Day: February 13, 2023

Preparation of poly(2-pyridone-3,5-diyl)s with -(CH₂)₄-SO₃M (M = H or Na) side chains was written by Yamamoto, Takakazu;Takei, Tohru;Kumagai, Naoto;Harada, Yosuke;Ohki, Takumi;Kudoh, Yasuo;Kojima, Takahiro;Koizumi, Take-aki;Shiramizu, Kohei;Abe, Masahiro;Oota, Masashi. And the article was included in Polymer in 2012.Application In Synthesis of 3,5-Dibromo-2-hydroxypyridine This article mentions the following:

Poly(2-pyridone-3,5-diyl)s with -(CH₂)₄-SO₃M (M = H or Na) side chains have been prepared by nickel-complex promoted dehalogenative polycondensation. A composite film of the polymer with -(CH₂)₄-SO₃H side chains and poly(vinyl alc.) showed a proton conductivity of 1.5 鑴?10^-1 S cm^-1 at 80 鎺矯 and 95% humidity. A copolymer with pyridine showed a high stability against oxidation by a Fenton reagent. In the experiment, the researchers used many compounds, for example, 3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6Application In Synthesis of 3,5-Dibromo-2-hydroxypyridine).

3,5-Dibromo-2-hydroxypyridine (cas: 13472-81-6) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Application In Synthesis of 3,5-Dibromo-2-hydroxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Investigation of reaction conditions in the synthesis of imidazolium, pyridinium and pyrrolidinium based ionic liquids was written by Adibi, M.;Mehdizadeh, A.;Ahmadi, A. N.. And the article was included in Pazhuhesh Naft in 2009.Recommanded Product: 125652-55-3 This article mentions the following:

Unique properties of ionic liquids such as low vapor pressure, high thermal stability, and their ability to dissolve polar compounds makes them potential alternatives for organic solvents lacking such characteristics. Studies show that substantial efforts are being made to synthesize these ionic liquids under milder reaction conditions. Quaternary imidazolium, pyridinium, and pyrrolidinium based salts are unfortunately prepared at high temperatures over long periods of time, making the syntheses economically inefficient. Parameters involved in the synthesis of each of these salts have been optimized in this work and the synthesis conditions have been compared. Results indicate that the synthesis of dialkyl imidazolium chlorides I (R = n-C₄H₉, n-C₆H₁₃, n-C₈H₁₇) gives higher yields and requires shorter reaction times in comparison with the other two groups. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Recommanded Product: 125652-55-3).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: 125652-55-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Efficient total synthesis of neocryptolepine and synthetic access to 6-methylquinindoline from a common intermediate was written by Mendez, Maria V.;Heredia, Daniel A.;Larghi, Enrique L.;Bracca, Andrea B. J.;Kaufman, Teodoro S.. And the article was included in RSC Advances in 2017.SDS of cas: 628-13-7 This article mentions the following:

A convenient approach toward the indoloquinolines neocryptolepine and 6-methylquinindoline from a common intermediate, is reported. Both sequences, designed for maximum use of accessible reagents and robust conditions, are straightforward and efficient. They involved the amidation of 2-aminobenzaldehyde (prepared by iron-mediated reduction of 2-nitrobenzaldehyde) with 2-nitrophenylacetic acid, followed by a K₂CO₃-assisted cyclization to form a 3-(2-nitrophenyl)quinolin-2-one as the common precursor. Me₂CO₃-mediated N-methylation of the lactam, reduction of the nitro moiety and final cyclization resulted in 55% overall yield of neocryptolepine, whereas cyclocondensation and N-methylation afforded 79% overall yield of 6-Me quinindoline. Thus, the sequences toward the targets entailed two POCl₃-promoted C-N bond forming reactions, two Fe-mediated nitro group reductions and two base-promoted transformations. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7SDS of cas: 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.SDS of cas: 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The synthesis of 4-benzylamino-6-methyl-1H-pyrrolo[3,2-c]pyridine and 4-benzylamino-6-methyl-1H-pyrrolo[2,3-b]pyridine was written by Meade, Eric A.;Beauchamp, Lilia M.. And the article was included in Journal of Heterocyclic Chemistry in 1996.Category: pyridine-derivatives This article mentions the following:

Deaza analogs of 2-methyl-N-(phenylmethyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine, i.e., 6-methyl-N-(phenylmethyl)-1H-pyrrolo[3,2-c]pyridin-4-amine (I) and 6-methyl-N-(phenylmethyl)-1H-pyrrolo[2,3-b]pyridin-4-amine (II) were prepared The 1-deaza analog I was prepared via a multi-step procedure from a pyrrole precursor, 1-benzyl-2-formylpyrrole, while the 3-deaza analog II was synthesized from 2-amino-3,6-dimethylpyridine. I and II were found to be devoid of anxiolytic activity. In the experiment, the researchers used many compounds, for example, 3,6-Dimethyl-2-pyridinamine (cas: 823-61-0Category: pyridine-derivatives).

3,6-Dimethyl-2-pyridinamine (cas: 823-61-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of vinylcycloalkyl-substituted benzimidazole TRPM8 antagonists effective in the treatment of cold allodynia was written by Calvo, Raul R.;Meegalla, Sanath K.;Parks, Daniel J.;Parsons, William H.;Ballentine, Shelley K.;Lubin, Mary Lou;Schneider, Craig;Colburn, Raymond W.;Flores, Christopher M.;Player, Mark R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2012.Related Products of 175205-82-0 This article mentions the following:

Thermosensitive transient receptor potential melastatin 8 (TRPM8) antagonists are considered to be potential therapeutic agents for the treatment of cold hypersensitivity. The discovery of a new class of TRPM8 antagonists that shows in vivo efficacy in the rat chronic constriction injury (CCI)-induced model of neuropathic pain is described. In the experiment, the researchers used many compounds, for example, 2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0Related Products of 175205-82-0).

2-Bromo-3-(trifluoromethyl)pyridine (cas: 175205-82-0) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Related Products of 175205-82-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Chemical constitution and activity of bipyridinium herbicides. Part XIV. Reduction potential and herbicidal activity of 4,4′-(1,3,4-thiadiazole-2,5-diyl)- and 4,4′-(1,3,4-oxadiazole-2,5-diyl)bis(1-methylpyridinium) diiodides was written by Kennedy, Debra A.;Summers, Lindsay A.. And the article was included in Journal of Heterocyclic Chemistry in 1981.Related Products of 15420-02-7 This article mentions the following:

The diquaternary salts 4,4′-(1,3,4-thiadiazole-2,5-diyl)bis(1-methylpyridinium) diiodide [23622-28-8] and 4,4′-(1,3,4-oxadiazole-2,5-diyl)bis(1-methylpyridinium) diiodide [78003-53-9] are reduced in aqueous solution in the pH range 5.4-8.0 to radical cations at a potential of -0.39 V and -0.48 V, resp. Herbicidal activity was demonstrated in postemergence tests at 8-16 kg/ha against a variety of grass flora, but herbicidal activity was 1/30 and 1/60, resp., less than that of paraquat. In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Related Products of 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Related Products of 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Preparation of Pyridinium-Functionalized Magnetic Adsorbent and Its Application for Nitrate Removal from Aqueous Solution was written by Ma, F.;Du, H. T.;Wang, Q.;Li, R. H.;Zhang, Z. Q.. And the article was included in Water, Air, & Soil Pollution in 2015.Synthetic Route of C5H6ClN This article mentions the following:

A novel magnetic pyridinium-functionalized mesoporous silica adsorbent (Fe₃O₄@SiO₂@Py-Cl) was synthesized for nitrate removal from aqueous solutions The adsorption performances were investigated by varying exptl. conditions such as pH, contact time, and initial concentration The adsorbent was characterized by transmission electron microscopy (TEM), XPS, Fourier transform IR (FT-IR) spectroscopy, and magnetic hysteresis loops. The results showed that the adsorption equilibrium could be reached within 30 min and the kinetic data were fitted well by pseudo-second-order and intra-particle diffusion model. The adsorbent exhibited a favorable performance, and its maximum adsorption capacity calculated by the Langmuir isotherm model was 1.755 mmol/g. The nitrate adsorption mechanism was mainly controlled by the material through ion exchange of nitrate with chloridion, as determined by XPS. This study indicated that this novel pyridinium-functionalized mesoporous material had excellent adsorption capacity. Meanwhile, compared with other adsorbents, it could remove nitrate fast and easy to be collected by magnetic separation, showing great potential application for nitrate removal from aqueous solution In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Synthetic Route of C5H6ClN).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Synthetic Route of C5H6ClN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Immobilization of Candida rugosa lipase onto an eco-friendly support in the presence of ionic liquid was written by Cabrera-Padilla, Rebeca Y.;Lisboa, Milena C.;Pereira, Matheus M.;Figueiredo, Renan T.;Franceschi, Elton;Fricks, Alini T.;Lima, Alvaro S.;Silva, Daniel P.;Soares, Cleide M. F.. And the article was included in Bioprocess and Biosystems Engineering in 2015.Recommanded Product: 125652-55-3 This article mentions the following:

Candida rugosa lipase (CRL) was immobilized on an eco-friendly support poly(3-hydroxybutyrate-co-hydroxyvalerate) (PHBV), by phys. adsorption, using different ionic liquids (ILs) as immobilization additives. This was to investigate the influence of cationic core ([C₄mpy]Cl, [C₄min]Cl), of anions ([C₄min]Cl, [C₄min]N(CN)₂, [C₄min]Tf₂N), and of cation chain length ([C₂min]Tf₂N, [C₄min]Tf₂N) in the immobilization process. The immobilized biocatalysts (IB) were characterized with respect to the morphol., physico-chem. properties, total activity recovery yield (Ya), and biochem. properties of more efficient IB were evaluated. Initially, it was found that the change of cationic core did not influence Ya compared to the control. With change of anions, it was seen that the best result was obtained for the more hydrophobic anion (Tf₂N), and finally increasing the cation chain length increased Ya. IB most efficient with [C₄min]Tf₂N obtained 78 % of Ya, more than twice the control value (30 %) and a considerable enhancement of operational stability compared with the control. In the experiment, the researchers used many compounds, for example, 1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3Recommanded Product: 125652-55-3).

1-Butyl-3-methylpyridinium Chloride (cas: 125652-55-3) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Recommanded Product: 125652-55-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

2-(Pyridinium-1-yl)-1,1-bis(triflyl)ethanides: structural behaviour and availability as bis(triflyl)ethylating reagents was written by Yanai, Hikaru;Takahashi, Yoichi;Fukaya, Haruhiko;Dobashi, Yasuo;Matsumoto, Takashi. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2013.Related Products of 644-98-4 This article mentions the following:

Stable and easy-to-handle zwitterions containing carbanion and pyridinium moieties were synthesized, and their structural studies by both X-ray crystallog. and theor. methods revealed the stereoelectronic effect in the zwitterionic ‘C^–-C-N⁺‘ system. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Related Products of 644-98-4).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Related Products of 644-98-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nickel-Catalyzed Cross-Coupling of Aryl 2-Pyridyl Ethers with Organozinc Reagents: Removal of the Directing Group via Cleavage of the Carbon-Oxygen Bonds was written by Dai, Wei-Can;Yang, Bo;Xu, Shi-He;Wang, Zhong-Xia. And the article was included in Journal of Organic Chemistry in 2021.Related Products of 4783-68-0 This article mentions the following:

Reaction of aryl 2-pyridyl ethers with arylzinc reagents under catalysis of NiCl₂(PCy₃)₂ afforded aryl-aryl cross-coupling products Ar²Ar¹ [R = Ph, 4-FC₆H₄, 4-MeOC₆H₄, etc.; Ar¹ = 4-N(Me)₂C₆H₄, 4-MeC₆H₄, 4-MeOC₆H₄, etc.] via selective cleavage of CAr-OPy bonds. The reaction features a wide substrate range and good compatibility of functional groups. 灏?H-free alkylzinc reagents were also applicable as the nucleophiles in the transformation, whereas 灏?H-containing alkylzinc reagents led to a mixture of cross-coupling and hydrogenation products Ar²Ar¹. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Related Products of 4783-68-0).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Related Products of 4783-68-0

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem