Day: February 9, 2023

The roles of metabolic pathways in maintaining primary dormancy of Pinus koraiensis seeds was written by Song, Yuan;Zhu, Jiaojun. And the article was included in BMC Plant Biology in 2019.Quality Control of Pyridin-4-ol This article mentions the following:

Background: Korean pine seeds have primary dormancy following dispersal, leading to poor seed germination and seedling establishment. Metabolic homeostasis determines whether the seeds are dormant or non-dormant. However, the specific metabolic pathways that maintain the primary dormancy of pine seeds are poorly understood. Results: Metabolic anal. was employed on the embryos of PDRS (seeds released from primary dormancy) and PDS (primary dormant seeds) on days 0, 5 and 11 after incubation under a germination-inductive temperature A larger metabolic switch occurred in PDRS embryos from days 0 to 11. The contents of ninety metabolites were significantly changed from days 0 to 5, 83% of which (including most sugars, organic acids and amino acids) increased, reflecting that biosynthetic metabolism processes are initiated. The contents of ninety-two metabolites showed distinct variations from days 5 to 11, 71% of which (including most organic acids and almost all amino acids) reduced substantially. Fructose 6-phosphate, inositol-3-phosphate, 3-phosphoglyceric and D-glucose-6-phosphate contents showed the most decrease with decreasing 409-, 75-, 58- and 41-fold, indicating that the glycolysis and tricarboxylic acid (TCA) cycle strongly slowed down. The contents of the most metabolites in PDS embryos also displayed a relatively larger alteration only from days 0 to 5. Although 64% of metabolites increased from days 0 to 5, their levels were still lower compared with PDRS embryos. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Quality Control of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Quality Control of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Photoarylation of Pyridines Using Aryldiazonium Salts and Visible Light: An EDA Approach was written by Bartolomeu, Aloisio de A.;Silva, Rodrigo C.;Brocksom, Timothy J.;Noel, Timothy;de Oliveira, Kleber T.. And the article was included in Journal of Organic Chemistry in 2019.Recommanded Product: Pyridinehydrochloride This article mentions the following:

A metal-free methodol. for the photoarylation of pyridines, in water, is described giving 2 and 4-arylated-pyridines in yields up to 96%. The scope of the aryldiazonium salts is presented showing important results depending on the nature and position of the substituent group in the diazonium salt, i.e., electron-donating or electron-withdrawing in the ortho, meta, or para positions. Further heteroaromatics were also successfully photoarylated. Mechanistic studies and comparison between our methodol. and similar metal-catalyzed procedures are presented, suggesting the occurrence of a visible-light EDA complex which generates the aryl radical with no need for an addnl. photocatalyst. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Recommanded Product: Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Catalytic activity of sterically hindered heterocyclic tertiary amines in thiosemicarbazide formation was written by Yanchuk, N. I.. And the article was included in Russian Journal of General Chemistry (Translation of Zhurnal Obshchei Khimii) in 1998.SDS of cas: 644-98-4 This article mentions the following:

Kinetics of the reaction of diphenylphosphinic hydrazide with Ph isothiocyanate in benzene at 25° in the presence of 2-alkyl-substituted pyridines and N-methylbenzimidazoles were studied. Steric and inductive components of the nucleophilicity of these tertiary amines were determined The catalytic activity of pyridines was more sensitive to steric demand of the catalytic center compared with that of benzimidazoles. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4SDS of cas: 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the π-bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the σ bonds. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of a tricyclic farnesoid X receptor agonist HEC96719, a clinical candidate for treatment of non-alcoholic steatohepatitis was written by Cao, Shengtian;Yang, Xinye;Zhang, Zheng;Wu, Junwen;Chi, Bo;Chen, Hong;Yu, Jianghong;Feng, Shanshan;Xu, Yulin;Li, Jing;Zhang, Yingjun;Wang, Xiaojun;Wang, Yan. And the article was included in European Journal of Medicinal Chemistry in 2022.SDS of cas: 51834-97-0 This article mentions the following:

Synthesis and characterization of compound HEC96719 I a novel tricyclic FXR agonist based on a prior high-affinity nonsteroidal mol. GW4064 was reported. HEC96719 I exhibited excellent potency superior to GW4064 and obeticholic acid in in vitro and in vivo assays of FXR activation. It also showed higher FXR selectivity and more favorable tissue distribution dominantly in liver and intestine. Preclin. data on pharmacokinetic properties, efficacy, and safety profiles overall indicate that HEC96719 I was a promising drug candidate for NASH treatment. In the experiment, the researchers used many compounds, for example, 5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0SDS of cas: 51834-97-0).

5-Hydroxy-2-methoxylpyridine (cas: 51834-97-0) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 51834-97-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Cobalt-Catalyzed Cross-Coupling Reactions of Arylboronic Esters and Aryl Halides was written by Duong, Hung A.;Wu, Wenqin;Teo, Yu-Yuan. And the article was included in Organometallics in 2017.Reference of 175205-82-0 This article mentions the following:

An efficient cobalt catalyst system for the Suzuki-Miyaura cross-coupling reaction of arylboronic esters and aryl halides has been identified. In the presence of cobalt(II)/terpyridine catalyst and potassium methoxide, a diverse array of (hetero)biaryls have been prepared in moderate to excellent yields. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Reference of 175205-82-0).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Reference of 175205-82-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Dimensional Reduction of Eu-Based Metal-Organic Framework as Catalysts for Oxidation Catalysis of C(sp³)-H Bond was written by Zhang, Yin;Yu, Wei-Dong;Zhao, Cai-Feng;Yan, Jun. And the article was included in Chinese Journal of Chemistry in 2022.SDS of cas: 91-02-1 This article mentions the following:

Developing new catalysts for highly selectivity and conversion of saturated C(sp³)-H bonds is of great significance. In order to obtain catalysts with high catalytic performance, six Eu-based MOFs with different structural characteristics were obtained by using europium ions and different organic acid ligands, namely Eu-1∼Eu-6. Eu-1, Eu-2 and Eu-3 featured three-dimensional structures, while Eu-4 and Eu-5 featured two-dimensional structures. Differently, a one-dimensional chain structure of Eu-6 was obtained by changing the ligand. All the six MOFs were applied to the catalytic reaction of C(sp³)-H bond, and it was found that the catalytic effect was gradually enhanced with the decrease of dimension and the increase of the size of channels. As expected, Eu-6 showed the highest selectivity (∼99%) and conversion (∼99%). Moreover, catalytic cycling and stability tests showed Eu-6 can be a reliable catalyst. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1SDS of cas: 91-02-1).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine has a conjugated system of six π electrons that are delocalized over the ring. The molecule is planar and, thus, follows the Hückel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C–H in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.SDS of cas: 91-02-1

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Reactions of the hydrazine derivatives. XXV. Action of acetic anhydride and polyphosphoric acid on acylhydra-zones was written by Sagitullin, R. S.;Kost, A. N.. And the article was included in Vestnik Moskovskogo Universiteta, Seriya Matematiki, Mekhaniki, Astronomii, Fiziki, Khimii in 1959.Recommanded Product: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole This article mentions the following:

In the interaction of various acylhydrazones (containing the NH group) with Ac₂O, independent of the structure of the acyl residue and the carbonyl components (acetone, cyclohexanone, or benzaldehyde), cyclization took place to yield N-acetyl-oxadiazolines. Under the action of polyphosphoric acid (I) as condensing agent, disproportionation, with the formation of diacylhydrazine and azine, took place; the diacylhydrazine, under the conditions of reaction, separated H₂O to give an oxadiazole. Acetone acetylhydrazone (II) (50 g.) and 60 ml. Ac₂O was refluxed 45 min., cooled, 100 ml. H₂O added, the mixture neutralized with KOH, the oil separated, the aqueous layer extracted twice with Et₂O, the combined extracts dried over KOH, the Et₂O evaporated, and the residue distilled to yield 70% 2,2,5-trimethyl-3-acetyl-1,3,4-oxadiazoline, b₁₈ 88-90°, m. 23-4°, n²⁰_D 1.4627, d₂₀ 1.0547, MR_D 40.75. Cyclohexanone acetylhydrazone, m. 124° (alc.), (2 g.) and 2.5 g. Ac₂O was refluxed 1 hr., cooled, 30 ml. H₂O added, the mixture neutralized with KOH, and the oil cooled with ice water to yield 51% 5-methyl-2,2-pentamethylene-3-acetyl-1,3,4-oxadiazoline, m. 63-5° (petr. ether). In an analogous manner, 3.5 g. benzaldehyde acetylhydrazone and 7 g. Ac₂O was boiled 40 min. to yield 80% 5-methyl-2-phenyl-3-acetyl-1,3,4-oxadiazoline, m. 90-2° (alc.). Acetone benzoylhydrazone (2.5 g.) and 3 g. Ac₂O yielded 83% 5,5-dimethyl-2-phenyl-3-acetyl-1,3,4-oxadiazoline, m. 49-50° (petr. ether), λ 292, 305 mμ, log ε 4.176, 4.041. Cyclohexanone benzoylhydrazone (2.5 g.) and 3.3 g. Ac₂O yielded (30 min. boiling) 84% 5-phenyl-2,2-pentamethylene-3-acetyl-1,3,4-oxadiazoline, m. 79-80 (petr. ether). Benzaldehyde benzoylhydrazone (15 g.) and 30 g. Ac₂O boiled 40 min. yielded 94% 2,5-diphenyl-3-acetyl-1,3,4-oxadiazoline, m. 92-4° (aqueous alc.), λ 290 mμ, log ε 4.16. Cyclohexanone isonicotinoylhydrazone (1 g.) and 2 g. Ac₂O yielded 84% 3-acetyl-5-(4-pyridyl)-2,2-pentamethylene-1,3,4-oxadiazoline, m. 104-5°. II (50 g.) and 100 g. I heated 1 hr. at 150-60°, while stirring occasionally the mixture dissolved in 200 ml. H₂O, saturated with KOH, the upper oily layer separated, dried thoroughly over KOH, and distilled yielded 82% 3,5,5-trimethylpyrazoline, m. 158-63°; HCl salt m. 168-71°. Acetone benzoylhydrazone (4.5 g.) and 17 g. I was heated 1 hr. at 180-90°, cooled, and poured into cold H₂O to yield quant. 2,5-diphenyl-1,3,4-oxadiazole, m. 138-39°, λ 280 mμ, log ε 4.43; traces only of 3,5,5-trimethylpyrazoline were found in the filtrate. In an analogous manner, 15 g. cyclohexanone benzoylhydrazone and 45 g. I boiled 1 hr. at 140-50° yielded 65% 2,5-diphenyl-1,3,4-oxadiazole, m. 137.5-8°; the aqueous solution after the separation of the oxadiazole was neutralized with KOH, extracted with Et₂O, the Et₂O layer dried over KOH, and Et₂O evaporated to yield 1.5 g. cyclohexanone azine, b₇ 140-3°. Acetone isonicotinoylhydrazone (2.1 g.) and 11 g. I kept 2 hrs. at 170-80° yielded 42% 2,5-di(4-pyridyl)-1,3,4-oxadiazole, m. 185-6° (MeOH). In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Recommanded Product: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. The pyridine ring occurs in many important compounds, including agrochemicals, pharmaceuticals, and vitamins. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of thiosemicarbazone derivatives as effective New Delhi metallo-β-lactamase-1 (NDM-1) inhibitors against NDM-1 producing clinical isolates was written by Zhao, Bing;Zhang, Xinhui;Yu, Tingting;Liu, Ying;Zhang, Xiaoling;Yao, Yongfang;Feng, Xuejian;Liu, Hongmin;Yu, Dequan;Ma, Liying;Qin, Shangshang. And the article was included in Acta Pharmaceutica Sinica B in 2021.Recommanded Product: Phenyl(pyridin-2-yl)methanone This article mentions the following:

In this study, structure-activity relationship based on thiosemicarbazone derivatives (E)-R¹C(S)NHN=C(R²)(R³) (I) (R¹ = phenylamino, Ph, cyclohexylamino, morpholin-4-yl, etc.; R² = H, Me; R³ = Ph, pyridin-2-yl, 3,4,5-trimethoxyphenyl, etc.) was systematically characterized and their potential activities combined with meropenem (MEM) were evaluated. Compounds (I).HCl [R¹ = piperazin-1-yl, R² = H, R³ = 2-hydroxyphenyl (II); R¹ = 4-methylpiperazin-1-yl, R² = H, R³ = 2-hydroxyphenyl (III)] exhibited excellent activity against 10 NDM-pos. isolate clin. isolates in reversing MEM resistance. Further studies demonstrated that compounds II and III were uncompetitive NDM-1 inhibitors with Ki = 0.63 and 0.44μmol/L, resp. Mol. docking speculated that compounds II and III were most likely to bind in the allosteric pocket which would affect the catalytic effect of NDM-1 on the substrate meropenem. Toxicity evaluation experiment showed that no hemolysis activities were found even at concentrations of 1000 mg/mL against red blood cells. In vivo exptl. results showed that a combination of MEM and compound III was markedly effective in treating infections caused by NDM-1 pos. strain and prolonging the survival time of sepsis mice. The finding showed that compound III might be a promising lead in developing new inhibitor to treat NDM-1 producing superbug. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Recommanded Product: Phenyl(pyridin-2-yl)methanone).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: Phenyl(pyridin-2-yl)methanone

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A Predictive Strategy Based on Volatile Profile and Chemometric Analysis for Traceability and Authenticity of Sugarcane Honey on the Global Market was written by Silva, Pedro;Freitas, Jorge;Nunes, Fernando M.;Camara, Jose S.. And the article was included in Foods in 2021.Electric Literature of C5H5NO This article mentions the following:

Sugarcane honey (SCH) is a syrup produced on Madeira Island and recognized by its unique aroma, a complex attribute of quality with an important influence on the final consumer’s acceptance of the product, and determined by a complex mixture of a large number of volatile organic compounds (VOCs) generated during its traditional making process and storage. Therefore, the purpose of this study was to establish the volatile profile of genuine SCH produced by a regional certified producer for seven years and compare it with syrups from non-certified regional producers and with producers from different geog. regions (Spain, Egypt, Brazil and Australia), as a powerful strategy to define the volat. fingerprint of SCH. Different volatile profiles were recognized for all samples, with 166 VOCs being identified belonging to different chem. classes, including furans, ketones, carboxylic acids, aldehydes and alcs. Chemometric anal. allowed (i) the differentiation between all syrups, being more pronounced between SCH and other syrups; and (ii) the identification of 32 VOCs as potential markers for the traceability and authenticity of SCH on the global market. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Electric Literature of C5H5NO).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of −48.7 × 10−6 cm3·mol−1.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ·mol−1 in the liquid phase and 140.4 kJ·mol−1 in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Electric Literature of C5H5NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Propionamide Derivatives as Dual μ-Opioid Receptor Agonists and σ₁ Receptor Antagonists for the Treatment of Pain was written by Garcia, Monica;Llorente, Virginia;Garriga, Lourdes;Christmann, Ute;Rodriguez-Escrich, Sergi;Virgili, Marina;Fernandez, Begona;Bordas, Magda;Ayet, Eva;Burgueno, Javier;Pujol, Marta;Dordal, Albert;Portillo-Salido, Enrique;Gris, Georgia;Vela, Jose Miguel;Almansa, Carmen. And the article was included in Journal of Medicinal Chemistry in 2021.SDS of cas: 175205-82-0 This article mentions the following:

A new series of propionamide derivatives was developed as dual μ-opioid receptor agonists and σ₁ receptor antagonists. Modification of a high-throughput screening hit originated a series of piperazinylcycloalkylmethyl propionamides, which were explored to overcome the challenge of achieving balanced dual activity and convenient drug-like properties. The lead compound identified, 18g (I), showed good analgesic effects in several animal models of both acute (paw pressure) and chronic (partial sciatic nerve ligation) pain, with reduced gastrointestinal effects in comparison with oxycodone. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0SDS of cas: 175205-82-0).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ·mol−1 in pyridine vs. 150 kJ·mol−1 in benzene). Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 175205-82-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem