Day: February 13, 2023

Synthesis of heteroarylsulfanyl- and heteroaryloxyfuroxans by nucleophilic substitution of nitro group in nitrofuroxans with heterocyclic thiol and hydroxy derivatives* was written by Fershtat, Leonid L.;Epishina, Margarita A.;Kulikov, Alexander S.;Struchkova, Marina I.;Makhova, Nina N.. And the article was included in Chemistry of Heterocyclic Compounds (New York, NY, United States) in 2015.Recommanded Product: 15128-90-2 This article mentions the following:

A general method for the synthesis of heteroaryl- and heteroaryloxyfuroxans, e.g., I, based on nucleophilic substitution of 4-nitrofuroxans with heterocyclic thiols and alcs. in 1,8-diazabicyclo[5.4.0]undec-7-ene/MeCN system at room temperature is reported. Hetarylthiols reacted with 4-nitrofuroxans containing aliphatic, benzyl, and aromatic substituents at the ring C-3 atom, allowing to obtain a library of heteroarylsulfanylfuroxans, while the reaction with hydroxy heterocycles was successful only in the case of 4-nitro-3-phenylfuroxan, the rest of the nitrofuroxans showing low reactivity, and substitution products could be obtained only in certain cases. 4-Nitrofuroxans with electron-withdrawing substituents (NO₂, CONH₂) acted as oxidants, forming 1,2-di(heteroaryl)disulfides. In the experiment, the researchers used many compounds, for example, 3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2Recommanded Product: 15128-90-2).

3-Hydroxy-6-methyl-2-nitropyridine (cas: 15128-90-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Recommanded Product: 15128-90-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Pyridinium and imidazolium 1,3,4-oxadiazole ionic liquid crystals: a thermal and photophysical systematic investigation was written by Westphal, Eduard;Henrique da Silva, Danilo;Molin, Fernando;Gallardo, Hugo. And the article was included in RSC Advances in 2013.Product Details of 15420-02-7 This article mentions the following:

The authors present the synthesis and complete structural characterization of twenty five 1,3,4-oxadiazole mols. (ionic and nonionic) with some systematic structural variations, such as number of counterions, number of alkoxy chains, alkyl chain size, type of counterion and its position on the mol. The thermal and photophys. properties for all compounds were studied allowing a complete and interesting simultaneous study of the effect of structural changes on these properties. Every parameter studied affected both the thermal and photophys. properties. For these bent core mols., the liquid crystalline behavior was observed only for compounds containing one counterion, SmA (monolayer or bilayer) being the predominant phase. The neutral (nonionic) compounds and the imidazolium derivatives showed emission at 閳?60 nm and a high quantum yield, while most of the pyridinium derivatives showed emission at 閳?30 nm, a low quantum yield and a complex photophys. behavior. In all cases, the quantum yield for the different counterions follows the sequence ClO₄^– > BF₄^– > DS^– > NO₃^– > Br^–(I^–). In the experiment, the researchers used many compounds, for example, 2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7Product Details of 15420-02-7).

2,5-Di(pyridin-4-yl)-1,3,4-oxadiazole (cas: 15420-02-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Product Details of 15420-02-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Expeditious synthesis and preliminary antimicrobial activity of deflazacort and its precursors was written by Esposito, Anna;De Gregorio, Eliana;De Fenza, Maria;D’Alonzo, Daniele;Satawani, Anil;Guaragna, Annalisa. And the article was included in RSC Advances in 2019.Application In Synthesis of Pyridinehydrochloride This article mentions the following:

The synthesis of deflazacort (DFZ) and a preliminary evaluation of its microbial activity against the human pathogens Acinetobacter baumannii and Staphylococcus aureus is herein reported. While DFZ is inactive, one of its synthetic precursors showed a strong antibacterial activity against both Gram-neg. and -pos. bacteria. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Application In Synthesis of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Morphology, surface properties and photocatalytic activity of the bismuth oxyhalides semiconductors prepared by ionic liquid assisted solvothermal method was written by Bielicka-Gieldon, Aleksandra;Wilczewska, Patrycja;Malankowska, Anna;Szczodrowski, Karol;Ryl, Jacek;Zielinska-Jurek, Anna;Siedlecka, Ewa Maria. And the article was included in Separation and Purification Technology in 2019.Synthetic Route of C10H16BrN This article mentions the following:

This is the first report of the effect of the ILs cation type (imidazolium, pyridinium and pyrrolidinium) on the morphol., surface properties and photoactivity of BiOX semiconductors type obtained by solvothermal method in glycerol. The various ionic liquids (IL) cation type as a halogen source and templating agent for the synthesis of the bismuth oxyhalides nanoparticles has been systematically investigated. The role of ILs in synthesis of the semiconductors was loosening of the structure and increasing the particle size of semiconductors. It was also found that ILs increased sp. surface area and pore volume of bismuth oxyhalides. Rhodamine B and 5-fluorouracil were used as the model contaminates to evaluate the adsorption capacity and photooxidation performance of studied BiOX. Removal of chromium (VI) from acidic solution were demonstrated photoreduction ability of BiOX. Generally the activity of bismuth oxyhalides was better for the samples prepared with ILs, although the increase in activity was different for various ionic liquids The changes of band gap structure were major causes of the enhanced photocatalytic activity of bismuth oxyhalides with ILs as the halogen source. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Synthetic Route of C10H16BrN).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Synthetic Route of C10H16BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Interactions between quaternary ammonium surfactants and polyethylenimine at high pH in film forming systems was written by Jaber, Robben;Wasbrough, Matthew J.;Holdaway, James A.;Edler, Karen J.. And the article was included in Journal of Colloid and Interface Science in 2015.Application of 104-73-4 This article mentions the following:

Film formation and film structure in films formed on solutions of cationic surfactants with polyethylenimine is affected by the surfactant structure, including both the tail length and the nature of the headgroup, which alter the micelle properties. A series of cationic surfactants were synthesized and conductivity measurements were used to compare the critical micelle concentrations for these surfactants and their behavior with and without polyethylenimine at high pH. Small angle neutron scattering measurements were used to characterize the size and shape of the micelles in the presence and absence of the polymer. Film formation between polyethylenimine and the various surfactants was trialled, and the interfacial film structures measured using neutron reflectivity. Film formation is shown to depend on surfactant tail length, with thicker films forming for surfactants with longer hydrophobic tails. The surfactant headgroup structure affects counterion binding to the micelles, and in the case of the aromatic headgroups, the headgroup affects the extent of micellar growth when polymer is added. Films with the greatest mesostructural ordering were grown using hexadecylpyridinium bromide surfactants. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Application of 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application of 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Preparation of some tricyclic fused ring iminopyrido[3,2-e]pyrimidines was written by Kwok, Russell. And the article was included in Journal of Heterocyclic Chemistry in 1978.Quality Control of 2-(Methylamino)nicotinonitrile This article mentions the following:

Iminopyridopyrimidines I [R = Me, PhCH₂, Ph, m-(F₃C)C₆H₄; n = 2, 3] were prepared Thus, treatment of 2-chloronicotinonitrile with primary amines gave 2-(alkylamino)-3-pyridinecarbonitriles which condensed with H₂N(CH₂)_nNH₂ to give cyclic amidines II. Treatment of II with BrCN gave I. The preparation of diaminopyrido[2,3-d]pyrimidines and tricyclic quinazolines by related procedures was discussed. In the experiment, the researchers used many compounds, for example, 2-(Methylamino)nicotinonitrile (cas: 52583-87-6Quality Control of 2-(Methylamino)nicotinonitrile).

2-(Methylamino)nicotinonitrile (cas: 52583-87-6) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Quality Control of 2-(Methylamino)nicotinonitrile

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Discovery of MK-8722: A Systemic, Direct Pan-Activator of AMP-Activated Protein Kinase was written by Feng, Danqing;Biftu, Tesfaye;Romero, F. Anthony;Kekec, Ahmet;Dropinski, James;Kassick, Andrew;Xu, Shiyao;Kurtz, Marc M.;Gollapudi, Anantha;Shao, Qing;Yang, Xiaodong;Lu, Ku;Zhou, Gaochao;Kemp, Daniel;Myers, Robert W.;Guan, Hong-Ping;Trujillo, Maria E.;Li, Cai;Weber, Ann;Sebhat, Iyassu K.. And the article was included in ACS Medicinal Chemistry Letters in 2018.Product Details of 203794-33-6 This article mentions the following:

5′-Adenosine monophosphate-activated protein kinase (AMPK) is a key regulator of mammalian energy homeostasis and has been implicated in mediating many of the beneficial effects of exercise and weight loss including lipid and glucose trafficking. As such, the enzyme has long been of interest as a target for the treatment of Type 2 Diabetes Mellitus. The authors describe the optimization of 灏?-selective, liver-targeted AMPK activators and their evolution into systemic pan-activators capable of acutely lowering glucose in mouse models. Identifying surrogates for the key acid moiety in early generation compounds proved essential in improving 灏?-activation and in balancing improvements in plasma unbound fraction while avoiding liver sequestration. In the experiment, the researchers used many compounds, for example, 5,6-Dichloro-3-nitropyridin-2-amine (cas: 203794-33-6Product Details of 203794-33-6).

5,6-Dichloro-3-nitropyridin-2-amine (cas: 203794-33-6) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Product Details of 203794-33-6

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

N-Phenyl indole derivatives as AT₁ antagonists with anti-hypertension activities: Design, synthesis and biological evaluation was written by Zhu, Weibo;Bao, Xiaolu;Ren, He;Da, Yajing;Wu, Dan;Li, Fuming;Yan, Yijia;Wang, Li;Chen, Zhilong. And the article was included in European Journal of Medicinal Chemistry in 2016.HPLC of Formula: 4373-61-9 This article mentions the following:

The design, synthesis, in vitro and in vivo evaluation of 6-substituted benzimidazole with 1, 4-disubstituted or 1, 5-disubstituted indole derivatives as novel angiotensin II receptor antagonists are outlined. Radioligand binding assays showed that several 6-substituted benzimidazole derivatives displayed high affinities binding to the angiotensin II type 1 receptor at the same order of magnitude to telmisartan. The biol. evaluation on spontaneously hypertensive rats showed that 2-[4-[[2-n-propyl-4-methyl-6-(1-methylbenzimidazol-2-yl)benzimidazole-1-yl]methyl]-1H-indol-1-yl]benzoic acid, I, could cause significant decrease on MBP in a dose dependent manner. Its maximal response lowered 53 mmHg of MBP at 5 mg/kg and 64 mmHg of MBP at 10 mg/kg after oral administration, and the significant antihypertensive effect lasted beyond 24 h, which was better than both losartan and telmisartan. A study designed to determine acute toxicity showed that I had low acute toxicity with no significant changes in the weight and no obvious untoward reactions. The encouraging results make I an effective and durable anti-hypertension drug candidate and deserve further investigation for therapeutic application. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9HPLC of Formula: 4373-61-9).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.HPLC of Formula: 4373-61-9

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis and sterilization property of heterocyclic surfactants was written by Wang, Li-yan;Wang, Lei;Qin, Hong-lei;Yu, Ting-ting;Xu, Qun;Ma, Wen-hui;Wang, Xue-dong. And the article was included in Huaxue Shijie in 2012.Recommanded Product: 104-73-4 This article mentions the following:

A series of heterocyclic surfactants were prepared with pyridine and 1-bromoalkanes (bromooctane, bromodecane, bromododecane or bromotetradecane). The best reaction conditions for synthesis of the target products were optimized by orthogonal test program. The reaction temperature was 90鎺矯, the reaction time was 5 h, and the mole ratio of bromoalkane and pyridine was 1 : 1. The products were characterized by IR and ¹H NMR. The target products’ sterilization properties for colibacillus, staphylococcus aureus, bacillus subtilis were determined The results showed that the heterocylic surfactants had excellent sterilization properties for the above three kinds of bacteria. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Recommanded Product: 104-73-4).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Recommanded Product: 104-73-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Molecular changes in particulate organic matter (POM) in a typical Chinese paddy soil under different long-term fertilizer treatments was written by Zhou, P.;Pan, G. X.;Spacclni, R.;Piccolo, A.. And the article was included in European Journal of Soil Science in 2010.SDS of cas: 28020-37-3 This article mentions the following:

A combination of solid-state CPMAS-¹³C-NMR and TMAH thermochemolysis-GC/MS was applied to investigate the mol. composition of particulate organic matter (POM) separated from a Chinese paddy soil, from the Tai Lake region, under a long-term field experiment with different fertilizer treatments. The treatments were: (i) no fertilizer application (NF), (ii) chem. fertilizers only (CF), (iii) chem. fertilizer plus pig manure (CFM) and (iv) chem. fertilizer plus crop straw (CFS). CPMAS-¹³C-NMR spectra showed that POM from all treated plots was rich in O-alkyl-C compounds, followed by alkyl-C and aromatic-C compounds However, as compared with a control (NF), POM under CFM and CFS treatments exhibited a smaller relative O-alkyl-C content and a larger contribution of aromatic-C and alkyl-C, thus increasing both aromaticity and hydrophobicity and, hence, recalcitrance of POM samples. Thermochemolysis of POM from all treatments demonstrated a dominance of aliphatic and lignin-derived compounds However, the distribution of lignin monomers (p-hydroxyphenyl, P, guaiacyl, G, and syringyl, S) revealed significant differences among the treatments. The relative distribution of lignin P, G and S monomers in NF, CF and CFS indicated a preferential contribution of annual crops and maize straw, as compared with that found for CFM. Concomitantly, a larger content of aliphatic thermochemolysis derivatives was found for CFS and CFM. The relative increase of aliphatic mols. in CFS was attributed to hydrophobic polyesters from higher plants. In the CF and CFM systems, the presence of aliphatic components of microbial origin suggested a greater microbial activity in comparison with NF and CFS. The combined application of solid state CPMAS-¹³C-NMR and TMAH thermochemolysis-GC/MS can be used to assess effectively the accumulation of recalcitrant organic compounds in soil POM under long-term fertilizer application with organic biomass. It is thus inferred that soil organic matter stabilization by mol. recalcitrance contributes to carbon sequestration in Chinese paddy soils under long-term managements. In the experiment, the researchers used many compounds, for example, 3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3SDS of cas: 28020-37-3).

3-Amino-2,6-dimethoxypyridine (cas: 28020-37-3) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. SDS of cas: 28020-37-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem