Day: February 13, 2023

Erlanson, Daniel A. et al. published their research in Bioorganic & Medicinal Chemistry Letters in 2011 | CAS: 1001413-01-9

1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid (cas: 1001413-01-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application In Synthesis of 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

Discovery of a potent and highly selective PDK1 inhibitor via fragment-based drug discovery was written by Erlanson, Daniel A.;Arndt, Joseph W.;Cancilla, Mark T.;Cao, Kathy;Elling, Robert A.;English, Nicki;Friedman, Jessica;Hansen, Stig K.;Hession, Cathy;Joseph, Ingrid;Kumaravel, Gnanasambandam;Lee, Wen-Cherng;Lind, Ken E.;McDowell, Robert S.;Miatkowski, Konrad;Nguyen, Christine;Nguyen, Thinh B.;Park, Sophia;Pathan, Nuzhat;Penny, David M.;Romanowski, Michael J.;Scott, Daniel;Silvian, Laura;Simmons, Robert L.;Tangonan, Bradley T.;Yang, Wenjin;Sun, Lihong. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2011.Application In Synthesis of 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid This article mentions the following:

We report the use of a fragment-based lead discovery method, Tethering with extenders, to discover a pyridinone fragment that binds in an adaptive site of the protein PDK1. With subsequent medicinal chem., this led to the discovery of the potent and highly selective inhibitor of PDK1 33 (I), which binds in the ‘DFG-out’ conformation. In the experiment, the researchers used many compounds, for example, 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid (cas: 1001413-01-9Application In Synthesis of 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid).

1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid (cas: 1001413-01-9) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application In Synthesis of 1-(3,4-Difluorobenzyl)-2-oxo-1,2-dihydropyridine-3-carboxylic acid

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Jaju, Karan et al. published their research in Chemical Physics Letters: X in 2019 | CAS: 626-64-2

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Safety of Pyridin-4-ol

Electronic substituent effect on Se-H璺矾璺疦 hydrogen bond: A computational study of para-substituted pyridine-SeH2 complexes was written by Jaju, Karan;Pal, Dhritabrata;Chakraborty, Amrita;Chakraborty, Shamik. And the article was included in Chemical Physics Letters: X in 2019.Safety of Pyridin-4-ol This article mentions the following:

Complexes between para-substituted pyridine and SeH2 have been investigated at the MP2/aug-cc-pVTZ level. Various electron donating and withdrawing substituents (-NH2, -OH, -CH3, -H, -F, -Cl, -CN, and -NO2) are chosen in order to characterize their influence on Se-H璺矾璺疦 intermol. hydrogen-bonding interaction. The electron donating substituents lead to an increase of the stabilization energy along with elongation in the Se-H bond length and red-shift in Se-H stretching frequency. Conventional electronic substitution effect has been observed on various hydrogen-bond parameters, such as, stabilization energy, change in Se-H bond length and stretching frequency, charge transfer, bond order, electron d. at hydrogen-bond critical point. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Safety of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Safety of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Das, Pranab Jyoti et al. published their research in Journal of Molecular Liquids in 2015 | CAS: 65350-59-6

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 1-Butyl-4-methylpyridin-1-ium bromide

Selective O-methylation of phenols and benzyl alcohols in simple pyridinium based ionic liquids was written by Das, Pranab Jyoti;Das, Jupitara. And the article was included in Journal of Molecular Liquids in 2015.Application In Synthesis of 1-Butyl-4-methylpyridin-1-ium bromide This article mentions the following:

Synthesis of pyridinium based ionic liquids were reported and applied as catalyst for the selective O-methylation of phenols and benzyl alcs. The reactions were carried out by using dimethylcarbonate (DMC) as the methylating agent. High selectivity, high yield and recyclability of the ionic liquids were important features of the reactions. In the experiment, the researchers used many compounds, for example, 1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6Application In Synthesis of 1-Butyl-4-methylpyridin-1-ium bromide).

1-Butyl-4-methylpyridin-1-ium bromide (cas: 65350-59-6) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application In Synthesis of 1-Butyl-4-methylpyridin-1-ium bromide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Liu, Xu-Ge et al. published their research in Advanced Synthesis & Catalysis in 2017 | CAS: 4373-61-9

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 2-(m-Tolyl)pyridine

(Pentamethylcyclopentadienyl)cobalt(III)-Catalyzed Direct Trifluoromethylthiolation of Arenes via C-H Activation was written by Liu, Xu-Ge;Li, Qingjiang;Wang, Honggen. And the article was included in Advanced Synthesis & Catalysis in 2017.Safety of 2-(m-Tolyl)pyridine This article mentions the following:

The direct trifluoromethylthiolation of arenes was realized via (pentamethylcyclopentadienyl)cobalt(III)-catalyzed C(sp2)-H activation and coupling with AgSCF3 under the assistance of a directing group. The reaction features redox-neutrality, mild conditions, broad substrate scope, and good functional group tolerance. Preliminary mechanistic studies have been conducted. In the experiment, the researchers used many compounds, for example, 2-(m-Tolyl)pyridine (cas: 4373-61-9Safety of 2-(m-Tolyl)pyridine).

2-(m-Tolyl)pyridine (cas: 4373-61-9) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 2-(m-Tolyl)pyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Zhao, Dongbing et al. published their research in Angewandte Chemie, International Edition in 2015 | CAS: 54151-74-5

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 54151-74-5

Cobalt(III)-Catalyzed Directed C-H Coupling with Diazo Compounds: Straightforward Access towards Extended 锜?Systems was written by Zhao, Dongbing;Kim, Ju Hyun;Stegemann, Linda;Strassert, Cristian A.;Glorius, Frank. And the article was included in Angewandte Chemie, International Edition in 2015.Recommanded Product: 54151-74-5 This article mentions the following:

The first highly efficient and scalable cobalt-catalyzed directed C-H functionalization with carbene precursors is presented. This methodol. provides a modular route towards a new class of conjugated polycyclic hydrocarbons with tunable emission wavelengths both in solution and in the solid state. In the experiment, the researchers used many compounds, for example, 2-Bromo-4-phenylpyridine (cas: 54151-74-5Recommanded Product: 54151-74-5).

2-Bromo-4-phenylpyridine (cas: 54151-74-5) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Recommanded Product: 54151-74-5

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kmentova, Iveta et al. published their research in Journal of Medicinal Chemistry in 2010 | CAS: 131747-45-0

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C6H6BrNO

Synthesis and structure-activity relationships of aza- and diazabiphenyl analogues of the antitubercular drug (6S)-2-nitro-6-{[4-(trifluoromethoxy)benzyl]oxy}-6,7-dihydro-5H-imidazo[2,1-b][1,3]oxazine (PA-824) was written by Kmentova, Iveta;Sutherland, Hamish S.;Palmer, Brian D.;Blaser, Adrian;Franzblau, Scott G.;Wan, Baojie;Wang, Yuehong;Ma, Zhenkun;Denny, William A.;Thompson, Andrew M.. And the article was included in Journal of Medicinal Chemistry in 2010.Formula: C6H6BrNO This article mentions the following:

New heterocyclic analogs of the potent biphenyl class derived from antitubercular drug I were prepared, aiming to improve aqueous solubility but maintain high metabolic stability and efficacy. The strategy involved replacement of one or both Ph groups by pyridine, pyridazine, pyrazine, or pyrimidine, in order to reduce lipophilicity. For para-linked biaryls, hydrophilicities (ClogP) correlated with measured solubilities, but highly soluble bipyridine analogs displayed weak antitubercular activities. A terminal pyridine or proximal heterocycle allowed retention of potency and provided solubility improvements, particularly at low pH, with examples from the latter classes displaying the better in vivo efficacies, high metabolic stabilities, and excellent pharmacokinetics. Five such compounds were >100-fold better than the parent drug in a mouse model of acute Mycobacterium tuberculosis infection, and two orally bioavailable pyridine analogs (3-4-fold more soluble than the parent at low pH) were superior to antitubercular drug II in a chronic infection model. In the experiment, the researchers used many compounds, for example, (4-Bromopyridin-2-yl)methanol (cas: 131747-45-0Formula: C6H6BrNO).

(4-Bromopyridin-2-yl)methanol (cas: 131747-45-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C6H6BrNO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Costa, Marta et al. published their research in Tetrahedron in 2011 | CAS: 17281-59-3

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C7H7ClN2

Selective synthesis of some imidazopyridine-fused chromones was written by Costa, Marta;Proenca, M. Fernanda. And the article was included in Tetrahedron in 2011.Formula: C7H7ClN2 This article mentions the following:

A fused heterocyclic scaffold combining the imidazo[1,2-a]pyridine with a substituted chromone was synthesized in a one-pot procedure. The reaction proceeds by intramol. cyclization of 1-(2-imino-2H-chromen-3-yl)pyridinium chloride in ethanol and in the presence of DABCO. A detailed study of the exptl. conditions allowed a clear understanding of the reaction pathway. In the experiment, the researchers used many compounds, for example, 1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3Formula: C7H7ClN2).

1-(Cyanomethyl)pyridin-1-ium chloride (cas: 17281-59-3) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Formula: C7H7ClN2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Yasukawa, Tomohiro et al. published their research in Journal of Organic Chemistry | CAS: 91-02-1

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C12H9NO

Effect of Activation Methods of Molecular Sieves on Ketimine Synthesis was written by Yasukawa, Tomohiro;Nakajima, Hanako;Masuda, Ryusuke;Yamashita, Yasuhiro;Kobayashi, Shu. And the article was included in Journal of Organic Chemistry.Formula: C12H9NO This article mentions the following:

Although the use of mol. sieves for imine synthesis is a common protocol, there have been no comprehensive studies on heat-drying methods, and this can be crucial for reproducibility. It was found that mol. sieve 5A dried at 160 鎺矯 for 5 h under vacuum efficiently promoted the condensation of various ketones RC(O)R1 (R = n-Pr, Ph, 4-flurophenyl, etc.; R1 = Ph, Me, pyridin-2-yl, etc.) and amines R2NH2 (R2 = Ph, 4-chlorophenyl, cyclohexyl, etc.) to afford even relatively bulky ketimines RC(R1)=NR2. Several control experiments and analyses revealed that only a small amount of Bronsted acid sites was important for the activity, rather than dehydration ability. Other types of mol. sieves could be utilized for the reaction after treatment with water followed by heat drying. A continuous-flow acetalization reaction of alcs. using the activated mol. sieve 5A was also demonstrated. In the experiment, the researchers used many compounds, for example, Phenyl(pyridin-2-yl)methanone (cas: 91-02-1Formula: C12H9NO).

Phenyl(pyridin-2-yl)methanone (cas: 91-02-1) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Formula: C12H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Li, Yinghua et al. published their research in Dalton Transactions in 2020 | CAS: 122637-39-2

6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Related Products of 122637-39-2

Copper(II)-hydroxide facilitated C-C bond formation: the carboxamido pyridine system versus the methylimino pyridine system was written by Li, Yinghua;Fan, Weibin;Zhang, Zilong;Xie, Xingkun;Xiang, Shiqun;Huang, Deguang. And the article was included in Dalton Transactions in 2020.Related Products of 122637-39-2 This article mentions the following:

A copper(II)-hydroxide-induced carbon-carbon bond formation reaction is explored with the synthesis of an asym. carboxamido-methylimino pyridine Cu(I) complex of [CuI(py(N-CO)(NC-C)ph2Me2)2]– (12). Two imine-Me groups are coupled to form a bridged C-C bond (NC-C-C-CN) at the Me positions with the reduction of two Cu2+ center ions to Cu+. The reaction is checked with three dicarboxamido pyridine [CuII-OH] complexes, with which dinuclear Cu(I) complexes of [Cu2(py(N-CO)2ph2R2)2]2- (R = Me (3), Me and allyl (6)) and trinuclear [CuII-CuI-CuII] complex of [Cu3(閳?sub>20-py(N-CO)2ph2dienMe3)2]+ (9) are obtained. The reactivities of the [CuII-L] (L = DMF, OH–) complexes in dicarboxamido pyridine, carboxamido-methylimino pyridine and dimethylimino pyridine systems are discussed in terms of the electron delocalization properties of ligands. A cooperative metal-ligand (Cu2+ and enamide ligand) interaction is proposed based on the characterization of ligated Cu(II) intermediates with the techniques of x-ray crystallog., UV-vis spectroscopy, cyclic voltammogram, EPR spectroscopy, and DFT calculations In the experiment, the researchers used many compounds, for example, 6-Acetylpicolinic acid (cas: 122637-39-2Related Products of 122637-39-2).

6-Acetylpicolinic acid (cas: 122637-39-2) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Related Products of 122637-39-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Kim, Dae Hyun et al. published their research in Kongop Hwahak in 2015 | CAS: 628-13-7

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Safety of Pyridinehydrochloride

A study on the reaction pathway for isomerization of tetrahydrotricyclopentadiene using ionic liquid catalyst was written by Kim, Dae Hyun;Han, Jeong-Sik;Jeon, Jong-Ki;Yim, Jin-Heong. And the article was included in Kongop Hwahak in 2015.Safety of Pyridinehydrochloride This article mentions the following:

The kinetic behavior of tetrahydrotricyclopentadiene (THTCPD) isomerization was studied by using two kinds of chloroaluminate ionic liquid (IL) catalyst with different Lewis acidity. THTCPD isomerization pathway was discussed under the different temperature and time as reaction parameters using IL catalysts consisting of 1-butyl-3-methylimidazolun chloride (BMIC)/AlCl3 with low acidity and pyridine hydrochloride (PHC)/AlCl3 with high acidity. The conversion of THTCPD isomerization increased with increasing Lewis acidity of IL catalyst. The THTCPD isomerization pathway changed as a function of reaction temperature and catalyst acidity. In the case of BMIC/AlCl3 IL catalyst, THTCPD isomerization pathway was similar to that of using conventional AlCl3 catalyst. However, two different types of addnl. pathways (endo, exo, endo-NB 閳?exo, exo, endo-NB 閳?exo, exo, exo-NB and endo, exo, endo-NB 閳?exo, exo, endo-NB 閳?exo, exo, exo- CP) were appeared when using PHC/AlCl3 IL catalyst. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Safety of Pyridinehydrochloride).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Safety of Pyridinehydrochloride

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem