Month: December 2022

Physicochemical and Electronic Properties of Cationic [6]Helicenes: from Chemical and Electrochemical Stabilities to Far-Red (Polarized) Luminescence was written by Bosson, Johann;Labrador, Geraldine M.;Pascal, Simon;Miannay, Francois-Alexandre;Yushchenko, Oleksandr;Li, Haidong;Bouffier, Laurent;Sojic, Neso;Tovar, Roberto C.;Muller, Gilles;Jacquemin, Denis;Laurent, Adele D.;Le Guennic, Boris;Vauthey, Eric;Lacour, Jerome. And the article was included in Chemistry – A European Journal in 2016.Related Products of 628-13-7 This article mentions the following:

The physicochem. properties of cationic dioxa (1), azaoxa (2), and diaza (3) [6]helicenes demonstrate a much higher chem. stability of the diaza adduct 3 (pK_R+=20.4, Ered1/2=-0.72 V) compared to its azaoxa 2 (pK_R+=15.2, Ered1/2=-0.45 V) and dioxa 1 (pK_R+=8.8, Ered1/2=-0.12 V) analogs. The fluorescence of these cationic chromophores is established, and ranges from the orange to the far-red regions. From 1 to 3, a bathochromic shift of the lowest energy transitions (up to 614 nm in acetonitrile) and an enhancement of the fluorescence quantum yields and lifetimes (up to 31 % and 9.8 ns, resp., at 658 nm) are observed The triplet quantum yields and circularly polarized luminescence are also reported. Finally, fine tuning of the optical properties of the diaza [6]helicene core is achieved through selective and orthogonal post-functionalization reactions (12 examples, compounds 4-15). The electronic absorption is modulated from the orange to the far-red spectral range (560-731 nm), and fluorescence is observed from 591 to 755 nm with enhanced quantum efficiency up to 70 % (619 nm). The influence of the peripheral auxochrome substituents is rationalized by first-principles calculations In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Related Products of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Related Products of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Controlled Oxygen Release from Pyridone Endoperoxides Promotes Cell Survival under Anoxic Conditions was written by Benz, Sebastian;Notzli, Sarah;Siegel, Jay S.;Eberli, Daniel;Jessen, Henning J.. And the article was included in Journal of Medicinal Chemistry in 2013.Recommanded Product: 3,5-Dimethylpyridine 1-oxide This article mentions the following:

In tissue engineering, survival of larger constructs remains challenging due to limited supply of oxygen caused by a lack of early vascularization. Controlled release of oxygen from small organic mols. represents a possible strategy to prevent cell death under anoxic conditions. A comprehensive study of methylated pyridone-derived endoperoxides has led to the development of water-soluble mols. that undergo retro-Diels-Alder reactions in aqueous environment releasing oxygen in high yield and with half-lives of up to 13 h. These mols. in combination with vitamin C as singlet oxygen quencher significantly improved survival of 3T3 fibroblasts and rat smooth muscle cells challenged with oxygen-depleted conditions. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Recommanded Product: 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Palladium-Catalyzed Regioselective C-H Acetoxylation of 2-Aryloxypyridines with 2-Pyridyloxy as a Removable Directing Group was written by Wang, Liang;Pan, Liang;Huang, Yibo;Chen, Qun;He, Mingyang. And the article was included in European Journal of Organic Chemistry in 2016.Quality Control of 2-Phenoxypyridine This article mentions the following:

A simple and regioselective palladium-catalyzed ortho-C(sp²)-H acetoxylation of 2-aryloxypyridines with PhI(OAc)₂ as both the oxidant and acetate source has been developed. The mono- and di-acetoxylated products can be achieved by tuning the equivalent of PhI(OAc)₂ and the reaction temperature A wide range of 2-aryloxypyridines is tolerated. Moreover, 2-pyridyloxyl and acetyl groups can be easily removed, which provides straightforward access to poly-substituted phenols. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Quality Control of 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Quality Control of 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Significant influence of particular unsaturated fatty acids and pH on the volatile compounds in meat-like model systems was written by Van Ba, Hoa;Amna, Touseef;Hwang, Inho. And the article was included in Meat Science in 2013.Formula: C11H9NO This article mentions the following:

The present study aimed to investigate the effects of particular unsaturated fatty acids and pH on volatile compounds in the meat-like model systems containing 21 amino acids and ribose. We have chosen oleic acid (C18:1n-9), linoleic acid (C18:2n-6) and linolenic acid (C18:3n-3) for the present investigation. The effect on the volatile compounds was evaluated at two different pH 5.5 and 6.2. The addition of C18:2n-6 and C18:3n-3 to the Maillard reaction mixtures inhibited the formation of many Maillard compounds or produced in low amount Whereas, the addition of C18:1n-9 resulted in an increase in the amount of many Maillard compounds The thiols and thiophenes were preferentially formed at pH 5.5 whereas pyrazines were preferentially favored at pH 6.2. Based on our results, it is suggested that a high level of C18:2n-6 and C18:3n-3 in meat probably causes an undesirable flavor. The pH value of 5.5 was found to be ideal for the formation of volatile compounds associated with desirable flavor of meat. In the experiment, the researchers used many compounds, for example, 5-Phenylpyridin-2-ol (cas: 76053-45-7Formula: C11H9NO).

5-Phenylpyridin-2-ol (cas: 76053-45-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Formula: C11H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Human carbonic anhydrase II as host protein for the creation of artificial metalloenzymes: the asymmetric transfer hydrogenation of imines was written by Monnard, Fabien W.;Nogueira, Elisa S.;Heinisch, Tillmann;Schirmer, Tilman;Ward, Thomas R.. And the article was included in Chemical Science in 2013.COA of Formula: C6H6BrNO This article mentions the following:

In the presence of human carbonic anhydrase II, aryl-sulfonamide-bearing IrCp* pianostool complexes catalyze the asym. transfer hydrogenation of imines. Critical cofactor-protein interactions revealed by the x-ray structure of [(η⁵-Cp*)Ir(pico 4)Cl] 9 ⊂ WT hCA II were genetically optimized to improve the catalytic performance of the artificial metalloenzyme (68% ee, k_cat/K_m 6.11 × 10^-3 min^-1 mM^-1). In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0COA of Formula: C6H6BrNO).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.COA of Formula: C6H6BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chiral Hexahalogenated 4,4′-Bipyridines was written by Mamane, V.;Peluso, P.;Aubert, E.;Cossu, S.;Pale, P.. And the article was included in Journal of Organic Chemistry in 2016.SDS of cas: 13472-81-6 This article mentions the following:

The preparation of 27 isomers of chiral hexahalogeno-4,4′-bipyridines by means of two complementary methods is described. The first one is convergent and based on the LDA-induced 4,4′-dimerization of trihalopyridines, whereas the second method is divergent and achieved through regioselective halogenation reactions of 4,4′-bipyridine-2,2′-diones. Iodine in 2,2′-positions of the 4,4′-bipyridines was introduced by a copper-catalyzed Finkelstein reaction (Buchwald procedure) performed on 2,2′-dibromo derivatives Selected compounds of this new family of atropisomeric 4,4′-bipyridines were enantiosepd. by high performance liquid chromatog. on chiral stationary phases, and the absolute configurations of the separated enantiomers were assigned by using X-ray diffraction anal. The latter revealed that various halogen bond types are responsible for crystal cohesion. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6SDS of cas: 13472-81-6).

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 13472-81-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rhodium(III)-catalyzed sp² C-H bond addition to CF₃-substituted unsaturated ketones was written by Jiang, Quanbin;Guo, Tenglong;Wu, Kaikai;Yu, Zhengkun. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2016.Formula: C12H11N This article mentions the following:

Rhodium(III)-catalyzed conjugate addition of aromatic and olefinic C-H bonds to CF₃-substituted unsaturated ketones was efficiently achieved. Both arene and olefin substrates bearing a chelate assisted-directing group were coupled with a variety of β-trifluoromethyl-α,β-unsaturated ketones with excellent atom-economy, high yields and broad substrate scopes. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Formula: C12H11N).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Formula: C12H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Simple Surfactant Concentration-Dependent Shape Control of Polyhedral Fe₃O₄ Nanoparticles and Their Magnetic Properties was written by Ge, Wanyin;Sato, Ryota;Wu, Hsin-Lun;Teranishi, Toshiharu. And the article was included in ChemPhysChem in 2015.COA of Formula: C5H6ClN This article mentions the following:

The shape and size of monodisperse Fe₃O₄ nanoparticles (NPs) are controlled using a chem. solution synthesis in the presence of the surfactant cetylpyridinium chloride (CPC). Cubic Fe₃O₄ NPs surrounded by six {100} planes were obtained in the absence of CPC. Increasing the CPC content during synthesis causes the shape of the resulting Fe₃O₄ NPs to change from cubic to truncated cubic, cuboctahedral, truncated octahedral, and finally octahedral. During this evolution, the predominantly exposed planes of the Fe₃O₄ NPs vary from {100} to {111}. The shape control results from the synergistic effect of the pyridinium cations, chloride anions, and long-chain alkyl groups of CPC, which is confirmed by comparison with NPs synthesized in the presence of various related cationic surfactants. The size of the cubic Fe₃O₄ NPs can be tuned from 50 to 200 nm, by changing the concentration of oleic acid in the reaction solution The Fe₃O₄ NPs exhibit shape-dependent saturation magnetization, remanent magnetization, and coercivity. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7COA of Formula: C5H6ClN).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.COA of Formula: C5H6ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of N-Aryl Piperazines as Selective mGluR₅ Potentiators with Improved In Vivo Utility was written by Zhou, Ya;Manka, Jason T.;Rodriguez, Alice L.;Weaver, C. David;Days, Emily L.;Vinson, Paige N.;Jadhav, Satyawan;Hermann, Elizabeth J.;Jones, Carrie K.;Conn, P. Jeffrey;Lindsley, Craig W.;Stauffer, Shaun R.. And the article was included in ACS Medicinal Chemistry Letters in 2010.SDS of cas: 175205-82-0 This article mentions the following:

This letter describes the discovery, structure-activity relation, and in vitro and in vivo pharmacol. profile of a novel non-MPEP-derived mGluR₅ pos. allosteric modulator (PAM) based upon an N-aryl piperazine chemotype. This mGluR₅ chemotype exhibits the ability to act as either a noncompetitive antagonist/neg. allosteric modulator or a potentiator of the glutamate response, depending on the identity of the amide substituent, i.e., a “mol. switch”. A rapidly optimized PAM, 10e (VU0364289), was shown to be potent and specific for the rat mGluR₅ receptor and subsequently demonstrated to be efficacious in a clin. relevant rodent model predictive of antipsychotic activity, thus providing the first example of a centrally active mGluR₅ PAM optimized from an HTS-derived mGluR₅ noncompetitive antagonist. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0SDS of cas: 175205-82-0).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.SDS of cas: 175205-82-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A novel and robust heterogeneous Cu catalyst using modified lignosulfonate as support for the synthesis of nitrogen-containing heterocycles was written by Lai, Bingbing;Ye, Meng;Liu, Ping;Li, Minghao;Bai, Rongxian;Gu, Yanlong. And the article was included in Beilstein Journal of Organic Chemistry in 2020.SDS of cas: 4373-61-9 This article mentions the following:

A waste biomass, sodium lignosulfonate, was treated with sodium 2-formylbenzenesulfonate, and the phenylaldehyde condensation product was then used as a robust supporting material to immobilize a copper species. The so-obtained catalyst was characterized by many physicochem. methods including FTIR, EA, FSEM, FTEM, XPS, and TG. This catalyst exhibited excellent catalytic activity in the synthesis of nitrogen-containing heterocycles such as tricyclic indoles bearing 3,4-fused seven-membered rings, 2-arylpyridines, aminonaphthalenes and 3-phenylisoquinolines. In addition, this catalyst showed to be recyclable and could be reused several times without significant loss in activity during the course of the reaction process. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9SDS of cas: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.SDS of cas: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem