounds (I).HCl [R¹ = piperazin-1-yl, R² = H, R³ = 2-hydroxyphenyl (II); R¹ = 4-methylpiperazin-1-yl, R² = H, R³ = 2-hydroxyphenyl (III)] exhibited excellent activity against 10 NDM-pos. isolate clin. isolates in reversing MEM resistance. Further studies demonstrated that compounds II and III were uncompetitive NDM-1 inhibitors with Ki = 0.63 and 0.44μmol/L, resp. Mol. docking speculated that compounds II and III were most likely to bind in the allosteric pocket which would affect the catalytic effect of NDM-1 on the substrate meropenem. Toxicity evaluation experiment showed that no hemolysis activities were found even at concentrations of 1000 mg/mL against red blood cells. In vivo exptl. results showed that a combination of MEM and compound III was markedly effective in treating infections caused by NDM-1 pos. strain and prolonging the survival time of sepsis mice. The finding showed that compound III might be a promising lead in developing new inhibitor to treat NDM-1 producing superbug.

Acta Pharmaceutica Sinica B published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C4H3Cl2N3, Formula: C12H9NO.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Wang, Lei published the artcileElectrochemical Reduction of Aldehydes and Ketones for the Synthesis of Alcohols and Diols under Ambient Conditions, Safety of Phenyl(pyridin-2-yl)methanone, the publication is Synlett (2022), 33(13), 1302-1308, database is CAplus.

A sustainable, practical, and direct strategy for the reduction of carbonyl compounds, including aldehydes and ketones, by an electrochem. pathway is presented, affording a variety of alcs. or diols as major products with decent yields. The reaction proceeds smoothly in the air at ambient temperatures with DABCO as the sacrificial reductant. Mechanistic studies revealed that direct electrochem. reduction followed by either protonation or radical-radical homocoupling is the main pathway.

Synlett published new progress about 91-02-1. 91-02-1 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene,Ketone, name is Phenyl(pyridin-2-yl)methanone, and the molecular formula is C14H26O2, Safety of Phenyl(pyridin-2-yl)methanone.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Zhang, Yi-Lin published the artcileCellular mechanism underlying the facilitation of contractile response induced by tumor necrosis factor-α in mouse tracheal smooth muscle, Product Details of C17H18N2O6, the publication is American Journal of Pathology (2022), 192(1), 104-111, database is CAplus and MEDLINE.

The proinflammatory cytokine tumor necrosis factor-α (TNF-α) augments intracellular Ca2+ signaling and contractile responses of airway smooth muscles, leading to airway hyperresponsiveness. However, the underlying mechanism has not been fully elucidated. This study aimed to investigate the cellular mechanism of the potentiated contraction of mouse tracheal smooth muscle induced by TNF-α. The results showed that TNF-α triggered facilitation of mouse tracheal smooth muscle contraction in an epithelium-independent manner. The TNF-α-induced hypercontractility could be suppressed by the protein kinase C inhibitor GF109203X, the tyrosine kinase inhibitor genistein, the Src inhibitor PP2, or the L-type voltage-dependent Ca2+ channel blocker nifedipine. Following TNF-α incubation, the α1C L-type Ca2+ channel (CaV1.2) was up-regulated in cultured primary mouse tracheal smooth muscle cells. Pronounced phosphotyrosine levels were observed in mouse tracheas. In conclusion, this study shows that TNF-α enhanced airway smooth muscle contraction via protein kinase C-Src-CaV1.2 pathways, which provides novel insights into the pathol. role of proinflammatory cytokines in mediating airway hyperresponsiveness.

American Journal of Pathology published new progress about 21829-25-4. 21829-25-4 belongs to pyridine-derivatives, auxiliary class Membrane Transporter/Ion Channel,Calcium Channel, name is Dimethyl 2,6-dimethyl-4-(2-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and the molecular formula is C14H10O4S2, Product Details of C17H18N2O6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Guo, Shuangxi published the artcileAg/C nanoparticles catalyzed aerobic oxidation of diaryl and aryl(hetero)methylenes into ketones, Synthetic Route of 197958-29-5, the publication is Nano Research (2017), 10(9), 3261-3267, database is CAplus.

The aerobic oxidation of diaryl and aryl(hetero)methylenes into ketones, catalyzed by Ag/C nanoparticles under mild conditions, was successfully developed. This method features a wide scope of substrates, good yields, and uncomplicated recycling of the catalyst.

Nano Research published new progress about 197958-29-5. 197958-29-5 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester, name is 2-Pyridinylboronic acid, and the molecular formula is C5H6BNO2, Synthetic Route of 197958-29-5.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Jia, Jing-jing published the artcileSynthesis, structure and magnetic analysis of the cobalt polymer based on N-[(3-pyridine)-sulfonyl]aspartate, Product Details of C5H5NO3S, the publication is Chinese Journal of Structural Chemistry (2017), 36(2), 266-272, database is CAplus.

One new cobalt polymer [Co(L)·3H₂O]_n (1, H₂L = N-[(3-pyridine)-sulfonyl]aspartate) has been synthesized and characterized by single-crystal x-ray diffraction and elemental anal. Polymer 1 belongs to the monoclinic system, space group P21/n with a = 11.479(2), b = 7.3180(15), c = 16.424(3) Å, β = 109.56(3) °, V = 1300.1(5) ų, M_r = 385.22, Z = 12, F(000) = 790, S = 1.054, R = 0.0670, wR = 0.1147,(Δρ)_max = 1.158 and (Δρ)_min = -0.754 e/ų. TGA showed that the polymer first lost one coordinated water mol. and then another two coordinated water mols. The values of the Curie and Curie-Weiss constants of polymer 1 are Cm = 2.67 cm³ mol^-1 K and θ = -21.66 K.

Chinese Journal of Structural Chemistry published new progress about 636-73-7. 636-73-7 belongs to pyridine-derivatives, auxiliary class Pyridine,Sulfonic acid, name is Pyridine-3-sulfonic acid, and the molecular formula is C5H5NO3S, Product Details of C5H5NO3S.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Panteleev, Jane published the artcileDomino Rhodium-Catalyzed Alkyne Arylation/Palladium-Catalyzed N Arylation: A Mechanistic Investigation, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid, the publication is Angewandte Chemie, International Edition (2011), 50(39), 9089-9092, S9089/1-S9089/32, database is CAplus and MEDLINE.

We report an example in which two different metals with two different phosphine ligands promote two out of three possible reactions and do so in a time-resolved way, thus leading to an efficient preparation of dihydroquinolines. Importantly, we show that one of the two phosphine ligands is selective in binding to only one of the metals, and the other ligand is nondiscriminating in its binding properties; yet one of the two metal-phosphine complexes is far more reactive and selectivity is observed This study raised the more general question of matching ligands and metals in order to efficiently promote only the desired reaction rather than competing processes. Thus, complex sequences of reactions that contain multiple catalytically active species can ultimately be created in a single reaction vessel.

Angewandte Chemie, International Edition published new progress about 612845-44-0. 612845-44-0 belongs to pyridine-derivatives, auxiliary class Pyridine,Boronic acid and ester,Ether,Boronic Acids,Boronic acid and ester, name is (6-Ethoxypyridin-3-yl)boronic acid, and the molecular formula is C7H10BNO3, Recommanded Product: (6-Ethoxypyridin-3-yl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Liao, Lihao published the artcileSelenium-π-Acid Catalyzed Oxidative Functionalization of Alkynes: Facile Access to Ynones and Multisubstituted Oxazoles, Application In Synthesis of 107263-95-6, the publication is ACS Catalysis (2018), 8(7), 6745-6750, database is CAplus.

In the presence of di-Ph diselenide, N-fluoropyridinium triflates, and water, propargyl phosphonates such as PhCCCH₂P(:O)(OEt)₂ and β,γ-alkynoates underwent regioselective oxidation to yield γ-ketoalkynyl phosphonates such as PhCOCCP(:O)(OEt)₂ and γ-keto-α,β-alkynoates. Ynamides such as PhCCN(CH₂Ph)R (R = MeSO₂, PhSO₂, 4-MeC₆H₄SO₂, 4-O₂NC₆H₄) underwent regioselective oxidative cycloadditions with acetonitrile or butanenitrile mediated by Selectfluor in the presence of di-Ph selenide to yield aminooxazoles such as I (R = MeSO₂, PhSO₂, 4-MeC₆H₄SO₂, 4-O₂NC₆H₄). N-Propargylamides underwent oxidative cyclization in the presence of di-Ph diselenide and mediated by Selectfluor to give 2-substituted-5-oxazolecarboxaldehydes. In all cases, the reactions are likely to involve the reactions of cationic phenylselenium species with alkynes to generate vinylselenium cations. The mechanism of the reactions were studied; vinyl selenides were prepared by reactions of phenylselenium triflate with propargyl phosphonates and ynamides and shown to yield the observed ketone and oxazole products upon elimination, while isotopic labeling experiments were undertaken to determine the fate of added water.

ACS Catalysis published new progress about 107263-95-6. 107263-95-6 belongs to pyridine-derivatives, auxiliary class Fluorination reagent, name is 1-Fluoropyridiniumtriflate, and the molecular formula is C6H5F4NO3S, Application In Synthesis of 107263-95-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem

Cao, Jingyi published the artcilePreparation and property of environmental friendly copper-free self-polishing antifouling coatings, COA of Formula: C23H20BN, the publication is Tuliao Gongye (2015), 45(3), 33-36, database is CAplus.

Title coatings were prepared from zinc-acrylate polymer as matrix, pyrithione zinc (ZnPT) and pyridine tri-Ph borane (PK) as biocides and other pigments. The basic properties of the antifouling coatings with different organic biocides are studied. Meanwhile, the antifouling property of the prepared coatings has been compared with that of the similar imported product via offshore immersion test. The title coatings comprising ZnPT and PK at mass ratio of 6:4 can exhibit excellent antifouling property.

Tuliao Gongye published new progress about 971-66-4. 971-66-4 belongs to pyridine-derivatives, auxiliary class Pyridine,Benzene, name is Triphenyl(pyridin-1-ium-1-yl)borate, and the molecular formula is C23H20BN, COA of Formula: C23H20BN.

Referemce:
https://en.wikipedia.org/wiki/Pyridine,
Pyridine | C5H5N – PubChem