Day: February 9, 2023

Design, synthesis and antitumor activities of thiazole-containing mitochondrial targeting agents was written by Zhang, Dongdong;Hu, Yixin;Hao, Zhiqiang;Zhang, Yang;Luo, Shuhua;Dang, Xin;Sun, Ran;Duan, Shixin;Lv, Dan;Jiang, Faqin;Fu, Lei. And the article was included in Bioorganic Chemistry in 2021.SDS of cas: 626-64-2 This article mentions the following:

In this study, a novel batch of thiazole-containing mitochondrial targeting agents e.g., I were designed and synthesized. Four kinds of mitochondrial targeting moieties and six kinds of linkers were designed. The screening of antiproliferative activity revealed that most compounds displayed cytotoxicity on HeLa cancer cell. In particular, II has an IC₅₀ value of 35.32μmol·L^-1 against HeLa cell. In addition, cellular respiratory activities were also tested on HeLa cancer cells. The II had a basal oxygen consumption rate of 8.84 pmol·s^-1·mL^-1. Also, II inhibited the mitochondrial respiration of HeLa cell significantly at 5μmol·L^-1, as well as a complete inhibitory of oxygen consumption for cellular ATP coupling. Furthermore, the pKa, logP, and logD under different pH conditions of all the compounds were calculated by the ACD/Percepta-PhysChem Suite, and the results manifested the correlation between physicochem. properties and chem. activity of compounds The results identify II as a promising mitochondria inhibitor and anticancer agent with appropriate physicochem. properties. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2SDS of cas: 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. SDS of cas: 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hierarchical nanostructures of a liquid crystalline block copolymer with a hydrogen-bonded calamitic mesogen was written by Pan, Hongbing;Xiao, Anqi;Zhang, Wei;Luo, Longfei;Shen, Zhihao;Fan, Xinghe. And the article was included in Polymer in 2019.HPLC of Formula: 626-64-2 This article mentions the following:

With a pyridine derivative containing a calamitic mesogen 4-((6-((4′-((4-hexylphenyl)ethynyl)-[1,1′-biphenyl]-4-yl)oxy)hexyl)oxy)pyridine (HEBC6) used as the hydrogen-bonding acceptor and polydimethylsiloxane-b-poly(2,5-bis(4-carboxy phenyl)styrene) (PDMS-b-PM3H) as the hydrogen-bonding donor, a series of supramol. liquid crystalline block copolymers (SLCBCPs) were prepared through hydrogen bonding. In the supramol. block, the calamitic mesogen was decoupled from the motion of PM3H chains by using a flexible spacer. Different microphase-separated nanostructures and liquid crystalline (LC) structures were obtained by varying the d.p. of the PM3H block and the molar ratio of HEBC6 to PDMS-b-PM3H. The SLCBCPs can self-assemble into hexagonally packed cylinders (HEX), lamellae (LAM), and inverted HEX. Smectic A phase and parallel packing of the calamitic mesogens were also observed on a smaller length scale, and these two ordered structures are synergistic and promotional. Therefore, hierarchically ordered structures can be obtained from these SLCBCPs. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2HPLC of Formula: 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. HPLC of Formula: 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Fluorine-19 nuclear magnetic resonance study of tin tetrafluoride diadducts of various aromatic amine oxides was written by Ragsdale, Ronald O.;Michelson, C. E.. And the article was included in Inorganic Chemistry in 1970.SDS of cas: 3718-65-8 This article mentions the following:

An 19F NMR study of diadducts of SnF4 with 19 aromatic amine oxides is reported. The results indicate that the steric nature of the ligand is probably more important than the base strength in determining the relative chem. shifts. The trans isomer is identified in all of the complexes whereas the cis isomer is present only with the less bulky ligands. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8SDS of cas: 3718-65-8).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.SDS of cas: 3718-65-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pd-catalyzed cross-coupling reactions with carbonyls: application in a very efficient synthesis of 4-aryltetrahydropyridines was written by Barluenga, Jose;Tomas-Gamasa, Maria;Moriel, Patricia;Aznar, Fernando;Valdes, Carlos. And the article was included in Chemistry – A European Journal in 2008.Computed Properties of C10H17NO2 This article mentions the following:

Readily available 4-piperidones are directly employed in a very efficient Pd-catalyzed synthesis of 4-aryltetrahydropyridines, which are important scaffolds in medicinal chem. The actual coupling partner, a tosylhydrazone, is generated in situ from the piperidone and tosylhydrazine. The reaction can be applied to other ketones and aldehydes, providing polysubstituted olefins directly from carbonyls by a very simple and efficient procedure. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Computed Properties of C10H17NO2).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Computed Properties of C10H17NO2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Impregnated copper on magnetite as catalyst for the O-arylation of phenols with aryl halides was written by Zhang, Ying-Peng;Shi, Ai-Hong;Yang, Yun-Shang;Li, Chun-Lei. And the article was included in Chinese Chemical Letters in 2014.HPLC of Formula: 4783-68-0 This article mentions the following:

Nanoparticle Fe₃O₄ encapsulated CuO, as a heterogeneous catalyst, is a facile system for the synthesis of diaryl ethers by the cross-coupling reaction of aryl halides with phenols, which avoids expensive ligands and can be recovered from the reaction mixture by using a simple magnet. Moreover, this catalyst can be reused 3 times with high catalytic activity. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0HPLC of Formula: 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. HPLC of Formula: 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Potent, Orally Active Corticotropin-Releasing Factor Receptor-1 Antagonists Containing a Tricyclic Pyrrolopyridine or Pyrazolopyridine Core was written by Dyck, Brian;Grigoriadis, Dimitri E.;Gross, Raymond S.;Guo, Zhiqiang;Marinkovic, Dragan;McCarthy, James R.;Moorjani, Manisha;Regan, Collin F.;Saunders, John;Schwaebe, Michael K.;Szabo, Tomas;Williams, John P.;Zhang, Xiaohu;Bozigian, Haig;Chen, Ta Kung. And the article was included in Journal of Medicinal Chemistry in 2005.Safety of 3-Amino-2,6-dimethoxypyridine This article mentions the following:

Two new classes of tricyclic-based corticotropin-releasing factor (CRF₁) receptor-1 antagonists were designed by constraining known 1H-pyrrolo[2,3-b]pyridine and 1H-pyrazolo[3,4-b]pyridine ligands. Pyrrole- and pyrazole-based mols. 19g and 22a, resp., were discovered that potently bind the recombinant CRF₁ receptor (K_i = 3.5, 2.9 nM) and inhibit adrenocorticotropic hormone (ACTH) release from rat pituitary cell culture (IC₅₀ = 14, 6.8 nM). These compounds show good oral bioavailability (F = 24%, 7.0%) and serum half-lives in rats (t_1/2 = 6.3, 12 h) and penetrate the rat brain ([brain]/[plasma] = 0.27, 0.52) but tend toward large volumes of distribution (V_D = 38, 44 L kg^-1) and rapid clearances (CL = 70, 43 mL min^-1 kg^-1). When given orally, both the pyrazole and the pyrrole leads dose-dependently inhibit stress-induced ACTH release in vivo. ACTH reductions of 84-86% were observed for 30 mg kg^-1 doses. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3Safety of 3-Amino-2,6-dimethoxypyridine).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of 3-Amino-2,6-dimethoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rapid synthesis of 2,5-disubstituted 1,3,4-oxadiazoles under microwave irradiation was written by Bentiss, Fouad;Lagrenee, Michel;Barbry, Didier. And the article was included in Synthetic Communications in 2001.Recommanded Product: 15420-02-7 This article mentions the following:

A number of sym. 2,5-disubstituted 1,3,4-oxadiazoles I (Ar = Ph, 2-ClC₆H₄, 4-pyridyl, etc.) are quickly prepared by the reaction of aromatic acids ArCO₂H with hydrazine dihydrochloride in a mixture of orthophosphoric acid and phosphorus pentoxide under microwave irradiation In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Recommanded Product: 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Recommanded Product: 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Syntheses of the piperidine alkaloids (±)-cassine, (±)-spectaline, (±)-spicigerine methyl ester and of (±)-azimic acid and (±)-carpamic acid was written by Hasseberg, Hans Albrecht;Gerlach, Hans. And the article was included in Liebigs Annalen der Chemie in 1989.Formula: C5H3Br2NO This article mentions the following:

The title compounds I, II, III, IV (n = 5, 7), resp., were prepared from 2,6-dibromo-3-pyridinol via coupling of the pyridine V with Grignard agents in presence of dichloro[bis(diphenylphosphino)propane]nickel. In the experiment, the researchers used many compounds, for example, 2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1Formula: C5H3Br2NO).

2,6-Dibromo-3-hydroxypyridine (cas: 6602-33-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C5H3Br2NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reactions of 4-aminopyridine with nitrous acid. VIII. 2-Fluoro-4-aminopyridine and 3-fluoro-4-aminopyridine was written by Talik, Tadeusz;Talik, Zofia. And the article was included in Roczniki Chemii in 1968.Related Products of 3939-14-8 This article mentions the following:

The fluorine atom in the 2 or 3 position of the pyridine ring exercised a weaker stabilizing influence on the diazonium group in position 4 than the Cl atom. Several products from reaction of diazonium compounds prepared from 2-fluoro-4-aminopyridine (I) and 3-fluoro-4-aminopyridine were obtained. Thus, a solution of 0.5 g. I in 5 ml. dilute H2SO4 (1:4) was diazotized at 0° with 0.9 g. NaNO2 in 3 ml. water. The mixture kept 20 min. at room temperature, diluted with 5 ml. H2O and refluxed for a few min., was neutralized with NH4OH to pH 5-6 and extracted with Et2O to give 0.4 g. 2-fluoro-4-hydroxypyridine, m. 157° (H2O). Similarly prepared were 88.1% 2-fluoro-4-iodopyridine, m. 58°, and 41.3% 2-fluoro-4-cyanopyridine (II), m. 31-2°. Hydrolysis of II with dilute HCl (1:1) yielded 86.8% 2-hydroxy-4-pyridinecarboxylic acid, m. 328° (H2O). The following compounds were reported (m.p., b.p., % yield, and m.p. picrate given): 3-fluoro-4-hydroxypyridine, 153°, -, 58.1, -; 3-fluoro-4-chloropyridine, -, 138°, 42.9, 134°; 3-fluoro-4-bromopyridine, -, 163°, 25.5, 115°; 3-fluoro-4-iodopyridine, 87°, -, 25.1, 140°. In the experiment, the researchers used many compounds, for example, 2-Fluoroisonicotinonitrile (cas: 3939-14-8Related Products of 3939-14-8).

2-Fluoroisonicotinonitrile (cas: 3939-14-8) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Related Products of 3939-14-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, Study, and Application of Pd(II) Hydrazone Complexes as the Emissive Components of Single-Layer Light-Emitting Electrochemical Cells was written by Emami, Marzieh;Shahroosvand, Hashem;Bikas, Rahman;Lis, Tadeusz;Daneluik, Cody;Pilkington, Melanie. And the article was included in Inorganic Chemistry in 2021.Application In Synthesis of Phenyl(pyridin-2-yl)methanone This article mentions the following:

For the first time, square planar Pd(II) complexes of hydrazone ligands have been investigated as the emissive components of light-emitting electrochem. cells (LECs). The neutral transition metal complex, [Pd(L¹)₂]·2CH₃OH (1), (HL¹ = (E)-N′-(phenyl(pyridin-2-yl)methylene)isonicotinhydrazide), was prepared and structurally characterized. Complex 1 displays quasireversible redox properties and is emissive at room temperature in solution with a λ_max of 590 nm. As a result, it was subsequently employed as the emissive material of a single-layer LEC with configuration FTO/1/Ga/In, where studies reveal that it has a yellow color with CIE(x, y) = (0.33, 0.55), a luminance of 134 cd cm^-2, and a turn-on voltage of 3.5 V. Protonation of the pendant pyridine nitrogen atoms of L¹ afforded a second ionic complex [Pd(L¹H)₂](ClO₄)₂ (2) which is also emissive at room temperature with a λ_max of 611 nm, resulting in an orange LEC with CIE(x, y) = (0.43, 0.53). The presence of mobile anions and cations in the second inorganic transition metal complex resulted in more efficient charge injection and transport which significantly improved the luminance and turn-on voltage of the device to 188.6 cd cm^-2 and 3 V, resp. This study establishes Pd(II) hydrazone complexes as a new class of materials whose emissive properties can be chem. tuned and provides proof-of-concept for their use in LECs, opening up exciting new avenues for potential applications in the field of solid state lighting. The emissive properties of two Pd(II) hydrazone complexes have been exploited for the fabrication of single-layer light-emitting electrochem. cells. We demonstrate that a neutral Pd(II) complex capable of undergoing proton transfer with the solvent can support a suitable ionic medium for LECs. Furthermore, selective protonation of the hydrazone ligands and the introduction of perchlorate counterions afford a second LEC device with increased c.d., a red-shifted emission, and significantly improved brightness. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Application In Synthesis of Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application In Synthesis of Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem