Month: January 2023

Synthesis of a new donor-acceptor-donor functionalized alkoxyamine and its use in a reversibly supported catalytic hybrid system for ATRP of MMA was written by Ben Osman, Chirine;Geagea, Roland;Stoffelbach, Francois. And the article was included in Polymer in 2016.Quality Control of N-(6-Aminopyridin-2-yl)acetamide This article mentions the following:

A new 2,6-diaminopyridine-functionalized SG1-based alkoxyamine has been synthesized and used to prepare a well-defined functional copolymer (poly(styrene-co-2-vinyl-4,4-dimethyl-5-oxazolone) – poly(S-co-VDM)) by nitroxide mediated polymerization After post-modification of the copolymer with an atom transfer radical polymerization (ATRP) ligand (N,N-dipicolyl propylamine), the macroligand was successfully used for the homogeneous ATRP of Me methacrylate (MMA) leading to a controlled polymerization process. The ATRP of the same monomer was also investigated with the macroligand being reversibly immobilized via hydrogen bonding onto thymine-functionalized silica nanoparticles. The ATRP of MMA involving the supported-catalyst was also effective leading to a good control over the polymerization as observed with the free macroligand and producing polymers with very low dispersity (<1.2). After separation of the supported catalyst by centrifugation, the amount of residual catalyst in the resulting polymers was determined In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Quality Control of N-(6-Aminopyridin-2-yl)acetamide).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Quality Control of N-(6-Aminopyridin-2-yl)acetamide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Identification of 2-Pyridinylindole-Based Dual Antagonists of Toll-like Receptors 7 and 8 (TLR7/8) was written by Sreekantha, Ratna Kumar;Mussari, Christopher P.;Dodd, Dharmpal S.;Pasunoori, Laxman;Hegde, Subramanya;Posy, Shana L.;Critton, David;Ruepp, Stefan;Subramanian, Murali;Salter-Cid, Luisa M.;Tagore, Debarati Mazumder;Sarodaya, Sanket;Dudhgaonkar, Shailesh;Poss, Michael A.;Schieven, Gary L.;Carter, Percy H.;Macor, John E.;Dyckman, Alaric J.. And the article was included in ACS Medicinal Chemistry Letters in 2022.Product Details of 131747-45-0 This article mentions the following:

The toll-like receptors (TLRs) play key roles in activation of the innate immune system. Aberrant activation of TLR7 and TLR8 pathways can occur in the context of autoimmune disorders due to the elevated presence and recognition of self-RNA as activating ligands. Control of this unintended activation via inhibition of TLR7/8 signaling holds promise for the treatment of diseases such as psoriasis, arthritis, and lupus. Optimization of a 2-pyridinylindole series of compounds led to the identification of potent dual inhibitors of TLR7 and TLR8, which demonstrated good selectivity against TLR9 and other family members. The in vitro characterization and in vivo evaluation in rodent pharmacokinetic/pharmacodynamic and efficacy studies of BMS-905 is detailed, along with structural information obtained through X-ray cocrystallog. studies. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Product Details of 131747-45-0).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Product Details of 131747-45-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Forecast pK_a and logP values of the substituted pyridine by natural atomic orbital charges was written by Fei, Ning-ye;Xu, Wei-hui;Zheng, Jing-da;Ding, Chao;Xu, Sha-sha;Xu, Sha-sha;Zhong, Ai-guo. And the article was included in Guangzhou Huagong in 2013.Computed Properties of C8H11N This article mentions the following:

Using the d. functional theory (DFT) and B3LYP/3-21G level group, optimization of the mol. structure of 24-substituted pyridines, it was found between the pyridine ring nitrogen atom natural AOs charge value (NBO) and its exptl. ionization constants values (logK_a) and n-octanol-water partition coefficient (logP), there was a good linear relationship (R₁=0.98, R₂=0.88). Then kinds of unknown logK_a/logP value of multi-substituted pyridine compounds NBO parameters were substituted into the fitted one-parameter linear equations. It was found that polysubstituted with popular software ACD Lab 6.0 was close to the forecast pyridine logK_a/logP values, with the correlation coefficient R between 0.80-0.90 and the relative deviation between 1%-3%. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Computed Properties of C8H11N).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Computed Properties of C8H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of melatonin analogues derived from furo[2,3-b]- and -[2,3-c]pyridines by use of a palladium-copper catalyst system was written by Van de Poel, Herve;Guillaumet, Gerald;Viaud-Massuard, Marie-Claude. And the article was included in Heterocycles in 2002.SDS of cas: 51834-97-0 This article mentions the following:

2,3,5-Substituted furo[2,3-b]pyridine was synthesized by palladium-catalyzed reaction of 5-bromo-2-hydroxy-3-iodopyridine and phenylacetylene with (Ph₃P)₂PdCl₂, CuI in Et₃N. A carbonylative cyclization of 5-hydroxy-2-methoxy-4-(2-phenylethynyl)pyridine with carbon monoxide in methanol with PdCl₂, CuCl₂ under basic conditions, has been accomplished to prepare Me 2,5-substituted furo[2,3-c]pyridine-3-carboxylate. In the experiment, the researchers used many compounds, for example, 5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0SDS of cas: 51834-97-0).

5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 51834-97-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A novel approach to predict a toxicological property of aromatic compounds in the Tetrahymena pyriformis was written by Gonzalez, Maykel Perez;Diaz, Humberto Gonzalez;Cabrera, Miguel Angel;Ruiz, Reinaldo Molina. And the article was included in Bioorganic & Medicinal Chemistry in 2004.Category: pyridine-derivatives This article mentions the following:

The TOPol. Substructural Mol. DEsign (TOPS-MODE) has been successfully used in order to explain the toxicity in the Tetrahymena pyriformis on a large data set. The obtained models for the training set had good statistical parameters (R²=0.72-0.81, p<0.05) an also the prediction power of the models found was adequate (Q²=0.70-0.80). A detailed study of the influence of variable numbers in the equation and the statistical outliers was carried out; leading to a good final model with a better physicochem. interpretation than the rest of the published models. Only two mol. descriptors codifying dipolar and hydrophobic features were introduced. Finally, the fragment contributions to the toxicity prediction evidenced the powerful of this topol. approach. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2Category: pyridine-derivatives).

3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Exceptional Substrate Diversity in Oxygenation Reactions Catalyzed by a Bis(μ-oxo) Copper Complex was written by Paul, Melanie;Teubner, Melissa;Grimm-Lebsanft, Benjamin;Golchert, Christiane;Meiners, Yannick;Senft, Laura;Keisers, Kristina;Liebhaeuser, Patricia;Roesener, Thomas;Biebl, Florian;Buchenau, Soeren;Naumova, Maria;Murzin, Vadim;Krug, Roxanne;Hoffmann, Alexander;Pietruszka, Joerg;Ivanovic-Burmazovic, Ivana;Ruebhausen, Michael;Herres-Pawlis, Sonja. And the article was included in Chemistry – A European Journal in 2020.HPLC of Formula: 626-64-2 This article mentions the following:

The enzyme tyrosinase contains a reactive side-on peroxo dicopper(II) center as catalytically active species in C-H oxygenation reactions. The tyrosinase activity of the isomeric bis(μ-oxo) dicopper(III) form has been discussed controversially. The synthesis of bis(μ-oxo) dicopper(III) species [Cu₂(μ-O)₂(L1)₂](X)₂ ([O1](X)₂, X = PF₆^–, BF₄^–, OTf^–, ClO₄^–), stabilized by the new hybrid guanidine ligand 2-(2-((dimethylamino)methyl)phenyl)-1,1,3,3-tetramethylguanidine (L1), and its characterization by UV/Vis, Raman, and XAS spectroscopy, as well as cryo-UHR-ESI mass spectrometry, are described. The highlight selective oxygenation of a plethora of phenolic substrates such as 1H-indol-7-ol, naphthalen-1-ol, pyridin-4-ol, etc. mediated by [O1](PF₆)₂, results in mono- and bicyclic quinones such as 3,4-pyridinedione, 1,2-naphthalenedione, 1H-indole-6,7-dione and provides an attractive strategy for designing new phenazines e.g., benzo[a]phenazine. The selectivity is predicted by using the Fukui function, which is hereby introduced into tyrosinase model chem. The bioinspired catalysis harnesses mol. dioxygen for organic transformations and achieves a substrate diversity reaching far beyond the scope of the enzyme. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2HPLC of Formula: 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.HPLC of Formula: 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Herbicidal activities of phenoxypyridines was written by Fujikawa, Kanichi;Kondo, Katushide;Yokomichi, Isao;Kimura, Fumio;Haga, Takahiro;Nishiyama, Ryuzo. And the article was included in Agricultural and Biological Chemistry in 1970.Application of 4783-68-0 This article mentions the following:

Among 307 phenoxypyridines prepared, the 3-phenoxypyridines and 4-phenoxypyr idines generally showed no significant herbicidal activities, but some of the 2-phenoxypyridines were very active. 2-(4-Nitrophenoxy)-3,5-dichloropyridine was the most effective. Comparison of the activity and structure of the 2-phenoxypyridines with those of the corresponding diphenyl ethers indicated that the 2-pyridoxy group was nearly equivalent physiol. to the phenoxy group. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Application of 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application of 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Potent Thiophene Antagonists of Human Complement C3a Receptor with Anti-Inflammatory Activity was written by Rowley, Jessica A.;Reid, Robert C.;Poon, Eunice K. Y.;Wu, Kai-Chen;Lim, Junxian;Lohman, Rink-Jan;Hamidon, Johan K.;Yau, Mei-Kwan;Halili, Maria A.;Durek, Thomas;Iyer, Abishek;Fairlie, David P.. And the article was included in Journal of Medicinal Chemistry in 2020.SDS of cas: 91-02-1 This article mentions the following:

Structure-activity relationships for a series of small-mol. thiophenes resulted in potent and selective antagonism of human Complement C3a receptor. The compounds are about 100-fold more potent than the most reported antagonist SB290157. A new compound JR14a was among the most potent of the new antagonists in vitro, assessed by (a) inhibition of intracellular calcium release (IC₅₀ 10 nM) induced in human monocyte-derived macrophages by 100 nM C3a, (b) inhibition of β-hexosaminidase secretion (IC₅₀ 8 nM) from human LAD2 mast cells degranulated by 100 nM C3a, and (c) selectivity for human C3aR over C5aR. JR14a was metabolically stable in rat plasma and in rat liver microsomes and efficacious in rats when given orally to suppress rat paw inflammation, macrophage and mast cell activation, and histopathol. induced by intraplantar paw administration of a C3aR agonist. Potent C3aR antagonists are now available for interrogating C3a receptor activation and suppressing C3aR-mediated inflammation in mammalian physiol. and disease. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1SDS of cas: 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. SDS of cas: 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

RuHCl(CO)(PPh₃)₃-Catalyzed Direct Amidation of Arene C-H Bond with Azides was written by Xiao, Xinsheng;Jia, Guokai;Liu, Fang;Ou, Guangchuan;Xie, Ying. And the article was included in Journal of Organic Chemistry in 2018.COA of Formula: C12H11N This article mentions the following:

The direct ortho C-H amidation of arenes with azides by using an inexpensive RuHCl(CO)(PPh₃)₃ catalyst, it reported. The reaction proceeds efficiently in high yield over a broad range of substrates without requirement of any addnl. silver salt or additive. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9COA of Formula: C12H11N).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.COA of Formula: C12H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Iron-Catalyzed Borylation of Aryl Ethers via Cleavage of C-O Bonds was written by Zeng, Xiaoqin;Zhang, Yuxuan;Liu, Zhengli;Geng, Shasha;He, Yun;Feng, Zhang. And the article was included in Organic Letters in 2020.Computed Properties of C11H9NO This article mentions the following:

Herein, the iron-catalyzed borylation of aryl ethers and aryl amines via cleavage of C-O and C-N bonds is reported. This protocol does not require the use of Grignard reagents and displays a broad substrate scope, which allows the late-stage borylation. It also provides facile access to multisubstituted arenes through C-H functionalization using 2-pyridyloxy as the directing group. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Computed Properties of C11H9NO).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Computed Properties of C11H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem