Day: February 7, 2023

Palladium-catalyzed C-H alkylation of 2-phenylpyridines with alkyl iodides was written by Wang, Xiaoling;Ji, Xiaoming;Shao, Changdong;Zhang, Yu;Zhang, Yanghui. And the article was included in Organic & Biomolecular Chemistry in 2017.HPLC of Formula: 4373-61-9 This article mentions the following:

Palladium-catalyzed C-H alkylation reaction of 2-phenylpyridines with alkyl iodides was successfully developed. The palladacycles obtained from 2-phenylpyridines act as the key intermediates in the alkylation reaction. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9HPLC of Formula: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.HPLC of Formula: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Solvothermal aluminophosphate zeotype synthesis with ionic liquid precursors was written by Wragg, David S.;Fullerton, Grace M.;Byrne, Peter J.;Slawin, Alexandra M. Z.;Warren, John E.;Teat, Simon J.;Morris, Russell E.. And the article was included in Dalton Transactions in 2011.Product Details of 65350-59-6 This article mentions the following:

The authors have carried out a study of aluminophosphate framework synthesis using several amine based ionic liquids and their parent amines as solvent and template. The results suggest that in the presence of fluoride ions from hydrofluoric acid the ionic liquids and their parent amines produce the same frameworks, while in synthesis without fluoride ions the products are not related. The results include the synthesis and crystal structure of a novel extra-large pore material using 1-methylpyrrolidine as solvent and template. The relation between this and sodalite, which can be synthesized in cobalt aluminophosphate form using an ionic liquid prepared from 1-methylpyrrolidine is described. The crystal structures of two other new layered materials are also presented. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Product Details of 65350-59-6).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Product Details of 65350-59-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reaction behavior of Cryptomeria japonica treated with pyridinium chloride-water mixture was written by Yoshioka, Koichi;Kawazoe, Yu;Kanbayashi, Toru;Yamada, Tatsuhiko;Ohno, Hiroyuki;Miyafuji, Hisashi. And the article was included in RSC Advances in 2016.Reference of 628-13-7 This article mentions the following:

Cryptomeria japonica was treated with 90% pyridinium chloride ([Py]Cl) and 10% water weight/weight solution at 80 and 120°C. Most hemicellulose in C. japonica was liquefied and over half the lignin in C. japonica was solubilized after treatments at 80 and 120°C. However, cellulose was mostly insoluble at 80°C and partially soluble at 120°C. The crystal structure of cellulose in the cell walls was retained after treatment at 80°C for 48 h. The degradation products from the polysaccharides were obtained in different yields. The 90% [Py]Cl and 10% water weight/weight solution is effective for the treatment of lignocellulosics, such as liquefaction of lignocellulosics and the production of useful low mol. weight compounds In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Reference of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Reference of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and anthelmintic activity of 7-substituted 3,4a-dimethyl-4a,5a,8a,8b-tetrahydro-6H-pyrrolo[3′,4′:4,5]furo[3,2-b]pyridine-6,8(7H)-diones was written by Jeschke, Peter;Harder, Achim;Etzel, Winfried;Gau, Wolfgang;Goehrt, Axel;Benet-Buchholz, Jordi;Thielking, Gerhard. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2005.Name: 3,5-Dimethylpyridine 1-oxide This article mentions the following:

The racemic 7-substituted 3,4a-dimethyl-4a,5a,8a,8b-tetrahydro-6H-pyrrolo[3′,4′:4,5]furo[3,2-b]pyridine-6,8(7H)-diones I [R = Me, Et, cyclopropyl, Bu, CH₂Ph, (S)CHMePh] represent novel tricyclic compounds with strong in vivo efficacy against the parasitic nematode Haemonchus contortus Rudolphi in sheep. The synthesis of endo-I and the resolution of I [R = Et] by HPLC are reported. The absolute configuration of the most anthelmintically active (4aS,5aS,8aS,8bR)-enantiomer was determined by single crystal X-ray anal. using its stable CuCl₂ (2:1)-complex. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Name: 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fluorescent trifluoromethylated imidazo[1,5-a]pyridines and their application in luminescent down-shifting conversion was written by Volpi, G.;Galliano, S.;Buscaino, R.;Viscardi, G.;Barolo, C.. And the article was included in Journal of Luminescence in 2022.COA of Formula: C12H9NO This article mentions the following:

In the last few years, imidazo[1,5-a]pyridine derivatives have attracted growing attention due to their unique optical behaviors. Herein, a series of trifluoromethylated substituted imidazo[1,5-a]pyridine derivatives were synthesized and their optical properties investigated. Depending on the position of the trifluoromethylated substituents on the imidazo[1,5-a]pyridine nucleus, we were able to tune the quantum yields (Φ) both in acetonitrile solution (from 13% to 39%) and in the polymeric matrix (10%-58%) with a remarkable large Stokes shift. The investigated fluorophores were dispersed in a transparent polyurethane resin, providing a possible luminescent low-cost material for down-shifting conversion. An anal. based on the chem. structures and spectroscopic data, both in solution and polymeric medium, is reported to address the best strategies to optimize the photophys. properties and prevent aggregation. Finally, optimized polyurethane-based films prepared with compounds 2 and 3 were tested as a luminescent coating on a com. photodiode, enabling their technol. application. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1COA of Formula: C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.COA of Formula: C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Infrared spectra of heterocyclic compounds. III. Infrared spectra of alkylpyridine 1-oxides was written by Shindo, Hideyo. And the article was included in Pharmaceutical Bulletin in 1956.Application In Synthesis of 3,5-Dimethylpyridine 1-oxide This article mentions the following:

Infrared absorption spectra were measured (curves shown) for pyridine 1-oxide (I), its 2-, 3-, and 4-Me derivatives, its 2,3-, 2,4-, 2,6-, and 3,5-di-Me (II) derivatives, its 2,3,4-, 2,3,6- (III), 2,4,5-, and 2,4,6-tri-Me derivatives, its 2,3,4,6-tetra-Me and 2,3,4,5,6-penta-Me derivatives, and its 3- and 4-Et derivatives All the compounds were prepared by well-known methods and were distilled in vacuo immediately before measuring. Only II and III were new, picrates, m. 138-9° and 102°, resp. By comparing these spectra with those previously reported (C.A. 51, 5557b) for the corresponding alkylpyridines (IV), the characteristic absorption band for the N-oxide group was established as between 1200 and 1300 cm.^-1 (cf. Costa and Blasina, C.A. 49, 8702i). This conclusion is discussed on the basis of the facts that (1) I and all its alkyl derivatives show this band with high intensity, (2) only this band shifts to lower frequency with traces of MeOH (because of H bonding), (3) very sensitive relations exist between the frequency of this band and the positions of the alkyl groups, and (4) this absorption region is appropriate to the double-bond nature of the N-H bond. No marked relation was found between the out-of-plane C-H deformation frequencies at 700-900 cm.^-1 in these compounds and those in the corresponding IV. The C:C and C:N stretching vibration frequencies at 1450-1650 cm.^-1 were quite different from, and often the reverse of, those of the corresponding IV. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Application In Synthesis of 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application In Synthesis of 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Ruthenium-Catalyzed ortho/meta-Selective Dual C-H Bonds Functionalizations of Arenes was written by Li, Gang;Zhu, Biao;Ma, Xingxing;Jia, Chunqi;Lv, Xulu;Wang, Junjie;Zhao, Feng;Lv, Yunhe;Yang, Suling. And the article was included in Organic Letters in 2017.Product Details of 4783-68-0 This article mentions the following:

The first example of transition-metal-catalyzed ortho/meta-selective dual C-H functionalizations of arenes in one reaction is described. In this transformation, ortho-C-H chlorination and meta-C-H sulfonation of 2-phenoxypyri(mi)dines were achieved simultaneously under catalysis by [Ru(p-cymene)Cl₂]₂. The other reactant, namely, an arylsulfonyl chloride, played the role of both a sulfonation and chlorination reagent. More importantly, the arylsulfonyl chloride was also an oxidant in the process. Mechanistic studies indicated that six-membered ruthenacycles were the key intermediate in the reaction. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Product Details of 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Product Details of 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of Well-Defined Poly(2-alkoxypyridine-3,5-diyl) via Ni-Catalyst-Transfer Condensation Polymerization was written by Nanashima, Yutaka;Yokoyama, Akihiro;Yokozawa, Tsutomu. And the article was included in Macromolecules (Washington, DC, United States) in 2012.Category: pyridine-derivatives This article mentions the following:

Ni-catalyzed Kumada-Tamao coupling polymerization of 5-bromo-3-chloromagnesio-2-(2-(2-methoxyethoxy)ethoxy)pyridine (1) was investigated. Monomer 1, which was obtained quant. by treatment of the corresponding bromoiodopyridine 3 with 1.0 equiv of ⁱPrMgCl at 0°, was polymerized with Ni(dppp)Cl₂ (dppp = 1,3-bis(diphenylphospino)propane) in the presence of 2.0 equiv of LiCl in THF at room temperature to yield poly(2-(2-(2-methoxyethoxy)ethoxy)pyridine-3,5-diyl) (m-PMEEOPy) with narrow polydispersity. The M_n value was controlled by the feed ratio of the monomer precursor 3 to Ni(dppp)Cl₂. MALDI-TOF mass spectra showed that m-PMEEOPy uniformly had a bromine atom at one end and a hydrogen atom at the other. Both end groups could be converted to aryl groups by addition of an excess of aryl magnesium chloride to the reaction mixture after completion of the polymerization These results indicate that the polymerization of 1 with Ni(dppp)Cl₂ involves the intramol. catalyst-transfer polymerization mechanism. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6Category: pyridine-derivatives).

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Magnesiate-Utilized/Benzyne-Mediated Approach to Indenopyridones from 2-Pyridones: An Attempt To Synthesize the Indenopyridine Core of Haouamine was written by Idzik, Tomasz J.;Borzyszkowska-Ledwig, Aleksandra;Struk, Lukasz;Sosnicki, Jacek G.. And the article was included in Organic Letters in 2019.SDS of cas: 76053-45-7 This article mentions the following:

An efficient, short-staged synthesis of cis-fused indeno[2,1-b]- and indeno[1,2-c]pyridin-2-ones, starting from 2-pyridones, using magnesiates of type R₃MgLi as nucleophilic and deprotonation agents, mediated by benzyne generated in situ, under optimized conditions, is described. Following the developed protocol, rare C4a-aryl substituted indeno[2,1-b]pyridones (e.g. I), resembling the core of haouamine, were obtained. The protocol offering the one-pot synthesis directly from 2-pyridone is also described. In the experiment, the researchers used many compounds, for example, 5-Phenylpyridin-2-ol (cas: 76053-45-7SDS of cas: 76053-45-7).

5-Phenylpyridin-2-ol (cas: 76053-45-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 76053-45-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Anticancer gold(III)-bisphosphine complex alters the mitochondrial electron transport chain to induce in vivo tumor inhibition was written by Kim, Jong Hyun;Ofori, Samuel;Parkin, Sean;Vekaria, Hemendra;Sullivan, Patrick G.;Awuah, Samuel G.. And the article was included in Chemical Science in 2021.Electric Literature of C11H9NO This article mentions the following:

Expanding the chem. diversity of metal complexes provides a robust platform to generate functional bioactive reagents. To access an excellent repository of metal-based compounds for probe/drug discovery, we capitalized on the rich chem. of gold to create organometallic gold(III) compounds by ligand tuning. We obtained novel organogold(III) compounds bearing a 1,2-bis(diphenylphosphino)benzene ligand, providing structural diversity with optimal physiol. stability. Biol. evaluation of the lead compound AuPhos-89 demonstrates mitochondrial complex I-mediated alteration of the mitochondrial electron transport chain (ETC) to drive respiration and diminish cellular energy in the form of ATP (ATP). Mechanism-of-action efforts, RNA-Seq, quant. proteomics, and NCI-60 screening reveal a highly potent anticancer agent that modulates mitochondrial ETC. AuPhos-89 inhibits the tumor growth of metastatic triple neg. breast cancer and represents a new strategy to study the modulation of mitochondrial respiration for the treatment of aggressive cancer and other disease states where mitochondria play a pivotal role in the pathobiol. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Electric Literature of C11H9NO).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Electric Literature of C11H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem