Day: February 13, 2023

Design, Synthesis and Anticancer Activity of Aza Heterocycles Containing Gallate Moiety (Part III) was written by El-Ebiary, N. M.;Swellem, R. H.;Nawwar, G. A. M.. And the article was included in Pharmaceutical Chemistry Journal in 2017.Related Products of 628-13-7 This article mentions the following:

Our previously reported compound, 3-(2-hydroxy-3,4-dimethoxyphenyl)-1-phenyl-1H-pyrazole-4-carbaldehyde, was allowed to react with acetophenone, Et cyanoacetate and/or malononitrile to give the corresponding compounds, e.g. I, which were treated with thiourea afforded thiopyrimidine derivatives The coupling of 3a and 3b with 2′,3′,4′,6′-tetra-O-acetyl-_-D-glucopyranosyl bromide (4) afforded compounds 5a and 5b, resp. Reaction of I with acetophenone yielded pyridone derivative II, which was fused in pyridine hydrochloride to give demethylated product. The coupling of II with some cyclic and acyclic halosugars afforded various N-glycoside derivatives New compounds were tested for their antitumor activity on MCF-7 human breast adenocarcinoma cell line and HepG2 liver carcinoma cell line. Almost all tested compounds exhibited antitumor activity, especially II, which displayed the most potent inhibitory activity with IC₅₀ = 2.97 and 2.67 g/mL against MCF-7 and HepG2 cell lines, resp. Compound 6 was tested for its acute toxicity (LD) and found to have very low toxicity based on LD₅₀ values (no label > 600 < 2000 mg/kg) as recommended by the Organization for Economic Co-operation and Development. In the experiment, the researchers used many compounds, for example, Pyridinehydrochloride (cas: 628-13-7Related Products of 628-13-7).

Pyridinehydrochloride (cas: 628-13-7) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Related Products of 628-13-7

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis, structural characterization and Hirshfeld surface analysis of NLO active 3-hydroxypyridinium 2,4-dinitrophenolate single crystals was written by Manikandan, A.;Manivannan, D.;Dhanalakshmi, M.;Guganathan, L.;Kokila, T.;Santhamoorthy, M.;Markkandan, R.;Kim, S. C.;Balakrishnan, C.. And the article was included in Journal of Materials Science: Materials in Electronics in 2022.Safety of Pyridin-4-ol This article mentions the following:

Single crystals of 3-hydroxypyridinium 2,4-dinitrophenolate (I) and 4-hydroxypyridinium 2,4-dinitrophenolate (II) was harvested under slow evaporation conditions. The yellow block crystals formed by O-H璺矾璺疧 and N-H璺矾璺疧 hydrogen bonding that made contacts through the cation and anion was characterized by single-crystal X-ray diffraction, IR spectrum, diffuse reflectance spectrum, thermogravimetric and Hirshfeld surface anal. Crystal (I) packed orthorhombic crystal system with acentric P212121 space group and (II) packed in monoclinic system with centric P21/c space group. Intra-/intermol. hydrogen bonds and weak van der Waals forces construct the supramol. network in the crystal packing. The bandgap energy was estimated using diffuse reflectance spectral data by the application of the Kubelka-Munk algorithm. The non-linear optical response is examined by the Kurtz-Perry technique gave the result that the efficacy of crystal (I) is 閳?4 times greater than that of reference KDP. TG/DTA anal. reveals the thermal pattern of the compounds Fingerprint plot used to locate and analyze the percentage contribution of hydrogen bonding interactions. First-order mol. hyperpolarizability calculated using theor. calculations shows a significant microlevel nonlinearity in both cases. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Safety of Pyridin-4-ol).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Safety of Pyridin-4-ol

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Synthesis of a Series of Non-Symmetric Bispyridinium and Related Compounds and Their Affinity Characterization at the Nicotinic Acetylcholine Receptor was written by Rappenglueck, Sebastian;Sichler, Sonja;Hoefner, Georg;Wein, Thomas;Niessen, Karin V.;Seeger, Thomas;Paintner, Franz F.;Worek, Franz;Thiermann, Horst;Wanner, Klaus T.. And the article was included in ChemMedChem in 2018.Electric Literature of C8H11N This article mentions the following:

The current standard therapy to counteract organophosphate intoxication is not effective in equal measure against all types of organophosphorus compounds (OPCs), as the outcome of oxime-induced reactivation of inactivated acetylcholinesterase (AChE) strongly depends on the particular OPC. In case the reactivation is insufficient, acetylcholine concentrations that rise to pathophysiol. levels force the nicotinic acetylcholine receptor (nAChR) into a desensitized state and hence a functionally inactive state. As a consequence, neurotransmission is irreversibly disrupted at the neuromuscular junction. Previous electrophysiol. studies identified the sym. bispyridinium compound 1,1′-(propane-1,3-diyl)bis[4-(tert-butyl)pyridin-1-ium] diiodide (MB327) as a re-sensitizer of the desensitized nAChR. MB327 is thereby capable of restoring the functional activity. Very recently, in silico modeling studies suggested non-sym. derivatives of MB327 as potential re-sensitizers with enhanced binding affinity and thus possible enhanced efficacy. In this study, 26 novel non-sym. bispyridinium compounds and related derivatives were synthesized. For the synthesis of the highly polar target compounds in sufficient quantities, newly developed and highly efficient two-step procedures were used. Compounds were characterized in terms of their binding affinity toward the MB327 binding site at the nAChR using recently developed mass spectrometry (MS) Binding Assays. Regarding structure-affinity relationships at the MB327 binding site, the presence of two quaternary aromatic nitrogen centers as well as pyridinium systems with a tert-Bu group at the 4-position or a NMe₂ group at the 3- or 4-positions appeared to be beneficial for high binding affinities. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Electric Literature of C8H11N).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Electric Literature of C8H11N

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Nickel-Catalyzed Amination of Aryl 2-Pyridyl Ethers via Cleavage of the Carbon-Oxygen Bond was written by Li, Jing;Wang, Zhong-Xia. And the article was included in Organic Letters in 2017.Application In Synthesis of 2-Phenoxypyridine This article mentions the following:

Reaction of aryl 2-pyridyl ethers with amines was carried out via Ni-catalyzed C-O_Py bond cleavage, giving aniline derivatives in reasonable to excellent yields. Both electron-rich and electron-poor aryl 2-pyridyl ethers and a wide range of amines can be used in the transformation. The method provides a conversion way for the 2-pyridyloxy directing group in the C-H bond functionalization reactions. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Application In Synthesis of 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Application In Synthesis of 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Regioselective organometallic synthesis of pyridines, 4-picolines, and 3,5-lutidines substituted in the 2-position by an unsaturated and/or functional group was written by Al-Arnaout, A.;Courtois, G.;Miginiac, L.. And the article was included in Journal of Organometallic Chemistry in 1987.Safety of 3,5-Dimethylpyridine 1-oxide This article mentions the following:

[(Alkoxycarbonyl)oxy]pyridinium chlorides I (R¹ = Et, CH₂CHMe₂; R² = H, Me; R³ = H, Me) were treated with 2-alkenylzinc bromides to give pyridines II (R⁴ = 2-alkenyl). Similarly, II [R⁴ = C椤氬挵(CH:CH)_nCH₂OR⁵ (n = 0, 1; R⁵ = H, Me)] were prepared from I and R⁵OCH₂(CH:CH)_nC椤氬挵MgBr. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Safety of 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Safety of 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Particular applications of MIM [molecules in molecules] method. V. Electronic states and 锜?锜?transitions of diphenyl ether, phenoxypyridines, and dipyridyl ethers was written by Trovato, Salvatore;Zuccarello, Felice;Favini, Giorgio. And the article was included in Gazzetta Chimica Italiana in 1973.Recommanded Product: 2-Phenoxypyridine This article mentions the following:

The MIM method was used for comparison of the uv spectra of Ph2O, phenoxypyridines, and dipyridyl ethers. The compounds have a C-O-C angle of 120鎺?with both aromatic rings twisted by 30鎺?around the C-O bond. The absorption band at 閳?20 nm was due to a perturbed p-band and the absorption band at 270 nm was due to a perturbed 浼?band. A comparison of measured dipole moments with those calculated from ground-state wave functions was used to determine most probable mol. conformations. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Recommanded Product: 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Recommanded Product: 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Thermal behaviour of nitrogen oxides relevant to oxidative denitrogenation was written by Mirshamsi, Sepideh;Yan, Yuwei;Kamal, Sidra;Yasemi, Amir-Arsalan;Gupta, Rajender;de Klerk, Arno;Prado, Glaucia H. C.. And the article was included in Journal of Chemical Thermodynamics in 2019.Formula: C7H9NO This article mentions the following:

Oxidative denitrogenation is an alternative method to hydro-treating, where the nitrogen compounds are oxidized to form nitrogen oxides, which can be separated from the oil by extraction with a polar solvent. During this separation process there is a loss of hydrocarbon material which can be between (10-20) wt% for an oil containing 1 wt% of N. The possibility to release nitrogen as NO_x by thermal treatment and consequently recover the hydrocarbon portion from the N-oxide mol. is the topic explored in this work. The thermochem. of the N-oxides of pyridine, 3-picoline, 2-mercaptopyridine, quinoline, 4-nitropyridine, 3,5-dimethylpyridine, picolinic acid, 4-picoline, 3-hydroxypyridine, nicotinic acid, isonicotinic acid, and nicotinamide was studied. The results showed that the N-oxides of pyridine and 3-picoline evaporated at atm. pressure while the other compounds decomposed after or during melting or during evaporation Decomposition temperatures could be determined for all the N-oxides during thermal anal. at 5 MPa gauge. Infra-red spectroscopy of the residues after thermal treatment indicated that the compounds still contained nitrogen. The suggested chem. taking place upon thermal decomposition in the liquid phase was discussed. N-oxides may form an oxaziridine intermediate, which results in formation of polymeric structures that still contain the nitrogen. Therefore, pyrolysis of the N-oxides subsequent to oxidation seems to be inefficient to liberate the nitrogen as NO_x. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Formula: C7H9NO).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine’s the lone pair does not contribute to the aromatic system but importantly influences the chemical properties of pyridine, as it easily supports bond formation via an electrophilic attack. Halopyridines are particularly attractive synthetic building blocks in a variety of cross-coupling methods, including the Suzuki-Miyaura cross-coupling reaction.Formula: C7H9NO

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

The Impact of the Interplay between Steric and Electronic Effects on the Synthesis and Optical Properties of Diketopyrrolopyrroles Bearing Pyridine Moieties was written by Vakuliuk, Olena;Purc, Anna;Clermont, Guillaume;Blanchard-Desce, Mireille;Gryko, Daniel T.. And the article was included in ChemPhotoChem in 2017.Reference of 1620-76-4 This article mentions the following:

The influence of a combination of steric and electronic factors on both the preparation and the optical properties of diketopyrrolopyrroles was investigated. The attachment of a cyano group to the electron-deficient pyridine ring overcame the neg. influence of the flanking Me group on the efficiency of the synthesis of diketopyrrolopyrroles. Diketopyrrolopyrroles possessing pyridine-N-oxide moieties were studied for the first time. We have also shown that reactions of cyanopyridines possessing an addnl. dialkylamino group were very capricious and depending on the relative position of all substituents, can lead to low yields of diketopyrrolopyrroles. The interplay between the dihedral angle between the diketopyrrolopyrrole core and the pyridyl substituents as well as the presence and position of electron-donating moieties made it possible to modulate the photophys. properties of N,N’-dialkyldiketopyrrolopyrroles. In particular, it was found that pyridine-N-oxides as the aryl moieties had a strong influence on the optical properties of diketopyrrolopyrroles, shifting both absorption and emission bands bathochromically. Two-photon absorption cross-sections had low values except for those dyes possessing a clear quadrupolar centrosym. nature. In the experiment, the researchers used many compounds, for example, 4-Methylpicolinonitrile (cas: 1620-76-4Reference of 1620-76-4).

4-Methylpicolinonitrile (cas: 1620-76-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Reference of 1620-76-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Aryl H-phosphonates. 19. New anti-HIV pro-nucleotide phosphoramidate diesters containing amino- and hydroxypyridine auxiliaries was written by Romanowska, Joanna;Kolodziej, Krystian;Sobkowski, Michal;Rachwalak, Marta;Jakubowski, Tomasz;Golebiewska, Justyna;Kraszewski, Adam;Boryski, Jerzy;Dabrowska, Aleksandra;Stawinski, Jacek. And the article was included in European Journal of Medicinal Chemistry in 2019.Application of 626-64-2 This article mentions the following:

We have designed a new type of AZT and ddU phosphoramidate diesters containing various combinations of 2-, 3-, 4-aminopyridine and 2-, 3-, 4-hydroxypyridine moieties attached to the phosphorus center, as potential anti-HIV pro-nucleotides. Depending on the pK_a values of the aminopyridines and the hydroxypyridines used, alternative synthetic strategies based on H-phosphonate chem. were developed for their preparation Synthetic aspects of these transformations and the biol. activity of the synthesized compounds are discussed. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Application of 626-64-2).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. In contrast to benzene, Pyridine’s electron density is not evenly distributed over the ring, reflecting the negative inductive effect of the nitrogen atom. Pyridine, its benzo and pyridine-based compounds play diverse roles in organic chemistry. Pyridine-based materials are valued for their optical and physical properties as well as their medical potential. Application of 626-64-2

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Oxidative Condensations To Form Benzimidazole-Substituted Potassium Organotrifluoroborates was written by Molander, Gary A.;Ajayi, Kehinde. And the article was included in Organic Letters in 2012.Quality Control of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde This article mentions the following:

A library of benzimidazole-substituted potassium organotrifluoroborates was prepared via the condensation of various potassium formyl-substituted aryl- and heteroaryltrifluoroborates with aromatic 1,2-diamines under oxidative conditions. The efficient Suzuki-Miyaura cross-coupling of products thus formed to various aryl and heteroaryl bromides was achieved in good yields. The method allows the facile preparation of benzimidazole-containing triarom. products in two steps from simple potassium formyl substituted aryl- or heteroaryltrifluoroborates. In the experiment, the researchers used many compounds, for example, 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde (cas: 1073354-14-9Quality Control of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde).

5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde (cas: 1073354-14-9) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Several pyridine derivatives play important roles in biological systems. While its biosynthesis is not fully understood, nicotinic acid (vitamin B3) occurs in some bacteria, fungi, and mammals.Quality Control of 5-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)picolinaldehyde

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem