Month: December 2022

An efficient one-pot synthesis of industrially valuable primary organic carbamates and N-substituted ureas by a reusable Merrifield anchored iron(II)-anthra catalyst [Fe^II(Anthra-Merf)] using urea as a sustainable carbonylation source was written by Basu, Priyanka;Dey, Tusar Kanto;Ghosh, Aniruddha;Biswas, Surajit;Khan, Aslam;Islam, Sk. Manirul. And the article was included in New Journal of Chemistry in 2020.Name: Pyridin-4-ol This article mentions the following:

An efficient synthesis of primary carbamates and N-substituted ureas is explored with a newly developed heterogeneous polymer supported iron catalyst in the presence of a sustainable carbonylation source. The Merrifield anchored iron(II)-anthra catalyst [FeII(Anthra-Merf)] was synthesized by functionalization of Merrifield polymer followed by grafting of iron metal. The catalyst [FeII(Anthra-Merf)] was characterized by several techniques, like SEM, EDAX, TGA, PXRD, XPS, FTIR, CHN, AAS and UV-Vis anal. The designed polymer embedded [FeII(Anthra-Merf)] complex is a remarkably successful catalyst for the synthesis of primary organic carbamates and N-substituted ureas by using safe carbonylation agent urea with different derivatives of alcs. and amines, resp. The reported catalyst is a potential candidate towards contributing a satisfactory yield of isolated products under suitable reaction conditions. The catalyst is recyclable and almost non-leaching in nature after six runs with an insignificant drop in catalytic activity. Thus we found an economical and viable catalyst [FeII(Anthra-Merf)] for primary carbamates and N-substituted urea synthesis under moderate reaction conditions. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Name: Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Name: Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Trisubstituted thiazoles as potent and selective inhibitors of Plasmodium falciparum protein kinase G (PfPKG) was written by Tsagris, Denise J.;Birchall, Kristian;Bouloc, Nathalie;Large, Jonathan M.;Merritt, Andy;Smiljanic-Hurley, Ela;Wheldon, Mary;Ansell, Keith H.;Kettleborough, Catherine;Whalley, David;Stewart, Lindsay B.;Bowyer, Paul W.;Baker, David A.;Osborne, Simon A.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2018.Product Details of 214834-18-1 This article mentions the following:

A series of trisubstituted thiazoles have been identified as potent inhibitors of Plasmodium falciparum (Pf) cGMP-dependent protein kinase (PfPKG) through template hopping from known Eimeria PKG (EtPKG) inhibitors. The thiazole series has yielded compounds with improved potency, kinase selectivity and good in vitro ADME properties. These compounds could be useful tools in the development of new anti-malarial drugs in the fight against drug resistant malaria. In the experiment, the researchers used many compounds, for example, tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1Product Details of 214834-18-1).

tert-Butyl 4-carbamothioylpiperidine-1-carboxylate (cas: 214834-18-1) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Product Details of 214834-18-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Push-Pull Stabilization of Parent Monochlorosilylenes was written by Hickox, Hunter P.;Wang, Yuzhong;Xie, Yaoming;Wei, Pingrong;Schaefer, Henry F.;Robinson, Gregory H.. And the article was included in Journal of the American Chemical Society in 2016.Recommanded Product: 628-13-7 This article mentions the following:

While reaction of carbene-stabilized disilicon LSi:SiL (L: = C{N(2,6-ⁱPr₂C₆H₃)CH}₂) (8) with HCl·NC₅H₅ results in carbene-stabilized Si₂Cl₂ (2) and substituted 1H-imidazole (9), combination of the corresponding Fe(CO)₄-modified disilicon carbene complex LSi:Si[Fe(CO)₄]L (6) with pyridine hydrochloride gives a species containing two push-pull-stabilized parent monochlorosilylenes that are bridged by an Fe(CO)₃ unit (7). The nature of 7 was further elucidated by spectroscopic, crystallog., and computational methods. Spectroscopic data suggest that 7 exists as two diastereoisomers. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Recommanded Product: 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Loss of isocyanic acid from the internal oxadiazole ring of protonated molecules of some 2,5-diaryl-1,3,4-oxadiazoles was written by Franski, Rafal;Schroeder, Grzegorz;Rybachenko, Volodymir;Szwajka, Oles P.. And the article was included in Rapid Communications in Mass Spectrometry in 2002.Formula: C12H8N4O This article mentions the following:

The fragmentation pattern of some protonated 2,5-diaryl-1,3,4-oxadiazoles is discussed. An unusual decomposition consisting of elimination of the isocyanic acid mol. from the internal oxadiazole ring was found. This fragmentation pathway was deduced on the basis of B/E linked scan mass spectra of metastable ions with liquid secondary ion mass spectrometry as the ionization method and also of low-energy CID mass spectra where electrospray was used as the ionization technique. High resolution measurements were also performed. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Formula: C12H8N4O).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Formula: C12H8N4O

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Production of furan compounds from Cryptomeria japonica using pyridinium chloride under various conditions was written by Yoshioka, Koichi;Yamada, Tatsuhiko;Ohno, Hiroyuki;Miyafuji, Hisashi. And the article was included in BioResources in 2018.Formula: C5H6ClN This article mentions the following:

Cryptomeria japonica was treated with pyridinium chloride ([Py]Cl)-water mixtures under various conditions to determine the optimum conditions for efficient production of furan compounds, such as 2-hydroxyacetylfuran (2- HAF), 5-hydroxymethylfurfural (5-HMF), and furfural. The maximum total yield of furan compounds, i.e., 9.24 weight%, was obtained by the treatment of C. japonica with a 90% [Py]Cl and 10% water (weight/weight) solution for 30 min at 120 °C with a sample loading of 6 weight%. The highest yield of 2-HAF from C. japonica was obtained by treatment for 3 min at 160 °C without the addition of water, although the total yield of furan compounds was lower than that obtained under the optimum treatment conditions. Scale-up of this process for efficient production of furan compounds from C. japonica was successfully performed under the optimum treatment conditions. In addition, the yields of 2-HAF and 5-HMF increased when ball-milled C. japonica containing low-crystallinity cellulose was treated under the optimum conditions. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Formula: C5H6ClN).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Formula: C5H6ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Purification of vitamins from tomatoes (Solanum lycopersicum) using ethanolic two-phases systems based on ionic liquids and polypropylene glycol was written by Lima, Thailan Souza Pereira;Borges, Milena Morgado;Buarque, Filipe Smith;Souza, Ranyere Lucena de;Soares, Cleide Mara Faria;Lima, Alvaro Silva. And the article was included in Fluid Phase Equilibria in 2022.Computed Properties of C10H16ClN This article mentions the following:

Tomatoes (Solanum lycopersicum) represent the second most produced and consumed vegetable crop in the world and can be considered a source of various nutrients, such as minerals, fiber, phenolic compounds, and vitamins A (precursors: β-carotene) and E (α -tocopherol). The actions of vitamins in the regulation of biol. functions and disease prevention have encouraged the food, cosmetic and pharmaceutical industries to formulate new products. In this sense, extraction procedures integrated with purification protocols should be increasingly considered. This work aims to extract β-carotene and α-tocopherol from tomatoes using ethanol followed by an integrated purification procedure in ethanolic two-phase systems (ETPSs). Initially, phase diagrams for systems based on polypropylene glycol (PPG) + ionic liquids (IL) + ethanol were constructed at 298.15 ± 1.00 K and 0.10 ± 0.01 MPa. The driving force for phase separation is the hydrophilic/hydrophobic balance between the constituents of the system, with the largest biphasic region formed by PPG with a higher mol. weight (PPG 4000), IL formed by short alkyl chain cations, the pyridinium family [C₂mpyr]⁺, and anion [CH₃SO₃]^–. The partitioning of β-carotene and α-tocopherol (pure mols.) was selective with preferential migration of β-carotene to the bottom phase (IL-rich), while α-tocopherol migrated preferentially to the top phase (PPG-rich). In real systems using tomatoes and the best condition of the model system formed by PPG-4000 (18.04 wt%) + [C₂mim]Cl (45.56 wt%) and ethanol (36.04 wt%), the partitioning was similar, and the purity was 2.82-fold for β-carotene in the bottom phase and 171.89-fold for α-tocopherol in the top phase. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Computed Properties of C10H16ClN).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Computed Properties of C10H16ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Biological activities and synergistic effects of Elsholtzia stauntoni essential oil from flowers and leaves and their major constituents against Tribolium castaneum was written by Liang, Junyu;Ning, Anqi;Lu, Peiyu;An, Yue;Wang, Zuoliang;Zhang, Ji;He, Chunyu;Wang, Yongfeng. And the article was included in European Food Research and Technology in 2021.Product Details of 626-64-2 This article mentions the following:

Stored-product pests are a major problem in food production and storage. Essential oils (EOs) have been reported to have a wide range of insecticidal activities. In this study, the EOs of flowers and leaves from Elsholtzia stauntoni were analyzed for their chem. composition by GC-MS. The two EOs and their two common main components (cuminol and caryophyllene) were evaluated for their bioactivities against T. castaneum adults. Results of GC-MS anal. indicated that the chem. composition of EOs of flowers and leaves from E. stauntoni had certain similarity and diversity. The two same major components of EOs of flowers and leaves were cuminol (27.81% and 27.62%, resp.) and caryophyllene (5.78% and 10.95%, resp.). The results of bioassays indicated that the EOs of flowers and leaves possessed obvious contact toxicities (LD₅₀ = 19.05 and 18.75μg/Adult, resp.) and repellent activities against T. castaneum. In addition, the EOs of flowers (LC₅₀ = 16.26 mg/L Air) showed the higher fumigant toxicity than that of leaves (LC₅₀ = 44.42 mg/L Air). Cuminol and caryophyllene exhibited contact toxicity and repellency against T. castaneum, but showed no fumigant toxicity. In particular, cuminol was still significantly repellent to T. castaneum within the testing concentration range of 78.63-0.13 nL/cm² after 48 h. Furthermore, cuminol and caryophyllene exhibited synergistic contact activity against T. castaneum in all exptl. ratios. Altogether, it suggests that EOs of E. stauntoni and their two major monomers have promising potential to serve as bio-insecticides for controlling T. castaneum. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Product Details of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Product Details of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

2-Carboxamido-6-(1H-pyrazol-3-yl)-pyridines as ligands for efficient separation of americium(III) from europium(III) was written by Song, Lianjun;Wang, Xueyu;Wang, Dongqi;Xiao, Qian;Xu, Haowei;Li, Qiuju;He, Lanlan;Ding, Songdong. And the article was included in Separation and Purification Technology in 2021.Recommanded Product: 6-Acetylpicolinic acid This article mentions the following:

The synthesis, Eu³⁺ complexation, and selective solvent extraction of Am³⁺ over Eu³⁺ in nitric acid solution by 2-carboxamido-6-(1H-pyrazol-3-yl)-pyridines (A-PzPy) ligands were described. Without the aid of any lipophilic anion source, A-PzPy ligands in Me iso-Bu ketone (MIBK) diluent demonstrated a more favorable affinity of Am³⁺ than Eu³⁺ at high acidity levels. Slope anal. showed the formation of 1:2 metal/ligand extracted species. The extraction was a spontaneous exothermic process. The analyses of fluorescence titration, Fourier transform IR (FT-IR), Raman, time-resolved laser fluorescence spectrum (TRLFS), electrospray ionization mass spectrometry (ESI-MS), conductivity and microcalorimetric titration revealed that the composition of complex is [Eu(NO₃)₂(H₂O)•2(Et-p-Tol-A-PzPy)](NO₃). Combining the results of solvent extraction and complexation study, the extraction mechanism was proposed. stability constants (log β) and thermodn. parameters (ΔH, ΔS, ΔG) for complexation of Eu³⁺ with Et-p-Tol-A-PzPy are presented. In the experiment, the researchers used many compounds, for example, 6-Acetylpicolinic acid (cas: 122637-39-2Recommanded Product: 6-Acetylpicolinic acid).

6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 6-Acetylpicolinic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dimethyl phosphorothioate and phosphoroselenoate ionic liquids as solvent media for cellulosic materials was written by Hummel, Michael;Froschauer, Carmen;Laus, Gerhard;Roeder, Thomas;Kopacka, Holger;Hauru, Lauri K. J.;Weber, Hedda K.;Sixta, Herbert;Schottenberger, Herwig. And the article was included in Green Chemistry in 2011.Computed Properties of C10H16ClN This article mentions the following:

A series of novel ionic liquids comprising two asym. phosphate-derived anions, namely di-Me phosphorothioate and di-Me phosphoroselenoate, and several imidazolium and non-imidazolium-based cations was prepared via a facile synthetic route. Thermal degradation was studied by dynamic thermogravimetric anal. (TGA) revealing a slightly higher stability of the imidazolium ionic liquids and an overall low thermal stability for the phosphoroselenoate salts. Long-term moisture sorption anal. showed correlation with the polarity of the cation and differences in absorption and desorption kinetics. Finally, a Eucalyptus globulus kraft paper grade pulp was dissolved and subsequently regenerated to assess the degradation of the various mol. weight fractions by size exclusion chromatog. In addition, pre-extracted xylan was subjected to the same dissolution procedure to examine the degradation of low-mol. weight components in more detail. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Computed Properties of C10H16ClN).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Computed Properties of C10H16ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthetic method to access fluorinated 2-benzylpyridines by using Negishi coupling reaction was written by Pothireddy, Mohanreddy;Bhukta, Swadhapriya;Babu, P. Vijaya;Thirupathi, Barla;Dandela, Rambabu. And the article was included in Synthetic Communications in 2022.COA of Formula: C6H3BrF3N This article mentions the following:

The 2-benzylpyridines scaffolds I (R = 4-Me, 3-Cl, 2-trifluoromethyl, etc.) have been found in various drugs, bioactive natural products, and medicinally important compounds This manuscript comprises the synthesis of various fluorinated analogs of 2-benzylpyridine compounds I by using a Negishi coupling reaction as a key reaction. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0COA of Formula: C6H3BrF3N).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.COA of Formula: C6H3BrF3N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem