Day: February 13, 2023

Interaction between nonpolar surfaces in solutions of cationic and nonionic surfactant mixtures was written by Ivanova, N. I.;Parfenova, A. M.;Amelina, E. A.. And the article was included in Vestnik Moskovskogo Universiteta, Seriya 2: Khimiya in 2007.Computed Properties of C17H30BrN This article mentions the following:

The influence of the concentration of cationic (dodecylpyridinium bromide) and nonionic (Triton X-100) surfactants on the interaction energy between hydrophobic silica particles in aqueous solutions was investigated. It is shown that the effect of synergism in mixed surfactant solutions manifests in a reduction of the surfactant concentration required to reach a given interaction energy in comparison to the concentration required to reach the same interaction energy in solutions of individual surfactants. The parameters of interaction between surfactant mols. in their mixtures were calculated based the Rosen model. Chain-chain interactions between nonionic and cationic surfactants are assumed to be the main reason for the observed synergism. In the experiment, the researchers used many compounds, for example, 1-Dodecylpyridin-1-ium bromide (cas: 104-73-4Computed Properties of C17H30BrN).

1-Dodecylpyridin-1-ium bromide (cas: 104-73-4) belongs to pyridine derivatives. Pyridine has a conjugated system of six 锜?electrons that are delocalized over the ring. The molecule is planar and, thus, follows the H鐪塩kel criteria for aromatic systems. Many analogues of pyridine are known where N is replaced by other heteroatoms . Substitution of one C閳ユ弻 in pyridine with a second N gives rise to the diazine heterocycles (C4H4N2), with the names pyridazine, pyrimidine, and pyrazine.Computed Properties of C17H30BrN

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

A facile and versatile electro-reductive system for hydrodefunctionalization under ambient conditions was written by Huang, Binbin;Guo, Lin;Xia, Wujiong. And the article was included in Green Chemistry in 2021.Category: pyridine-derivatives This article mentions the following:

A general electrochem. system for reductive hydrodefunctionalization is described, employing the inexpensive and easily available triethylamine (Et₃N) as a sacrificial reductant. This protocol is characterized by facile operation, sustainable conditions, and exceptionally wide substrate e.g., 9-bromophenanthrene scope covering the cleavage of C-halogen, N-S, N-C, O-S, O-C, C-C and C-N bonds. Notably, the selectivity and capability of reduction can be conveniently switched by simple incorporation or removal of an ethanol. as a co-solvent. In the experiment, the researchers used many compounds, for example, Ethyl 2-bromoisonicotinate (cas: 89978-52-9Category: pyridine-derivatives).

Ethyl 2-bromoisonicotinate (cas: 89978-52-9) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

MINDO/3-derived geometries and energies of alkylpyridines and the related N-methylpyridinium cations was written by Seeman, Jeffrey I.;Schug, John C.;Viers, Jimmy W.. And the article was included in Journal of Organic Chemistry in 1983.Category: pyridine-derivatives This article mentions the following:

The structures of 25 alkyl-substituted pyridines and their corresponding N-methylpyridinium cations were calculated by using GEOMO/RV, utilizing semiempirical all-valence electron (MINDO/3) self-consistent-field procedures. The effects of substituents on the ring systems were examined with particular attention focused on the changes in the aromatic ring bond angles. The energy of methylation for these 25 pyridines was calculated by subtracting the total energy of each pyridine-free base from the total energy of the corresponding N-methylpyridinium cation. An excellent correlation was obtained between this calculated energy of methylation and Brown’s exptl. heats of trifluoroboronations for the same pyridines; implications of this correlation are discussed. Nonadditive structural parameters and energetic effects are calculated and evaluated. In the experiment, the researchers used many compounds, for example, 2-Isopropylpyridine (cas: 644-98-4Category: pyridine-derivatives).

2-Isopropylpyridine (cas: 644-98-4) belongs to pyridine derivatives. Pyridines are an important class of heterocycles and occur in polysubstituted forms in many naturally occurring biologically active compounds, drug molecules and chiral ligands. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Mass Spectrometry Metabolomics of Hot Steep Malt Extracts and Association to Sensory Traits was written by Bettenhausen, Harmonie M.;Barr, Lindsay;Omerigic, Heather;Yao, Linxing;Heuberger, Adam L.. And the article was included in Journal of the American Society of Brewing Chemists in 2021.Category: pyridine-derivatives This article mentions the following:

In the brewing industry, there is value in defining sensory attributes of malt, and recent protocols have been developed that enable anal. of aroma and taste. One method, the “hot steep” is a hot water extract that is highly reproducible and able to distinguish malt flavor. However, the chem. of the hot steep extracts has not been fully defined, and the links between specific metabolites of the hot steep and their resulting sensory attributes remains largely unknown. Here, a study was designed to describe the metabolite chem. of hot steep extracts, and to characterize variation in this chem. and corresponding sensory by comparative anal. of 12 com. pale malts. Metabolomics was performed on the 12 malt hot steep extracts using three mass spectrometry platforms to detect volatiles (HS/SPME-GC-MS) and non-volatiles (UHPLC-TOF-MS and GC-MS). The anal. detected a total of 1,026 compounds including lipids, organic acids, esters, and Maillard Reaction Products (MRPs), of which 162 compounds (15.7%) varied among the 12 hot steep extracts Sensory of the 12 hot steep extracts was performed using an integrated Check All That Apply and quant. anal. method for 14 traits, and the data revealed cereal, grassy, and dough aromas were the attributes that varied. The metabolomics and sensory data were integrated using OPLS anal. The anal. revealed 64 compounds strongly associated with cereal aroma and included MRPs. A total of 23 compounds were strongly associated with grassy aroma including alkane/alkenes, benzenoids, organic acids, lipids, and fatty acid esters. Taken together, these data highlight the utility of the hot steep extract to differentiate malt for flavor and chem. and indicate specific compounds that drive the most dominant flavors observed in this population of pale malts. In the experiment, the researchers used many compounds, for example, Pyridin-4-ol (cas: 626-64-2Category: pyridine-derivatives).

Pyridin-4-ol (cas: 626-64-2) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Category: pyridine-derivatives

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Elaboration of a proprietary thymidylate kinase inhibitor motif towards anti-tuberculosis agents was written by Song, Lijun;Risseeuw, Martijn D. P.;Froeyen, Matheus;Karalic, Izet;Goeman, Jan;Cappoen, Davie;Van der Eycken, Johan;Cos, Paul;Munier-Lehmann, Helene;Van Calenbergh, Serge. And the article was included in Bioorganic & Medicinal Chemistry in 2016.Reference of 85838-94-4 This article mentions the following:

We report the design and synthesis of a series of non-nucleoside MtbTMPK inhibitors (1-14) based on the gram-pos. bacterial TMPK inhibitor hit compound 1. A practical synthesis was developed to access these analogs. Several compounds show promising MtbTMPK inhibitory potency and allow the establishment of a structure-activity relationship, which is helpful for further optimization. In the experiment, the researchers used many compounds, for example, tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4Reference of 85838-94-4).

tert-Butyl 5,6-dihydropyridine-1(2H)-carboxylate (cas: 85838-94-4) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Pyridine derivatives are also useful as small-molecule 浼?helix mimetics that inhibit protein-protein interactions, as well as functionally selective GABA ligands.Reference of 85838-94-4

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Merging Visible Light Photoredox Catalysis with Metal Catalyzed C-H Activations: On the Role of Oxygen and Superoxide Ions as Oxidants was written by Fabry, David C.;Rueping, Magnus. And the article was included in Accounts of Chemical Research in 2016.Name: 2-Phenoxypyridine This article mentions the following:

Visible light photoredox catalysis as a new alternative to conventionally applied regeneration/oxidation procedures was examined This account summarizes these recent advances in this expanding area and will highlight the new concept of merging distinct redox catalytic processes for C-H functionalizations through the application of visible light photoredox catalysis. Photoredox catalysis can be considered as catalytic electron-donating or -accepting processes, making use of visible-light absorbing homogeneous and heterogeneous metal-based catalysts, as well as organic dye sensitizers or polymers. As a consequence, photoredox catalysis is, in principle, an ideal tool for the recycling of any given metal catalyst via a coupled electron transfer (ET) process. Here we describe our first successful endeavors to address the above challenges by combining visible light photoredox catalysis with different ruthenium, rhodium, or palladium catalyzed C-H activations. Since only small amounts of the oxidant are generated and are immediately consumed in these transformations, side reactions of substrates or products can be avoided. Thus, usually oxidant-sensible substrates can be used, which makes these methods highly suitable for complex mol. structure syntheses. Moreover, mechanistic studies shed light on new reaction pathways, intermediates, and in situ generated species. The successful development of our dual catalysis concept, consisting of combined visible light photoredox catalysis and metal catalyzed C-H functionalization, provides many new opportunities for further explorations in the field of C-H functionalization. In the experiment, the researchers used many compounds, for example, 2-Phenoxypyridine (cas: 4783-68-0Name: 2-Phenoxypyridine).

2-Phenoxypyridine (cas: 4783-68-0) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Name: 2-Phenoxypyridine

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Stimuli-responsive supramolecular materials: photo-tunable properties and molecular recognition behavior was written by Huang, Cheng-Wei;Wu, Pei-Wei;Su, Wei-Hung;Zhu, Chao-Yuan;Kuo, Shiao-Wei. And the article was included in Polymer Chemistry in 2016.Related Products of 1075-62-3 This article mentions the following:

A new homopolymer of polystyrene (PS) presenting pendant diaminopyridine (DAP) moieties was prepared using controlled free radical polymerization and a CuAAC click reaction. Through directional complementary multiple H bonding, this PVB-DAP polymer underwent complexation with a thymine-functionalized azobenzene (Azo-T). The resulting supramol. complex exhibited amorphous and chromophoric behavior without microphase separation This strategy allowed the fabrication of homogeneous stimuli-responsive thin films with photocontrollable behavior through photoinduced trans-cis isomerization. The PVB-DAP/Azo-T supramol. complex facilitated the dispersion of an azo-dye through noncovalent interactions; the resulting complex was used to fabricate a surface relief grating displaying an interference pattern. The recordability and rewritability of these supramol. complexes suggest that they are promising materials for optical applications and therefore advance the pathway for supramol. development. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Related Products of 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). Reduced pyridines, namely tetrahydropyridines, dihydropyridines and piperidines, are found in numerous natural and synthetic compounds. The synthesis and reactivity of these compounds have often been driven by the fact many of these compounds have interesting and unique pharmacological properties. Related Products of 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

2,6-Diaminopyridine and Acrylamide-Based Copolymers with Upper Critical Solution Temperature-type Behavior in Aqueous Solution was written by Asadujjaman, Asad;Ahmadi, Vahid;Michel Claude Franc, Antoine;Bertin, Annabelle. And the article was included in Journal of Polymer Science, Part A: Polymer Chemistry in 2019.Application of 1075-62-3 This article mentions the following:

A novel copolymer based on supramol. motif 2,6-diaminopyridine and water-soluble acrylamide, poly[N-(6-acetamidopyridin-2-yl) acrylamide-co-acrylamide], was synthesized via reversible addition-fragmentation chain transfer (RAFT) polymerization with various monomer compositions The thermoresponsive behavior of the copolymers was studied by turbidimetry and dynamic light scattering. The obtained copolymers showed an upper critical solution temperature (UCST)-type phase transition behavior in water and electrolyte solution The phase transition temperature was found to increase with decreasing amount of acrylamide in the copolymer and increasing concentration of the solution Furthermore, the phase transition temperature varied in aqueous solutions of electrolytes according to the nature and concentration of the electrolyte in accordance with the Hoffmeister series. A dramatic solvent isotope effect on the transition temperature was observed in this study, as the transition temperature was almost 10-12 鎺矯 higher in D₂O than in H₂O at the same concentration and acrylamide composition The size of the aggregates below the transition temperature was larger in D₂O compared to that in H₂O that can be explained by deuterium isotope effect. The thermoresponsive behavior of the copolymers was also investigated in different cell medium and found to be exhibited UCST-type phase transition behavior in different cell medium. Such behavior of the copolymers can be useful in many applications including biomedical, microfluidics, optical materials, and in drug delivery. In the experiment, the researchers used many compounds, for example, N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3Application of 1075-62-3).

N-(6-Aminopyridin-2-yl)acetamide (cas: 1075-62-3) belongs to pyridine derivatives. Pyridine has a dipole moment and a weaker resonant stabilization than benzene (resonance energy 117 kJ璺痬ol閳? in pyridine vs. 150 kJ璺痬ol閳? in benzene). One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Application of 1075-62-3

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Photochemical C-H Silylation and Hydroxymethylation of Pyridines and Related Structures: Synthetic Scope and Mechanisms was written by Rammal, Fatima;Gao, Di;Boujnah, Sondes;Hussein, Aqeel A.;Lalevee, Jacques;Gaumont, Annie-Claude;Morlet-Savary, Fabrice;Lakhdar, Sami. And the article was included in ACS Catalysis in 2020.Application of 3718-65-8 This article mentions the following:

Described herein is an efficient approach for C-H silylation and hydroxymethylation of pyridines and related heterocycles by the combination of silanes or methanol with readily available N-methoxypyridinium ions with a low catalyst loading (2 mol %) under blue light irradiation The synthetic importance of the developed reactions is demonstrated by the synthesis of biol. relevant compounds ESR spectroscopy, quantum yield measurements, and d.-functional theory calculations allowed to understand reaction mechanisms of both photocatalytic reactions. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Application of 3718-65-8).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. Pyridine is diamagnetic and has a diamagnetic susceptibility of 閳?8.7 鑴?10閳? cm3璺痬ol閳?.The molecular electric dipole moment is 2.2 debyes. The standard enthalpy of formation is 100.2 kJ璺痬ol閳? in the liquid phase and 140.4 kJ璺痬ol閳? in the gas phase. Pyridine groups exist in countless molecules, and their applications include catalysis, drug design, molecular recognition, and natural product synthesis.Application of 3718-65-8

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem

Syntheses, crystallization and spectroscopic characterization of 3,5-lutidine N-oxide dehydrate was written by Merino-Garcia, Rosario;Hernandez-Anzaldo, Samuel;Reyes-Ortega, Yasmi. And the article was included in Journal of Visualized Experiments in 2018.Safety of 3,5-Dimethylpyridine 1-oxide This article mentions the following:

3,5-Lutidine N-oxide dehydrate was prepared from 3,5-dimethylpyridine, which reacted with H₂O₂, followed by crystallization The X-ray suitable crystals of 3,5-lutidine N-oxide dehydrate were possible due to the stabilization of the neg. charge in the oxygen by the presence of two water mols. where the hydrogen atoms donate pos. charge into the ring; such water mols. serve well to construct a supramol. interaction. The hydrated mols. may be possible for the alk. system that was reached by adjusting the pH to 10. Importantly, the double Me substituted ring and a reaction time of 5 h made it a more versatile method and with wider chem. applications for future ring insertions. In the experiment, the researchers used many compounds, for example, 3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8Safety of 3,5-Dimethylpyridine 1-oxide).

3,5-Dimethylpyridine 1-oxide (cas: 3718-65-8) belongs to pyridine derivatives. The ring atoms in the pyridine molecule are sp2-hybridized. The nitrogen is involved in the 锜?bonding aromatic system using its unhybridized p orbital. The lone pair is in an sp2 orbital, projecting outward from the ring in the same plane as the 锜?bonds. One of the examples of pyridines is the well-known alkaloid lithoprimidine, which is an A3 adenosine receptor antagonist and N,N-dimethylaminopyridine (DMAP) analog, commonly used in organic synthesis.Safety of 3,5-Dimethylpyridine 1-oxide

Referemce:
Pyridine – Wikipedia,
Pyridine | C5H5N – PubChem