Day: February 6, 2023

Polynuclear zinc(II) complexes of thiosemicarbazone: Synthesis, X-ray structure and biological evaluation was written by Saswati;Mohanty, Monalisa;Banerjee, Atanu;Biswal, Sonaleen;Horn, Adolfo Jr.;Schenk, Gerhard;Brzezinski, Krzysztof;Sinn, Ekkehard;Reuter, Hans;Dinda, Rupam. And the article was included in Journal of Inorganic Biochemistry in 2020.Quality Control of Phenyl(pyridin-2-yl)methanone This article mentions the following:

Two new dimeric Zn(II) ([{ZnL¹(DMSO₂)}₂]·DMSO (1), [{ZnL²Cl}₂] (2)) and a novel tetrameric Zn(II) complex ([(Zn₂L³)₂(μ-OAc)₂(μ₃-O)₂] (3)), where H₂L¹ = 4-(p-methoxyphenyl)thiosemicarbazone of o-hydroxynaphthaldehyde, HL² = 4-(p-methoxyphenyl)thiosemicarbazone of benzoyl pyridine and H₂L³ = 4-(p-chlorophenyl)thiosemicarbazone of o-vanillin are reported. Ligands and their complexes were characterized by spectroscopic and single crystal x-ray diffraction techniques. In addition, the complexes exhibited good binding affinity towards HSA (10¹² M^-1), which is supported by their ability to quench the tryptophan fluorescence emission spectra of HSA. The complexes were also screened for their DNA binding propensity through UV-vis absorption titration, CD and fluorescence spectral studies. Results show that they effectively interact with CT-DNA through an intercalative mode of binding, with binding constants ranging from 10³ to 10⁴ M^-1. Among the three complexes 1 has the highest binding affinity towards CT-DNA. Further, the phosphatase activity was evaluated using bis(2,4-dinitrophenyl)phosphate (BDNPP) as substrate, however, the complexes did not yield any measurable catalytic activity. Nevertheless the complexes showed significant cytotoxic potential against HeLa and HT-29 cancer cell lines that was assessed through MTT assay and DAPI staining. Remarkably, complex 1 showed better activity than cisplatin against HT-29 cell line. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Quality Control of Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Quality Control of Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Insight into the mechanism of oxidative kinetic resolution of racemic secondary alcohols by using manganese(III)(salen) complexes as catalysts was written by Li, Zhen;Tang, Zhong H.;Hu, Xiao X.;Xia, Chun G.. And the article was included in Chemistry – A European Journal in 2005.HPLC of Formula: 65350-59-6 This article mentions the following:

The oxidative kinetic resolution of various racemic secondary alcs. with PhI(OAc)₂ catalyzed by chiral [Mn^III(salen)] complexes in the presence of KBr was studied in a water/organic solvent mixture The dramatic, synergetic effect of additives, organic solvent, and the substituents of chiral salen ligands on the enantioselectivities of the reactions is reported. Results from UV/Vis spectroscopy and ESI-MS studies provide evidence that these reactions are induced by the formation of a high-valent manganese intermediate. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6HPLC of Formula: 65350-59-6).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. HPLC of Formula: 65350-59-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oxygen-Bridged Triphenylamine Units Tuning the Photophysical Properties of Classical Phosphorescent Iridium(III) Complex was written by Cao, Yibo;Song, Jialiang;Li, Gang;Zheng, Ying;Shi, Chao;Li, Qiuxia;Yuan, Aihua. And the article was included in ChemistrySelect in 2021.Application of 54151-74-5 This article mentions the following:

A new yellow phosphorescent iridium(III) complex Ir(ppybop)₂acac with two oxygen-bridged triphenylamine units were prepared and investigated. The cyclometalating ligand ppybop was synthesized by the efficient Suzuki-Miyaura cross-coupling reaction of oxygen-bridged triarylamine unit based boron reagent 1-a and 2-(4-Bromophenyl)pyridine, and the acetylacetone (acac) was used as an auxiliary ligand. Notably, the complex Ir(ppybop)₂acac measured with a fluorescence spectrophotometer can show a larger red shift emission (λ_em = 568 nm), a narrower full width at half maximum (FWHM = 59 nm), a longer emission lifetime (τ[b] = 3127 ns) and a better solubility in comparison with the classical green complex Ir(ppy)2acac (λ_em = 520 nm, FWHM = 70 nm, τ[b] = 1206 ns). In addition, the DFT calculation results indicate that the strong electron-donating ability of the unit can lead to the unusual ligand-to-metal charge transfer (3LMCT) excited state characteristics of Ir(ppybop)2acac, which is completely different from the metal-to-ligand charge transfer (3MLCT) in Ir(ppy)₂acac. This result can provide a new strategy for the design of new phosphorescent iridium(III) complexes. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Application of 54151-74-5).

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application of 54151-74-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Water-mediated C-H activation of arenes with secure carbene precursors: the reaction and its application was written by Nie, Ruifang;Lai, Ruizhi;Lv, Songyang;Xu, Yingying;Guo, Li;Wang, Qiantao;Wu, Yong. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.SDS of cas: 4373-61-9 This article mentions the following:

A water-mediated C-H activation using sulfoxonium ylides was reported, providing a general, green and step-economic approach to construct a C-C bond and varieties of useful N-heterocycle scaffolds. Three series of aryl-alkylketones RCOCH²R¹ [R = t-Bu, 1-adamantanyl, Ph; R¹ = 2-(2-pyridyl)phenyl, 2-(2-pyridyl)-3-thienyl, 2-pyrazol-1-ylphenyl, etc.], benzothiazines I [R² = Me, i-Pr, Ph, Bn; R³ = i-Pr, t-Bu, Ph; R⁴ = H, 6-Me, 6-OMe, 6-F, 8-OMe] and isoquinolines II [R⁵ = H, 8-F, 6-Br, etc.; R⁶ = H, Me; R⁷ = 2,6-di-MeOC₆H₃, 2-naphthyl, 2-thienyl, etc.] were synthesized via rhodium-catalyzed coupling of arenes/sulfoximines/benzylamines with sulfoxonium ylides. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9SDS of cas: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reaction of 3-substituted and 3,5-disubstituted pyridine N-oxides with phenyl isocyanate was written by Hisano, Takuzo;Matsuoka, Toshikazu;Ichikawa, Masataka. And the article was included in Organic Preparations and Procedures International in 1974.Electric Literature of C7H9NO This article mentions the following:

3,5-Dimethylpyridine N-oxide was treated with PhNCO to give I, which was hydrolyzed to give 2-anilino-3,5-dimethylpyridine. 3-Bromopyridine and PhNCO gave 46% oxazolopyridinone II, 3% 2-anilino-3-bromopyridine, and 3% 6-anilino-3-bromopyridine. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Electric Literature of C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A highly selective on-off-on responsive lanthanide(III) based probe for recognition of copper and hydrogen sulfide was written by Yip, Yuk-Wang;Law, Ga-Lai;Wong, Wing-Tak. And the article was included in Dalton Transactions in 2016.Application In Synthesis of (4-Bromopyridin-2-yl)methanol This article mentions the following:

The development of a europium(III) based probe (EuL1) for the detection of Cu(II) ions and hydrogen sulfide is presented. With the addition of Cu(II) ions, EuL1 displayed the greatest quenching among the other cations examined The binding constant was 74 026 ± 2899 M^-1. Once combined with Cu(II) ions, EuL1Cu demonstrated high specificity for hydrogen sulfide compared to other organic and inorganic sulfur compounds EuL1Cu exhibited an on-off-on type luminescence change with the alternate addition of Cu(II) ions and H₂S along with reversible forming-separating of the complex. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Application In Synthesis of (4-Bromopyridin-2-yl)methanol).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of (4-Bromopyridin-2-yl)methanol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Phase diagrams of ionic liquids-based aqueous biphasic systems as a platform for extraction processes was written by Sintra, Tania E.;Cruz, Rafaela;Ventura, Sonia P. M.;Coutinho, Joao A. P.. And the article was included in Journal of Chemical Thermodynamics in 2014.Electric Literature of C10H16ClN This article mentions the following:

In the past few years, ionic liquid-based aqueous biphasic systems have become the subject of considerable interest as a promising technique for the extraction and purification of several macro/biomols. Aiming at developing guidelines for more benign and efficient extraction processes, phase diagrams for aqueous biphasic systems composed of ionic liquids and inorganic/organic salts are here reported. Several combinations of ionic liquid families (imidazolium, pyridinium, phosphonium, quaternary ammonium and cholinium) and salts [potassium phosphate buffer (KH₂PO₄/K₂HPO₄ at pH 7), potassium citrate buffer (C₆H₅K₃O₇/C₆H₈O₇ at pH 5, 6, 7 and 8) and potassium carbonate (K₂CO₃ at pH ∼13)] were evaluated to highlight the influence of the ionic liquid structure (cation core, anion and alkyl chain length), the pH and the salt nature on the formation of aqueous biphasic systems. The binodal curves and resp. tie-lines reported for these systems were exptl. determined at (298 ± 1) K. In general, the ability to promote the aqueous biphasic systems formation increases with the pH and alkyl chain length. While the influence of the cation core and anion nature of the ionic liquids on their ability to form aqueous biphasic systems closely correlates with ionic liquids capacity to be hydrated by water, the effect of the different salts depends of the ionic liquid nature and salt valency. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Electric Literature of C10H16ClN).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Electric Literature of C10H16ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Metalloporphyrin as a Biomimetic Catalyst for the Catalytic Oxidative Degradation of Lignin to Produce Aromatic Monomers was written by Xie, Jinfeng;Ma, Guanfeng;Ouyang, Xinping;Zhao, Lisha;Qiu, Xueqing. And the article was included in Waste and Biomass Valorization in 2020.Electric Literature of C5H5NO This article mentions the following:

Lignin, an abundant biomass waste, was degraded under microwave irradiation with H₂O₂ as the oxidant and metalloporphyrin as the catalyst. The effect of substituent group (4-methylphenyl, 4-methoxyphenyl, 4-bromophenyl and 4-carboxyphenyl) at the meso-benzene ring of metalloporphyrin, central metal ion (Co, Mn, Ni and Fe) and axial ligand (chlorine, p-hydroxypyridine, p-pyridinecarboxaldehyde) on the degradation of lignin was investigated. The electron-withdrawing group not only reduces the electron cloud d. on the porphyrin ring, but also promotes the formation of higher active intermediate [(Porp)MeIV=O]^+·. Therefore, the presence of stronger electron-withdrawing substituents makes the metalloporphyrins more efficient in lignin degradation Compared to Co porphyrin, there are less amount of [(Porp)MeIV=O]^+· formed when Mn, Fe or Ni porphyrin was used as the catalyst for degrading lignin. Consequently, Co porphyrin contributed to a higher YAM (the yield of aromatic monomers). The strong nucleophilicity and the low steric hindrance of axial ligand was advantageous for the stability of metalloporphyrins, which is favorable for improving the catalytic activity to the degradation of lignin. It is found that the YAM increases 20.1% from 5.6% by using CoTBrPPCl as the reaction catalyst under the optimized conditions. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Electric Literature of C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Electric Literature of C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

α-Halo carbonyls enable meta selective primary, secondary and tertiary C-H alkylations by ruthenium catalysis was written by Paterson, Andrew J.;Heron, Callum J.;McMullin, Claire L.;Mahon, Mary F.;Press, Neil J.;Frost, Christopher G.. And the article was included in Organic & Biomolecular Chemistry in 2017.Recommanded Product: 2-(m-Tolyl)pyridine This article mentions the following:

A catalytic meta selective C-H alkylation of arenes is described using a wide range of α-halo carbonyls as coupling partners. Previously unreported primary alkylations with high meta selectivity have been enabled by this methodol. whereas using straight chain alkyl halides affords ortho substituted products. Mechanistic anal. reveals an activation pathway whereby cyclometalation with a ruthenium(II) complex activates the substrate mol. and is responsible for the meta selectivity observed A distinct second activation of the coupling partner allows site selective reaction between both components. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Recommanded Product: 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Recommanded Product: 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, Characterization and Conductivity of Quaternary Nitrogen Surfactants Modified by the Addition of a Hydroxymethyl Substructure on the Head Group was written by Jordan, Deborah;Tan, Eng;Hegh, Dylan. And the article was included in Journal of Surfactants and Detergents in 2012.Electric Literature of C17H30BrN This article mentions the following:

Two novel series of hydroxymethyl group-appended quaternary nitrogen surfactants (QNSs) based on the aliphatic N-alkyl-trimethylammonium and aromatic N-alkylpyridinium head groups were synthesized from the appropriate nitrogen head group precursor and 1-bromoalkane. The QNSs were characterized using ¹H and ¹³C NMR and IR spectroscopy, and their purity confirmed using elemental anal. The solution behavior of the QNSs was investigated by conductivity, assessing both the aggregation concentration as well as the amount of counter-ion dissociation The results showed a general decrease in the aggregation concentration for the compounds with the hydroxymethyl addition, where the pyridinium compounds were more affected than the ammonium QNSs. In contrast, the extent of counter-ion dissociation (α) from the aggregate was slightly increased for the ammonium compounds but that of the pyridinium compounds was not generally affected by the structural modification. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Electric Literature of C17H30BrN).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Electric Literature of C17H30BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem