Day: February 9, 2023

Adams, Christopher J. et al. published their research in Chemical Communications (Cambridge, United Kingdom) in 2015 | CAS: 628-13-7

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C5H6ClN

Two-step solid-state synthesis of PEPPSI-type compounds was written by Adams, Christopher J.;Lusi, Matteo;Mutambi, Emily M.;Guy Orpen, A.. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2015.Formula: C5H6ClN This article mentions the following:

The two-step mechanochem. preparation of carbene-pyridine complexes of palladium and platinum is reported. The organometallic products, which represent a class of com. available catalysts, are rapidly formed in excellent yield proving solvent-free synthesis to be a viable synthetic alternative even in the case of NHC-containing compounds In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Formula: C5H6ClN).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C5H6ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yip, Yuk-Wang et al. published their research in European Journal of Inorganic Chemistry in 2019 | CAS: 131747-45-0

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Reference of 131747-45-0

Reaction-Based Europium Complex for Specific Detection of Cysteine Over Homocysteine and Glutathione with Variable-Temperature Kinetic Studies was written by Yip, Yuk-Wang;Yan, Zhiyuan;Law, Ga-Lai;Wong, Wing-Tak. And the article was included in European Journal of Inorganic Chemistry in 2019.Reference of 131747-45-0 This article mentions the following:

A water-soluble europium(III)-based probe, EuL, has been designed and synthesized for selective recognition of cysteine (Cys) over other structurally similar thiols and amino derivatives due to formation of a more stable and preferable seven-membered ring. Addition of Cys shows a significant response with quenching of over 90% of the initial signal (Hcys: 10.5%, GSH: 3.6% resp.). A good linear correlation between the emission intensities and concentrations of Cys has been established. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Reference of 131747-45-0).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Reference of 131747-45-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Keith, John M. et al. published their research in Journal of Organic Chemistry in 2010 | CAS: 3718-65-8

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Product Details of 3718-65-8

One-Step Conversion of Azine N-Oxides to α-1,2,4-Triazolo-, 1,2,3-Triazolo, Imidazolo-, and Pyrazoloheteroarenes was written by Keith, John M.. And the article was included in Journal of Organic Chemistry in 2010.Product Details of 3718-65-8 This article mentions the following:

Pyridine, quinoline, isoquinoline, azaindole, and pyrimidine N-oxides, e.g. I, were converted to their α-triazole and α-diazole derivatives, e.g. II, by treatment with the corresponding p-toluenesulfonylazoles and Hunig’s base at elevated temperatures In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Product Details of 3718-65-8).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Product Details of 3718-65-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kharitonova, T. V. et al. published their research in Colloid Journal in 2005 | CAS: 104-73-4

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Product Details of 104-73-4

Adsorption of cationic and nonionic surfactants on a SiO2 surface from aqueous solutions: 2. Adsorption of dodecylpyridinium bromide and Triton X-100 from mixed solutions was written by Kharitonova, T. V.;Ivanova, N. I.;Summ, B. D.. And the article was included in Colloid Journal in 2005.Product Details of 104-73-4 This article mentions the following:

Adsorption of cationic (dodecylpyridinium bromide) and nonionic (Triton X-100) surfactants from their mixed aqueous solutions on a SiO2 surface at pH 3.6, 6.5, and 10 was studied by the UV spectroscopy, capillary zone electrophoresis, and wetting measurements. The adsorption of cationic and nonionic surfactants from mixed solutions is accompanied by synergistic effects manifesting themselves as an enhanced adsorption of both surfactants compared to their adsorption from individual solutions The effect of 2nd component becomes most pronounced under conditions when differences in adsorption abilities of individual surfactants are rather large (at pH 3.6 and 10). The adsorption of surfactants from mixed solutions can be controlled by the adsorption ability of components via the variations in solution pH. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Product Details of 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule α-helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Product Details of 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Singh, Tejwant et al. published their research in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2008 | CAS: 125652-55-3

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Quality Control of 1-Butyl-3-methylpyridinium Chloride

Self-aggregation of ionic liquids in aqueous media: A thermodynamic study was written by Singh, Tejwant;Kumar, Arvind. And the article was included in Colloids and Surfaces, A: Physicochemical and Engineering Aspects in 2008.Quality Control of 1-Butyl-3-methylpyridinium Chloride This article mentions the following:

Aggregation process of the ionic liquids (ILs), 1-butyl-3-methylimidazolium tetrafluoroborate [C4mim][BF4], 3-methyl-1-octylimidazolium tetrafluoroborate [C8mim][BF4], 3-methyl-1-octylimidazolium chloride [C8mim][Cl], and N-butyl-3-methylpyridinium chloride [C4mpy][Cl], in the aqueous solutions was characterized by elec. conductivity, d., and speed of sound measurements at 298.15 K. The critical aggregation concentration (CAC), the standard Gibbs energy of aggregation ΔGagg, isentropic compressibility κs, and changes in the isentropic compressibility upon aggregation Δκ s,agg for the ionic liquids were derived from the exptl. data. The dependence of the CAC, ΔGagg and Δκs,agg on the nature of the cations and anions was examined The aggregation number n for various ILs was determined by applying the mass action theory to the concentration dependence of elec. conductivity and compressibility. Aggregation properties showed fairly good agreement with the authors’ previously reported results of 1H NMR and fluorescence spectroscopy. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Quality Control of 1-Butyl-3-methylpyridinium Chloride).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Quality Control of 1-Butyl-3-methylpyridinium Chloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mo, Jia-Nan et al. published their research in Organic Letters in 2018 | CAS: 628-13-7

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Quality Control of Pyridinehydrochloride

Regiospecific Three-Component Aminofluorination of Olefins via Photoredox Catalysis was written by Mo, Jia-Nan;Yu, Wan-Lei;Chen, Jian-Qiang;Hu, Xiu-Qin;Xu, Peng-Fei. And the article was included in Organic Letters in 2018.Quality Control of Pyridinehydrochloride This article mentions the following:

Direct visible-light-mediated aminofluorination of styrenes has been developed with high regioselectivity. Shelf-stable N-Ts-protected 1-aminopyridine salt was used as the nitrogen-radical precursor, and the com. available hydrogen fluoride-pyridine was used as the nucleophilic fluoride source. The synthesis of an analog of LY503430 was performed to demonstrate the synthetic value of this strategy. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Quality Control of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Quality Control of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kollipara, Mohan Rao et al. published their research in Journal of Organometallic Chemistry in 2020 | CAS: 91-02-1

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Computed Properties of C12H9NO

Fluorenone Schiff base derivative complexes of ruthenium, rhodium and iridium exhibiting efficient antibacterial activity and DNA-binding affinity was written by Kollipara, Mohan Rao;Shadap, Lathewdeipor;Banothu, Venkanna;Agarwal, Nipanshu;Poluri, Krishna Mohan;Kaminsky, Werner. And the article was included in Journal of Organometallic Chemistry in 2020.Computed Properties of C12H9NO This article mentions the following:

Half-sandwich ruthenium, rhodium and iridium pyridyl fluorenylidene azine Schiff base complexes [LMCl(2-pyCR:NN:Fl)] (1–9; M = Ru, L = p-cymene; M = Rh, Ir, L = C5Me5; R = Ph, Me, H; py = pyridyl, Fl = 9-fluorenylidene) were prepared and examined for their antibacterial activity. Metal precursors [(arene)MCl2]2 (arene = p-cymene, Cp*; M = Ru, Rh and Ir) on reacting with 9-fluorenone derivative ligands L1, L2 and L3 resulted in the formation of mononuclear bidentate cationic N-N bonded complexes. The biol. studies of these complexes such as antibacterial activity studies (against Gram-pos. and Gram-neg. bacteria) revealed significant antibacterial activity with complexes 4, 7 and 9 having the highest activity potency (in-vitro). While for DNA-binding studies, the results revealed that complexes 4 and 5 displayed significant changes in their spectral features upon addition of SM-DNA, thus, indicating that these complexes bind to DNA with a significant affinity. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Computed Properties of C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Computed Properties of C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Rhoufal, Ferdaousse et al. published their research in Acta Crystallographica, Section E: Crystallographic Communications in 2019 | CAS: 15420-02-7

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Safety of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Crystal structure, spectroscopic characterization and Hirshfeld surface analysis of trans-diaqua[2,5-bis(pyridin-4-yl)-1,3,4-oxadiazole]dithiocyanatonickel(II) was written by Rhoufal, Ferdaousse;Bentiss, Fouad;Guesmi, Salaheddine;Ketatni, El Mostafa;Saadi, Mohamed;El Ammari, Lahcen. And the article was included in Acta Crystallographica, Section E: Crystallographic Communications in 2019.Safety of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole This article mentions the following:

The reaction of 2,5-bis(pyridin-4-yl)-1,3,4-oxadiazole (4-pox) and thiocyanate ions, used as co-ligand with nickel salt NiCl2·6H2O, produced the title complex, [Ni(NCS)2(C12H8N4O)2(H2O)2]. The NiII atom is located on an inversion center and is octahedrally coordinated by four N atoms from two ligands and two pseudohalide ions, forming the equatorial plane. The axial positions are occupied by two O atoms of coordinated water mols. In the crystal, the mols. are linked into a three-dimensional network through strong O-H···N hydrogen bonds. Hirshfeld surface anal. was used to investigate the intermol. interactions in the crystal packing. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Safety of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Safety of 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Hirano, Tomohiro et al. published their research in Polymer in 2008 | CAS: 3718-65-8

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Category: pyridine-derivatives

Metal-free isotactic-specific radical polymerization of N-isopropylacrylamide with pyridine N-oxide derivatives: The effect of methyl substituents of pyridine N-oxide on the isotactic specificity and the proposed mechanism for the isotactic-specific radical polymerization was written by Hirano, Tomohiro;Ishizu, Hideaki;Sato, Tsuneyuki. And the article was included in Polymer in 2008.Category: pyridine-derivatives This article mentions the following:

The radical polymerizations of N-isopropylacrylamide (NIPAAm) in chloroform at low temperatures in the presence of pyridine N-oxide (PNO) derivatives were investigated. It was found that the methylation at meta-positions of PNO improved the isotactic specificity induced by PNO, whereas the methylation at ortho-positions prevented the induction of the isotactic specificity. NMR anal. revealed that NIPAAm and PNO derivatives formed predominantly 2:1 complex through a hydrogen-bonding interaction. Furthermore, the induction of the isotactic specificity was attributed to the conformationally limited propagating radicals. Based on these findings, the mechanism of the isotactic-specific radical polymerization was discussed. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Category: pyridine-derivatives).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Storozhenko, Olga A. et al. published their research in Beilstein Journal of Organic Chemistry in 2018 | CAS: 17281-59-3

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 1-(Cyanomethyl)pyridin-1-ium chloride

Mn-mediated sequential three-component domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction towards annulated imidazo[1,2-a]pyridines was written by Storozhenko, Olga A.;Festa, Alexey A.;Bella Ndoutoume, Delphine R.;Aksenov, Alexander V.;Varlamov, Alexey V.;Voskressensky, Leonid G.. And the article was included in Beilstein Journal of Organic Chemistry in 2018.Application In Synthesis of 1-(Cyanomethyl)pyridin-1-ium chloride This article mentions the following:

The sequential three-component reaction between o-hydroxybenzaldehydes, N-(cyanomethyl)pyridinium salts and a nucleophile towards substituted chromenoimidazopyridines under oxidative conditions has been developed. The employment of Mn(OAc)3·2H2O or KMnO4 as stoichiometric oxidants allowed the use of a wide range of nucleophiles, such as nitromethane, (aza)indoles, pyrroles, phenols, pyrazole, indazole and di-Et malonate. The formation of the target compounds presumably proceeds through a domino Knoevenagel/cyclization/Michael addition/oxidative cyclization reaction sequence. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Application In Synthesis of 1-(Cyanomethyl)pyridin-1-ium chloride).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 1-(Cyanomethyl)pyridin-1-ium chloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem