Day: December 30, 2022

Synthesis of the mutagenic 2-amino-1,6-dimethylimidazo[4,5-b]pyridine (1,6-DMIP) and five of its isomers was written by Lindstroem, Stefan;Ahmad, Tania;Grivas, Spiros. And the article was included in Heterocycles in 1994.Formula: C6H6N2O3 This article mentions the following:

Synthetic routes to 2-amino-1,6(1,5-, 1,7)-dimethylimidazo[4,5-b]pyridine I (R = Me), and its 3,5-, 3,6- and 3,7-di-Me isomers II (R = Me) from Me derivatives of 3-hydroxy- or 2-aminopyridine and 2-chloronicotinic acid are described. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2Formula: C6H6N2O3).

3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C6H6N2O3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Proton affinities of candidates for positively charged ambient ions in boreal forests was written by Ruusuvuori, K.;Kurten, T.;Ortega, I. K.;Faust, J.;Vehkamaki, H.. And the article was included in Atmospheric Chemistry and Physics in 2013.Product Details of 644-98-4 This article mentions the following:

The optimized structures and proton affinities of a total of 81 nitrogen-containing bases, chosen based on field measurements of ambient pos. ions, were studied using the CBS-QB3 quantum chem. method. The results were compared to values given in the National Institute of Standards and Technol. (NIST) Chem. WebBook in cases where a value was listed. The computed values show good agreement with the values listed in NIST. Grouping the mols. based on their mol. formula, the largest calculated proton affinities for each group were also compared with exptl. observed ambient cation concentrations in a boreal forest. This comparison allows us to draw qual. conclusions about the relative ambient concentrations of different nitrogen-containing organic base mols. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Product Details of 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Product Details of 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of novel tetrahydroisoquinoline bronchodilators was written by Dalence-Guzman, Maria F.;Toftered, Joergen;Oltner, Viveca Thornqvist;Wensbo, David;Johansson, Martin H.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2010.Name: 2-Bromo-5-(methylsulfonyl)pyridine This article mentions the following:

The synthesis and bronchorelaxing effects of a series of novel tetrahydroisoquinoline amides are described. The compounds were evaluated for their ability to relax LTD₄ contracted isolated human small airways ex-vivo. Several compounds demonstrated highly efficacious bronchorelaxing properties. Cinnamide I was selected for further studies and constitutes a promising candidate as a novel bronchorelaxing agent for the treatment of pulmonary disorders. In the experiment, the researchers used many compounds, for example, 2-Bromo-5-(methylsulfonyl)pyridine (cas: 343262-51-1Name: 2-Bromo-5-(methylsulfonyl)pyridine).

2-Bromo-5-(methylsulfonyl)pyridine (cas: 343262-51-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Name: 2-Bromo-5-(methylsulfonyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chemical shift of meso-carbon: a powerful probe to determine the coordination structure and electron configuration of ferric porphyrin complexes was written by Nakamura, Mikio;Hoshino, Akito;Ikezaki, Akira;Ikeue, Takahisa. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2003.HPLC of Formula: 3718-65-8 This article mentions the following:

The meso-¹³C chem. shifts were revealed to serve as a powerful probe to determine the coordination structure (five vs. six coordinate) and electron configuration (high spin vs. low spin) of ferric porphyrin complexes. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8HPLC of Formula: 3718-65-8).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.HPLC of Formula: 3718-65-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The marine mammal class II major histocompatibility complex organization was written by de Sa, Andre Luiz Alves;Breaux, Breanna;Burlamaqui, Tiberio Cesar Tortola;Deiss, Thaddeus Charles;Sena, Leonardo;Criscitiello, Michael Frederick;Schneider, Maria Paula Cruz. And the article was included in Frontiers in Immunology in 2019.Safety of 1-Dodecylpyridin-1-ium bromide This article mentions the following:

This study aims to characterize the organization of the marine mammal class II MHC using publicly available genomes. We located class II sequences in the genomes of one sirenian, four pinnipeds and eight cetaceans using NCBI-BLAST and reannotated the sequences using local BLAST search with exon and intron libraries. The manatee class II region shares overall synteny with other mammals, however most DR loci were translocated from the canonical location, past the extended class II region. Detailed anal. of the genomes of closely related taxa revealed that this presumed translocation is shared with all other living afrotherians. Other presumptive chromosome rearrangements in Afrotheria are the deletion of DQ loci in Afrosoricida and deletion of DP in E. telfairi. All cetaceans share the Cetartiodactyla inversion separating class II genes into two subregions: class IIa, with DR and DQ genes, and class IIb, with non-classic genes and a DRB pseudogene. These results point to three distinct and unheralded class II MHC structures in marine mammals: one canonical organization but lacking DP genes in pinnipeds; one bearing an inversion separating IIa and IIb subregions lacking DP genes found in cetaceans; and one with a translocation separating the most diverse class II gene from the MHC found in afrotherians and presumptive functional DR, DQ, and DP genes. Future functional research will reveal how these aquatic mammals cope with pathogen pressures with these divergent MHC organizations. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Safety of 1-Dodecylpyridin-1-ium bromide).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 1-Dodecylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Palladium-Catalyzed Methoxycarbonylation of 1,3-Butadiene to Methyl-3-Pentenoate: Introduction of a Continuous Process was written by Han, Li-Jun;Rao, Chong-Shun;Ma, Shuang-Shuang;Sheng, Gui-Yang;Zhang, Jun-Ping;Xu, Bao-Hua. And the article was included in Journal of Catalysis in 2021.Application In Synthesis of 4-Hexylpyridine This article mentions the following:

The base-assisted Pd(cod)Cl₂/xantphos-catalyzed methoxycarbonylation of 1,3-butadiene (BD) to methyl-3-pentenoate (MP) was explored. Mechanistic studies suggested excessive xantphos (beyond an equimolar amount per Pd) as well as its substitute, pyridines of proper steric and electronic functionality, do participate catalytic cycle and significantly reduce activation energy by accelerating rate-limiting methanolysis step. As thus, all reaction parameters, especially solvents, were optimized based on Pd(cod)Cl₂/Xantphos/4-hexylpyridine catalytic system, enabling construction of a continuous process. Systematic optimization demonstrated that a yield of 82% of MP with a purity of 99.8% could be reached under steady-state operation. In the experiment, the researchers used many compounds, for example, 4-Hexylpyridine (cas: 27876-24-0Application In Synthesis of 4-Hexylpyridine).

4-Hexylpyridine (cas: 27876-24-0) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 4-Hexylpyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Switchable (pH-driven) aqueous biphasic systems formed by ionic liquids as integrated production-separation platforms was written by Ferreira, Ana M.;Claudio, Ana Filipa M.;Valega, Monica;Domingues, Fernando M. J.;Silvestre, Armando J. D.;Rogers, Robin D.;Coutinho, Joao A. P.;Freire, Mara G.. And the article was included in Green Chemistry in 2017.Name: 1-Butyl-3-methylpyridinium Chloride This article mentions the following:

The ability to induce reversible transitions between homogeneous solutions and biphasic systems is of paramount relevance in separation processes. In this context, pH-triggered aqueous biphasic systems composed of ionic liquids and salts are here disclosed as switchable mono/biphasic systems, and their potential application is further demonstrated through an integrated approach comprising both the production and separation of hydroxymethylfurfural from fructose. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Name: 1-Butyl-3-methylpyridinium Chloride).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Name: 1-Butyl-3-methylpyridinium Chloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery, design and synthesis of novel potent and selective sphingosine-1-phosphate 4 receptor (S1P₄-R) agonists was written by Guerrero, Miguel;Urbano, Mariangela;Zhao, Jian;Crisp, Melissa;Chase, Peter;Hodder, Peter;Schaeffer, Marie-Therese;Brown, Steven;Rosen, Hugh;Roberts, Edward. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Recommanded Product: 6602-33-1 This article mentions the following:

High affinity and selective small mol. agonists of the S1P₄ receptor (S1P₄-R) may have significant therapeutic utility in diverse disease areas including autoimmune diseases, viral infections and thrombocytopenia. A high-throughput screening (HTS) of the Mol. Libraries-Small Mol. Repository library identified 3-(2-(2,4-dichlorophenoxy)ethoxy)-6-methyl-2-nitropyridine (I) as a moderately potent and selective S1P₄-R hit agonist. Design, synthesis and systematic structure-activity relationships study of the HTS-derived hit led to the development of novel potent S1P₄-R agonists exquisitely selective over the remaining S1P_1-3,5-Rs family members. Remarkably, the mols. herein reported provide novel pharmacol. tools to decipher the biol. function and assess the therapeutic utility of the S1P₄-R. In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1Recommanded Product: 6602-33-1).

2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 6602-33-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Design, synthesis and antimycobacterial activity of novel nitrobenzamide derivatives was written by Wang, Hongjian;Lv, Kai;Li, Xiaoning;Wang, Bo;Wang, Apeng;Tao, Zeyu;Geng, Yunhe;Wang, Bin;Huang, Menghao;Liu, Mingliang;Guo, Huiyuan;Lu, Yu. And the article was included in Chinese Chemical Letters in 2019.Recommanded Product: 3939-12-6 This article mentions the following:

A series of nitrobenzamide derivatives containing N-benzyl or N-pyridinylmethyl moieties I [R = H, 5-CF₃, 5-F, etc.; R¹ = F, 4-chloro-1-piperidyl, 4-(4-fluorophenyl)piperazin-1-yl, etc.; X = Y = CH; X = CH, Y = N; X = N, Y = CH] was designed and synthesized as new anti-tubercular agents. Many of synthesized compounds I exhibited potent in vitro antitubercular activity. Four compounds I [R = 5-NO₂; R¹ = 4-MeO, 4-(trifluoromethyl)-1-piperidyl, 4-chloro-1-piperidyl, 4-(4-fluorophenyl)piperazin-1-yl] had not only the same excellent MIC values against both drug-sensitive MTB strain H37Rv and two drug-resistant clin. isolates as PBTZ169 and the lead I [R = 5-NO₂; R¹ = 4-(trifluoromethyl)-1-piperidyl; X = Y = CH], but also acceptable safety indexes. In the experiment, the researchers used many compounds, for example, 6-Fluoronicotinonitrile (cas: 3939-12-6Recommanded Product: 3939-12-6).

6-Fluoronicotinonitrile (cas: 3939-12-6) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Recommanded Product: 3939-12-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Desymmetrization of myo-inositol derivatives by lanthanide catalyzed phosphitylation with C₂-symmetric phosphites was written by Duss, Michael;Capolicchio, Samanta;Linden, Anthony;Ahmed, Nisar;Jessen, Henning J.. And the article was included in Bioorganic & Medicinal Chemistry in 2015.COA of Formula: C5H6ClN This article mentions the following:

Desymmetrization by phosphorylation represents a promising method with potential impact in many different areas of research. C₂-Sym. phosphoramidites have been used to desymmetrize myo-inositol derivatives by functionalization at different positions. With this method, 1:1 mixtures of diastereomers are obtained that can be separated subsequently. In this work, activation of a C₂-sym. phosphoramidite is achieved by addition of pentafluorophenol (PFP) and leads to a reactive PFP phosphite, which can then be coupled to protected myo-inositol derivatives with reactive OH groups at the 1, 3, 4 and 6 positions. This strategy enhances the diastereoselectivity of the coupling reaction with a preference towards phosphitylation at position 6 (up to 3:1) or position 3 (up to 2:1). The concept of activation of phosphoramidites via in situ generated pentafluorophenol phosphite triesters is thus proven in these studies. It is further shown that Lewis-Acid catalysis enhances the rate of phosphite triester coupling without affecting the diastereoselectivity. This novel strategy improves access to different phosphorylated myo-inositol derivatives and will thus enable further studies into the function of these important intracellular second messengers. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7COA of Formula: C5H6ClN).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.COA of Formula: C5H6ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem