Day: February 9, 2023

[CN̂]-Alkenyl Gold(III) Complexes by Proximal Ring-Opening of (2-Pyridyl)alkylidenecyclopropanes: Mechanistic Insights was written by Gonzalez, Jorge A.;Verdugo, Felipe;Mascarenas, Jose Luis;Lopez, Fernando;Nevado, Cristina. And the article was included in Angewandte Chemie, International Edition in 2020.Electric Literature of C12H9NO This article mentions the following:

Pyridine-substituted alkylidenecyclopropanes (Py-ACPs) react with gold(III) salts under mild reaction conditions through an unprecedented, proximal ring-opening pathway, to generate highly appealing, catalytically active pyridine alkenyl [CN̂]-gold(III) species. Mechanistic studies reveal that the activation of the C-C bond of the ACP takes place through an unusual concerted, σ-bond metathesis type-process. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Electric Literature of C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Electric Literature of C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Thioether-Assisted Cu-Catalyzed C5-H Arylation of Imidazo[1,5-a]pyridines was written by Wang, Linhua;Zheng, Xuesong;Zheng, Qinze;Li, Zhenlong;Wu, Jian;Gao, Ge. And the article was included in Organic Letters in 2022.Application In Synthesis of 4-Methylpicolinonitrile This article mentions the following:

A series of ethylthio (hetero)arylimidazo[1,5-a]pyridine derivatives I (R = 4-methylphenyl, pyridin-4-yl, 1-methyl-1H-indol-5-yl, etc.; R¹ = H, Cl, Br, Me, Ph, 4-methoxyphenyl, 4-trifluoromethylphenyl; R² = H, 6-Cl, 7-Me) was prepared via Cu-catalyzed regioselective C5-H arylation of imidazo[1,5-a]pyridines I (R = H) with aryl iodides RI with the assistance of an ethylthio group at the C3 position. This directing group could be easily removed to furnish a range of 5-(hetero)arylimidazo[1,5-a]pyridine derivatives e.g., II. The reaction tolerates a variety of functionalities and is compatible with sterically hindered substrates. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Application In Synthesis of 4-Methylpicolinonitrile).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application In Synthesis of 4-Methylpicolinonitrile

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Supramolecular liquid crystals displaying competitive hydrogen bonding: Mesogenic associative chain structures using rigid and flexible pyridyl groups was written by John, Eric A.;Heltne, Michael D.;Bornowski, Evan C.;Lindberg, David J.;Carli, Joshua D.;Legare, Seth B.;Carli, John T.;Wiegel, Kurt N.. And the article was included in Molecular Crystals and Liquid Crystals in 2019.Reference of 626-64-2 This article mentions the following:

A series of liquid-crystalline supramol. copolymers formed through hydrogen bonding has been created. These polymers are composed of a bis-benzoic acid and two different pyridyl species – a small rigid bispyridyl capable of forming a mesophase when assembled and one of a pair of flexible bis pyridyl non-mesogenic “disruptor” species. The latter set of mols. consist of the pyridyl functionality separated by six or ten methylene units (6BPD and 10BPD, resp.). It was found that the associative chain polymers display monotropic characteristics depending upon the length of the methylene spacer group. The hexamethylene chain produced smectic phases up to 15% composition and cleared nematic characteristics at 70% loading. The decamethylene species eliminated smectic phases at 5% loading and displayed nematic phases up to 40% inclusion. It is believed that the increased length and flexibility of the alkyl chain allows for too much conformational mobility and freedom to efficiently form liquid-crystalline phases at high concentrations In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Reference of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Reference of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Titrimetric determination of furosemide using aqueous-micellar solutions of surfactants was written by Kulichenko, S. A.;Fesenko, S. A.. And the article was included in Journal of Analytical Chemistry (Translation of Zhurnal Analiticheskoi Khimii) in 2002.Safety of 1-Dodecylpyridin-1-ium bromide This article mentions the following:

The solubility and acid-base properties of 4-chloro-N-(2-furylmethyl)-5-sulfamoylanthranilic acid (furosemide) were studied in aqueous-micellar solutions of surfactants of different nature. Conditions of the determination of furosemide by acid-base titration in a micellar solution of tridecylpyridinium bromide were found. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Safety of 1-Dodecylpyridin-1-ium bromide).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Safety of 1-Dodecylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stereodivergent Synthesis of Tertiary Fluoride-Tethered Allenes via Copper and Palladium Dual Catalysis was written by Yang, Shao-Qian;Wang, Yi-Fan;Zhao, Wei-Cheng;Lin, Guo-Qiang;He, Zhi-Tao. And the article was included in Journal of the American Chemical Society in 2021.Related Products of 917023-06-4 This article mentions the following:

Herein we describe a protocol for the unprecedented stereodivergent synthesis of tertiary fluoride-tethered allenes bearing a stereogenic center and stereogenic axis via Cu/Pd synergistic catalysis. A broad scope of conjugated enynes are coupled with various α-fluoroesters in high yields with high diastereoselectivities and generally >99% ee. In addition, the four stereoisomers of the allene products ensure precise access to the corresponding four stereoisomers of the fluorinated hydrofurans via a novel stereodivergent axial-to-central chirality transfer process. In the experiment, the researchers used many compounds, for example, Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4Related Products of 917023-06-4).

Methyl 2-(5-bromopyridin-2-yl)acetate (cas: 917023-06-4) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Related Products of 917023-06-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A three-step synthesis of 4-(4-iodo-1H-pyrazol-1-yl)piperidine, a key intermediate in the synthesis of Crizotinib was written by Fussell, Steven J.;Luan, Amy;Peach, Philip;Scotney, Gemma. And the article was included in Tetrahedron Letters in 2012.Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate This article mentions the following:

4-(4-Iodo-1H-pyrazol-1-yl)piperidine is a key intermediate in the synthesis of Crizotinib. We report a robust three-step synthesis that has successfully delivered multi-kilogram quantities of the key intermediate. The process includes nucleophilic aromatic substitution of 4-chloropyridine with pyrazole, followed by hydrogenation of the pyridine moiety and subsequent iodination of the pyrazole which all required optimization to ensure successful scale-up. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Iridium-Catalyzed Regio- and Enantioselective Hydroarylation of Alkenyl Ethers by Olefin Isomerization was written by Ebe, Yusuke;Onoda, Mitsuki;Nishimura, Takahiro;Yorimitsu, Hideki. And the article was included in Angewandte Chemie, International Edition in 2017.HPLC of Formula: 4373-61-9 This article mentions the following:

Iridium-catalyzed hydroarylation of alkenyl ethers, such as allylic and homoallylic ethers, by C-H bond activation gave high yields of the corresponding addition products, where the aryl groups were selectively installed at the α-carbon atom to the alkoxy group. The reaction involves an isomerization of the alkenyl ethers into the corresponding 1-alkenyl ethers, which then undergo the regio- and enantioselective hydroarylation. Thus, e.g., cinnamyl Me ether + 2-phenylpyridine → I (85% yield, 92% ee) in presence of [IrCl(cod)]₂, (R)-binap* and NaBAr^F₄ in toluene. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9HPLC of Formula: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.HPLC of Formula: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Metabolomic investigation of ultraviolet ray-inactivated white spot syndrome virus-induced trained immunity in Marsupenaeus japonicus was written by Zang, Shaoqing;Lv, Li-Xia;Liu, Chen-Fei;Zhang, Peng;Li, Cang;Wang, Jin-Xing. And the article was included in Frontiers in Immunology in 2022.Formula: C5H5NO This article mentions the following:

Trained immunity is driven by metabolism and epigenetics in innate immune cells in mammals. The phenomenon of trained immunity has been identified in invertebrates, including shrimp, but the underlying mechanisms remain unclear. To elucidate mechanisms of trained immunity in shrimp, the metabolomic changes in hemolymph of Marsupenaeus japonicus trained by the UV-inactivated white spot syndrome virus (UVWSSV) were analyzed using tandem gas chromatog.-mass/mass spectrometry. The metabolomic profiles of shrimp trained with UV-WSSV followed WSSV infection showed significant differences comparison with the control groups, PBS injection followed WSSV infection. 16 differential metabolites in total of 154 metabolites were identified, including Dfructose-6-phosphate, D-glucose-6-phosphate, and D-fructose-6-phosphate, and metabolic pathways, glycolysis, pentose phosphate pathway, and AMPK signaling pathway were enriched in the UV-WSSV trained groups. Further study found that histone monomethylation and trimethylation at H3K4 (H3K4me1 and H3K4me3) were involved in the trained immunity. Our data suggest that the UV-WSSV induced trained immunity leads to metabolism reprogramming in the shrimp and provide insights for WSSV control in shrimp aquaculture. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Formula: C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide as selective glycine antagonist with in vivo activity was written by Micheli, Fabrizio;Cugola, Alfredo;Donati, Daniele;Missio, Andrea;Pecunioso, Angelo;Reggiani, Angelo;Tarzia, Giorgio. And the article was included in Bioorganic & Medicinal Chemistry in 1997.Application of 203794-33-6 This article mentions the following:

2,3-Dihydro-6,7-dichloro-pyrido[2,3-b]pyrazine-8-oxide was synthesized and evaluated for in vitro/in vivo antagonistic activity at the strychnine insensitive glycine binding site on the NMDA receptor revealing it to be a useful tool to evaluate the effectiveness of glycine antagonists in vivo. In the experiment, the researchers used many compounds, for example, 5,6-Dichloro-3-nitropyridin-2-amine (cas: 203794-33-6Application of 203794-33-6).

5,6-Dichloro-3-nitropyridin-2-amine (cas: 203794-33-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Application of 203794-33-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Assessment and prediction of joint algal toxicity of binary mixtures of graphene and ionic liquids was written by Wang, Zhuang;Zhang, Fan;Wang, Se;Peijnenburg, Willie J. G. M.. And the article was included in Chemosphere in 2017.Product Details of 125652-55-3 This article mentions the following:

Graphene and ionic liquids (ILs) released into the environment will interact with each other. So far however, the risks associated with the concurrent exposure of biota to graphene and ILs in the environment have received little attention. The research reported here focused on observing and predicting the joint toxicity effects in the green alga Scenedesmus obliquus exposed to binary mixtures of intrinsic graphene (iG)/graphene oxide (GO) and five ILs of varying anionic and cationic types. The isolated ILs in the binary mixtures were the main contributors to toxicity. The binary GO-IL mixtures resulted in more severe joint toxicity than the binary iG-IL mixtures, irresp. of mixture ratios. The mechanism of the joint toxicity may be associated with the adsorption capability of the graphenes for the ILs, the dispersion stability of the graphenes in aquatic media, and modulation of the binary mixtures-induced oxidative stress. A toxic unit assessment showed that the graphene and IL toxicities were additive at low concentration of the mixtures but antagonistic at high concentration of the mixtures Predictions made using the concentration addition and independent action models were close to the observed joint toxicities regardless of mixture types and mixture ratios. These findings provide new insights that are of use in the risk assessment of mixtures of engineered nanoparticles and other environmentally relevant contaminants. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Product Details of 125652-55-3).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 125652-55-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem